Project name: 254

Chain sequence(s)	H: EVQLVESGGGLVQPGGSLRLSCAASGFTFSSSVMFWLRQAPGKGLEWLSTIKPTGSTIYPGSGKGRFTISRDNAKNTLYLQINNLKPEDTALYYCARDIGGTVRGQGTQVTVSS
Selected Chain(s)	H
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with H chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:00:38)
[INFO]       Main:     Simulation completed successfully.                                          (00:00:39)

• Minimal score value: -2.6303
• Maximal score value: 1.6535
• Average score: -0.624
• Total score value: -71.1413

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-2.0430
2	V	H	-1.2004
3	Q	H	-1.2856
4	L	H	0.0000
5	V	H	0.4054
6	E	H	0.0000
7	S	H	-0.6544
8	G	H	-1.1566
9	G	H	-0.6794
11	G	H	0.1622
12	L	H	1.1380
13	V	H	-0.0019
14	Q	H	-1.4669
15	P	H	-2.0043
16	G	H	-1.9385
17	G	H	-1.5302
18	S	H	-1.6793
19	L	H	-1.0987
20	R	H	-2.0509
21	L	H	0.0000
22	S	H	-0.4859
23	C	H	0.0000
24	A	H	-0.2576
25	A	H	0.0000
26	S	H	-0.8594
27	G	H	-1.2964
28	F	H	-0.5984
29	T	H	-0.3200
30	F	H	0.0000
35	S	H	-0.8313
36	S	H	-0.5160
37	S	H	0.0000
38	V	H	0.0000
39	M	H	0.0000
40	F	H	0.2528
41	W	H	0.0000
42	L	H	0.3602
43	R	H	0.0000
44	Q	H	-0.7815
45	A	H	-1.2574
46	P	H	-1.0132
47	G	H	-1.4716
48	K	H	-2.2097
49	G	H	-1.1866
50	L	H	0.0260
51	E	H	-0.3642
52	W	H	0.4083
53	L	H	0.0000
54	S	H	0.0000
55	T	H	0.0000
56	I	H	0.0000
57	K	H	-0.8956
58	P	H	-0.8509
59	T	H	-0.5899
63	G	H	-0.6996
64	S	H	-0.3868
65	T	H	0.1663
66	I	H	0.7023
67	Y	H	-0.0855
68	P	H	-0.5195
69	G	H	-1.1623
70	S	H	-1.0632
71	G	H	0.0000
72	K	H	-2.0088
74	G	H	-1.7292
75	R	H	-1.7583
76	F	H	0.0000
77	T	H	-0.8159
78	I	H	0.0000
79	S	H	-0.4882
80	R	H	-1.1582
81	D	H	-1.5995
82	N	H	-1.9834
83	A	H	-1.5513
84	K	H	-2.4184
85	N	H	-2.0357
86	T	H	-1.1688
87	L	H	0.0000
88	Y	H	-0.5694
89	L	H	0.0000
90	Q	H	-1.3695
91	I	H	0.0000
92	N	H	-2.1851
93	N	H	-2.4478
94	L	H	0.0000
95	K	H	-2.6303
96	P	H	-1.9444
97	E	H	-2.3313
98	D	H	0.0000
99	T	H	-0.8533
100	A	H	0.0000
101	L	H	-0.1276
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	-0.0865
107	D	H	0.4001
108	I	H	1.6535
114	G	H	0.4600
115	G	H	0.2318
116	T	H	0.1828
117	V	H	0.0914
118	R	H	-0.9906
119	G	H	-0.7850
120	Q	H	-1.1908
121	G	H	0.0000
122	T	H	-0.6566
123	Q	H	-0.8066
124	V	H	0.0000
125	T	H	-0.2385
126	V	H	0.0000
127	S	H	-0.4840
128	S	H	-0.8768