| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIIKNGKVVVPKVSGYQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGSVGHPLFNKLGDTENPTEPQHCGEDDRVNFSFDPKQTQLFIVGCEPPTGEHWDLAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYRRCGEVGHPLPDAPPPSPLYVPPPPSSPYAVRPPYDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLSTPANNVYDPSNFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9405 | |
| 2 | L | A | 1.9630 | |
| 3 | P | A | 0.6496 | |
| 4 | P | A | 0.3550 | |
| 5 | T | A | 0.1139 | |
| 6 | T | A | 0.1255 | |
| 7 | P | A | 0.1540 | |
| 8 | V | A | 1.2356 | |
| 9 | A | A | 0.0821 | |
| 10 | K | A | -1.0273 | |
| 11 | V | A | -0.1715 | |
| 12 | Q | A | -1.4082 | |
| 13 | S | A | -1.5490 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4076 | |
| 16 | E | A | -2.4331 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4649 | |
| 20 | P | A | 0.1304 | |
| 21 | T | A | 0.1593 | |
| 22 | S | A | -0.0967 | |
| 23 | L | A | 0.0869 | |
| 24 | F | A | -0.0357 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2911 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.9104 | |
| 31 | R | A | -2.6957 | |
| 32 | L | A | -0.8062 | |
| 33 | L | A | 1.1576 | |
| 34 | T | A | 1.3682 | |
| 35 | V | A | 1.8251 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.1765 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.5685 | |
| 40 | K | A | -1.4994 | |
| 41 | D | A | -0.6433 | |
| 42 | I | A | 1.0399 | |
| 43 | I | A | 1.2779 | |
| 44 | K | A | -1.0525 | |
| 45 | N | A | -1.8788 | |
| 46 | G | A | -1.1800 | |
| 47 | K | A | -0.8924 | |
| 48 | V | A | 1.5373 | |
| 49 | V | A | 2.1041 | |
| 50 | V | A | 1.3308 | |
| 51 | P | A | 0.5400 | |
| 52 | K | A | -0.5662 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1460 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.4017 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2673 | |
| 70 | K | A | -1.7856 | |
| 71 | F | A | -0.6343 | |
| 72 | A | A | -0.5746 | |
| 73 | L | A | -0.8639 | |
| 74 | P | A | -1.2067 | |
| 75 | Q | A | -2.5024 | |
| 76 | K | A | -3.1076 | |
| 77 | D | A | -2.9895 | |
| 78 | F | A | -1.6733 | |
| 79 | Y | A | -1.8898 | |
| 80 | D | A | -2.6931 | |
| 81 | P | A | -2.3680 | |
| 82 | E | A | -3.0535 | |
| 83 | K | A | -3.3957 | |
| 84 | E | A | -2.4617 | |
| 85 | R | A | -1.2966 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6644 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9687 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3689 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.7037 | |
| 99 | G | A | -0.5396 | |
| 100 | P | A | -0.4094 | |
| 101 | L | A | 0.0337 | |
| 102 | G | A | -0.2203 | |
| 103 | K | A | -0.6416 | |
| 104 | G | A | -0.4994 | |
| 105 | S | A | -0.5334 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | -0.1262 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | -0.1499 | |
| 110 | L | A | -0.0673 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.2831 | |
| 113 | K | A | -0.5460 | |
| 114 | L | A | -0.9261 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.4920 | |
| 117 | T | A | -1.1302 | |
| 118 | E | A | -1.8916 | |
| 119 | N | A | -2.2509 | |
| 120 | P | A | -2.0614 | |
| 121 | T | A | -1.7170 | |
| 122 | E | A | -2.4840 | |
| 123 | P | A | -1.4639 | |
| 124 | Q | A | -1.5163 | |
| 125 | H | A | -0.8563 | |
| 126 | C | A | -1.5192 | |
| 127 | G | A | -2.2324 | |
| 128 | E | A | -3.0980 | |
| 129 | D | A | -3.1240 | |
| 130 | D | A | -2.1988 | |
| 131 | R | A | -1.6473 | |
| 132 | V | A | -0.4574 | |
| 133 | N | A | -0.8768 | |
| 134 | F | A | -0.3750 | |
| 135 | S | A | -0.3900 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.5091 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5633 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.1887 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1962 | |
| 157 | D | A | 0.3667 | |
| 158 | L | A | 0.8377 | |
| 159 | A | A | 0.2077 | |
| 160 | E | A | -1.4392 | |
| 161 | P | A | -0.1981 | |
| 162 | C | A | 0.1914 | |
| 163 | P | A | -0.1654 | |
| 164 | G | A | -0.0701 | |
| 165 | L | A | 0.6026 | |
| 166 | P | A | -0.1093 | |
| 167 | P | A | -0.3385 | |
| 168 | G | A | -0.6228 | |
| 169 | A | A | -0.0246 | |
| 170 | C | A | 0.6679 | |
| 171 | P | A | 0.5473 | |
| 172 | P | A | 0.8920 | |
| 173 | I | A | 2.0841 | |
| 174 | Q | A | 0.9005 | |
| 175 | L | A | 1.5182 | |
| 176 | V | A | 0.8700 | |
| 177 | N | A | -0.2946 | |
| 178 | S | A | 0.0260 | |
| 179 | V | A | 0.4258 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3797 | |
| 182 | D | A | 0.0808 | |
| 183 | G | A | -0.1599 | |
| 184 | D | A | -0.5259 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1273 | |
| 190 | F | A | 0.0628 | |
| 191 | G | A | -0.1036 | |
| 192 | N | A | -0.2445 | |
| 193 | M | A | -0.0905 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.3999 | |
| 197 | E | A | -2.6328 | |
| 198 | L | A | -1.2300 | |
| 199 | Q | A | -2.5751 | |
| 200 | Q | A | -3.3284 | |
| 201 | D | A | -3.6249 | |
| 202 | R | A | -3.3306 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.1900 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3564 | |
| 211 | S | A | -1.8847 | |
| 212 | T | A | -1.4189 | |
| 213 | R | A | -2.0326 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1526 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3870 | |
| 220 | L | A | 0.6266 | |
| 221 | K | A | -1.0714 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.7949 | |
| 224 | N | A | -1.5592 | |
| 225 | E | A | -1.2194 | |
| 226 | A | A | -0.6051 | |
| 227 | Y | A | -0.3586 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6658 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | 0.0832 | |
| 234 | F | A | 0.2654 | |
| 235 | G | A | -0.8153 | |
| 236 | R | A | -2.5624 | |
| 237 | R | A | -2.7781 | |
| 238 | E | A | -1.9655 | |
| 239 | Q | A | -0.0779 | |
| 240 | V | A | 1.4967 | |
| 241 | Y | A | 1.1296 | |
| 242 | A | A | 0.2271 | |
| 243 | R | A | -0.9426 | |
| 244 | H | A | -0.9518 | |
| 245 | F | A | 0.0542 | |
| 246 | Y | A | 0.0000 | |
| 247 | R | A | 0.0000 | |
| 248 | R | A | -0.5717 | |
| 249 | C | A | -1.3960 | |
| 250 | G | A | -2.0707 | |
| 251 | E | A | -2.2533 | |
| 252 | V | A | -1.5096 | |
| 253 | G | A | -1.4122 | |
| 254 | H | A | -1.3929 | |
| 255 | P | A | -1.2007 | |
| 256 | L | A | -0.2538 | |
| 257 | P | A | -0.8467 | |
| 258 | D | A | -1.8843 | |
| 259 | A | A | -0.6283 | |
| 260 | P | A | -0.6856 | |
| 261 | P | A | -0.1808 | |
| 262 | P | A | 0.0689 | |
| 263 | S | A | 0.2918 | |
| 264 | P | A | 0.6867 | |
| 265 | L | A | 1.8609 | |
| 266 | Y | A | 1.5329 | |
| 267 | V | A | 1.9071 | |
| 268 | P | A | 0.5603 | |
| 269 | P | A | 0.4477 | |
| 270 | P | A | -0.1853 | |
| 271 | P | A | -0.1548 | |
| 272 | S | A | -0.1529 | |
| 273 | S | A | 0.1950 | |
| 274 | P | A | 0.0092 | |
| 275 | Y | A | 0.9585 | |
| 276 | A | A | 0.8451 | |
| 277 | V | A | 1.5245 | |
| 278 | R | A | 0.2819 | |
| 279 | P | A | -0.3253 | |
| 280 | P | A | 0.0000 | |
| 281 | Y | A | -0.1068 | |
| 282 | D | A | -0.5745 | |
| 283 | Y | A | 1.0649 | |
| 284 | F | A | 0.7840 | |
| 285 | G | A | 0.2471 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9279 | |
| 291 | L | A | 1.6235 | |
| 292 | V | A | 0.6298 | |
| 293 | S | A | -0.1639 | |
| 294 | S | A | -0.9632 | |
| 295 | D | A | -1.8430 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.0994 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6382 | |
| 301 | R | A | -1.8352 | |
| 302 | P | A | -0.9768 | |
| 303 | F | A | -0.1951 | |
| 304 | W | A | -0.5683 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0863 | |
| 307 | R | A | -2.8250 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.3555 | |
| 310 | G | A | -1.2051 | |
| 311 | N | A | -1.2584 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.8543 | |
| 319 | N | A | -0.8603 | |
| 320 | E | A | -1.0405 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3493 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.1065 | |
| 333 | N | A | 0.5143 | |
| 334 | F | A | 1.7222 | |
| 335 | T | A | 0.8479 | |
| 336 | I | A | 0.3907 | |
| 337 | S | A | -1.0604 | |
| 338 | Q | A | -1.8726 | |
| 339 | Q | A | -1.7754 | |
| 340 | L | A | 0.1562 | |
| 341 | S | A | -0.1769 | |
| 342 | T | A | -0.3765 | |
| 343 | P | A | -0.7789 | |
| 344 | A | A | -0.7400 | |
| 345 | N | A | -1.2505 | |
| 346 | N | A | -0.8655 | |
| 347 | V | A | 1.1228 | |
| 348 | Y | A | 1.1361 | |
| 349 | D | A | -0.3576 | |
| 350 | P | A | -0.6932 | |
| 351 | S | A | -0.5440 | |
| 352 | N | A | -0.5740 | |
| 353 | F | A | -1.0782 | |
| 354 | K | A | -2.0318 | |
| 355 | N | A | -1.8460 | |
| 356 | Y | A | -0.1539 | |
| 357 | L | A | 0.6251 | |
| 358 | R | A | 0.9566 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.3786 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0880 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -2.0834 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6944 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.3014 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3132 | |
| 376 | L | A | -1.7093 | |
| 377 | D | A | -1.9805 | |
| 378 | P | A | -1.0333 | |
| 379 | G | A | -1.0142 | |
| 380 | V | A | -0.9345 | |
| 381 | L | A | -0.5339 | |
| 382 | A | A | -0.6599 | |
| 383 | H | A | -0.8132 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4249 | |
| 386 | T | A | -0.5601 | |
| 387 | M | A | -0.3048 | |
| 388 | N | A | -0.8682 | |
| 389 | P | A | -1.2586 | |
| 390 | T | A | -1.4773 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.4766 | |
| 393 | E | A | -2.8261 | |
| 394 | N | A | -2.4440 | |
| 395 | W | A | -1.4297 | |
| 396 | N | A | -1.1791 | |
| 397 | L | A | -0.2014 | |
| 398 | G | A | 0.4976 | |
| 399 | F | A | 2.4067 | |
| 400 | V | A | 1.8223 | |
| 401 | P | A | 0.0434 | |
| 402 | P | A | -1.8839 | |
| 403 | K | A | -3.3444 | |
| 404 | E | A | -3.8196 | |
| 405 | R | A | -4.0081 | |
| 406 | E | A | -3.8391 | |
| 407 | D | A | -2.9085 | |
| 408 | P | A | -1.7835 | |
| 409 | Y | A | -0.9949 | |
| 410 | K | A | -2.1219 | |
| 411 | G | A | -0.6423 | |
| 412 | L | A | 0.6700 | |
| 413 | I | A | 1.5888 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3915 | |
| 416 | E | A | -1.6861 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9506 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0573 | |
| 421 | E | A | -2.7941 | |
| 422 | R | A | -2.6589 | |
| 423 | F | A | -1.2967 | |
| 424 | S | A | -1.4874 | |
| 425 | Q | A | -1.8865 | |
| 426 | D | A | -2.9881 | |
| 427 | L | A | -2.1757 | |
| 428 | D | A | -3.0439 | |
| 429 | Q | A | -2.7624 | |
| 430 | F | A | -1.6071 | |
| 431 | A | A | -1.1330 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.2651 | |
| 435 | K | A | -1.0794 | |
| 436 | F | A | -0.1028 | |
| 437 | L | A | 0.7875 | |
| 438 | Y | A | 0.6317 | |
| 439 | Q | A | -0.3842 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine