Project name: 5035daad835226c

Chain sequence(s)	H: QVQLQESGPGLVRPSQTLSLTCTVSGFTFTDFYMNWVRQPPGRGLEWIGFIRDKAKGYTTEYNPSVKGRVTMLVDTSKNQFSLRLSSVTAADTAVYYCAREGHTAAPFDYWGQGSLVTVSS; L: DIQMTQSPSSLSASVGDRVTITCKASQNIDKYLNWYQQKPGKAPKLLIYNTNNLQTGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCLQHISRPRTFGQGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:16)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:18)

• Minimal score value: -3.1002
• Maximal score value: 0.7452
• Average score: -0.6877
• Total score value: -156.7865

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.3840
2	V	H	-0.6383
3	Q	H	-1.2798
4	L	H	0.0000
5	Q	H	-1.2463
6	E	H	0.0000
7	S	H	-0.7245
8	G	H	-0.4789
9	P	H	-0.0812
10	G	H	0.2847
11	L	H	0.6446
12	V	H	0.0000
13	R	H	-2.1479
14	P	H	-1.5002
15	S	H	-1.4508
16	Q	H	-1.9982
17	T	H	-1.4668
18	L	H	0.0000
19	S	H	-0.9893
20	L	H	0.0000
21	T	H	-0.5140
22	C	H	0.0000
23	T	H	-1.1139
24	V	H	0.0000
25	S	H	-1.1310
26	G	H	-0.9451
27	F	H	-0.3794
28	T	H	-0.2523
29	F	H	0.0000
30	T	H	-1.0452
31	D	H	-1.1980
32	F	H	-0.3894
33	Y	H	-0.3661
34	M	H	0.0000
35	N	H	0.0000
36	W	H	0.0000
37	V	H	0.0000
38	R	H	0.0000
39	Q	H	-0.6783
40	P	H	-0.8178
41	P	H	-0.9445
42	G	H	-1.5166
43	R	H	-2.4588
44	G	H	-1.5876
45	L	H	0.0000
46	E	H	-0.7804
47	W	H	0.0000
48	I	H	0.0000
49	G	H	0.0000
50	F	H	0.0000
51	I	H	0.0000
52	R	H	-1.0325
53	D	H	-1.5776
54	K	H	-2.4116
55	A	H	-1.6837
56	K	H	-2.1704
57	G	H	-1.6530
58	Y	H	-0.9731
59	T	H	-0.7554
60	T	H	-0.2986
61	E	H	-0.7718
62	Y	H	-0.9027
63	N	H	0.0000
64	P	H	-1.5193
65	S	H	-0.9294
66	V	H	0.0000
67	K	H	-2.1930
68	G	H	-1.5571
69	R	H	-1.5021
70	V	H	0.0000
71	T	H	-0.8288
72	M	H	0.0000
73	L	H	0.2461
74	V	H	-0.1623
75	D	H	-1.2280
76	T	H	-1.3851
77	S	H	-1.4107
78	K	H	-2.3690
79	N	H	-1.8138
80	Q	H	-1.3857
81	F	H	0.0000
82	S	H	-0.3477
83	L	H	0.0000
84	R	H	-1.3686
85	L	H	0.0000
86	S	H	-1.1686
87	S	H	-1.1233
88	V	H	0.0000
89	T	H	-0.6014
90	A	H	-0.2542
91	A	H	0.0587
92	D	H	0.0000
93	T	H	0.2542
94	A	H	0.0000
95	V	H	0.4213
96	Y	H	0.0000
97	Y	H	0.0000
98	C	H	0.0000
99	A	H	0.0000
100	R	H	0.0590
101	E	H	0.0000
102	G	H	0.0000
103	H	H	-0.6623
104	T	H	-0.3856
105	A	H	0.0000
106	A	H	0.0000
107	P	H	0.0000
108	F	H	0.0000
109	D	H	-0.0903
110	Y	H	0.3379
111	W	H	-0.4064
112	G	H	0.0000
113	Q	H	-1.6767
114	G	H	0.0000
115	S	H	-0.1124
116	L	H	0.7452
117	V	H	0.0000
118	T	H	0.2350
119	V	H	0.0000
120	S	H	-0.5955
121	S	H	-0.7755
1	D	L	-2.6533
2	I	L	0.0000
3	Q	L	-2.2011
4	M	L	0.0000
5	T	L	-1.3474
6	Q	L	0.0000
7	S	L	-0.6659
8	P	L	-0.4881
9	S	L	-0.7842
10	S	L	-0.9565
11	L	L	-0.8061
12	S	L	-1.2145
13	A	L	-1.1521
14	S	L	-0.7806
15	V	L	0.3019
16	G	L	-0.7376
17	D	L	-1.8594
18	R	L	-2.3398
19	V	L	0.0000
20	T	L	-0.6641
21	I	L	0.0000
22	T	L	-0.8737
23	C	L	0.0000
24	K	L	-2.6959
25	A	L	0.0000
26	S	L	-2.1564
27	Q	L	-2.8205
28	N	L	-2.6030
29	I	L	0.0000
30	D	L	-2.1661
31	K	L	-2.2429
32	Y	L	-0.6668
33	L	L	0.0000
34	N	L	0.0000
35	W	L	0.0000
36	Y	L	0.0000
37	Q	L	0.0000
38	Q	L	-1.2586
39	K	L	-1.6720
40	P	L	-1.1949
41	G	L	-1.7176
42	K	L	-2.6178
43	A	L	-1.5434
44	P	L	0.0000
45	K	L	-1.2919
46	L	L	0.0000
47	L	L	0.0000
48	I	L	0.0000
49	Y	L	-0.3878
50	N	L	-0.9198
51	T	L	0.0000
52	N	L	-1.6931
53	N	L	-0.8368
54	L	L	-0.1619
55	Q	L	-0.3921
56	T	L	-0.2711
57	G	L	-0.4442
58	V	L	-0.2775
59	P	L	-0.3152
60	S	L	-0.3846
61	R	L	-0.7920
62	F	L	0.0000
63	S	L	-0.6097
64	G	L	-0.8071
65	S	L	-1.3629
66	G	L	-1.8726
67	S	L	-1.9758
68	G	L	-2.2850
69	T	L	-2.5649
70	D	L	-3.1002
71	F	L	0.0000
72	T	L	-0.9842
73	F	L	0.0000
74	T	L	0.0000
75	I	L	0.0000
76	S	L	-1.4863
77	S	L	-1.2841
78	L	L	0.0000
79	Q	L	-0.6758
80	P	L	-0.8665
81	E	L	-1.2283
82	D	L	0.0000
83	I	L	-0.3851
84	A	L	0.0000
85	T	L	-0.8273
86	Y	L	0.0000
87	Y	L	0.0000
88	C	L	0.0000
89	L	L	0.0000
90	Q	L	0.0000
91	H	L	-0.1810
92	I	L	0.0339
93	S	L	-0.8390
94	R	L	-2.1020
95	P	L	0.0000
96	R	L	0.0000
97	T	L	-1.0107
98	F	L	0.0000
99	G	L	0.0000
100	Q	L	-1.6281
101	G	L	0.0000
102	T	L	0.0000
103	K	L	-1.4135
104	V	L	0.0000
105	E	L	-1.7631
106	I	L	-0.8762
107	K	L	-1.6435