| Chain sequence(s) |
A: DELAFSPPFYPSPWANGQGEWAEAYQRAVAIVSQMTLDEKVNLTTGTGWELEKCVGQTGGVPRLNIGGMCLQDSPLGIRDSDYNSAFPAGVNVAATWDKNLAYLRGQAMGQEFSDKGIDVQLGPAAGPLGRSPDGGRNWEGFSPDPALTGVLFAETIKGIQDAGVVATAKHYILNEQEHFRQVAEAAGYGFNISDTISSNVDDKTIHEMYLWPFADAVRAGVGAIMCSYNQINNSYGCQNSYTLNKLLKAELGFQGFVMSDWGAHHSGVGSALAGLDMSMPGDITFDSATSFWGTNLTIAVLNGTVPQWRVDDMAVRIMAAYYKVGRDRLYQPPNFSSWTRDEYGFKYFYPQEGPYEKVNHFVNVQRNHSEVIRKLGADSTVLLKNNNALPLTGKERKVAILGEDAGSNSYGANGCSDRGCDNGTLAMAWGSGTAEFPYLVTPEQAIQAEVLKHKGSVYAITDNWALSQVETLAKQASVSLVFVNSDAGEGYISVDGNEGDRNNLTLWKNGDNLIKAAANNCNNTIVVIHSVGPVLVDEWYDHPNVTAILWAGLPGQESGNSLADVLYGRVNPGAKSPFTWGKTREAYGDYLVRELNNGNGAPQDDFSEGVFIDYRGFDKRNETPIYEFGHGLSYTTFNYSGLHIQVLNASSNAQVATETGAAPTFGQVGNASDYVYPEGLTRISKFIYPWLNSTDLKASSGDPYYGVDTAEHVPEGATDGSPQPVLPAGGGSGGNPRLYDELIRVSVTVKNTGRVAGDAVPQLYVSLGGPNEPKVVLRKFDRLTLKPSEETVWTTTLTRRDLSNWDVAAQDWVITSYPKKVHVGSSSRQLPLHAALPKVQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Mutated residues | VK441A,LR440A,YR411A,YM459A,IT284A,VI647A,FR5A,AR4A,SQ6A,FR9A,YR705A,VR808A,VK793A,YR439A |
| Energy difference between WT (input) and mutated protein (by FoldX) | -4.88409 kcal/mol |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:01)
[INFO] FoldX: Building mutant model (00:03:12)
[INFO] FoldX: Starting FoldX energy minimalization (00:08:21)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:11:16)
[INFO] Main: Simulation completed successfully. (00:11:24)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | D | A | -2.4591 | |
| 2 | E | A | -2.7690 | |
| 3 | L | A | -1.7713 | |
| 4 | R | A | -2.5536 | mutated: AR4A |
| 5 | R | A | -2.6960 | mutated: FR5A |
| 6 | Q | A | 0.0000 | mutated: SQ6A |
| 7 | P | A | -0.9596 | |
| 8 | P | A | -0.8823 | |
| 9 | R | A | -0.6156 | mutated: FR9A |
| 10 | Y | A | -0.5273 | |
| 11 | P | A | 0.0000 | |
| 12 | S | A | 0.0000 | |
| 13 | P | A | -0.2016 | |
| 14 | W | A | -0.2611 | |
| 15 | A | A | 0.0000 | |
| 16 | N | A | -1.7216 | |
| 17 | G | A | 0.0000 | |
| 18 | Q | A | -2.0205 | |
| 19 | G | A | -2.1077 | |
| 20 | E | A | -2.6374 | |
| 21 | W | A | 0.0000 | |
| 22 | A | A | -2.5068 | |
| 23 | E | A | -3.0779 | |
| 24 | A | A | 0.0000 | |
| 25 | Y | A | -1.9518 | |
| 26 | Q | A | -2.4449 | |
| 27 | R | A | -2.3429 | |
| 28 | A | A | 0.0000 | |
| 29 | V | A | -0.9637 | |
| 30 | A | A | -0.9109 | |
| 31 | I | A | 0.0000 | |
| 32 | V | A | 0.0000 | |
| 33 | S | A | -0.9421 | |
| 34 | Q | A | -1.5577 | |
| 35 | M | A | 0.0000 | |
| 36 | T | A | -0.9332 | |
| 37 | L | A | 0.0000 | |
| 38 | D | A | -0.4031 | |
| 39 | E | A | -0.7671 | |
| 40 | K | A | 0.0000 | |
| 41 | V | A | 0.0000 | |
| 42 | N | A | -0.4040 | |
| 43 | L | A | 0.0000 | |
| 44 | T | A | 0.0000 | |
| 45 | T | A | 0.0000 | |
| 46 | G | A | 0.0000 | |
| 47 | T | A | 0.0000 | |
| 48 | G | A | 0.0000 | |
| 49 | W | A | 0.4730 | |
| 50 | E | A | -0.0067 | |
| 51 | L | A | 0.0000 | |
| 52 | E | A | -0.4004 | |
| 53 | K | A | -0.4730 | |
| 54 | C | A | 0.0000 | |
| 55 | V | A | -0.0384 | |
| 56 | G | A | 0.0000 | |
| 57 | Q | A | -0.3070 | |
| 58 | T | A | 0.0000 | |
| 59 | G | A | -0.4013 | |
| 60 | G | A | -0.8719 | |
| 61 | V | A | 0.0000 | |
| 62 | P | A | -1.6284 | |
| 63 | R | A | -2.3126 | |
| 64 | L | A | -1.4750 | |
| 65 | N | A | -1.7900 | |
| 66 | I | A | -1.0962 | |
| 67 | G | A | -0.8671 | |
| 68 | G | A | -0.4478 | |
| 69 | M | A | 0.0000 | |
| 70 | C | A | 0.0000 | |
| 71 | L | A | 0.0000 | |
| 72 | Q | A | 0.0000 | |
| 73 | D | A | 0.0000 | |
| 74 | S | A | 0.0000 | |
| 75 | P | A | 0.0000 | |
| 76 | L | A | 0.0000 | |
| 77 | G | A | 0.0000 | |
| 78 | I | A | 0.0000 | |
| 79 | R | A | -0.7124 | |
| 80 | D | A | -0.9167 | |
| 81 | S | A | 0.0000 | |
| 82 | D | A | -0.6603 | |
| 83 | Y | A | -0.0364 | |
| 84 | N | A | 0.0000 | |
| 85 | S | A | 0.0000 | |
| 86 | A | A | 0.0000 | |
| 87 | F | A | 0.0000 | |
| 88 | P | A | 0.0000 | |
| 89 | A | A | 0.0000 | |
| 90 | G | A | 0.0000 | |
| 91 | V | A | 0.0000 | |
| 92 | N | A | 0.0000 | |
| 93 | V | A | 0.0000 | |
| 94 | A | A | 0.0000 | |
| 95 | A | A | 0.0000 | |
| 96 | T | A | 0.0000 | |
| 97 | W | A | 0.0000 | |
| 98 | D | A | -1.2722 | |
| 99 | K | A | -1.7423 | |
| 100 | N | A | -1.6460 | |
| 101 | L | A | -0.7227 | |
| 102 | A | A | 0.0000 | |
| 103 | Y | A | -0.7648 | |
| 104 | L | A | 0.1524 | |
| 105 | R | A | 0.0000 | |
| 106 | G | A | 0.0000 | |
| 107 | Q | A | -0.8679 | |
| 108 | A | A | -0.5069 | |
| 109 | M | A | 0.0000 | |
| 110 | G | A | 0.0000 | |
| 111 | Q | A | -1.4137 | |
| 112 | E | A | 0.0000 | |
| 113 | F | A | 0.0000 | |
| 114 | S | A | -0.6219 | |
| 115 | D | A | -1.3363 | |
| 116 | K | A | 0.0000 | |
| 117 | G | A | 0.0000 | |
| 118 | I | A | 0.0000 | |
| 119 | D | A | 0.0000 | |
| 120 | V | A | 0.0000 | |
| 121 | Q | A | 0.0000 | |
| 122 | L | A | 0.0000 | |
| 123 | G | A | 0.0000 | |
| 124 | P | A | 0.0000 | |
| 125 | A | A | 0.0000 | |
| 126 | A | A | 0.0000 | |
| 127 | G | A | -0.0997 | |
| 128 | P | A | 0.0000 | |
| 129 | L | A | 0.0000 | |
| 130 | G | A | -0.1216 | |
| 131 | R | A | 0.0000 | |
| 132 | S | A | 0.0000 | |
| 133 | P | A | 0.0000 | |
| 134 | D | A | 0.0000 | |
| 135 | G | A | 0.0000 | |
| 136 | G | A | 0.0000 | |
| 137 | R | A | 0.0000 | |
| 138 | N | A | -0.1959 | |
| 139 | W | A | 0.0000 | |
| 140 | E | A | 0.0000 | |
| 141 | G | A | 0.0000 | |
| 142 | F | A | 0.0000 | |
| 143 | S | A | 0.0000 | |
| 144 | P | A | 0.0000 | |
| 145 | D | A | 0.0000 | |
| 146 | P | A | 0.0000 | |
| 147 | A | A | 0.0000 | |
| 148 | L | A | 0.0000 | |
| 149 | T | A | 0.0000 | |
| 150 | G | A | 0.0000 | |
| 151 | V | A | -0.0876 | |
| 152 | L | A | 0.0000 | |
| 153 | F | A | 0.0000 | |
| 154 | A | A | -0.6546 | |
| 155 | E | A | -0.9808 | |
| 156 | T | A | 0.0000 | |
| 157 | I | A | 0.0000 | |
| 158 | K | A | -1.4897 | |
| 159 | G | A | 0.0000 | |
| 160 | I | A | 0.0000 | |
| 161 | Q | A | -1.4586 | |
| 162 | D | A | -2.2491 | |
| 163 | A | A | -1.1150 | |
| 164 | G | A | 0.0000 | |
| 165 | V | A | 0.0000 | |
| 166 | V | A | 0.0000 | |
| 167 | A | A | 0.0000 | |
| 168 | T | A | 0.0000 | |
| 169 | A | A | 0.0000 | |
| 170 | K | A | 0.0000 | |
| 171 | H | A | 0.0000 | |
| 172 | Y | A | 0.0000 | |
| 173 | I | A | 0.0000 | |
| 174 | L | A | 0.0000 | |
| 175 | N | A | 0.0000 | |
| 176 | E | A | 0.0000 | |
| 177 | Q | A | 0.0000 | |
| 178 | E | A | 0.0000 | |
| 179 | H | A | -0.5224 | |
| 180 | F | A | 0.0000 | |
| 181 | R | A | 0.0000 | |
| 182 | Q | A | -0.1080 | |
| 183 | V | A | 0.0220 | |
| 184 | A | A | -0.1118 | |
| 185 | E | A | 0.0017 | |
| 186 | A | A | 0.0000 | |
| 187 | A | A | -0.4349 | |
| 188 | G | A | -0.3856 | |
| 189 | Y | A | -0.1119 | |
| 190 | G | A | -0.5823 | |
| 191 | F | A | -0.8365 | |
| 192 | N | A | -1.6208 | |
| 193 | I | A | 0.0000 | |
| 194 | S | A | -1.0477 | |
| 195 | D | A | -0.9412 | |
| 196 | T | A | 0.0000 | |
| 197 | I | A | 0.0000 | |
| 198 | S | A | 0.0000 | |
| 199 | S | A | 0.0000 | |
| 200 | N | A | 0.0000 | |
| 201 | V | A | 0.0000 | |
| 202 | D | A | -1.6408 | |
| 203 | D | A | -1.4550 | |
| 204 | K | A | -1.6131 | |
| 205 | T | A | 0.0000 | |
| 206 | I | A | 0.0000 | |
| 207 | H | A | 0.0000 | |
| 208 | E | A | -0.4941 | |
| 209 | M | A | 0.0000 | |
| 210 | Y | A | 0.0000 | |
| 211 | L | A | 0.0000 | |
| 212 | W | A | 0.0000 | |
| 213 | P | A | 0.0000 | |
| 214 | F | A | 0.0000 | |
| 215 | A | A | 0.0000 | |
| 216 | D | A | -0.6753 | |
| 217 | A | A | 0.0000 | |
| 218 | V | A | 0.0000 | |
| 219 | R | A | -1.5277 | |
| 220 | A | A | 0.0000 | |
| 221 | G | A | -1.1416 | |
| 222 | V | A | 0.0000 | |
| 223 | G | A | 0.0000 | |
| 224 | A | A | 0.0000 | |
| 225 | I | A | 0.0000 | |
| 226 | M | A | 0.0000 | |
| 227 | C | A | 0.0000 | |
| 228 | S | A | 0.0000 | |
| 229 | Y | A | -0.0491 | |
| 230 | N | A | 0.0000 | |
| 231 | Q | A | 0.0000 | |
| 232 | I | A | 0.0000 | |
| 233 | N | A | -1.5338 | |
| 234 | N | A | -1.1655 | |
| 235 | S | A | -0.7806 | |
| 236 | Y | A | -0.2624 | |
| 237 | G | A | 0.0000 | |
| 238 | C | A | 0.0000 | |
| 239 | Q | A | -0.4179 | |
| 240 | N | A | 0.0000 | |
| 241 | S | A | 0.0000 | |
| 242 | Y | A | -0.1634 | |
| 243 | T | A | 0.0000 | |
| 244 | L | A | 0.0000 | |
| 245 | N | A | 0.0000 | |
| 246 | K | A | -0.2009 | |
| 247 | L | A | 0.0000 | |
| 248 | L | A | 0.0000 | |
| 249 | K | A | 0.0000 | |
| 250 | A | A | -0.0692 | |
| 251 | E | A | 0.0000 | |
| 252 | L | A | 0.0000 | |
| 253 | G | A | -0.5906 | |
| 254 | F | A | 0.0000 | |
| 255 | Q | A | 0.0000 | |
| 256 | G | A | 0.0000 | |
| 257 | F | A | 0.0000 | |
| 258 | V | A | 0.0000 | |
| 259 | M | A | 0.0000 | |
| 260 | S | A | 0.0000 | |
| 261 | D | A | -0.1724 | |
| 262 | W | A | -0.0056 | |
| 263 | G | A | -0.1274 | |
| 264 | A | A | 0.0000 | |
| 265 | H | A | 0.0000 | |
| 266 | H | A | -0.8385 | |
| 267 | S | A | -0.3118 | |
| 268 | G | A | 0.0077 | |
| 269 | V | A | 0.2048 | |
| 270 | G | A | -0.2866 | |
| 271 | S | A | 0.0000 | |
| 272 | A | A | 0.0000 | |
| 273 | L | A | 0.0000 | |
| 274 | A | A | 0.0000 | |
| 275 | G | A | 0.0000 | |
| 276 | L | A | 0.0000 | |
| 277 | D | A | 0.0000 | |
| 278 | M | A | 0.0000 | |
| 279 | S | A | 0.0000 | |
| 280 | M | A | 0.0000 | |
| 281 | P | A | 0.0000 | |
| 282 | G | A | 0.0000 | |
| 283 | D | A | 0.0000 | |
| 284 | T | A | 0.0860 | mutated: IT284A |
| 285 | T | A | 0.4026 | |
| 286 | F | A | 0.9555 | |
| 287 | D | A | -0.0727 | |
| 288 | S | A | -0.0894 | |
| 289 | A | A | -0.1298 | |
| 290 | T | A | -0.1006 | |
| 291 | S | A | 0.1654 | |
| 292 | F | A | 0.2130 | |
| 293 | W | A | 0.0000 | |
| 294 | G | A | 0.0000 | |
| 295 | T | A | -0.0943 | |
| 296 | N | A | -0.3625 | |
| 297 | L | A | 0.0000 | |
| 298 | T | A | 0.0000 | |
| 299 | I | A | 0.0000 | |
| 300 | A | A | 0.0000 | |
| 301 | V | A | 0.0000 | |
| 302 | L | A | -0.7020 | |
| 303 | N | A | -1.0493 | |
| 304 | G | A | -0.8754 | |
| 305 | T | A | -0.6011 | |
| 306 | V | A | 0.0000 | |
| 307 | P | A | -0.7265 | |
| 308 | Q | A | -1.1073 | |
| 309 | W | A | 0.0000 | |
| 310 | R | A | 0.0000 | |
| 311 | V | A | 0.0000 | |
| 312 | D | A | 0.0000 | |
| 313 | D | A | 0.0000 | |
| 314 | M | A | 0.0000 | |
| 315 | A | A | 0.0000 | |
| 316 | V | A | 0.0000 | |
| 317 | R | A | 0.0000 | |
| 318 | I | A | 0.0000 | |
| 319 | M | A | 0.0000 | |
| 320 | A | A | 0.0000 | |
| 321 | A | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | Y | A | -1.2180 | |
| 324 | K | A | -1.3685 | |
| 325 | V | A | -0.6330 | |
| 326 | G | A | -0.7551 | |
| 327 | R | A | 0.0000 | |
| 328 | D | A | -1.5484 | |
| 329 | R | A | -1.7211 | |
| 330 | L | A | -0.1316 | |
| 331 | Y | A | -0.5837 | |
| 332 | Q | A | -1.2668 | |
| 333 | P | A | -0.8953 | |
| 334 | P | A | 0.0000 | |
| 335 | N | A | 0.0000 | |
| 336 | F | A | 0.0000 | |
| 337 | S | A | 0.0000 | |
| 338 | S | A | 0.0000 | |
| 339 | W | A | -0.2097 | |
| 340 | T | A | -1.1372 | |
| 341 | R | A | -2.0127 | |
| 342 | D | A | -2.9119 | |
| 343 | E | A | -3.0085 | |
| 344 | Y | A | -1.4725 | |
| 345 | G | A | -1.1327 | |
| 346 | F | A | -0.4771 | |
| 347 | K | A | -1.2684 | |
| 348 | Y | A | -0.5270 | |
| 349 | F | A | 0.0000 | |
| 350 | Y | A | 0.2359 | |
| 351 | P | A | -0.5238 | |
| 352 | Q | A | -1.0860 | |
| 353 | E | A | -1.1081 | |
| 354 | G | A | -1.1254 | |
| 355 | P | A | -0.7310 | |
| 356 | Y | A | -0.0163 | |
| 357 | E | A | -1.7879 | |
| 358 | K | A | -2.2011 | |
| 359 | V | A | 0.0000 | |
| 360 | N | A | 0.0000 | |
| 361 | H | A | -0.9034 | |
| 362 | F | A | 0.0600 | |
| 363 | V | A | 0.0703 | |
| 364 | N | A | -1.2594 | |
| 365 | V | A | 0.0000 | |
| 366 | Q | A | -1.6098 | |
| 367 | R | A | -2.9340 | |
| 368 | N | A | -2.4163 | |
| 369 | H | A | 0.0000 | |
| 370 | S | A | -1.9331 | |
| 371 | E | A | -2.8056 | |
| 372 | V | A | -1.3434 | |
| 373 | I | A | 0.0000 | |
| 374 | R | A | -2.0145 | |
| 375 | K | A | -2.0066 | |
| 376 | L | A | 0.0000 | |
| 377 | G | A | 0.0000 | |
| 378 | A | A | 0.0000 | |
| 379 | D | A | 0.0000 | |
| 380 | S | A | 0.0000 | |
| 381 | T | A | 0.0000 | |
| 382 | V | A | 0.0000 | |
| 383 | L | A | 0.0000 | |
| 384 | L | A | 0.0000 | |
| 385 | K | A | -1.0048 | |
| 386 | N | A | -1.3913 | |
| 387 | N | A | -2.1944 | |
| 388 | N | A | -2.0539 | |
| 389 | A | A | -1.2358 | |
| 390 | L | A | 0.0000 | |
| 391 | P | A | -0.6844 | |
| 392 | L | A | 0.0000 | |
| 393 | T | A | -0.7051 | |
| 394 | G | A | 0.0000 | |
| 395 | K | A | -2.8179 | |
| 396 | E | A | -2.4435 | |
| 397 | R | A | -3.1923 | |
| 398 | K | A | -1.9905 | |
| 399 | V | A | 0.0000 | |
| 400 | A | A | 0.0000 | |
| 401 | I | A | 0.0000 | |
| 402 | L | A | 0.0000 | |
| 403 | G | A | 0.0000 | |
| 404 | E | A | -0.9083 | |
| 405 | D | A | 0.0000 | |
| 406 | A | A | 0.0000 | |
| 407 | G | A | 0.0000 | |
| 408 | S | A | -0.9963 | |
| 409 | N | A | -1.3080 | |
| 410 | S | A | -1.3723 | |
| 411 | R | A | -2.3410 | mutated: YR411A |
| 412 | G | A | -1.7842 | |
| 413 | A | A | -1.5152 | |
| 414 | N | A | -1.7659 | |
| 415 | G | A | -1.6767 | |
| 416 | C | A | 0.0000 | |
| 417 | S | A | -0.5940 | |
| 418 | D | A | -0.7125 | |
| 419 | R | A | 0.0000 | |
| 420 | G | A | -0.1462 | |
| 421 | C | A | -0.5996 | |
| 422 | D | A | 0.0000 | |
| 423 | N | A | -0.7935 | |
| 424 | G | A | 0.0000 | |
| 425 | T | A | 0.0000 | |
| 426 | L | A | 0.0000 | |
| 427 | A | A | 0.0000 | |
| 428 | M | A | 0.0000 | |
| 429 | A | A | 0.0000 | |
| 430 | W | A | 0.0000 | |
| 431 | G | A | 0.0000 | |
| 432 | S | A | -0.2011 | |
| 433 | G | A | 0.0000 | |
| 434 | T | A | 0.0000 | |
| 435 | A | A | 0.0000 | |
| 436 | E | A | -0.8777 | |
| 437 | F | A | 0.0000 | |
| 438 | P | A | -0.7586 | |
| 439 | R | A | -1.3463 | mutated: YR439A |
| 440 | R | A | -1.1282 | mutated: LR440A |
| 441 | K | A | -1.0318 | mutated: VK441A |
| 442 | T | A | 0.0000 | |
| 443 | P | A | 0.0000 | |
| 444 | E | A | -0.7864 | |
| 445 | Q | A | -1.1603 | |
| 446 | A | A | 0.0000 | |
| 447 | I | A | 0.0000 | |
| 448 | Q | A | -0.2869 | |
| 449 | A | A | -0.4152 | |
| 450 | E | A | 0.0000 | |
| 451 | V | A | 0.0000 | |
| 452 | L | A | -0.2704 | |
| 453 | K | A | -1.9033 | |
| 454 | H | A | -2.5400 | |
| 455 | K | A | -2.6610 | |
| 456 | G | A | -2.1917 | |
| 457 | S | A | -0.8425 | |
| 458 | V | A | 0.0804 | |
| 459 | M | A | 0.7316 | mutated: YM459A |
| 460 | A | A | -0.0708 | |
| 461 | I | A | 0.0000 | |
| 462 | T | A | -0.8365 | |
| 463 | D | A | -1.3655 | |
| 464 | N | A | 0.0000 | |
| 465 | W | A | 0.3947 | |
| 466 | A | A | -0.2485 | |
| 467 | L | A | -0.4192 | |
| 468 | S | A | -0.7044 | |
| 469 | Q | A | -1.4094 | |
| 470 | V | A | 0.0000 | |
| 471 | E | A | -2.1458 | |
| 472 | T | A | -1.6644 | |
| 473 | L | A | 0.0000 | |
| 474 | A | A | 0.0000 | |
| 475 | K | A | -3.0238 | |
| 476 | Q | A | -2.4825 | |
| 477 | A | A | -1.8090 | |
| 478 | S | A | -1.8043 | |
| 479 | V | A | 0.0000 | |
| 480 | S | A | 0.0000 | |
| 481 | L | A | 0.0000 | |
| 482 | V | A | 0.0000 | |
| 483 | F | A | 0.0000 | |
| 484 | V | A | 0.0000 | |
| 485 | N | A | 0.0000 | |
| 486 | S | A | 0.0000 | |
| 487 | D | A | 0.0000 | |
| 488 | A | A | 0.0000 | |
| 489 | G | A | 0.0000 | |
| 490 | E | A | 0.0000 | |
| 491 | G | A | 0.0000 | |
| 492 | Y | A | 0.7750 | |
| 493 | I | A | 0.3605 | |
| 494 | S | A | -0.4963 | |
| 495 | V | A | -0.9787 | |
| 496 | D | A | -2.1951 | |
| 497 | G | A | -1.6540 | |
| 498 | N | A | 0.0000 | |
| 499 | E | A | -0.8382 | |
| 500 | G | A | 0.0000 | |
| 501 | D | A | 0.0000 | |
| 502 | R | A | 0.0000 | |
| 503 | N | A | -2.2532 | |
| 504 | N | A | -1.7303 | |
| 505 | L | A | 0.0000 | |
| 506 | T | A | -0.6500 | |
| 507 | L | A | 0.0000 | |
| 508 | W | A | 0.0000 | |
| 509 | K | A | -0.9010 | |
| 510 | N | A | -0.7046 | |
| 511 | G | A | 0.0000 | |
| 512 | D | A | -1.4456 | |
| 513 | N | A | -1.1623 | |
| 514 | L | A | 0.0000 | |
| 515 | I | A | 0.0000 | |
| 516 | K | A | -1.7094 | |
| 517 | A | A | 0.0000 | |
| 518 | A | A | 0.0000 | |
| 519 | A | A | 0.0000 | |
| 520 | N | A | -2.2536 | |
| 521 | N | A | -2.3039 | |
| 522 | C | A | 0.0000 | |
| 523 | N | A | -2.1160 | |
| 524 | N | A | -1.5171 | |
| 525 | T | A | 0.0000 | |
| 526 | I | A | 0.0000 | |
| 527 | V | A | 0.0000 | |
| 528 | V | A | 0.0000 | |
| 529 | I | A | 0.0000 | |
| 530 | H | A | 0.0000 | |
| 531 | S | A | 0.0000 | |
| 532 | V | A | 0.0000 | |
| 533 | G | A | 0.0000 | |
| 534 | P | A | 0.0000 | |
| 535 | V | A | 0.0000 | |
| 536 | L | A | -0.8918 | |
| 537 | V | A | 0.0000 | |
| 538 | D | A | -2.6526 | |
| 539 | E | A | -2.5786 | |
| 540 | W | A | 0.0000 | |
| 541 | Y | A | -1.5551 | |
| 542 | D | A | -2.3945 | |
| 543 | H | A | -1.9261 | |
| 544 | P | A | -1.4159 | |
| 545 | N | A | -1.7441 | |
| 546 | V | A | 0.0000 | |
| 547 | T | A | 0.0000 | |
| 548 | A | A | 0.0000 | |
| 549 | I | A | 0.0000 | |
| 550 | L | A | 0.0000 | |
| 551 | W | A | 0.0000 | |
| 552 | A | A | 0.0000 | |
| 553 | G | A | 0.0000 | |
| 554 | L | A | 0.0000 | |
| 555 | P | A | 0.0000 | |
| 556 | G | A | 0.0000 | |
| 557 | Q | A | 0.0000 | |
| 558 | E | A | 0.0000 | |
| 559 | S | A | 0.0000 | |
| 560 | G | A | 0.0000 | |
| 561 | N | A | -0.7436 | |
| 562 | S | A | 0.0000 | |
| 563 | L | A | 0.0000 | |
| 564 | A | A | 0.0000 | |
| 565 | D | A | 0.0000 | |
| 566 | V | A | 0.0000 | |
| 567 | L | A | 0.0000 | |
| 568 | Y | A | -0.5617 | |
| 569 | G | A | -1.0562 | |
| 570 | R | A | -1.8716 | |
| 571 | V | A | -1.0275 | |
| 572 | N | A | -0.4075 | |
| 573 | P | A | 0.0000 | |
| 574 | G | A | 0.0000 | |
| 575 | A | A | 0.0000 | |
| 576 | K | A | -0.1558 | |
| 577 | S | A | 0.0000 | |
| 578 | P | A | 0.0000 | |
| 579 | F | A | 0.0000 | |
| 580 | T | A | 0.0000 | |
| 581 | W | A | 0.0000 | |
| 582 | G | A | 0.0000 | |
| 583 | K | A | -1.9474 | |
| 584 | T | A | -1.4779 | |
| 585 | R | A | 0.0000 | |
| 586 | E | A | -2.4681 | |
| 587 | A | A | 0.0000 | |
| 588 | Y | A | 0.0000 | |
| 589 | G | A | -1.4053 | |
| 590 | D | A | -2.1623 | |
| 591 | Y | A | -1.0787 | |
| 592 | L | A | 0.0000 | |
| 593 | V | A | 0.0000 | |
| 594 | R | A | -1.8528 | |
| 595 | E | A | -2.3749 | |
| 596 | L | A | -1.9610 | |
| 597 | N | A | -2.2568 | |
| 598 | N | A | -1.8186 | |
| 599 | G | A | -1.8490 | |
| 600 | N | A | -2.2907 | |
| 601 | G | A | -1.6054 | |
| 602 | A | A | 0.0000 | |
| 603 | P | A | 0.0000 | |
| 604 | Q | A | 0.0000 | |
| 605 | D | A | 0.0000 | |
| 606 | D | A | -1.3098 | |
| 607 | F | A | 0.0000 | |
| 608 | S | A | -0.5656 | |
| 609 | E | A | 0.0000 | |
| 610 | G | A | -0.3938 | |
| 611 | V | A | 0.0065 | |
| 612 | F | A | -0.0817 | |
| 613 | I | A | 0.0000 | |
| 614 | D | A | 0.0000 | |
| 615 | Y | A | 0.0000 | |
| 616 | R | A | 0.0000 | |
| 617 | G | A | 0.0000 | |
| 618 | F | A | 0.0000 | |
| 619 | D | A | -1.7980 | |
| 620 | K | A | -2.2363 | |
| 621 | R | A | -2.1423 | |
| 622 | N | A | -2.2583 | |
| 623 | E | A | -1.6196 | |
| 624 | T | A | -0.8444 | |
| 625 | P | A | -0.6903 | |
| 626 | I | A | -0.5325 | |
| 627 | Y | A | 0.0000 | |
| 628 | E | A | -0.4774 | |
| 629 | F | A | 0.0000 | |
| 630 | G | A | 0.0000 | |
| 631 | H | A | -0.3424 | |
| 632 | G | A | 0.0135 | |
| 633 | L | A | 0.3409 | |
| 634 | S | A | 0.2156 | |
| 635 | Y | A | -0.1300 | |
| 636 | T | A | 0.0000 | |
| 637 | T | A | -0.4095 | |
| 638 | F | A | -0.8275 | |
| 639 | N | A | -1.5397 | |
| 640 | Y | A | -1.0114 | |
| 641 | S | A | -0.8780 | |
| 642 | G | A | -0.6480 | |
| 643 | L | A | -0.6949 | |
| 644 | H | A | -1.1610 | |
| 645 | I | A | -0.1885 | |
| 646 | Q | A | -0.3030 | |
| 647 | I | A | 0.7581 | mutated: VI647A |
| 648 | L | A | 0.0117 | |
| 649 | N | A | -1.1360 | |
| 650 | A | A | -1.0804 | |
| 651 | S | A | -1.3082 | |
| 652 | S | A | -1.2973 | |
| 653 | N | A | -1.7205 | |
| 654 | A | A | -1.3079 | |
| 655 | Q | A | -1.5243 | |
| 656 | V | A | -0.8388 | |
| 657 | A | A | -0.7213 | |
| 658 | T | A | -0.9887 | |
| 659 | E | A | -1.9600 | |
| 660 | T | A | -1.3652 | |
| 661 | G | A | -1.1496 | |
| 662 | A | A | -0.6253 | |
| 663 | A | A | -0.5512 | |
| 664 | P | A | -0.3378 | |
| 665 | T | A | -0.4566 | |
| 666 | F | A | -0.5793 | |
| 667 | G | A | -1.3162 | |
| 668 | Q | A | -1.7725 | |
| 669 | V | A | -1.2387 | |
| 670 | G | A | -1.7012 | |
| 671 | N | A | -2.1751 | |
| 672 | A | A | -1.6922 | |
| 673 | S | A | -1.7187 | |
| 674 | D | A | -2.1800 | |
| 675 | Y | A | 0.0000 | |
| 676 | V | A | -0.7151 | |
| 677 | Y | A | -0.2112 | |
| 678 | P | A | -0.8824 | |
| 679 | E | A | -1.7842 | |
| 680 | G | A | -1.3921 | |
| 681 | L | A | -0.8904 | |
| 682 | T | A | -1.1019 | |
| 683 | R | A | -1.7321 | |
| 684 | I | A | -0.9309 | |
| 685 | S | A | -0.7935 | |
| 686 | K | A | -0.4782 | |
| 687 | F | A | -0.1761 | |
| 688 | I | A | 0.0000 | |
| 689 | Y | A | 0.1253 | |
| 690 | P | A | 0.0000 | |
| 691 | W | A | 0.0600 | |
| 692 | L | A | 0.0000 | |
| 693 | N | A | -1.4843 | |
| 694 | S | A | -1.3883 | |
| 695 | T | A | -1.7338 | |
| 696 | D | A | -2.3175 | |
| 697 | L | A | -1.7477 | |
| 698 | K | A | -2.6371 | |
| 699 | A | A | -1.6928 | |
| 700 | S | A | 0.0000 | |
| 701 | S | A | -1.5088 | |
| 702 | G | A | -1.5400 | |
| 703 | D | A | -1.6804 | |
| 704 | P | A | -1.5493 | |
| 705 | R | A | -2.2263 | mutated: YR705A |
| 706 | Y | A | -1.4124 | |
| 707 | G | A | -1.0962 | |
| 708 | V | A | -0.7255 | |
| 709 | D | A | -2.0789 | |
| 710 | T | A | -1.4594 | |
| 711 | A | A | -1.7760 | |
| 712 | E | A | -2.6737 | |
| 713 | H | A | -2.0589 | |
| 714 | V | A | -1.3715 | |
| 715 | P | A | -1.5545 | |
| 716 | E | A | -2.2818 | |
| 717 | G | A | -1.2393 | |
| 718 | A | A | 0.0000 | |
| 719 | T | A | -0.8207 | |
| 720 | D | A | -1.0386 | |
| 721 | G | A | -0.6966 | |
| 722 | S | A | -0.5752 | |
| 723 | P | A | -1.0084 | |
| 724 | Q | A | -1.0096 | |
| 725 | P | A | -1.0204 | |
| 726 | V | A | -0.4125 | |
| 727 | L | A | -0.1965 | |
| 728 | P | A | -0.2267 | |
| 729 | A | A | 0.0000 | |
| 730 | G | A | 0.0000 | |
| 731 | G | A | -0.4292 | |
| 732 | G | A | -0.7948 | |
| 733 | S | A | -1.1097 | |
| 734 | G | A | 0.0000 | |
| 735 | G | A | 0.0000 | |
| 736 | N | A | -0.5506 | |
| 737 | P | A | -0.9386 | |
| 738 | R | A | -1.2075 | |
| 739 | L | A | 0.0000 | |
| 740 | Y | A | -0.5312 | |
| 741 | D | A | 0.0000 | |
| 742 | E | A | -1.4190 | |
| 743 | L | A | 0.0000 | |
| 744 | I | A | 0.0000 | |
| 745 | R | A | -0.6839 | |
| 746 | V | A | 0.0000 | |
| 747 | S | A | -0.9587 | |
| 748 | V | A | 0.0000 | |
| 749 | T | A | -1.7128 | |
| 750 | V | A | 0.0000 | |
| 751 | K | A | -2.8134 | |
| 752 | N | A | 0.0000 | |
| 753 | T | A | -1.4646 | |
| 754 | G | A | -1.1224 | |
| 755 | R | A | -1.6627 | |
| 756 | V | A | -0.3405 | |
| 757 | A | A | -0.9474 | |
| 758 | G | A | -0.5258 | |
| 759 | D | A | -0.5567 | |
| 760 | A | A | 0.0000 | |
| 761 | V | A | 0.0000 | |
| 762 | P | A | 0.0000 | |
| 763 | Q | A | 0.0000 | |
| 764 | L | A | 0.0000 | |
| 765 | Y | A | 0.0000 | |
| 766 | V | A | 0.0000 | |
| 767 | S | A | -0.7601 | |
| 768 | L | A | 0.0000 | |
| 769 | G | A | -0.6528 | |
| 770 | G | A | -0.7421 | |
| 771 | P | A | -1.1658 | |
| 772 | N | A | -1.7425 | |
| 773 | E | A | -1.3151 | |
| 774 | P | A | 0.0000 | |
| 775 | K | A | -1.9303 | |
| 776 | V | A | -0.9686 | |
| 777 | V | A | 0.0000 | |
| 778 | L | A | 0.0000 | |
| 779 | R | A | -0.2658 | |
| 780 | K | A | -0.4711 | |
| 781 | F | A | 0.0000 | |
| 782 | D | A | -1.1829 | |
| 783 | R | A | -0.8965 | |
| 784 | L | A | -0.7253 | |
| 785 | T | A | -0.9788 | |
| 786 | L | A | 0.0000 | |
| 787 | K | A | -2.7362 | |
| 788 | P | A | -2.0085 | |
| 789 | S | A | -2.0473 | |
| 790 | E | A | -3.1442 | |
| 791 | E | A | -3.6019 | |
| 792 | T | A | -2.1865 | |
| 793 | K | A | -2.2196 | mutated: VK793A |
| 794 | W | A | 0.0000 | |
| 795 | T | A | -0.7840 | |
| 796 | T | A | -0.7208 | |
| 797 | T | A | -0.5705 | |
| 798 | L | A | 0.0000 | |
| 799 | T | A | -0.8158 | |
| 800 | R | A | -0.6540 | |
| 801 | R | A | 0.0000 | |
| 802 | D | A | 0.0000 | |
| 803 | L | A | 0.0000 | |
| 804 | S | A | 0.0000 | |
| 805 | N | A | 0.0000 | |
| 806 | W | A | 0.0000 | |
| 807 | D | A | -1.2412 | |
| 808 | R | A | -1.9721 | mutated: VR808A |
| 809 | A | A | -0.8476 | |
| 810 | A | A | -0.6670 | |
| 811 | Q | A | -1.0666 | |
| 812 | D | A | -0.7764 | |
| 813 | W | A | -0.1722 | |
| 814 | V | A | 0.2832 | |
| 815 | I | A | 0.2558 | |
| 816 | T | A | 0.2138 | |
| 817 | S | A | 0.0340 | |
| 818 | Y | A | 0.4703 | |
| 819 | P | A | -0.3923 | |
| 820 | K | A | -0.7602 | |
| 821 | K | A | -1.3173 | |
| 822 | V | A | 0.0000 | |
| 823 | H | A | -0.7521 | |
| 824 | V | A | 0.0000 | |
| 825 | G | A | 0.0000 | |
| 826 | S | A | -0.4418 | |
| 827 | S | A | 0.0000 | |
| 828 | S | A | 0.0000 | |
| 829 | R | A | -1.2001 | |
| 830 | Q | A | -1.0552 | |
| 831 | L | A | -0.5993 | |
| 832 | P | A | -0.7078 | |
| 833 | L | A | -0.5379 | |
| 834 | H | A | -1.1718 | |
| 835 | A | A | -0.7440 | |
| 836 | A | A | -0.7487 | |
| 837 | L | A | 0.0000 | |
| 838 | P | A | -0.7645 | |
| 839 | K | A | -1.6935 | |
| 840 | V | A | 0.0000 | |
| 841 | Q | A | -1.6484 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine