Chain sequence(s) |
A: SDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
input PDB |
Selected Chain(s) | A |
Distance of aggregation | 10 Å |
FoldX usage | Yes |
Dynamic mode | No |
Automated mutations | No |
Downloads | Download all the data |
Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01) [WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow to prevent this behavior) (00:00:01) [INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01) [INFO] runJob: Creating pdb object from: input.pdb (00:00:01) [INFO] FoldX: Starting FoldX energy minimalization (00:00:01) [INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:06:07) [INFO] Main: Simulation completed successfully. (00:06:09) |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
1 | S | A | -1.3114 | |
2 | D | A | -2.3854 | |
3 | T | A | -1.7159 | |
4 | G | A | -1.8589 | |
5 | R | A | -1.5745 | |
6 | P | A | 0.0000 | |
7 | F | A | 0.0000 | |
8 | V | A | 0.4648 | |
9 | E | A | 0.1167 | |
10 | M | A | -0.0373 | |
11 | Y | A | -0.1224 | |
12 | S | A | -0.7371 | |
13 | E | A | -1.0763 | |
14 | I | A | 1.0702 | |
15 | P | A | 0.4610 | |
16 | E | A | -0.1584 | |
17 | I | A | 0.5207 | |
18 | I | A | -0.2584 | |
19 | H | A | -1.3082 | |
20 | M | A | 0.0000 | |
21 | T | A | -2.2678 | |
22 | E | A | -2.2547 | |
23 | G | A | -2.3676 | |
24 | R | A | -3.6618 | |
25 | E | A | -3.2819 | |
26 | L | A | 0.0000 | |
27 | V | A | -0.1751 | |
28 | I | A | 0.0000 | |
29 | P | A | -0.8110 | |
30 | C | A | 0.0000 | |
31 | R | A | -1.5183 | |
32 | V | A | 0.0000 | |
33 | T | A | -0.9242 | |
34 | S | A | -1.1468 | |
35 | P | A | -1.3399 | |
36 | N | A | -1.3418 | |
37 | I | A | -0.5734 | |
38 | T | A | -0.3113 | |
39 | V | A | 0.0000 | |
40 | T | A | 0.0181 | |
41 | L | A | 0.0000 | |
42 | K | A | -0.0298 | |
43 | K | A | 0.4797 | |
44 | F | A | 1.9504 | |
45 | P | A | 1.3215 | |
46 | L | A | 1.4988 | |
47 | D | A | 0.2436 | |
48 | T | A | 0.3554 | |
49 | L | A | 0.0000 | |
50 | I | A | 1.3195 | |
51 | P | A | -0.2185 | |
52 | D | A | -1.9897 | |
53 | G | A | -1.6840 | |
54 | K | A | -2.5509 | |
55 | R | A | -1.9570 | |
56 | I | A | 0.0000 | |
57 | I | A | -0.1620 | |
58 | W | A | -0.0788 | |
59 | D | A | -1.1766 | |
60 | S | A | -1.8889 | |
61 | R | A | -2.7305 | |
62 | K | A | -2.2905 | |
63 | G | A | 0.0000 | |
64 | F | A | 0.0000 | |
65 | I | A | -0.4301 | |
66 | I | A | 0.0000 | |
67 | S | A | -2.2808 | |
68 | N | A | -3.0171 | |
69 | A | A | 0.0000 | |
70 | T | A | -0.8323 | |
71 | Y | A | 0.7435 | |
72 | K | A | -0.2032 | |
73 | E | A | 0.0000 | |
74 | I | A | 0.4271 | |
75 | G | A | 0.6404 | |
76 | L | A | 0.7626 | |
77 | L | A | 0.0000 | |
78 | T | A | 0.0000 | |
79 | C | A | 0.0000 | |
80 | E | A | -0.5117 | |
81 | A | A | 0.0000 | |
82 | T | A | -0.4041 | |
83 | V | A | -0.7797 | |
84 | N | A | -1.6111 | |
85 | G | A | -1.2443 | |
86 | H | A | -1.1109 | |
87 | L | A | -0.0251 | |
88 | Y | A | -0.4427 | |
89 | K | A | -0.9776 | |
90 | T | A | 0.0000 | |
91 | N | A | -0.3528 | |
92 | Y | A | 0.0000 | |
93 | L | A | 0.4528 | |
94 | T | A | 0.0000 | |
95 | H | A | -1.2176 | |
96 | R | A | -1.8469 | |
97 | Q | A | -2.2198 | |
98 | T | A | -1.2918 | |
99 | N | A | -0.3233 | |
100 | T | A | -0.2624 | |
101 | I | A | 0.0000 | |
102 | I | A | 0.0664 | |
103 | D | A | -0.5622 | |
104 | V | A | 0.0000 | |
105 | V | A | 0.1596 | |
106 | L | A | 0.0000 | |
107 | S | A | 0.1017 | |
108 | P | A | -0.0214 | |
109 | S | A | -0.6430 | |
110 | H | A | -1.3577 | |
111 | G | A | -1.5612 | |
112 | I | A | 0.0000 | |
113 | E | A | -2.8297 | |
114 | L | A | -2.6730 | |
115 | S | A | -2.8568 | |
116 | V | A | -2.2716 | |
117 | G | A | -2.3738 | |
118 | E | A | -2.7009 | |
119 | K | A | -2.9115 | |
120 | L | A | 0.0000 | |
121 | V | A | -0.0937 | |
122 | L | A | 0.0000 | |
123 | N | A | -0.0816 | |
124 | C | A | 0.0000 | |
125 | T | A | -0.5104 | |
126 | A | A | 0.0000 | |
127 | R | A | -0.6491 | |
128 | T | A | 0.0000 | |
129 | E | A | -1.3022 | |
130 | L | A | -1.0605 | |
131 | N | A | -1.6113 | |
132 | V | A | 0.0000 | |
133 | G | A | -1.4586 | |
134 | I | A | -1.5739 | |
135 | D | A | -2.2208 | |
136 | F | A | -1.5906 | |
137 | N | A | -2.1250 | |
138 | W | A | -1.4428 | |
139 | E | A | -1.8790 | |
140 | Y | A | 0.0000 | |
141 | P | A | -0.8991 | |
142 | S | A | 0.0000 | |
143 | S | A | -1.7121 | |
144 | K | A | -2.4347 | |
145 | H | A | -2.5191 | |
146 | Q | A | -2.8489 | |
147 | H | A | -3.1381 | |
148 | K | A | -2.9098 | |
149 | K | A | -1.7242 | |
150 | L | A | 0.3159 | |
151 | V | A | -0.1247 | |
152 | N | A | -2.0395 | |
153 | R | A | -3.2511 | |
154 | D | A | -3.3580 | |
155 | L | A | -2.2667 | |
156 | K | A | -2.5167 | |
157 | T | A | -1.7491 | |
158 | Q | A | -1.4724 | |
159 | S | A | -1.0951 | |
160 | G | A | -1.1764 | |
161 | S | A | -1.3997 | |
162 | E | A | -2.0234 | |
163 | M | A | -1.3535 | |
164 | K | A | -1.8930 | |
165 | K | A | -1.6756 | |
166 | F | A | 0.0000 | |
167 | L | A | -1.1561 | |
168 | S | A | 0.0000 | |
169 | T | A | -0.1921 | |
170 | L | A | 0.0000 | |
171 | T | A | 0.0000 | |
172 | I | A | 0.0000 | |
173 | D | A | -3.6757 | |
174 | G | A | -2.4214 | |
175 | V | A | 0.0000 | |
176 | T | A | -2.0612 | |
177 | R | A | -2.8968 | |
178 | S | A | -1.3832 | |
179 | D | A | 0.0000 | |
180 | Q | A | -1.8419 | |
181 | G | A | -0.0451 | |
182 | L | A | 1.2048 | |
183 | Y | A | 0.0000 | |
184 | T | A | -0.9420 | |
185 | C | A | 0.0000 | |
186 | A | A | 0.0000 | |
187 | A | A | 0.0000 | |
188 | S | A | -1.0712 | |
189 | S | A | -0.3239 | |
190 | G | A | 0.0003 | |
191 | L | A | 1.4250 | |
192 | M | A | 0.6835 | |
193 | T | A | -0.7591 | |
194 | K | A | -1.7387 | |
195 | K | A | -2.5420 | |
196 | N | A | -1.5092 | |
197 | S | A | -0.4670 | |
198 | T | A | 0.0000 | |
199 | F | A | 0.4683 | |
200 | V | A | 0.0000 | |
201 | R | A | -2.6213 | |
202 | V | A | 0.0000 | |
203 | H | A | -3.3906 | |
204 | E | A | -3.9751 | |
205 | K | A | -4.1606 | |
206 | D | A | -4.3188 | |
207 | K | A | -3.5204 | |
208 | T | A | -2.0616 | |
209 | H | A | -1.8595 | |
210 | T | A | -0.7398 | |
211 | C | A | 0.3385 | |
212 | P | A | -0.0001 | |
213 | P | A | 0.1080 | |
214 | C | A | 0.5363 | |
215 | P | A | -0.2662 | |
216 | A | A | -0.2738 | |
217 | P | A | -0.6525 | |
218 | E | A | -0.8422 | |
219 | L | A | 1.1796 | |
220 | L | A | 1.5580 | |
221 | G | A | 0.2997 | |
222 | G | A | -0.1389 | |
223 | P | A | 0.0000 | |
224 | S | A | 0.0796 | |
225 | V | A | 0.0000 | |
226 | F | A | 0.9821 | |
227 | L | A | 0.7607 | |
228 | F | A | 0.9658 | |
229 | P | A | -0.2604 | |
230 | P | A | 0.0000 | |
231 | K | A | -2.1838 | |
232 | P | A | -1.4982 | |
233 | K | A | -1.4400 | |
234 | D | A | -1.4568 | |
235 | T | A | 0.0000 | |
236 | L | A | 0.0000 | |
237 | M | A | 0.2087 | |
238 | I | A | 1.3444 | |
239 | S | A | 0.0010 | |
240 | R | A | -1.3426 | |
241 | T | A | -0.9216 | |
242 | P | A | 0.0000 | |
243 | E | A | -1.3674 | |
244 | V | A | 0.0000 | |
245 | T | A | 0.0719 | |
246 | C | A | 0.0000 | |
247 | V | A | 0.0000 | |
248 | V | A | 0.0000 | |
249 | V | A | -0.7376 | |
250 | D | A | -1.5956 | |
251 | V | A | 0.0000 | |
252 | S | A | -2.0823 | |
253 | H | A | -2.6250 | |
254 | E | A | -2.9662 | |
255 | D | A | -2.5933 | |
256 | P | A | -2.5113 | |
257 | E | A | -3.0957 | |
258 | V | A | -1.9934 | |
259 | K | A | -2.2249 | |
260 | F | A | -1.1167 | |
261 | N | A | -1.0463 | |
262 | W | A | 0.0000 | |
263 | Y | A | -0.5597 | |
264 | V | A | -0.8765 | |
265 | D | A | -2.1546 | |
266 | G | A | -0.8811 | |
267 | V | A | 0.6355 | |
268 | E | A | -0.5288 | |
269 | V | A | -0.4764 | |
270 | H | A | -1.8524 | |
271 | N | A | -2.1662 | |
272 | A | A | -1.8839 | |
273 | K | A | -2.3717 | |
274 | T | A | -1.7892 | |
275 | K | A | -1.9635 | |
276 | P | A | -2.0601 | |
277 | R | A | -3.1045 | |
278 | E | A | -3.1269 | |
279 | E | A | -3.2067 | |
280 | Q | A | -1.8161 | |
281 | Y | A | -0.6395 | |
282 | N | A | -1.3090 | |
283 | S | A | -1.1462 | |
284 | T | A | -1.9728 | |
285 | Y | A | 0.0000 | |
286 | R | A | -2.1707 | |
287 | V | A | 0.0000 | |
288 | V | A | 0.0000 | |
289 | S | A | 0.0000 | |
290 | V | A | 0.0000 | |
291 | L | A | 0.0000 | |
292 | T | A | -0.8086 | |
293 | V | A | 0.0000 | |
294 | L | A | 0.4056 | |
295 | H | A | -0.3412 | |
296 | Q | A | -1.2282 | |
297 | D | A | -1.2940 | |
298 | W | A | 0.0000 | |
299 | L | A | -0.9615 | |
300 | N | A | -2.0822 | |
301 | G | A | -2.0366 | |
302 | K | A | -2.2533 | |
303 | E | A | -2.3159 | |
304 | Y | A | 0.0000 | |
305 | K | A | -1.5488 | |
306 | C | A | 0.0000 | |
307 | K | A | -1.2837 | |
308 | V | A | 0.0000 | |
309 | S | A | -1.3642 | |
310 | N | A | 0.0000 | |
311 | K | A | -2.5581 | |
312 | A | A | -1.3004 | |
313 | L | A | -0.5560 | |
314 | P | A | -0.4742 | |
315 | A | A | -0.4012 | |
316 | P | A | -0.7104 | |
317 | I | A | -0.5450 | |
318 | E | A | -1.4154 | |
319 | K | A | -1.1009 | |
320 | T | A | -0.9919 | |
321 | I | A | -0.3030 | |
322 | S | A | -1.2187 | |
323 | K | A | -1.2903 | |
324 | A | A | -1.1490 | |
325 | K | A | -2.3417 | |
326 | G | A | -1.9576 | |
327 | Q | A | -2.1204 | |
328 | P | A | -1.7402 | |
329 | R | A | -2.1704 | |
330 | E | A | -2.8040 | |
331 | P | A | 0.0000 | |
332 | Q | A | -1.5867 | |
333 | V | A | -0.4698 | |
334 | Y | A | 0.5929 | |
335 | T | A | 0.5100 | |
336 | L | A | 0.5192 | |
337 | P | A | -0.2134 | |
338 | P | A | -0.9366 | |
339 | S | A | -1.7062 | |
340 | R | A | -2.8573 | |
341 | D | A | -3.0976 | |
342 | E | A | -2.6230 | |
343 | L | A | -2.2514 | |
344 | T | A | -2.0911 | |
345 | K | A | -3.0816 | |
346 | N | A | -2.9210 | |
347 | Q | A | -2.5946 | |
348 | V | A | 0.0000 | |
349 | S | A | -0.7593 | |
350 | L | A | 0.0000 | |
351 | T | A | -0.2064 | |
352 | C | A | 0.0000 | |
353 | L | A | 0.4512 | |
354 | V | A | 0.0000 | |
355 | K | A | -0.7030 | |
356 | G | A | -1.3483 | |
357 | F | A | 0.0000 | |
358 | Y | A | -0.9930 | |
359 | P | A | 0.0000 | |
360 | S | A | 0.0569 | |
361 | D | A | -1.0720 | |
362 | I | A | 0.0000 | |
363 | A | A | -0.6274 | |
364 | V | A | 0.0000 | |
365 | E | A | -1.1332 | |
366 | W | A | 0.0000 | |
367 | E | A | -1.9209 | |
368 | S | A | 0.0000 | |
369 | N | A | -1.9413 | |
370 | G | A | -1.8239 | |
371 | Q | A | -2.3393 | |
372 | P | A | -2.0431 | |
373 | E | A | -2.0462 | |
374 | N | A | -2.4824 | |
375 | N | A | -2.3289 | |
376 | Y | A | -2.1463 | |
377 | K | A | -2.4585 | |
378 | T | A | -1.0808 | |
379 | T | A | -0.3352 | |
380 | P | A | 0.1332 | |
381 | P | A | 0.6867 | |
382 | V | A | 1.6081 | |
383 | L | A | 1.2990 | |
384 | D | A | -0.5902 | |
385 | S | A | -1.1283 | |
386 | D | A | -2.0646 | |
387 | G | A | -0.9449 | |
388 | S | A | 0.0000 | |
389 | F | A | 0.3993 | |
390 | F | A | 0.7339 | |
391 | L | A | 0.0000 | |
392 | Y | A | 0.3826 | |
393 | S | A | 0.0000 | |
394 | K | A | -1.7952 | |
395 | L | A | 0.0000 | |
396 | T | A | -1.5452 | |
397 | V | A | 0.0000 | |
398 | D | A | -2.6419 | |
399 | K | A | -2.7600 | |
400 | S | A | -2.1823 | |
401 | R | A | -1.9963 | |
402 | W | A | 0.0000 | |
403 | Q | A | -2.3187 | |
404 | Q | A | -2.1362 | |
405 | G | A | -1.2742 | |
406 | N | A | -0.9639 | |
407 | V | A | -0.0675 | |
408 | F | A | 0.0000 | |
409 | S | A | 0.0000 | |
410 | C | A | 0.0000 | |
411 | S | A | 0.0000 | |
412 | V | A | 0.0000 | |
413 | M | A | 0.0000 | |
414 | H | A | 0.0000 | |
415 | E | A | -1.0426 | |
416 | A | A | -1.4496 | |
417 | L | A | -1.4105 | |
418 | H | A | -1.6905 | |
419 | N | A | -1.6003 | |
420 | H | A | -1.1061 | |
421 | Y | A | -0.2124 | |
422 | T | A | -0.7075 | |
423 | Q | A | -1.0623 | |
424 | K | A | -0.9903 | |
425 | S | A | -0.4692 | |
426 | L | A | 0.0000 | |
427 | S | A | -0.1832 | |
428 | L | A | -0.3787 | |
429 | S | A | -0.7110 | |
430 | P | A | -0.9358 | |
431 | G | A | -1.4104 | |
432 | K | A | -2.0235 |