| Chain sequence(s) |
A: IPVKQADSGSSEEKQLYNKYPDAVATWLNPDPSQKQNLLAPQNAVSSEETNDFKQETLPSKSNESHDHMDDMDDEDDDDHVDSQDSIDSNDSDDVDDTDDSHQSDESHHSDESDELVTDFPTDLPATEVFTPVVPTVDTYDGRGDSVVYGLRSKSKKFRRPDIQYPDATDEDITSHMESEELNGAYKAIPVAQDLNAPSDWDSRGKDSYETSQLDDQSAETHSHKQSRLYKRKANDESNEHSDVIDSQELSKVSREFHSHEFHSHEDMLVVDPKSKEEDKHLKFRISHELDSASSEVN
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:02)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:02)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:02)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:02)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:02)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:01:53)
[INFO] Main: Simulation completed successfully. (00:01:55)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | I | A | 2.1321 | |
| 2 | P | A | 0.9969 | |
| 3 | V | A | 1.0272 | |
| 4 | K | A | -1.4656 | |
| 5 | Q | A | -2.0717 | |
| 6 | A | A | -1.7705 | |
| 7 | D | A | -2.5798 | |
| 8 | S | A | -1.5531 | |
| 9 | G | A | -1.7305 | |
| 10 | S | A | -2.0235 | |
| 11 | S | A | -2.4919 | |
| 12 | E | A | -3.5127 | |
| 13 | E | A | -3.4343 | |
| 14 | K | A | -3.2362 | |
| 15 | Q | A | -2.6795 | |
| 16 | L | A | -0.3319 | |
| 17 | Y | A | 0.2246 | |
| 18 | N | A | -1.5564 | |
| 19 | K | A | -1.4148 | |
| 20 | Y | A | 0.1860 | |
| 21 | P | A | -0.6532 | |
| 22 | D | A | -1.3399 | |
| 23 | A | A | 0.2821 | |
| 24 | V | A | 1.5798 | |
| 25 | A | A | 0.6119 | |
| 26 | T | A | 0.1914 | |
| 27 | W | A | 1.4508 | |
| 28 | L | A | 1.5553 | |
| 29 | N | A | -0.5867 | |
| 30 | P | A | -1.3925 | |
| 31 | D | A | -2.7455 | |
| 32 | P | A | -2.5887 | |
| 33 | S | A | -2.4109 | |
| 34 | Q | A | -2.6822 | |
| 35 | K | A | -2.6188 | |
| 36 | Q | A | -2.1237 | |
| 37 | N | A | -1.4256 | |
| 38 | L | A | 0.5663 | |
| 39 | L | A | 0.9235 | |
| 40 | A | A | -0.2015 | |
| 41 | P | A | -0.6906 | |
| 42 | Q | A | -1.2541 | |
| 43 | N | A | -1.4288 | |
| 44 | A | A | -0.1903 | |
| 45 | V | A | 0.8114 | |
| 46 | S | A | -0.4548 | |
| 47 | S | A | -1.2745 | |
| 48 | E | A | -2.8294 | |
| 49 | E | A | -3.5003 | |
| 50 | T | A | -2.4561 | |
| 51 | N | A | -2.6346 | |
| 52 | D | A | -2.4505 | |
| 53 | F | A | -0.8267 | |
| 54 | K | A | -2.6445 | |
| 55 | Q | A | -2.3829 | |
| 56 | E | A | -2.2502 | |
| 57 | T | A | -0.9301 | |
| 58 | L | A | 0.3909 | |
| 59 | P | A | -0.3969 | |
| 60 | S | A | -0.9874 | |
| 61 | K | A | -2.3929 | |
| 62 | S | A | -2.3754 | |
| 63 | N | A | -2.9707 | |
| 64 | E | A | -3.3801 | |
| 65 | S | A | -2.6328 | |
| 66 | H | A | -2.8223 | |
| 67 | D | A | -2.9788 | |
| 68 | H | A | -2.4587 | |
| 69 | M | A | -1.3433 | |
| 70 | D | A | -2.6160 | |
| 71 | D | A | -2.7487 | |
| 72 | M | A | -1.8590 | |
| 73 | D | A | -3.6553 | |
| 74 | D | A | -4.2394 | |
| 75 | E | A | -4.6657 | |
| 76 | D | A | -4.9871 | |
| 77 | D | A | -4.7951 | |
| 78 | D | A | -4.2656 | |
| 79 | D | A | -3.5250 | |
| 80 | H | A | -2.0527 | |
| 81 | V | A | -0.4780 | |
| 82 | D | A | -1.9472 | |
| 83 | S | A | -1.8142 | |
| 84 | Q | A | -2.2849 | |
| 85 | D | A | -2.4525 | |
| 86 | S | A | -0.8681 | |
| 87 | I | A | 0.2834 | |
| 88 | D | A | -1.4314 | |
| 89 | S | A | -1.6649 | |
| 90 | N | A | -2.5056 | |
| 91 | D | A | -2.9456 | |
| 92 | S | A | -2.5055 | |
| 93 | D | A | -2.9421 | |
| 94 | D | A | -2.2981 | |
| 95 | V | A | -0.8821 | |
| 96 | D | A | -2.5836 | |
| 97 | D | A | -2.9492 | |
| 98 | T | A | -2.5689 | |
| 99 | D | A | -3.5317 | |
| 100 | D | A | -3.4635 | |
| 101 | S | A | -2.4874 | |
| 102 | H | A | -2.7206 | |
| 103 | Q | A | -2.8775 | |
| 104 | S | A | -2.5411 | |
| 105 | D | A | -3.4493 | |
| 106 | E | A | -3.4023 | |
| 107 | S | A | -2.4816 | |
| 108 | H | A | -2.5883 | |
| 109 | H | A | -2.6802 | |
| 110 | S | A | -2.5106 | |
| 111 | D | A | -3.5271 | |
| 112 | E | A | -3.8005 | |
| 113 | S | A | -2.8645 | |
| 114 | D | A | -2.8301 | |
| 115 | E | A | -1.7288 | |
| 116 | L | A | 0.6629 | |
| 117 | V | A | 1.4061 | |
| 118 | T | A | 0.7291 | |
| 119 | D | A | -0.1833 | |
| 120 | F | A | 1.0676 | |
| 121 | P | A | -0.1211 | |
| 122 | T | A | -0.3744 | |
| 123 | D | A | -0.9248 | |
| 124 | L | A | 0.6902 | |
| 125 | P | A | -0.2425 | |
| 126 | A | A | -0.2187 | |
| 127 | T | A | 0.0487 | |
| 128 | E | A | -0.4088 | |
| 129 | V | A | 1.7619 | |
| 130 | F | A | 2.3990 | |
| 131 | T | A | 1.7777 | |
| 132 | P | A | 1.8325 | |
| 133 | V | A | 2.7076 | |
| 134 | V | A | 2.6482 | |
| 135 | P | A | 1.2933 | |
| 136 | T | A | 0.9150 | |
| 137 | V | A | 1.1837 | |
| 138 | D | A | -0.8463 | |
| 139 | T | A | -0.4243 | |
| 140 | Y | A | -0.2897 | |
| 141 | D | A | -2.1305 | |
| 142 | G | A | -2.2531 | |
| 143 | R | A | -2.9905 | |
| 144 | G | A | -2.4210 | |
| 145 | D | A | -1.9009 | |
| 146 | S | A | 0.1152 | |
| 147 | V | A | 2.3259 | |
| 148 | V | A | 3.1518 | |
| 149 | Y | A | 2.7235 | |
| 150 | G | A | 1.4703 | |
| 151 | L | A | 0.8862 | |
| 152 | R | A | -1.5875 | |
| 153 | S | A | -1.7987 | |
| 154 | K | A | -2.9087 | |
| 155 | S | A | -2.3825 | |
| 156 | K | A | -2.8182 | |
| 157 | K | A | -2.6264 | |
| 158 | F | A | -0.8491 | |
| 159 | R | A | -2.8313 | |
| 160 | R | A | -2.7457 | |
| 161 | P | A | -1.8738 | |
| 162 | D | A | -1.8854 | |
| 163 | I | A | 0.5221 | |
| 164 | Q | A | -0.4572 | |
| 165 | Y | A | 0.4607 | |
| 166 | P | A | -0.5972 | |
| 167 | D | A | -1.9691 | |
| 168 | A | A | -1.3663 | |
| 169 | T | A | -2.1608 | |
| 170 | D | A | -3.1344 | |
| 171 | E | A | -3.0969 | |
| 172 | D | A | -2.2158 | |
| 173 | I | A | 0.2600 | |
| 174 | T | A | -0.2248 | |
| 175 | S | A | -0.4691 | |
| 176 | H | A | -0.8843 | |
| 177 | M | A | -0.6198 | |
| 178 | E | A | -2.1261 | |
| 179 | S | A | -2.1464 | |
| 180 | E | A | -2.9013 | |
| 181 | E | A | -2.4151 | |
| 182 | L | A | -0.5647 | |
| 183 | N | A | -1.2449 | |
| 184 | G | A | -0.7114 | |
| 185 | A | A | -0.1140 | |
| 186 | Y | A | 0.5249 | |
| 187 | K | A | -0.5241 | |
| 188 | A | A | 0.7575 | |
| 189 | I | A | 2.1282 | |
| 190 | P | A | 1.2419 | |
| 191 | V | A | 1.7464 | |
| 192 | A | A | 0.2884 | |
| 193 | Q | A | -1.4183 | |
| 194 | D | A | -1.6898 | |
| 195 | L | A | -0.2981 | |
| 196 | N | A | -1.2182 | |
| 197 | A | A | -0.9528 | |
| 198 | P | A | -0.8020 | |
| 199 | S | A | -1.2275 | |
| 200 | D | A | -1.8961 | |
| 201 | W | A | -0.9875 | |
| 202 | D | A | -2.4431 | |
| 203 | S | A | -2.2184 | |
| 204 | R | A | -3.1099 | |
| 205 | G | A | -3.0314 | |
| 206 | K | A | -3.1615 | |
| 207 | D | A | -2.9072 | |
| 208 | S | A | -1.3822 | |
| 209 | Y | A | -0.3725 | |
| 210 | E | A | -1.6599 | |
| 211 | T | A | -0.8989 | |
| 212 | S | A | -0.9755 | |
| 213 | Q | A | -1.4685 | |
| 214 | L | A | -0.6103 | |
| 215 | D | A | -2.5896 | |
| 216 | D | A | -3.0503 | |
| 217 | Q | A | -2.6753 | |
| 218 | S | A | -1.8653 | |
| 219 | A | A | -1.5257 | |
| 220 | E | A | -2.2716 | |
| 221 | T | A | -1.6797 | |
| 222 | H | A | -1.9960 | |
| 223 | S | A | -2.0090 | |
| 224 | H | A | -2.4838 | |
| 225 | K | A | -3.2092 | |
| 226 | Q | A | -2.8745 | |
| 227 | S | A | -1.7970 | |
| 228 | R | A | -1.5602 | |
| 229 | L | A | 0.5639 | |
| 230 | Y | A | 0.1748 | |
| 231 | K | A | -2.1788 | |
| 232 | R | A | -3.1334 | |
| 233 | K | A | -3.3950 | |
| 234 | A | A | -2.6301 | |
| 235 | N | A | -3.1798 | |
| 236 | D | A | -3.6351 | |
| 237 | E | A | -3.4996 | |
| 238 | S | A | -2.7191 | |
| 239 | N | A | -2.9474 | |
| 240 | E | A | -3.2138 | |
| 241 | H | A | -2.5177 | |
| 242 | S | A | -1.5996 | |
| 243 | D | A | -1.0697 | |
| 244 | V | A | 1.2136 | |
| 245 | I | A | 1.4530 | |
| 246 | D | A | -0.8906 | |
| 247 | S | A | -1.2635 | |
| 248 | Q | A | -2.3717 | |
| 249 | E | A | -2.0733 | |
| 250 | L | A | -0.0323 | |
| 251 | S | A | -0.4315 | |
| 252 | K | A | -1.0112 | |
| 253 | V | A | 0.1755 | |
| 254 | S | A | -1.1103 | |
| 255 | R | A | -2.1577 | |
| 256 | E | A | -1.8874 | |
| 257 | F | A | -0.1523 | |
| 258 | H | A | -1.4459 | |
| 259 | S | A | -1.1708 | |
| 260 | H | A | -1.6094 | |
| 261 | E | A | -1.8741 | |
| 262 | F | A | 0.0671 | |
| 263 | H | A | -1.3381 | |
| 264 | S | A | -1.6324 | |
| 265 | H | A | -2.3725 | |
| 266 | E | A | -2.8623 | |
| 267 | D | A | -1.7576 | |
| 268 | M | A | 1.0138 | |
| 269 | L | A | 2.4187 | |
| 270 | V | A | 2.8907 | |
| 271 | V | A | 2.0717 | |
| 272 | D | A | -0.8461 | |
| 273 | P | A | -1.4798 | |
| 274 | K | A | -2.9039 | |
| 275 | S | A | -3.0177 | |
| 276 | K | A | -3.8371 | |
| 277 | E | A | -4.4817 | |
| 278 | E | A | -4.7202 | |
| 279 | D | A | -4.1299 | |
| 280 | K | A | -3.7574 | |
| 281 | H | A | -2.0345 | |
| 282 | L | A | -0.1307 | |
| 283 | K | A | -0.7804 | |
| 284 | F | A | 1.0690 | |
| 285 | R | A | -0.3793 | |
| 286 | I | A | 0.8430 | |
| 287 | S | A | -0.3212 | |
| 288 | H | A | -1.4155 | |
| 289 | E | A | -1.8677 | |
| 290 | L | A | -0.5849 | |
| 291 | D | A | -1.7593 | |
| 292 | S | A | -0.9291 | |
| 293 | A | A | -0.7367 | |
| 294 | S | A | -0.8862 | |
| 295 | S | A | -0.8762 | |
| 296 | E | A | -1.4379 | |
| 297 | V | A | 0.1870 | |
| 298 | N | A | -0.8980 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine