| Chain sequence(s) |
A: MGNNSSSLEVSRNGRSLGEYYRDDHYDYDPRGRRGSRWQEEEDMYNPRMRGGNPDYYDERSGGYRSGPDDRNTYHNVHPIPAYDDQRDDKDNVIRPDQPAPVKPDGDDTGKGDDSSVTPSPENPDDPNNPPSTTETPGNSDGEHKDDEGNVIRPAGKHVVKPDDEKDDKSDNDPIKPNVPSEHHHDGSHDGSDDGSHDGSHPDQPGHHDGLKGTMSQGPYGPDPRGDRSGDEREFRHNQHGRVFDDRRGRGGFDDYNGPDGYGSDYGRRYGDDGREIHYSRSEKSFDDEYHGRGGDDRSFHFSKTNRVIDENMPYPPNGPFRGGDNRSIRSEQIAAMNYEEQFHQGPRGGRMGSANPFNVPPRGGRDDDHTFHSAHHHHHH
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:02:39)
[INFO] Main: Simulation completed successfully. (00:02:42)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | M | A | 0.3598 | |
| 2 | G | A | -0.9471 | |
| 3 | N | A | -1.9442 | |
| 4 | N | A | -2.0813 | |
| 5 | S | A | -1.2313 | |
| 6 | S | A | -0.9307 | |
| 7 | S | A | -0.0906 | |
| 8 | L | A | 0.7862 | |
| 9 | E | A | -0.8665 | |
| 10 | V | A | 0.0019 | |
| 11 | S | A | -1.3082 | |
| 12 | R | A | -2.8018 | |
| 13 | N | A | -2.7047 | |
| 14 | G | A | -2.1699 | |
| 15 | R | A | -2.3529 | |
| 16 | S | A | -0.7603 | |
| 17 | L | A | 0.6054 | |
| 18 | G | A | -0.1705 | |
| 19 | E | A | -0.9109 | |
| 20 | Y | A | 0.3854 | |
| 21 | Y | A | -0.2347 | |
| 22 | R | A | -2.6129 | |
| 23 | D | A | -3.1401 | |
| 24 | D | A | -3.3871 | |
| 25 | H | A | -2.3655 | |
| 26 | Y | A | -0.5929 | |
| 27 | D | A | -1.5031 | |
| 28 | Y | A | -0.4512 | |
| 29 | D | A | -2.3534 | |
| 30 | P | A | -2.1446 | |
| 31 | R | A | -3.2543 | |
| 32 | G | A | -3.1286 | |
| 33 | R | A | -3.8823 | |
| 34 | R | A | -3.6030 | |
| 35 | G | A | -2.7235 | |
| 36 | S | A | -2.1192 | |
| 37 | R | A | -2.6159 | |
| 38 | W | A | -1.5178 | |
| 39 | Q | A | -3.3284 | |
| 40 | E | A | -4.1591 | |
| 41 | E | A | -3.9751 | |
| 42 | E | A | -3.7831 | |
| 43 | D | A | -3.1368 | |
| 44 | M | A | -0.7293 | |
| 45 | Y | A | -0.2454 | |
| 46 | N | A | -1.8140 | |
| 47 | P | A | -1.5941 | |
| 48 | R | A | -2.2841 | |
| 49 | M | A | -1.5068 | |
| 50 | R | A | -2.5932 | |
| 51 | G | A | -1.9674 | |
| 52 | G | A | -1.7180 | |
| 53 | N | A | -2.2432 | |
| 54 | P | A | -1.3867 | |
| 55 | D | A | -1.5853 | |
| 56 | Y | A | -0.0079 | |
| 57 | Y | A | -0.1571 | |
| 58 | D | A | -2.4752 | |
| 59 | E | A | -3.1528 | |
| 60 | R | A | -3.3682 | |
| 61 | S | A | -2.2882 | |
| 62 | G | A | -1.3994 | |
| 63 | G | A | -0.7546 | |
| 64 | Y | A | 0.0091 | |
| 65 | R | A | -1.6555 | |
| 66 | S | A | -1.7874 | |
| 67 | G | A | -1.8402 | |
| 68 | P | A | -1.9663 | |
| 69 | D | A | -3.0233 | |
| 70 | D | A | -3.1267 | |
| 71 | R | A | -3.1645 | |
| 72 | N | A | -2.3801 | |
| 73 | T | A | -1.1803 | |
| 74 | Y | A | 0.0278 | |
| 75 | H | A | -0.7043 | |
| 76 | N | A | -0.8223 | |
| 77 | V | A | 0.7710 | |
| 78 | H | A | -0.2140 | |
| 79 | P | A | 0.5079 | |
| 80 | I | A | 1.9770 | |
| 81 | P | A | 0.7561 | |
| 82 | A | A | 0.4894 | |
| 83 | Y | A | 0.2520 | |
| 84 | D | A | -2.4004 | |
| 85 | D | A | -3.6707 | |
| 86 | Q | A | -4.2925 | |
| 87 | R | A | -4.8870 | |
| 88 | D | A | -5.3607 | |
| 89 | D | A | -5.1105 | |
| 90 | K | A | -4.4638 | |
| 91 | D | A | -3.3183 | |
| 92 | N | A | -2.1600 | |
| 93 | V | A | 0.3989 | |
| 94 | I | A | 0.7504 | |
| 95 | R | A | -1.6090 | |
| 96 | P | A | -1.6398 | |
| 97 | D | A | -2.8335 | |
| 98 | Q | A | -2.4060 | |
| 99 | P | A | -1.1085 | |
| 100 | A | A | -0.2996 | |
| 101 | P | A | -0.0891 | |
| 102 | V | A | 0.4806 | |
| 103 | K | A | -1.5903 | |
| 104 | P | A | -1.9118 | |
| 105 | D | A | -3.1348 | |
| 106 | G | A | -3.0608 | |
| 107 | D | A | -3.5162 | |
| 108 | D | A | -3.4655 | |
| 109 | T | A | -2.2365 | |
| 110 | G | A | -2.4598 | |
| 111 | K | A | -3.0619 | |
| 112 | G | A | -2.8032 | |
| 113 | D | A | -3.4631 | |
| 114 | D | A | -2.9172 | |
| 115 | S | A | -1.2246 | |
| 116 | S | A | -0.1391 | |
| 117 | V | A | 1.2673 | |
| 118 | T | A | 0.5105 | |
| 119 | P | A | -0.2876 | |
| 120 | S | A | -0.8622 | |
| 121 | P | A | -1.6541 | |
| 122 | E | A | -3.2913 | |
| 123 | N | A | -3.2259 | |
| 124 | P | A | -2.8874 | |
| 125 | D | A | -3.6728 | |
| 126 | D | A | -3.9166 | |
| 127 | P | A | -2.5331 | |
| 128 | N | A | -2.8200 | |
| 129 | N | A | -3.0712 | |
| 130 | P | A | -1.6681 | |
| 131 | P | A | -1.0083 | |
| 132 | S | A | -0.8797 | |
| 133 | T | A | -0.9019 | |
| 134 | T | A | -1.1403 | |
| 135 | E | A | -2.0800 | |
| 136 | T | A | -1.3908 | |
| 137 | P | A | -1.3824 | |
| 138 | G | A | -1.7587 | |
| 139 | N | A | -2.1939 | |
| 140 | S | A | -2.2197 | |
| 141 | D | A | -3.0312 | |
| 142 | G | A | -2.8910 | |
| 143 | E | A | -3.5934 | |
| 144 | H | A | -3.6661 | |
| 145 | K | A | -4.1914 | |
| 146 | D | A | -4.5005 | |
| 147 | D | A | -4.3537 | |
| 148 | E | A | -3.6032 | |
| 149 | G | A | -1.8609 | |
| 150 | N | A | -0.8937 | |
| 151 | V | A | 1.2144 | |
| 152 | I | A | 1.5076 | |
| 153 | R | A | -0.6879 | |
| 154 | P | A | -0.7010 | |
| 155 | A | A | -1.0698 | |
| 156 | G | A | -1.6416 | |
| 157 | K | A | -1.6988 | |
| 158 | H | A | -0.7572 | |
| 159 | V | A | 1.1167 | |
| 160 | V | A | 0.9781 | |
| 161 | K | A | -1.2856 | |
| 162 | P | A | -1.9473 | |
| 163 | D | A | -3.6877 | |
| 164 | D | A | -4.4715 | |
| 165 | E | A | -4.6464 | |
| 166 | K | A | -4.7513 | |
| 167 | D | A | -4.6215 | |
| 168 | D | A | -4.3836 | |
| 169 | K | A | -3.9500 | |
| 170 | S | A | -3.0986 | |
| 171 | D | A | -3.6364 | |
| 172 | N | A | -3.0854 | |
| 173 | D | A | -2.7116 | |
| 174 | P | A | -1.1335 | |
| 175 | I | A | 0.2023 | |
| 176 | K | A | -1.2757 | |
| 177 | P | A | -0.8211 | |
| 178 | N | A | -0.8086 | |
| 179 | V | A | 0.5357 | |
| 180 | P | A | -0.3979 | |
| 181 | S | A | -1.2759 | |
| 182 | E | A | -2.4936 | |
| 183 | H | A | -2.8971 | |
| 184 | H | A | -2.8868 | |
| 185 | H | A | -2.7124 | |
| 186 | D | A | -2.9020 | |
| 187 | G | A | -2.2257 | |
| 188 | S | A | -1.7884 | |
| 189 | H | A | -2.2448 | |
| 190 | D | A | -2.6674 | |
| 191 | G | A | -2.2762 | |
| 192 | S | A | -2.4048 | |
| 193 | D | A | -3.0119 | |
| 194 | D | A | -3.1509 | |
| 195 | G | A | -2.3181 | |
| 196 | S | A | -2.1024 | |
| 197 | H | A | -2.4099 | |
| 198 | D | A | -2.7586 | |
| 199 | G | A | -1.9388 | |
| 200 | S | A | -1.5457 | |
| 201 | H | A | -1.9154 | |
| 202 | P | A | -1.9129 | |
| 203 | D | A | -2.7810 | |
| 204 | Q | A | -2.4649 | |
| 205 | P | A | -1.7499 | |
| 206 | G | A | -1.7670 | |
| 207 | H | A | -2.3280 | |
| 208 | H | A | -2.4334 | |
| 209 | D | A | -2.6371 | |
| 210 | G | A | -1.1823 | |
| 211 | L | A | -0.1544 | |
| 212 | K | A | -1.3795 | |
| 213 | G | A | -0.7476 | |
| 214 | T | A | -0.2371 | |
| 215 | M | A | 0.3232 | |
| 216 | S | A | -0.3286 | |
| 217 | Q | A | -1.1224 | |
| 218 | G | A | -0.6579 | |
| 219 | P | A | -0.1796 | |
| 220 | Y | A | 0.4588 | |
| 221 | G | A | -0.5103 | |
| 222 | P | A | -1.4131 | |
| 223 | D | A | -2.6088 | |
| 224 | P | A | -2.4810 | |
| 225 | R | A | -3.3609 | |
| 226 | G | A | -3.1738 | |
| 227 | D | A | -3.5059 | |
| 228 | R | A | -3.5237 | |
| 229 | S | A | -2.5556 | |
| 230 | G | A | -2.9976 | |
| 231 | D | A | -3.9880 | |
| 232 | E | A | -4.0432 | |
| 233 | R | A | -3.9248 | |
| 234 | E | A | -3.1782 | |
| 235 | F | A | -1.0099 | |
| 236 | R | A | -2.6327 | |
| 237 | H | A | -2.6231 | |
| 238 | N | A | -2.9145 | |
| 239 | Q | A | -3.0548 | |
| 240 | H | A | -2.4696 | |
| 241 | G | A | -1.5969 | |
| 242 | R | A | -1.2568 | |
| 243 | V | A | 0.8986 | |
| 244 | F | A | 0.6214 | |
| 245 | D | A | -2.2956 | |
| 246 | D | A | -3.6264 | |
| 247 | R | A | -4.2086 | |
| 248 | R | A | -4.2905 | |
| 249 | G | A | -3.2761 | |
| 250 | R | A | -3.0447 | |
| 251 | G | A | -1.6322 | |
| 252 | G | A | -1.0215 | |
| 253 | F | A | 0.1484 | |
| 254 | D | A | -1.6744 | |
| 255 | D | A | -1.9287 | |
| 256 | Y | A | -0.6040 | |
| 257 | N | A | -1.9515 | |
| 258 | G | A | -1.6515 | |
| 259 | P | A | -1.4805 | |
| 260 | D | A | -2.1722 | |
| 261 | G | A | -1.1279 | |
| 262 | Y | A | 0.0974 | |
| 263 | G | A | -0.5944 | |
| 264 | S | A | -0.7468 | |
| 265 | D | A | -1.5836 | |
| 266 | Y | A | -0.6101 | |
| 267 | G | A | -1.5757 | |
| 268 | R | A | -2.5090 | |
| 269 | R | A | -2.4769 | |
| 270 | Y | A | -1.0564 | |
| 271 | G | A | -2.0167 | |
| 272 | D | A | -3.3290 | |
| 273 | D | A | -3.6311 | |
| 274 | G | A | -3.1257 | |
| 275 | R | A | -3.3014 | |
| 276 | E | A | -2.2263 | |
| 277 | I | A | 0.3816 | |
| 278 | H | A | -0.4595 | |
| 279 | Y | A | 0.4848 | |
| 280 | S | A | -0.7882 | |
| 281 | R | A | -2.5690 | |
| 282 | S | A | -2.3857 | |
| 283 | E | A | -3.1294 | |
| 284 | K | A | -2.6785 | |
| 285 | S | A | -1.3501 | |
| 286 | F | A | -0.4884 | |
| 287 | D | A | -2.2913 | |
| 288 | D | A | -2.8188 | |
| 289 | E | A | -2.5453 | |
| 290 | Y | A | -1.1182 | |
| 291 | H | A | -1.7351 | |
| 292 | G | A | -1.8962 | |
| 293 | R | A | -2.6900 | |
| 294 | G | A | -2.4675 | |
| 295 | G | A | -2.7808 | |
| 296 | D | A | -3.7674 | |
| 297 | D | A | -3.5312 | |
| 298 | R | A | -2.9978 | |
| 299 | S | A | -0.9767 | |
| 300 | F | A | 1.1358 | |
| 301 | H | A | 0.3098 | |
| 302 | F | A | 1.4018 | |
| 303 | S | A | -0.3087 | |
| 304 | K | A | -2.0802 | |
| 305 | T | A | -1.6123 | |
| 306 | N | A | -1.9442 | |
| 307 | R | A | -1.4866 | |
| 308 | V | A | 0.6906 | |
| 309 | I | A | 0.6948 | |
| 310 | D | A | -1.6029 | |
| 311 | E | A | -2.0791 | |
| 312 | N | A | -1.8014 | |
| 313 | M | A | 0.0119 | |
| 314 | P | A | 0.1950 | |
| 315 | Y | A | 0.7286 | |
| 316 | P | A | -0.0542 | |
| 317 | P | A | -0.8385 | |
| 318 | N | A | -1.2811 | |
| 319 | G | A | -1.0732 | |
| 320 | P | A | -0.4496 | |
| 321 | F | A | 0.4339 | |
| 322 | R | A | -1.5873 | |
| 323 | G | A | -1.6553 | |
| 324 | G | A | -2.3990 | |
| 325 | D | A | -3.4981 | |
| 326 | N | A | -3.0073 | |
| 327 | R | A | -2.8065 | |
| 328 | S | A | -1.4022 | |
| 329 | I | A | -0.0265 | |
| 330 | R | A | -2.0455 | |
| 331 | S | A | -1.3941 | |
| 332 | E | A | -2.3036 | |
| 333 | Q | A | -1.4208 | |
| 334 | I | A | 1.1417 | |
| 335 | A | A | 0.4726 | |
| 336 | A | A | 0.7771 | |
| 337 | M | A | 0.9313 | |
| 338 | N | A | -0.7555 | |
| 339 | Y | A | -0.5569 | |
| 340 | E | A | -2.3727 | |
| 341 | E | A | -2.7468 | |
| 342 | Q | A | -1.8051 | |
| 343 | F | A | -0.1082 | |
| 344 | H | A | -1.2447 | |
| 345 | Q | A | -1.8055 | |
| 346 | G | A | -1.7027 | |
| 347 | P | A | -1.9152 | |
| 348 | R | A | -2.7954 | |
| 349 | G | A | -2.1699 | |
| 350 | G | A | -1.8110 | |
| 351 | R | A | -2.0404 | |
| 352 | M | A | -0.3202 | |
| 353 | G | A | -0.8267 | |
| 354 | S | A | -0.7580 | |
| 355 | A | A | -0.3970 | |
| 356 | N | A | -0.9659 | |
| 357 | P | A | 0.0674 | |
| 358 | F | A | 1.2716 | |
| 359 | N | A | 0.0009 | |
| 360 | V | A | 0.9822 | |
| 361 | P | A | -0.1675 | |
| 362 | P | A | -1.1584 | |
| 363 | R | A | -2.3159 | |
| 364 | G | A | -2.3167 | |
| 365 | G | A | -2.7940 | |
| 366 | R | A | -3.9956 | |
| 367 | D | A | -4.3999 | |
| 368 | D | A | -4.3769 | |
| 369 | D | A | -3.6807 | |
| 370 | H | A | -2.2377 | |
| 371 | T | A | -0.6444 | |
| 372 | F | A | 0.8910 | |
| 373 | H | A | -0.4051 | |
| 374 | S | A | -0.5367 | |
| 375 | A | A | -0.9361 | |
| 376 | H | A | -2.0111 | |
| 377 | H | A | -2.3287 | |
| 378 | H | A | -2.5714 | |
| 379 | H | A | -2.5540 | |
| 380 | H | A | -2.3143 | |
| 381 | H | A | -1.7989 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine