| Chain sequence(s) |
A: FSRPGLPVEYLQVPSPSMGRDIKVQFQSGGNNSPAVYLLDGLRAQDDYNGWDINTPAFEWYYQSGLSIVMPVGGQSSFYSDWYSPACGKAGCQTYKWETFLTSELPQWLSANRAVKPTGSAAIGLSMAGSSAMILAAYHPQQFIYAGSLSALLDPSQGMGPSLIGLAMGDAGGYKAADMWGPSSDPAWERNDPTQQIPKLVANNTRLWVYCGNGTPNELGGANIPAEFLENFVRSSNLKFQDAYNAAGGHNAVFNFPPNGTHSWEYWGAQLNAMKGDLQSSLGAGAEAAAKEAAAKEAAAKEAAAKALEAEAAAKEAAAKEAAAKEAAAKAFAVTNDGVI
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:03:03)
[INFO] Main: Simulation completed successfully. (00:03:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | F | A | 1.3708 | |
| 2 | S | A | -0.2526 | |
| 3 | R | A | -1.7182 | |
| 4 | P | A | -1.1109 | |
| 5 | G | A | -1.0336 | |
| 6 | L | A | -0.7384 | |
| 7 | P | A | -0.2661 | |
| 8 | V | A | -0.0028 | |
| 9 | E | A | -0.2737 | |
| 10 | Y | A | 0.6249 | |
| 11 | L | A | 0.0000 | |
| 12 | Q | A | -1.8140 | |
| 13 | V | A | 0.0000 | |
| 14 | P | A | -1.6155 | |
| 15 | S | A | 0.0000 | |
| 16 | P | A | -1.0035 | |
| 17 | S | A | -0.6965 | |
| 18 | M | A | 0.0000 | |
| 19 | G | A | -1.3723 | |
| 20 | R | A | -1.9622 | |
| 21 | D | A | -2.7134 | |
| 22 | I | A | 0.0000 | |
| 23 | K | A | -1.3822 | |
| 24 | V | A | 0.0000 | |
| 25 | Q | A | 0.0000 | |
| 26 | F | A | 0.0000 | |
| 27 | Q | A | 0.0000 | |
| 28 | S | A | -0.8406 | |
| 29 | G | A | -0.9607 | |
| 30 | G | A | -1.5512 | |
| 31 | N | A | -2.1520 | |
| 32 | N | A | -1.9103 | |
| 33 | S | A | 0.0000 | |
| 34 | P | A | -0.8513 | |
| 35 | A | A | 0.0000 | |
| 36 | V | A | 0.0000 | |
| 37 | Y | A | 0.0000 | |
| 38 | L | A | 0.0000 | |
| 39 | L | A | 0.0000 | |
| 40 | D | A | 0.0000 | |
| 41 | G | A | 0.0000 | |
| 42 | L | A | -1.0141 | |
| 43 | R | A | -2.4418 | |
| 44 | A | A | 0.0000 | |
| 45 | Q | A | -2.4400 | |
| 46 | D | A | -2.9497 | |
| 47 | D | A | -2.0568 | |
| 48 | Y | A | -0.4059 | |
| 49 | N | A | 0.0000 | |
| 50 | G | A | 0.0000 | |
| 51 | W | A | 0.0000 | |
| 52 | D | A | 0.0000 | |
| 53 | I | A | 0.8615 | |
| 54 | N | A | -0.0469 | |
| 55 | T | A | 0.0000 | |
| 56 | P | A | -0.2322 | |
| 57 | A | A | 0.0000 | |
| 58 | F | A | 0.0000 | |
| 59 | E | A | -0.9052 | |
| 60 | W | A | -0.4407 | |
| 61 | Y | A | 0.0000 | |
| 62 | Y | A | -0.2449 | |
| 63 | Q | A | -1.1478 | |
| 64 | S | A | 0.0000 | |
| 65 | G | A | -1.0379 | |
| 66 | L | A | 0.0000 | |
| 67 | S | A | 0.0000 | |
| 68 | I | A | 0.0000 | |
| 69 | V | A | 0.0000 | |
| 70 | M | A | 0.0000 | |
| 71 | P | A | 0.0000 | |
| 72 | V | A | 0.0000 | |
| 73 | G | A | 0.0000 | |
| 74 | G | A | 0.0000 | |
| 75 | Q | A | -1.3611 | |
| 76 | S | A | 0.0000 | |
| 77 | S | A | 0.0000 | |
| 78 | F | A | 0.0000 | |
| 79 | Y | A | 0.0000 | |
| 80 | S | A | 0.0000 | |
| 81 | D | A | -0.5756 | |
| 82 | W | A | 0.0000 | |
| 83 | Y | A | 0.9594 | |
| 84 | S | A | 0.0583 | |
| 85 | P | A | -0.2183 | |
| 86 | A | A | 0.0000 | |
| 87 | C | A | -0.5617 | |
| 88 | G | A | -1.5641 | |
| 89 | K | A | -2.0091 | |
| 90 | A | A | -0.9326 | |
| 91 | G | A | -0.6763 | |
| 92 | C | A | -0.0513 | |
| 93 | Q | A | -0.7487 | |
| 94 | T | A | -0.5454 | |
| 95 | Y | A | 0.0000 | |
| 96 | K | A | -0.8916 | |
| 97 | W | A | 0.0000 | |
| 98 | E | A | -0.5798 | |
| 99 | T | A | -0.5185 | |
| 100 | F | A | 0.0000 | |
| 101 | L | A | 0.0000 | |
| 102 | T | A | -0.3448 | |
| 103 | S | A | -0.5157 | |
| 104 | E | A | -0.6904 | |
| 105 | L | A | 0.0000 | |
| 106 | P | A | 0.0000 | |
| 107 | Q | A | -1.5713 | |
| 108 | W | A | -0.8438 | |
| 109 | L | A | 0.0000 | |
| 110 | S | A | -1.4402 | |
| 111 | A | A | -0.9676 | |
| 112 | N | A | -1.2555 | |
| 113 | R | A | -1.5961 | |
| 114 | A | A | -1.5817 | |
| 115 | V | A | 0.0000 | |
| 116 | K | A | -1.8642 | |
| 117 | P | A | -1.2287 | |
| 118 | T | A | -0.9101 | |
| 119 | G | A | -0.5440 | |
| 120 | S | A | 0.0000 | |
| 121 | A | A | 0.0000 | |
| 122 | A | A | 0.0000 | |
| 123 | I | A | 0.0000 | |
| 124 | G | A | 0.0000 | |
| 125 | L | A | 0.0000 | |
| 126 | S | A | -0.1599 | |
| 127 | M | A | 0.0000 | |
| 128 | A | A | 0.0000 | |
| 129 | G | A | 0.0000 | |
| 130 | S | A | 0.0000 | |
| 131 | S | A | 0.0000 | |
| 132 | A | A | 0.0000 | |
| 133 | M | A | 0.0000 | |
| 134 | I | A | 0.0000 | |
| 135 | L | A | 0.0000 | |
| 136 | A | A | 0.0000 | |
| 137 | A | A | 0.0000 | |
| 138 | Y | A | -0.0912 | |
| 139 | H | A | -0.3352 | |
| 140 | P | A | -0.8977 | |
| 141 | Q | A | -1.2075 | |
| 142 | Q | A | 0.0000 | |
| 143 | F | A | 0.0000 | |
| 144 | I | A | -0.2839 | |
| 145 | Y | A | 0.0000 | |
| 146 | A | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | S | A | 0.0000 | |
| 149 | L | A | 0.0000 | |
| 150 | S | A | 0.0000 | |
| 151 | A | A | 0.0000 | |
| 152 | L | A | 0.2815 | |
| 153 | L | A | 0.0000 | |
| 154 | D | A | 0.0000 | |
| 155 | P | A | 0.0000 | |
| 156 | S | A | -1.0519 | |
| 157 | Q | A | -0.9857 | |
| 158 | G | A | -0.3068 | |
| 159 | M | A | 0.6607 | |
| 160 | G | A | 0.0000 | |
| 161 | P | A | 0.0795 | |
| 162 | S | A | 0.4107 | |
| 163 | L | A | 0.9109 | |
| 164 | I | A | 0.0000 | |
| 165 | G | A | -0.1125 | |
| 166 | L | A | 0.6384 | |
| 167 | A | A | -0.3670 | |
| 168 | M | A | 0.0000 | |
| 169 | G | A | -1.4560 | |
| 170 | D | A | -2.1563 | |
| 171 | A | A | 0.0000 | |
| 172 | G | A | 0.0000 | |
| 173 | G | A | -1.8259 | |
| 174 | Y | A | 0.0000 | |
| 175 | K | A | -1.8930 | |
| 176 | A | A | -0.7695 | |
| 177 | A | A | -0.6741 | |
| 178 | D | A | -0.4917 | |
| 179 | M | A | 0.0000 | |
| 180 | W | A | 0.0000 | |
| 181 | G | A | 0.0000 | |
| 182 | P | A | -0.6321 | |
| 183 | S | A | -0.9386 | |
| 184 | S | A | -0.8790 | |
| 185 | D | A | -1.1065 | |
| 186 | P | A | -1.1763 | |
| 187 | A | A | -0.8295 | |
| 188 | W | A | 0.0000 | |
| 189 | E | A | -2.1159 | |
| 190 | R | A | -1.2555 | |
| 191 | N | A | 0.0000 | |
| 192 | D | A | 0.0000 | |
| 193 | P | A | 0.0000 | |
| 194 | T | A | -0.9624 | |
| 195 | Q | A | -1.0981 | |
| 196 | Q | A | 0.0000 | |
| 197 | I | A | 0.0000 | |
| 198 | P | A | -0.9100 | |
| 199 | K | A | -1.2016 | |
| 200 | L | A | 0.0000 | |
| 201 | V | A | -1.2567 | |
| 202 | A | A | -0.9200 | |
| 203 | N | A | -1.4645 | |
| 204 | N | A | -1.8602 | |
| 205 | T | A | 0.0000 | |
| 206 | R | A | -0.9672 | |
| 207 | L | A | 0.0000 | |
| 208 | W | A | 0.0000 | |
| 209 | V | A | 0.0000 | |
| 210 | Y | A | 0.0000 | |
| 211 | C | A | 0.0000 | |
| 212 | G | A | 0.0000 | |
| 213 | N | A | -0.8361 | |
| 214 | G | A | 0.0000 | |
| 215 | T | A | -1.1611 | |
| 216 | P | A | -1.5853 | |
| 217 | N | A | -2.1276 | |
| 218 | E | A | -2.1545 | |
| 219 | L | A | -0.8943 | |
| 220 | G | A | -1.1664 | |
| 221 | G | A | -0.9834 | |
| 222 | A | A | -0.8067 | |
| 223 | N | A | -0.5706 | |
| 224 | I | A | 1.3994 | |
| 225 | P | A | 0.6842 | |
| 226 | A | A | 0.0650 | |
| 227 | E | A | -0.1659 | |
| 228 | F | A | 1.5830 | |
| 229 | L | A | 1.2913 | |
| 230 | E | A | 0.0000 | |
| 231 | N | A | -0.7464 | |
| 232 | F | A | 0.4067 | |
| 233 | V | A | 0.0000 | |
| 234 | R | A | -0.3840 | |
| 235 | S | A | -0.6425 | |
| 236 | S | A | 0.0000 | |
| 237 | N | A | 0.0000 | |
| 238 | L | A | -0.5469 | |
| 239 | K | A | -1.8043 | |
| 240 | F | A | 0.0000 | |
| 241 | Q | A | -1.5504 | |
| 242 | D | A | -2.5775 | |
| 243 | A | A | -1.7235 | |
| 244 | Y | A | 0.0000 | |
| 245 | N | A | -2.4249 | |
| 246 | A | A | -1.3387 | |
| 247 | A | A | -0.9930 | |
| 248 | G | A | -1.1364 | |
| 249 | G | A | -1.7804 | |
| 250 | H | A | -1.7150 | |
| 251 | N | A | -1.3865 | |
| 252 | A | A | -0.6511 | |
| 253 | V | A | 0.1984 | |
| 254 | F | A | 0.4171 | |
| 255 | N | A | -0.1374 | |
| 256 | F | A | 0.0174 | |
| 257 | P | A | -0.3201 | |
| 258 | P | A | -0.6532 | |
| 259 | N | A | -0.7439 | |
| 260 | G | A | 0.0000 | |
| 261 | T | A | 0.0000 | |
| 262 | H | A | -0.6639 | |
| 263 | S | A | -0.4922 | |
| 264 | W | A | -0.4800 | |
| 265 | E | A | -1.1019 | |
| 266 | Y | A | 0.0000 | |
| 267 | W | A | 0.0000 | |
| 268 | G | A | 0.0000 | |
| 269 | A | A | -0.4694 | |
| 270 | Q | A | -0.6094 | |
| 271 | L | A | 0.0000 | |
| 272 | N | A | -0.9478 | |
| 273 | A | A | -0.6280 | |
| 274 | M | A | 0.0000 | |
| 275 | K | A | -1.0733 | |
| 276 | G | A | -1.0685 | |
| 277 | D | A | -0.8437 | |
| 278 | L | A | 0.0000 | |
| 279 | Q | A | -0.9235 | |
| 280 | S | A | -0.7703 | |
| 281 | S | A | -0.5159 | |
| 282 | L | A | -0.3244 | |
| 283 | G | A | -0.7560 | |
| 284 | A | A | -0.8082 | |
| 285 | G | A | -1.3679 | |
| 286 | A | A | -1.3041 | |
| 287 | E | A | -2.4486 | |
| 288 | A | A | -2.0045 | |
| 289 | A | A | -1.5822 | |
| 290 | A | A | -2.0158 | |
| 291 | K | A | -3.3282 | |
| 292 | E | A | -3.4556 | |
| 293 | A | A | -2.5373 | |
| 294 | A | A | -2.2379 | |
| 295 | A | A | -2.5568 | |
| 296 | K | A | -3.6181 | |
| 297 | E | A | -3.6706 | |
| 298 | A | A | -2.5364 | |
| 299 | A | A | -2.1978 | |
| 300 | A | A | -2.5309 | |
| 301 | K | A | -3.4207 | |
| 302 | E | A | -3.2503 | |
| 303 | A | A | -2.0302 | |
| 304 | A | A | -1.4378 | |
| 305 | A | A | -1.9010 | |
| 306 | K | A | -2.6888 | |
| 307 | A | A | -1.4187 | |
| 308 | L | A | -0.5533 | |
| 309 | E | A | -2.2641 | |
| 310 | A | A | -1.9399 | |
| 311 | E | A | -2.5124 | |
| 312 | A | A | -2.1234 | |
| 313 | A | A | -1.8049 | |
| 314 | A | A | -2.1115 | |
| 315 | K | A | -3.5096 | |
| 316 | E | A | -3.4681 | |
| 317 | A | A | -2.5460 | |
| 318 | A | A | -2.2259 | |
| 319 | A | A | -2.5497 | |
| 320 | K | A | -3.6311 | |
| 321 | E | A | -3.6873 | |
| 322 | A | A | -2.5586 | |
| 323 | A | A | -2.2302 | |
| 324 | A | A | -2.5477 | |
| 325 | K | A | -3.4282 | |
| 326 | E | A | -3.2167 | |
| 327 | A | A | -1.7858 | |
| 328 | A | A | -1.0800 | |
| 329 | A | A | -0.8711 | |
| 330 | K | A | -1.2458 | |
| 331 | A | A | 0.2017 | |
| 332 | F | A | 1.2718 | |
| 333 | A | A | 0.3290 | |
| 334 | V | A | 1.0662 | |
| 335 | T | A | 0.2753 | |
| 336 | N | A | -0.4204 | |
| 337 | D | A | -0.8394 | |
| 338 | G | A | 0.1120 | |
| 339 | V | A | 1.8228 | |
| 340 | I | A | 2.1657 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine