Project name: 53251e1576dc38c

Chain sequence(s)	A: MRVLYLLFSFLFIFLMPLPGVFGGIGDPVTCLKSGAICHPVFCPRRYKQIGTCGLPGTKCCKKPEAAKPEEELVKANSWNQFLQSGKKVSEYARKKLAATERTYGLRFKDQRVHVVSKSERVKMPKKKKEEDIRKLVTMYPDNITIAEERKKRLSFFTGFDSVEHGPGPGTPSIQAIVPLLVPEEGPGPGMWIFLLSNKLSGHSVGPGPGKGEVVVNGRIAYVPQAAYRVKVKSMSKGPGPGSVIPMLMSFGPGPGHLSFLTFSW
Selected Chain(s)	A
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:04:43)
[INFO]       Main:     Simulation completed successfully.                                          (00:04:44)

• Minimal score value: -4.7419
• Maximal score value: 5.775
• Average score: -0.2636
• Total score value: -69.8555

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	1.3687
2	R	A	0.5267
3	V	A	2.7555
4	L	A	3.3101
5	Y	A	3.2418
6	L	A	3.6114
7	L	A	4.1248
8	F	A	4.5908
9	S	A	4.4441
10	F	A	5.4290
11	L	A	5.3608
12	F	A	5.7750
13	I	A	5.7056
14	F	A	5.5369
15	L	A	4.8789
16	M	A	3.8826
17	P	A	2.1028
18	L	A	2.7545
19	P	A	1.0748
20	G	A	1.1322
21	V	A	2.5194
22	F	A	2.4332
23	G	A	0.6507
24	G	A	0.2971
25	I	A	0.0255
26	G	A	-0.4217
27	D	A	-0.4806
28	P	A	0.5268
29	V	A	1.3684
30	T	A	0.1916
31	C	A	0.0000
32	L	A	1.2206
33	K	A	-0.6085
34	S	A	-0.2501
35	G	A	-0.6330
36	A	A	0.0000
37	I	A	0.5957
38	C	A	0.9062
39	H	A	0.3505
40	P	A	0.9080
41	V	A	1.9925
42	F	A	1.5168
43	C	A	-0.4153
44	P	A	-1.4261
45	R	A	-2.8174
46	R	A	-3.3119
47	Y	A	-2.6704
48	K	A	-2.8569
49	Q	A	-1.6620
50	I	A	-0.6950
51	G	A	-0.6976
52	T	A	-0.7616
53	C	A	0.0000
54	G	A	-0.2403
55	L	A	0.7388
56	P	A	0.2614
57	G	A	0.3249
58	T	A	0.4196
59	K	A	-0.1871
60	C	A	0.0000
61	C	A	0.0000
62	K	A	-1.9266
63	K	A	-3.0859
64	P	A	-2.5615
65	E	A	-2.6005
66	A	A	-1.5608
67	A	A	-1.7870
68	K	A	-2.9932
69	P	A	-2.8616
70	E	A	-3.7096
71	E	A	-3.1260
72	E	A	-2.2941
73	L	A	0.0698
74	V	A	0.7347
75	K	A	-0.8908
76	A	A	-0.7654
77	N	A	-1.7885
78	S	A	-0.8213
79	W	A	0.0765
80	N	A	-1.5048
81	Q	A	-1.6364
82	F	A	-0.2274
83	L	A	-0.5901
84	Q	A	-1.6531
85	S	A	-1.5674
86	G	A	-1.8196
87	K	A	-2.5083
88	K	A	-2.7167
89	V	A	-1.1395
90	S	A	-1.5916
91	E	A	-2.5523
92	Y	A	-0.9848
93	A	A	-1.7266
94	R	A	-3.1552
95	K	A	-3.2108
96	K	A	-2.8411
97	L	A	-1.5118
98	A	A	-1.7095
99	A	A	-1.6207
100	T	A	-1.0523
101	E	A	-0.8393
102	R	A	-1.8861
103	T	A	-0.3391
104	Y	A	0.6891
105	G	A	-0.0517
106	L	A	0.8001
107	R	A	-0.7528
108	F	A	-0.6578
109	K	A	-2.7738
110	D	A	-3.3609
111	Q	A	-2.8511
112	R	A	-2.3958
113	V	A	0.5121
114	H	A	0.4702
115	V	A	2.2868
116	V	A	1.6692
117	S	A	-0.0489
118	K	A	-1.9531
119	S	A	-2.0661
120	E	A	-3.0800
121	R	A	-2.4688
122	V	A	-0.2313
123	K	A	-1.3620
124	M	A	-0.2895
125	P	A	-1.4511
126	K	A	-3.2079
127	K	A	-3.8792
128	K	A	-4.4493
129	K	A	-4.7419
130	E	A	-4.5864
131	E	A	-4.3858
132	D	A	-3.3580
133	I	A	-2.0526
134	R	A	-3.0831
135	K	A	-2.1994
136	L	A	0.3303
137	V	A	0.3134
138	T	A	0.1465
139	M	A	1.0640
140	Y	A	1.0487
141	P	A	-0.1569
142	D	A	-1.7536
143	N	A	-1.1011
144	I	A	0.5512
145	T	A	0.3839
146	I	A	1.3290
147	A	A	-0.6056
148	E	A	-2.7932
149	E	A	-3.9409
150	R	A	-4.6347
151	K	A	-4.3150
152	K	A	-3.8606
153	R	A	-2.4191
154	L	A	0.4048
155	S	A	1.2833
156	F	A	2.8956
157	F	A	3.1347
158	T	A	1.4433
159	G	A	0.7632
160	F	A	1.2564
161	D	A	-0.8258
162	S	A	-0.3826
163	V	A	0.2205
164	E	A	-1.8766
165	H	A	-1.7917
166	G	A	-1.4644
167	P	A	-1.2595
168	G	A	-1.0864
169	P	A	-0.8094
170	G	A	-0.8515
171	T	A	-0.3484
172	P	A	-0.1188
173	S	A	0.0605
174	I	A	1.4798
175	Q	A	0.4260
176	A	A	1.5862
177	I	A	3.3380
178	V	A	3.4066
179	P	A	2.7318
180	L	A	3.3509
181	L	A	2.8193
182	V	A	1.4593
183	P	A	-0.5941
184	E	A	-2.4311
185	E	A	-2.9044
186	G	A	-2.1418
187	P	A	-1.3228
188	G	A	-1.2285
189	P	A	-0.9442
190	G	A	0.0364
191	M	A	1.5517
192	W	A	2.1256
193	I	A	2.6832
194	F	A	2.4270
195	L	A	1.9193
196	L	A	1.4373
197	S	A	-0.1708
198	N	A	-1.3279
199	K	A	-1.6611
200	L	A	-0.2284
201	S	A	-0.5607
202	G	A	-0.5088
203	H	A	-0.0447
204	S	A	0.3391
205	V	A	1.2390
206	G	A	-0.1016
207	P	A	-0.6971
208	G	A	-1.0809
209	P	A	-1.1027
210	G	A	-1.5740
211	K	A	-1.8585
212	G	A	-0.6121
213	E	A	-0.0629
214	V	A	0.8367
215	V	A	0.7401
216	V	A	-0.2465
217	N	A	-1.5891
218	G	A	-1.2679
219	R	A	-1.4663
220	I	A	0.3667
221	A	A	0.8716
222	Y	A	0.9391
223	V	A	0.5433
224	P	A	-0.3771
225	Q	A	-1.2454
226	A	A	-0.3820
227	A	A	-0.1056
228	Y	A	-0.3526
229	R	A	-1.5549
230	V	A	-0.8751
231	K	A	-1.8745
232	V	A	-0.5382
233	K	A	-1.3650
234	S	A	-0.8447
235	M	A	-0.1241
236	S	A	-1.0562
237	K	A	-1.7994
238	G	A	-1.1713
239	P	A	-1.0079
240	G	A	-1.3595
241	P	A	-0.9491
242	G	A	-0.8018
243	S	A	-0.0204
244	V	A	1.3731
245	I	A	1.6454
246	P	A	1.5213
247	M	A	1.7557
248	L	A	1.6357
249	M	A	1.3230
250	S	A	0.7824
251	F	A	0.3930
252	G	A	-0.7281
253	P	A	-0.9364
254	G	A	-1.0353
255	P	A	-1.2198
256	G	A	-1.5903
257	H	A	-1.1972
258	L	A	-0.0438
259	S	A	0.6041
260	F	A	1.7946
261	L	A	1.8327
262	T	A	1.7745
263	F	A	2.5448
264	S	A	1.5952
265	W	A	1.8340