| Chain sequence(s) |
A: SDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:06:07)
[INFO] Main: Simulation completed successfully. (00:06:09)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | S | A | -1.3114 | |
| 2 | D | A | -2.3854 | |
| 3 | T | A | -1.7159 | |
| 4 | G | A | -1.8589 | |
| 5 | R | A | -1.5745 | |
| 6 | P | A | 0.0000 | |
| 7 | F | A | 0.0000 | |
| 8 | V | A | 0.4648 | |
| 9 | E | A | 0.1167 | |
| 10 | M | A | -0.0373 | |
| 11 | Y | A | -0.1224 | |
| 12 | S | A | -0.7371 | |
| 13 | E | A | -1.0763 | |
| 14 | I | A | 1.0702 | |
| 15 | P | A | 0.4610 | |
| 16 | E | A | -0.1584 | |
| 17 | I | A | 0.5207 | |
| 18 | I | A | -0.2584 | |
| 19 | H | A | -1.3082 | |
| 20 | M | A | 0.0000 | |
| 21 | T | A | -2.2678 | |
| 22 | E | A | -2.2547 | |
| 23 | G | A | -2.3676 | |
| 24 | R | A | -3.6618 | |
| 25 | E | A | -3.2819 | |
| 26 | L | A | 0.0000 | |
| 27 | V | A | -0.1751 | |
| 28 | I | A | 0.0000 | |
| 29 | P | A | -0.8110 | |
| 30 | C | A | 0.0000 | |
| 31 | R | A | -1.5183 | |
| 32 | V | A | 0.0000 | |
| 33 | T | A | -0.9242 | |
| 34 | S | A | -1.1468 | |
| 35 | P | A | -1.3399 | |
| 36 | N | A | -1.3418 | |
| 37 | I | A | -0.5734 | |
| 38 | T | A | -0.3113 | |
| 39 | V | A | 0.0000 | |
| 40 | T | A | 0.0181 | |
| 41 | L | A | 0.0000 | |
| 42 | K | A | -0.0298 | |
| 43 | K | A | 0.4797 | |
| 44 | F | A | 1.9504 | |
| 45 | P | A | 1.3215 | |
| 46 | L | A | 1.4988 | |
| 47 | D | A | 0.2436 | |
| 48 | T | A | 0.3554 | |
| 49 | L | A | 0.0000 | |
| 50 | I | A | 1.3195 | |
| 51 | P | A | -0.2185 | |
| 52 | D | A | -1.9897 | |
| 53 | G | A | -1.6840 | |
| 54 | K | A | -2.5509 | |
| 55 | R | A | -1.9570 | |
| 56 | I | A | 0.0000 | |
| 57 | I | A | -0.1620 | |
| 58 | W | A | -0.0788 | |
| 59 | D | A | -1.1766 | |
| 60 | S | A | -1.8889 | |
| 61 | R | A | -2.7305 | |
| 62 | K | A | -2.2905 | |
| 63 | G | A | 0.0000 | |
| 64 | F | A | 0.0000 | |
| 65 | I | A | -0.4301 | |
| 66 | I | A | 0.0000 | |
| 67 | S | A | -2.2808 | |
| 68 | N | A | -3.0171 | |
| 69 | A | A | 0.0000 | |
| 70 | T | A | -0.8323 | |
| 71 | Y | A | 0.7435 | |
| 72 | K | A | -0.2032 | |
| 73 | E | A | 0.0000 | |
| 74 | I | A | 0.4271 | |
| 75 | G | A | 0.6404 | |
| 76 | L | A | 0.7626 | |
| 77 | L | A | 0.0000 | |
| 78 | T | A | 0.0000 | |
| 79 | C | A | 0.0000 | |
| 80 | E | A | -0.5117 | |
| 81 | A | A | 0.0000 | |
| 82 | T | A | -0.4041 | |
| 83 | V | A | -0.7797 | |
| 84 | N | A | -1.6111 | |
| 85 | G | A | -1.2443 | |
| 86 | H | A | -1.1109 | |
| 87 | L | A | -0.0251 | |
| 88 | Y | A | -0.4427 | |
| 89 | K | A | -0.9776 | |
| 90 | T | A | 0.0000 | |
| 91 | N | A | -0.3528 | |
| 92 | Y | A | 0.0000 | |
| 93 | L | A | 0.4528 | |
| 94 | T | A | 0.0000 | |
| 95 | H | A | -1.2176 | |
| 96 | R | A | -1.8469 | |
| 97 | Q | A | -2.2198 | |
| 98 | T | A | -1.2918 | |
| 99 | N | A | -0.3233 | |
| 100 | T | A | -0.2624 | |
| 101 | I | A | 0.0000 | |
| 102 | I | A | 0.0664 | |
| 103 | D | A | -0.5622 | |
| 104 | V | A | 0.0000 | |
| 105 | V | A | 0.1596 | |
| 106 | L | A | 0.0000 | |
| 107 | S | A | 0.1017 | |
| 108 | P | A | -0.0214 | |
| 109 | S | A | -0.6430 | |
| 110 | H | A | -1.3577 | |
| 111 | G | A | -1.5612 | |
| 112 | I | A | 0.0000 | |
| 113 | E | A | -2.8297 | |
| 114 | L | A | -2.6730 | |
| 115 | S | A | -2.8568 | |
| 116 | V | A | -2.2716 | |
| 117 | G | A | -2.3738 | |
| 118 | E | A | -2.7009 | |
| 119 | K | A | -2.9115 | |
| 120 | L | A | 0.0000 | |
| 121 | V | A | -0.0937 | |
| 122 | L | A | 0.0000 | |
| 123 | N | A | -0.0816 | |
| 124 | C | A | 0.0000 | |
| 125 | T | A | -0.5104 | |
| 126 | A | A | 0.0000 | |
| 127 | R | A | -0.6491 | |
| 128 | T | A | 0.0000 | |
| 129 | E | A | -1.3022 | |
| 130 | L | A | -1.0605 | |
| 131 | N | A | -1.6113 | |
| 132 | V | A | 0.0000 | |
| 133 | G | A | -1.4586 | |
| 134 | I | A | -1.5739 | |
| 135 | D | A | -2.2208 | |
| 136 | F | A | -1.5906 | |
| 137 | N | A | -2.1250 | |
| 138 | W | A | -1.4428 | |
| 139 | E | A | -1.8790 | |
| 140 | Y | A | 0.0000 | |
| 141 | P | A | -0.8991 | |
| 142 | S | A | 0.0000 | |
| 143 | S | A | -1.7121 | |
| 144 | K | A | -2.4347 | |
| 145 | H | A | -2.5191 | |
| 146 | Q | A | -2.8489 | |
| 147 | H | A | -3.1381 | |
| 148 | K | A | -2.9098 | |
| 149 | K | A | -1.7242 | |
| 150 | L | A | 0.3159 | |
| 151 | V | A | -0.1247 | |
| 152 | N | A | -2.0395 | |
| 153 | R | A | -3.2511 | |
| 154 | D | A | -3.3580 | |
| 155 | L | A | -2.2667 | |
| 156 | K | A | -2.5167 | |
| 157 | T | A | -1.7491 | |
| 158 | Q | A | -1.4724 | |
| 159 | S | A | -1.0951 | |
| 160 | G | A | -1.1764 | |
| 161 | S | A | -1.3997 | |
| 162 | E | A | -2.0234 | |
| 163 | M | A | -1.3535 | |
| 164 | K | A | -1.8930 | |
| 165 | K | A | -1.6756 | |
| 166 | F | A | 0.0000 | |
| 167 | L | A | -1.1561 | |
| 168 | S | A | 0.0000 | |
| 169 | T | A | -0.1921 | |
| 170 | L | A | 0.0000 | |
| 171 | T | A | 0.0000 | |
| 172 | I | A | 0.0000 | |
| 173 | D | A | -3.6757 | |
| 174 | G | A | -2.4214 | |
| 175 | V | A | 0.0000 | |
| 176 | T | A | -2.0612 | |
| 177 | R | A | -2.8968 | |
| 178 | S | A | -1.3832 | |
| 179 | D | A | 0.0000 | |
| 180 | Q | A | -1.8419 | |
| 181 | G | A | -0.0451 | |
| 182 | L | A | 1.2048 | |
| 183 | Y | A | 0.0000 | |
| 184 | T | A | -0.9420 | |
| 185 | C | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | A | A | 0.0000 | |
| 188 | S | A | -1.0712 | |
| 189 | S | A | -0.3239 | |
| 190 | G | A | 0.0003 | |
| 191 | L | A | 1.4250 | |
| 192 | M | A | 0.6835 | |
| 193 | T | A | -0.7591 | |
| 194 | K | A | -1.7387 | |
| 195 | K | A | -2.5420 | |
| 196 | N | A | -1.5092 | |
| 197 | S | A | -0.4670 | |
| 198 | T | A | 0.0000 | |
| 199 | F | A | 0.4683 | |
| 200 | V | A | 0.0000 | |
| 201 | R | A | -2.6213 | |
| 202 | V | A | 0.0000 | |
| 203 | H | A | -3.3906 | |
| 204 | E | A | -3.9751 | |
| 205 | K | A | -4.1606 | |
| 206 | D | A | -4.3188 | |
| 207 | K | A | -3.5204 | |
| 208 | T | A | -2.0616 | |
| 209 | H | A | -1.8595 | |
| 210 | T | A | -0.7398 | |
| 211 | C | A | 0.3385 | |
| 212 | P | A | -0.0001 | |
| 213 | P | A | 0.1080 | |
| 214 | C | A | 0.5363 | |
| 215 | P | A | -0.2662 | |
| 216 | A | A | -0.2738 | |
| 217 | P | A | -0.6525 | |
| 218 | E | A | -0.8422 | |
| 219 | L | A | 1.1796 | |
| 220 | L | A | 1.5580 | |
| 221 | G | A | 0.2997 | |
| 222 | G | A | -0.1389 | |
| 223 | P | A | 0.0000 | |
| 224 | S | A | 0.0796 | |
| 225 | V | A | 0.0000 | |
| 226 | F | A | 0.9821 | |
| 227 | L | A | 0.7607 | |
| 228 | F | A | 0.9658 | |
| 229 | P | A | -0.2604 | |
| 230 | P | A | 0.0000 | |
| 231 | K | A | -2.1838 | |
| 232 | P | A | -1.4982 | |
| 233 | K | A | -1.4400 | |
| 234 | D | A | -1.4568 | |
| 235 | T | A | 0.0000 | |
| 236 | L | A | 0.0000 | |
| 237 | M | A | 0.2087 | |
| 238 | I | A | 1.3444 | |
| 239 | S | A | 0.0010 | |
| 240 | R | A | -1.3426 | |
| 241 | T | A | -0.9216 | |
| 242 | P | A | 0.0000 | |
| 243 | E | A | -1.3674 | |
| 244 | V | A | 0.0000 | |
| 245 | T | A | 0.0719 | |
| 246 | C | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | V | A | 0.0000 | |
| 249 | V | A | -0.7376 | |
| 250 | D | A | -1.5956 | |
| 251 | V | A | 0.0000 | |
| 252 | S | A | -2.0823 | |
| 253 | H | A | -2.6250 | |
| 254 | E | A | -2.9662 | |
| 255 | D | A | -2.5933 | |
| 256 | P | A | -2.5113 | |
| 257 | E | A | -3.0957 | |
| 258 | V | A | -1.9934 | |
| 259 | K | A | -2.2249 | |
| 260 | F | A | -1.1167 | |
| 261 | N | A | -1.0463 | |
| 262 | W | A | 0.0000 | |
| 263 | Y | A | -0.5597 | |
| 264 | V | A | -0.8765 | |
| 265 | D | A | -2.1546 | |
| 266 | G | A | -0.8811 | |
| 267 | V | A | 0.6355 | |
| 268 | E | A | -0.5288 | |
| 269 | V | A | -0.4764 | |
| 270 | H | A | -1.8524 | |
| 271 | N | A | -2.1662 | |
| 272 | A | A | -1.8839 | |
| 273 | K | A | -2.3717 | |
| 274 | T | A | -1.7892 | |
| 275 | K | A | -1.9635 | |
| 276 | P | A | -2.0601 | |
| 277 | R | A | -3.1045 | |
| 278 | E | A | -3.1269 | |
| 279 | E | A | -3.2067 | |
| 280 | Q | A | -1.8161 | |
| 281 | Y | A | -0.6395 | |
| 282 | N | A | -1.3090 | |
| 283 | S | A | -1.1462 | |
| 284 | T | A | -1.9728 | |
| 285 | Y | A | 0.0000 | |
| 286 | R | A | -2.1707 | |
| 287 | V | A | 0.0000 | |
| 288 | V | A | 0.0000 | |
| 289 | S | A | 0.0000 | |
| 290 | V | A | 0.0000 | |
| 291 | L | A | 0.0000 | |
| 292 | T | A | -0.8086 | |
| 293 | V | A | 0.0000 | |
| 294 | L | A | 0.4056 | |
| 295 | H | A | -0.3412 | |
| 296 | Q | A | -1.2282 | |
| 297 | D | A | -1.2940 | |
| 298 | W | A | 0.0000 | |
| 299 | L | A | -0.9615 | |
| 300 | N | A | -2.0822 | |
| 301 | G | A | -2.0366 | |
| 302 | K | A | -2.2533 | |
| 303 | E | A | -2.3159 | |
| 304 | Y | A | 0.0000 | |
| 305 | K | A | -1.5488 | |
| 306 | C | A | 0.0000 | |
| 307 | K | A | -1.2837 | |
| 308 | V | A | 0.0000 | |
| 309 | S | A | -1.3642 | |
| 310 | N | A | 0.0000 | |
| 311 | K | A | -2.5581 | |
| 312 | A | A | -1.3004 | |
| 313 | L | A | -0.5560 | |
| 314 | P | A | -0.4742 | |
| 315 | A | A | -0.4012 | |
| 316 | P | A | -0.7104 | |
| 317 | I | A | -0.5450 | |
| 318 | E | A | -1.4154 | |
| 319 | K | A | -1.1009 | |
| 320 | T | A | -0.9919 | |
| 321 | I | A | -0.3030 | |
| 322 | S | A | -1.2187 | |
| 323 | K | A | -1.2903 | |
| 324 | A | A | -1.1490 | |
| 325 | K | A | -2.3417 | |
| 326 | G | A | -1.9576 | |
| 327 | Q | A | -2.1204 | |
| 328 | P | A | -1.7402 | |
| 329 | R | A | -2.1704 | |
| 330 | E | A | -2.8040 | |
| 331 | P | A | 0.0000 | |
| 332 | Q | A | -1.5867 | |
| 333 | V | A | -0.4698 | |
| 334 | Y | A | 0.5929 | |
| 335 | T | A | 0.5100 | |
| 336 | L | A | 0.5192 | |
| 337 | P | A | -0.2134 | |
| 338 | P | A | -0.9366 | |
| 339 | S | A | -1.7062 | |
| 340 | R | A | -2.8573 | |
| 341 | D | A | -3.0976 | |
| 342 | E | A | -2.6230 | |
| 343 | L | A | -2.2514 | |
| 344 | T | A | -2.0911 | |
| 345 | K | A | -3.0816 | |
| 346 | N | A | -2.9210 | |
| 347 | Q | A | -2.5946 | |
| 348 | V | A | 0.0000 | |
| 349 | S | A | -0.7593 | |
| 350 | L | A | 0.0000 | |
| 351 | T | A | -0.2064 | |
| 352 | C | A | 0.0000 | |
| 353 | L | A | 0.4512 | |
| 354 | V | A | 0.0000 | |
| 355 | K | A | -0.7030 | |
| 356 | G | A | -1.3483 | |
| 357 | F | A | 0.0000 | |
| 358 | Y | A | -0.9930 | |
| 359 | P | A | 0.0000 | |
| 360 | S | A | 0.0569 | |
| 361 | D | A | -1.0720 | |
| 362 | I | A | 0.0000 | |
| 363 | A | A | -0.6274 | |
| 364 | V | A | 0.0000 | |
| 365 | E | A | -1.1332 | |
| 366 | W | A | 0.0000 | |
| 367 | E | A | -1.9209 | |
| 368 | S | A | 0.0000 | |
| 369 | N | A | -1.9413 | |
| 370 | G | A | -1.8239 | |
| 371 | Q | A | -2.3393 | |
| 372 | P | A | -2.0431 | |
| 373 | E | A | -2.0462 | |
| 374 | N | A | -2.4824 | |
| 375 | N | A | -2.3289 | |
| 376 | Y | A | -2.1463 | |
| 377 | K | A | -2.4585 | |
| 378 | T | A | -1.0808 | |
| 379 | T | A | -0.3352 | |
| 380 | P | A | 0.1332 | |
| 381 | P | A | 0.6867 | |
| 382 | V | A | 1.6081 | |
| 383 | L | A | 1.2990 | |
| 384 | D | A | -0.5902 | |
| 385 | S | A | -1.1283 | |
| 386 | D | A | -2.0646 | |
| 387 | G | A | -0.9449 | |
| 388 | S | A | 0.0000 | |
| 389 | F | A | 0.3993 | |
| 390 | F | A | 0.7339 | |
| 391 | L | A | 0.0000 | |
| 392 | Y | A | 0.3826 | |
| 393 | S | A | 0.0000 | |
| 394 | K | A | -1.7952 | |
| 395 | L | A | 0.0000 | |
| 396 | T | A | -1.5452 | |
| 397 | V | A | 0.0000 | |
| 398 | D | A | -2.6419 | |
| 399 | K | A | -2.7600 | |
| 400 | S | A | -2.1823 | |
| 401 | R | A | -1.9963 | |
| 402 | W | A | 0.0000 | |
| 403 | Q | A | -2.3187 | |
| 404 | Q | A | -2.1362 | |
| 405 | G | A | -1.2742 | |
| 406 | N | A | -0.9639 | |
| 407 | V | A | -0.0675 | |
| 408 | F | A | 0.0000 | |
| 409 | S | A | 0.0000 | |
| 410 | C | A | 0.0000 | |
| 411 | S | A | 0.0000 | |
| 412 | V | A | 0.0000 | |
| 413 | M | A | 0.0000 | |
| 414 | H | A | 0.0000 | |
| 415 | E | A | -1.0426 | |
| 416 | A | A | -1.4496 | |
| 417 | L | A | -1.4105 | |
| 418 | H | A | -1.6905 | |
| 419 | N | A | -1.6003 | |
| 420 | H | A | -1.1061 | |
| 421 | Y | A | -0.2124 | |
| 422 | T | A | -0.7075 | |
| 423 | Q | A | -1.0623 | |
| 424 | K | A | -0.9903 | |
| 425 | S | A | -0.4692 | |
| 426 | L | A | 0.0000 | |
| 427 | S | A | -0.1832 | |
| 428 | L | A | -0.3787 | |
| 429 | S | A | -0.7110 | |
| 430 | P | A | -0.9358 | |
| 431 | G | A | -1.4104 | |
| 432 | K | A | -2.0235 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine