| Chain sequence(s) |
A: GPPPLNPEPEIKKTTEYVEPTDLLYIAETDTITEVGHPTKDIVVNGKVLVPKVSATQWRVFKLTLPDPNKLPLPSEDFVDPSTEILIWQLRAFEIHVGGPLGYGEYGHPHFNRLGNVDNPTEYQHGTADDTVNYSWRPKLLQEYIIGCLPPLGVYTAPAAPAPGLPPGARPPLTRVTTIIEDGDAADIGFGARDYAALLPRKDEVPDIILDTTTKRVDYEGMKAEPYGLRMFDSDRYEKSYAKEKLVLDGPDLEPLPDAPPPSPLYTPPPPWSPTWVRPSTRYFTIPDRGEITEEDLLFNKPRFFEEAEGNNDFILWHNQLYVTVLDNRRAEIETKRTRISTPEPDVYDPSNYVTSKTYSRTYQLSLIIQLCKIPLTPEVLEYLRRLDPSILVEANLPDIPPVDRPDPLAGKKFHEIDLTKKLSSDLSKYPLGRLYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.6874 | |
| 2 | P | A | -0.4001 | |
| 3 | P | A | -0.4571 | |
| 4 | P | A | -0.5204 | |
| 5 | L | A | 0.4389 | |
| 6 | N | A | -1.3493 | |
| 7 | P | A | -1.9022 | |
| 8 | E | A | -2.6610 | |
| 9 | P | A | -2.2353 | |
| 10 | E | A | -2.2781 | |
| 11 | I | A | -0.8213 | |
| 12 | K | A | -1.3081 | |
| 13 | K | A | -1.7555 | |
| 14 | T | A | 0.0000 | |
| 15 | T | A | -1.8920 | |
| 16 | E | A | -2.4497 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | E | A | -1.9972 | |
| 20 | P | A | -1.3796 | |
| 21 | T | A | -1.2532 | |
| 22 | D | A | -1.5925 | |
| 23 | L | A | -0.4597 | |
| 24 | L | A | -0.1208 | |
| 25 | Y | A | -0.0367 | |
| 26 | I | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -0.9048 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.0489 | |
| 31 | T | A | -1.2050 | |
| 32 | I | A | 0.0000 | |
| 33 | T | A | -0.0428 | |
| 34 | E | A | 0.0000 | |
| 35 | V | A | 1.3885 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -1.1101 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -1.5399 | |
| 40 | K | A | -1.9892 | |
| 41 | D | A | -0.6556 | |
| 42 | I | A | 1.4431 | |
| 43 | V | A | 2.3907 | |
| 44 | V | A | 1.6861 | |
| 45 | N | A | -0.5478 | |
| 46 | G | A | -0.3661 | |
| 47 | K | A | -0.0554 | |
| 48 | V | A | 2.1269 | |
| 49 | L | A | 2.7317 | |
| 50 | V | A | 1.8376 | |
| 51 | P | A | 0.4278 | |
| 52 | K | A | -0.7501 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | T | A | 0.0000 | |
| 57 | Q | A | -0.4267 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | -0.4903 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | K | A | -1.3538 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.3619 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.3397 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.9022 | |
| 70 | K | A | -1.9529 | |
| 71 | L | A | -0.7529 | |
| 72 | P | A | -0.5611 | |
| 73 | L | A | -0.5205 | |
| 74 | P | A | -0.5863 | |
| 75 | S | A | -1.4848 | |
| 76 | E | A | -2.8095 | |
| 77 | D | A | -2.8629 | |
| 78 | F | A | -1.4980 | |
| 79 | V | A | 0.0000 | |
| 80 | D | A | -2.2301 | |
| 81 | P | A | -1.5264 | |
| 82 | S | A | -1.1931 | |
| 83 | T | A | -0.7471 | |
| 84 | E | A | -0.9928 | |
| 85 | I | A | 0.0000 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | Q | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.7814 | |
| 92 | A | A | 0.0000 | |
| 93 | F | A | 0.0000 | |
| 94 | E | A | 0.0000 | |
| 95 | I | A | 0.0000 | |
| 96 | H | A | -0.9657 | |
| 97 | V | A | 0.0000 | |
| 98 | G | A | -0.6177 | |
| 99 | G | A | -0.8307 | |
| 100 | P | A | -0.5001 | |
| 101 | L | A | -0.1926 | |
| 102 | G | A | 0.0000 | |
| 103 | Y | A | -0.3284 | |
| 104 | G | A | 0.0000 | |
| 105 | E | A | -1.9898 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -1.3031 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | -1.3169 | |
| 110 | H | A | -1.8807 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | R | A | -1.1163 | |
| 114 | L | A | 0.0000 | |
| 115 | G | A | 0.0000 | |
| 116 | N | A | -1.5451 | |
| 117 | V | A | -1.3103 | |
| 118 | D | A | -2.7987 | |
| 119 | N | A | -2.6500 | |
| 120 | P | A | -1.7577 | |
| 121 | T | A | -1.5564 | |
| 122 | E | A | -2.0568 | |
| 123 | Y | A | -0.8193 | |
| 124 | Q | A | -1.2586 | |
| 125 | H | A | -1.5063 | |
| 126 | G | A | -1.4985 | |
| 127 | T | A | -1.2009 | |
| 128 | A | A | -1.0248 | |
| 129 | D | A | -2.1265 | |
| 130 | D | A | -1.5998 | |
| 131 | T | A | -1.3057 | |
| 132 | V | A | -0.8860 | |
| 133 | N | A | -1.4675 | |
| 134 | Y | A | -0.7400 | |
| 135 | S | A | -0.9707 | |
| 136 | W | A | 0.0000 | |
| 137 | R | A | -1.1274 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | L | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | E | A | -1.5129 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | L | A | 0.2929 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | L | A | -0.1930 | |
| 153 | G | A | 0.0000 | |
| 154 | V | A | 0.0000 | |
| 155 | Y | A | -1.1290 | |
| 156 | T | A | -0.6420 | |
| 157 | A | A | -0.2559 | |
| 158 | P | A | -0.1070 | |
| 159 | A | A | 0.1969 | |
| 160 | A | A | 0.0774 | |
| 161 | P | A | -0.2849 | |
| 162 | A | A | -0.1442 | |
| 163 | P | A | -0.3379 | |
| 164 | G | A | -0.3592 | |
| 165 | L | A | -0.1535 | |
| 166 | P | A | -0.5175 | |
| 167 | P | A | -0.7495 | |
| 168 | G | A | -0.7595 | |
| 169 | A | A | -0.9270 | |
| 170 | R | A | -1.6416 | |
| 171 | P | A | -0.8014 | |
| 172 | P | A | 0.0366 | |
| 173 | L | A | 0.6997 | |
| 174 | T | A | -0.2262 | |
| 175 | R | A | -1.4422 | |
| 176 | V | A | -0.4993 | |
| 177 | T | A | -0.3715 | |
| 178 | T | A | 0.2105 | |
| 179 | I | A | -0.1230 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | -1.2788 | |
| 182 | D | A | -1.4436 | |
| 183 | G | A | -0.9128 | |
| 184 | D | A | -0.7954 | |
| 185 | A | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.2799 | |
| 190 | F | A | 0.0000 | |
| 191 | G | A | -0.6655 | |
| 192 | A | A | 0.0000 | |
| 193 | R | A | -1.2833 | |
| 194 | D | A | -0.8732 | |
| 195 | Y | A | 0.0000 | |
| 196 | A | A | -1.0993 | |
| 197 | A | A | -0.3326 | |
| 198 | L | A | -0.3423 | |
| 199 | L | A | -1.0679 | |
| 200 | P | A | -1.1798 | |
| 201 | R | A | -2.2848 | |
| 202 | K | A | -2.2535 | |
| 203 | D | A | 0.0000 | |
| 204 | E | A | -1.1322 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.8318 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -1.5063 | |
| 211 | D | A | -1.9623 | |
| 212 | T | A | -1.2222 | |
| 213 | T | A | -0.7821 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | R | A | -1.7772 | |
| 217 | V | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | Y | A | -1.4862 | |
| 220 | E | A | -2.4068 | |
| 221 | G | A | -1.5838 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.7888 | |
| 224 | A | A | -1.5227 | |
| 225 | E | A | -1.2992 | |
| 226 | P | A | -0.7333 | |
| 227 | Y | A | -0.2907 | |
| 228 | G | A | 0.0000 | |
| 229 | L | A | -0.0878 | |
| 230 | R | A | -0.2414 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | D | A | -1.3154 | |
| 234 | S | A | -1.4422 | |
| 235 | D | A | -2.2035 | |
| 236 | R | A | -2.7786 | |
| 237 | Y | A | -2.1364 | |
| 238 | E | A | -2.4648 | |
| 239 | K | A | -1.3885 | |
| 240 | S | A | -0.6927 | |
| 241 | Y | A | 0.2665 | |
| 242 | A | A | -0.3903 | |
| 243 | K | A | -1.3993 | |
| 244 | E | A | -1.7740 | |
| 245 | K | A | -1.8459 | |
| 246 | L | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | L | A | 0.0000 | |
| 249 | D | A | -1.2422 | |
| 250 | G | A | -0.6838 | |
| 251 | P | A | -0.8530 | |
| 252 | D | A | -0.6540 | |
| 253 | L | A | 0.0026 | |
| 254 | E | A | -1.2452 | |
| 255 | P | A | -1.1053 | |
| 256 | L | A | -0.1930 | |
| 257 | P | A | -0.8266 | |
| 258 | D | A | -1.7720 | |
| 259 | A | A | -0.7619 | |
| 260 | P | A | -0.9316 | |
| 261 | P | A | -0.6035 | |
| 262 | P | A | -0.3172 | |
| 263 | S | A | -0.1557 | |
| 264 | P | A | 0.4572 | |
| 265 | L | A | 1.3999 | |
| 266 | Y | A | 0.7662 | |
| 267 | T | A | 0.1598 | |
| 268 | P | A | -0.1353 | |
| 269 | P | A | 0.2371 | |
| 270 | P | A | 0.2183 | |
| 271 | P | A | 0.6768 | |
| 272 | W | A | 1.2949 | |
| 273 | S | A | 0.8184 | |
| 274 | P | A | 0.4180 | |
| 275 | T | A | 0.3356 | |
| 276 | W | A | 1.2835 | |
| 277 | V | A | 1.2060 | |
| 278 | R | A | -0.7954 | |
| 279 | P | A | -0.7325 | |
| 280 | S | A | -0.7015 | |
| 281 | T | A | -0.1934 | |
| 282 | R | A | -0.0529 | |
| 283 | Y | A | 0.9453 | |
| 284 | F | A | 0.3428 | |
| 285 | T | A | -0.3047 | |
| 286 | I | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | 0.0000 | |
| 289 | R | A | 0.0000 | |
| 290 | G | A | -0.9548 | |
| 291 | E | A | -1.6455 | |
| 292 | I | A | -1.1091 | |
| 293 | T | A | -2.0677 | |
| 294 | E | A | -3.0008 | |
| 295 | E | A | -3.5123 | |
| 296 | D | A | -2.9624 | |
| 297 | L | A | -2.1487 | |
| 298 | L | A | 0.0000 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.4195 | |
| 301 | K | A | -1.6235 | |
| 302 | P | A | -0.7256 | |
| 303 | R | A | -0.6506 | |
| 304 | F | A | -0.5331 | |
| 305 | F | A | 0.0000 | |
| 306 | E | A | -2.7029 | |
| 307 | E | A | -3.2255 | |
| 308 | A | A | -2.4587 | |
| 309 | E | A | -2.7167 | |
| 310 | G | A | -2.0234 | |
| 311 | N | A | -1.6133 | |
| 312 | N | A | 0.0000 | |
| 313 | D | A | 0.0000 | |
| 314 | F | A | 0.0000 | |
| 315 | I | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.6356 | |
| 319 | N | A | -0.4782 | |
| 320 | Q | A | -0.5226 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | R | A | 0.0000 | |
| 330 | R | A | 0.0000 | |
| 331 | A | A | 0.0000 | |
| 332 | E | A | -2.0127 | |
| 333 | I | A | -2.1560 | |
| 334 | E | A | -3.0647 | |
| 335 | T | A | -2.8227 | |
| 336 | K | A | -3.2898 | |
| 337 | R | A | -2.4024 | |
| 338 | T | A | -0.8583 | |
| 339 | R | A | -0.8025 | |
| 340 | I | A | 1.2782 | |
| 341 | S | A | 0.1982 | |
| 342 | T | A | -0.5772 | |
| 343 | P | A | -1.3505 | |
| 344 | E | A | -2.1907 | |
| 345 | P | A | -1.3883 | |
| 346 | D | A | -1.2448 | |
| 347 | V | A | 1.0203 | |
| 348 | Y | A | 1.2500 | |
| 349 | D | A | -0.1281 | |
| 350 | P | A | -0.2549 | |
| 351 | S | A | 0.0767 | |
| 352 | N | A | 0.0696 | |
| 353 | Y | A | 0.2553 | |
| 354 | V | A | 0.9682 | |
| 355 | T | A | -1.2809 | |
| 356 | S | A | -1.8325 | |
| 357 | K | A | -2.7491 | |
| 358 | T | A | -1.6067 | |
| 359 | Y | A | 0.0000 | |
| 360 | S | A | -0.1890 | |
| 361 | R | A | 0.0000 | |
| 362 | T | A | -0.1894 | |
| 363 | Y | A | 0.0000 | |
| 364 | Q | A | -1.1273 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | I | A | 0.0000 | |
| 370 | Q | A | -0.3298 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -1.0247 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.8309 | |
| 376 | L | A | -0.6090 | |
| 377 | T | A | -0.9360 | |
| 378 | P | A | -1.4942 | |
| 379 | E | A | -2.4277 | |
| 380 | V | A | 0.0000 | |
| 381 | L | A | -1.6523 | |
| 382 | E | A | -2.8283 | |
| 383 | Y | A | 0.0000 | |
| 384 | L | A | 0.0000 | |
| 385 | R | A | -2.1553 | |
| 386 | R | A | -1.7251 | |
| 387 | L | A | -0.8436 | |
| 388 | D | A | -0.8633 | |
| 389 | P | A | -1.0947 | |
| 390 | S | A | -0.9049 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -1.2119 | |
| 394 | E | A | -1.6990 | |
| 395 | A | A | -1.6198 | |
| 396 | N | A | -2.0707 | |
| 397 | L | A | -1.4089 | |
| 398 | P | A | -1.3357 | |
| 399 | D | A | -1.9700 | |
| 400 | I | A | -0.8841 | |
| 401 | P | A | -0.6720 | |
| 402 | P | A | -0.5831 | |
| 403 | V | A | 0.2288 | |
| 404 | D | A | -1.9182 | |
| 405 | R | A | -2.3215 | |
| 406 | P | A | -1.9197 | |
| 407 | D | A | -2.3535 | |
| 408 | P | A | -1.3804 | |
| 409 | L | A | 0.0000 | |
| 410 | A | A | -1.3086 | |
| 411 | G | A | -1.4818 | |
| 412 | K | A | -2.1025 | |
| 413 | K | A | -2.6586 | |
| 414 | F | A | -1.8133 | |
| 415 | H | A | -1.7609 | |
| 416 | E | A | -2.5599 | |
| 417 | I | A | -1.9269 | |
| 418 | D | A | -2.6278 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.5884 | |
| 421 | K | A | -2.2754 | |
| 422 | K | A | -1.8834 | |
| 423 | L | A | -0.6392 | |
| 424 | S | A | -0.7404 | |
| 425 | S | A | -0.5038 | |
| 426 | D | A | -1.2870 | |
| 427 | L | A | 0.0000 | |
| 428 | S | A | -1.3084 | |
| 429 | K | A | -2.1617 | |
| 430 | Y | A | -1.0733 | |
| 431 | P | A | -0.6590 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.1721 | |
| 435 | L | A | 0.1770 | |
| 436 | Y | A | 0.0830 | |
| 437 | L | A | 0.3005 | |
| 438 | N | A | -1.3556 | |
| 439 | R | A | -1.7673 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine