Project name: 538cf57153c4c2e

Chain sequence(s)	H: EVQLVESGGGVVQPGGSLRLSCVASGFSFSDFGMNWVRQAPGKGLEWVAFVPFDRRINYYAESVRGRFTISRDDSKNTVFLQMDSLRPEDTAIYYCAKHRSQWNFWPREGGLDHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP; L: QSALTQPASVSGSPGQSITISCTGTSSDVGGYNYVSWYRQHPGEAPKAIIFDVTNRPSGISNRFSGSKFGNTASLTISGLQAEDEADYYCAAYTVASTLLFGGGTKVTVLRQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPT
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:05:11)
[INFO]       Main:     Simulation completed successfully.                                          (00:05:15)

• Minimal score value: -3.1858
• Maximal score value: 1.7349
• Average score: -0.6619
• Total score value: -289.9137

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	L	-1.6145
2	S	L	-0.8154
3	A	L	-0.6181
4	L	L	0.0000
5	T	L	-0.3385
6	Q	L	-0.3835
7	P	L	-0.2434
8	A	L	-0.3323
9	S	L	-0.3489
11	V	L	-0.0445
12	S	L	-0.4452
13	G	L	0.0000
14	S	L	-1.1483
15	P	L	-1.3596
16	G	L	-1.4799
17	Q	L	-1.8032
18	S	L	-1.1932
19	I	L	0.0000
20	T	L	-0.1469
21	I	L	0.0000
22	S	L	-0.2412
23	C	L	0.0000
24	T	L	-0.3134
25	G	L	-0.5501
26	T	L	-0.6680
27	S	L	-0.4502
27A	S	L	0.2017
27B	D	L	0.0000
27C	V	L	0.0000
28	G	L	-0.7238
29	G	L	-0.3455
30	Y	L	-0.3376
31	N	L	-1.3229
32	Y	L	-0.6393
33	V	L	0.0000
34	S	L	0.0000
35	W	L	0.0000
36	Y	L	0.0000
37	R	L	-1.4053
38	Q	L	0.0000
39	H	L	-1.8605
40	P	L	-1.4029
41	G	L	-1.6836
42	E	L	-2.7200
43	A	L	-1.8828
44	P	L	0.0000
45	K	L	-2.1624
46	A	L	0.0000
47	I	L	0.0000
48	I	L	0.0000
49	F	L	-0.6725
50	D	L	-1.0350
51	V	L	0.0000
52	T	L	-0.9726
53	N	L	-1.2765
54	R	L	-1.7422
55	P	L	-0.9835
56	S	L	-0.8733
57	G	L	-0.8082
58	I	L	-0.9644
59	S	L	-1.0830
60	N	L	-1.8030
61	R	L	-1.2788
62	F	L	0.0000
63	S	L	-0.9857
64	G	L	-0.6601
65	S	L	-0.3438
66	K	L	-0.0596
67	F	L	1.2589
68	G	L	-0.0975
69	N	L	-0.6827
70	T	L	-0.1847
71	A	L	0.0000
72	S	L	-0.0540
73	L	L	0.0000
74	T	L	-0.3184
75	I	L	0.0000
76	S	L	-1.1882
77	G	L	-1.2570
78	L	L	0.0000
79	Q	L	-1.7934
80	A	L	-1.6019
81	E	L	-2.1775
82	D	L	0.0000
83	E	L	-1.3316
84	A	L	0.0000
85	D	L	-1.1450
86	Y	L	0.0000
87	Y	L	0.0000
88	C	L	0.0000
89	A	L	0.0000
90	A	L	0.0000
91	Y	L	0.0000
92	T	L	0.0000
93	V	L	1.7349
94	A	L	0.9587
95	S	L	0.6710
95A	T	L	0.2904
96	L	L	0.0000
97	L	L	-0.1200
98	F	L	0.0000
99	G	L	0.0000
100	G	L	-0.9256
101	G	L	-0.8936
102	T	L	0.0000
103	K	L	-0.6800
104	V	L	0.0000
105	T	L	0.0000
106	V	L	0.0000
106A	L	L	-1.2482
107	R	L	-2.3239
108	Q	L	-1.9178
109	P	L	-1.6156
110	K	L	-2.2501
111	A	L	-1.2317
112	A	L	-0.6231
113	P	L	0.0000
114	S	L	-0.4944
115	V	L	0.0000
116	T	L	-0.7158
117	L	L	0.0000
118	F	L	0.0000
119	P	L	-0.3176
120	P	L	0.0000
121	S	L	-1.0238
122	S	L	-1.4801
123	E	L	-2.5676
124	E	L	0.0000
125	L	L	-2.0773
126	Q	L	-2.4126
127	A	L	-1.9543
128	N	L	-2.6642
129	K	L	-2.5540
130	A	L	0.0000
131	T	L	0.0000
132	L	L	0.0000
133	V	L	0.0000
134	C	L	0.0000
135	L	L	0.0000
136	I	L	0.0000
137	S	L	-0.7022
138	D	L	-1.4140
139	F	L	0.0000
140	Y	L	0.0000
141	P	L	0.0000
142	G	L	0.0000
143	A	L	-0.1036
144	V	L	0.0183
145	T	L	-0.0298
146	V	L	-0.0388
147	A	L	-0.5301
148	W	L	0.0000
149	K	L	-0.9669
150	A	L	0.0000
151	D	L	-1.2970
152	S	L	-0.8656
153	S	L	-0.7862
154	P	L	-0.8809
155	V	L	-0.8846
156	K	L	-1.7810
157	A	L	-0.9510
158	G	L	-0.8821
159	V	L	-0.8586
160	E	L	-1.1176
161	T	L	-0.3838
162	T	L	-0.4501
163	T	L	-0.7279
164	P	L	-0.6235
165	S	L	-1.2416
166	K	L	-2.6247
167	Q	L	-2.1437
168	S	L	-1.7324
169	N	L	-2.2980
170	N	L	-2.8698
171	K	L	-2.3703
172	Y	L	0.0000
173	A	L	0.0000
174	A	L	0.0000
175	S	L	0.0000
176	S	L	0.0000
177	Y	L	0.0000
178	L	L	0.0000
179	S	L	-0.7241
180	L	L	0.0000
181	T	L	-1.8243
182	P	L	-2.4751
183	E	L	-3.1858
184	Q	L	-2.3513
185	W	L	0.0000
186	K	L	-3.1517
187	S	L	-2.3943
188	H	L	-2.3546
189	R	L	-2.5084
190	S	L	-1.5460
191	Y	L	0.0000
192	S	L	-1.0009
193	C	L	0.0000
194	Q	L	-1.0588
195	V	L	0.0000
196	T	L	-0.5307
197	H	L	0.0000
198	E	L	-1.3957
199	G	L	-1.0251
200	S	L	-0.6192
201	T	L	-0.6512
202	V	L	-0.7701
203	E	L	-2.0933
204	K	L	-1.8571
205	T	L	-1.2090
206	V	L	0.0000
207	A	L	-1.0811
208	P	L	-1.0911
209	T	L	-0.4055
1	E	H	-2.1397
2	V	H	-1.4439
3	Q	H	-1.2004
4	L	H	0.0000
5	V	H	1.5913
6	E	H	0.0000
7	S	H	0.1311
8	G	H	-0.5664
9	G	H	0.1405
10	G	H	0.8508
11	V	H	1.5709
12	V	H	0.0699
13	Q	H	-1.2169
14	P	H	-1.5328
15	G	H	-1.4529
16	G	H	-1.0115
17	S	H	-1.3893
18	L	H	-1.0615
19	R	H	-2.1348
20	L	H	0.0000
21	S	H	-0.0346
22	C	H	0.0000
23	V	H	0.9536
24	A	H	0.0000
25	S	H	-0.5671
26	G	H	-1.2217
27	F	H	-0.5684
28	S	H	-0.5121
29	F	H	0.0000
30	S	H	-1.0125
31	D	H	-0.5774
32	F	H	-0.2006
33	G	H	0.0000
34	M	H	0.0000
35	N	H	0.0000
36	W	H	0.0000
37	V	H	0.0000
38	R	H	0.0000
39	Q	H	-0.6389
40	A	H	-1.0463
41	P	H	-0.7836
42	G	H	-1.5276
43	K	H	-2.2824
44	G	H	-1.5487
45	L	H	0.0000
46	E	H	-0.9489
47	W	H	0.0000
48	V	H	0.0000
49	A	H	0.0000
50	F	H	0.0000
51	V	H	0.0000
52	P	H	0.0000
52A	F	H	0.0000
53	D	H	-2.2550
54	R	H	-2.8413
55	R	H	-1.7577
56	I	H	0.6599
57	N	H	0.0944
58	Y	H	0.0028
59	Y	H	-0.9635
60	A	H	-1.5874
61	E	H	-2.7500
62	S	H	-1.8059
63	V	H	0.0000
64	R	H	-2.7086
65	G	H	-1.8774
66	R	H	-1.6562
67	F	H	0.0000
68	T	H	-1.0079
69	I	H	0.0000
70	S	H	-0.6520
71	R	H	-1.1756
72	D	H	-1.3442
73	D	H	-1.8154
74	S	H	-1.5874
75	K	H	-2.1818
76	N	H	-1.4895
77	T	H	0.0000
78	V	H	0.0000
79	F	H	-0.3556
80	L	H	0.0000
81	Q	H	-1.3576
82	M	H	0.0000
82A	D	H	-1.7369
82B	S	H	-1.3871
82C	L	H	0.0000
83	R	H	-2.3399
84	P	H	-1.9481
85	E	H	-2.3108
86	D	H	0.0000
87	T	H	-0.4204
88	A	H	0.0000
89	I	H	0.6966
90	Y	H	0.0000
91	Y	H	0.0000
92	C	H	0.0000
93	A	H	0.0000
94	K	H	0.0000
95	H	H	0.0000
96	R	H	-0.7736
97	S	H	-0.7067
98	Q	H	-0.8028
99	W	H	0.4255
100	N	H	0.0000
100A	F	H	0.2249
100B	W	H	0.5297
100C	P	H	0.0000
100D	R	H	-0.6111
100E	E	H	-0.9467
100F	G	H	0.0000
100G	G	H	0.0000
100H	L	H	0.0000
101	D	H	-0.8267
102	H	H	-1.2770
103	W	H	-0.7051
104	G	H	0.0000
105	Q	H	-1.1915
106	G	H	0.0000
107	T	H	0.4988
108	L	H	1.2671
109	V	H	0.0000
110	T	H	0.3714
111	V	H	0.0000
112	S	H	-0.7121
113	S	H	-0.4523
114	A	H	-0.2666
115	S	H	-0.3999
116	T	H	-0.7216
117	K	H	-0.9542
118	G	H	-1.3366
119	P	H	0.0000
120	S	H	-0.3384
121	V	H	0.0000
122	F	H	0.0000
123	P	H	-1.0747
124	L	H	0.0000
125	A	H	-0.9106
126	P	H	0.0000
127	S	H	-1.1827
128	S	H	-1.2253
129	K	H	-2.0364
130	S	H	-1.1202
131	T	H	-1.0349
132	S	H	-0.9631
133	G	H	-0.8523
134	G	H	-0.9105
135	T	H	-0.6265
136	A	H	0.0000
137	A	H	-0.3299
138	L	H	0.0000
139	G	H	0.0000
140	C	H	0.0000
141	L	H	0.0000
142	V	H	0.0000
143	K	H	-0.3557
144	D	H	-0.5288
145	Y	H	0.0000
146	F	H	-0.4667
147	P	H	-0.9942
148	E	H	-1.5345
149	P	H	-1.3997
150	V	H	0.0000
151	T	H	-0.9400
152	V	H	0.0000
153	S	H	-0.4426
154	W	H	0.0000
155	N	H	-0.7670
156	S	H	-0.6384
157	G	H	-0.6057
158	A	H	-0.2514
159	L	H	-0.0124
160	T	H	-0.2095
161	S	H	-0.3128
162	G	H	-0.3279
163	V	H	0.1750
164	H	H	-0.1083
165	T	H	0.0013
166	F	H	0.0000
167	P	H	-0.2785
168	A	H	-0.1253
169	V	H	0.0000
170	L	H	0.1348
171	Q	H	-0.3469
172	S	H	-0.7236
173	S	H	-0.3338
174	G	H	-0.1248
175	L	H	-0.2293
176	Y	H	-0.1597
177	S	H	0.0000
178	L	H	0.0000
179	S	H	0.0000
180	S	H	0.0000
181	V	H	0.1640
182	V	H	0.0000
183	T	H	-0.1765
184	V	H	0.0000
185	P	H	-0.6122
186	S	H	-0.5969
187	S	H	-0.5711
188	S	H	0.0000
189	L	H	-0.8511
190	G	H	-1.0096
191	T	H	-0.7097
192	Q	H	-1.2244
193	T	H	-1.1406
194	Y	H	0.0000
195	I	H	-1.2467
196	C	H	0.0000
197	N	H	0.0000
198	V	H	0.0000
199	N	H	-2.2339
200	H	H	0.0000
201	K	H	-3.0025
202	P	H	-1.8139
203	S	H	-1.9111
204	N	H	-2.6466
205	T	H	-2.1683
206	K	H	-2.7519
207	V	H	-1.4921
208	D	H	-2.3321
209	K	H	-2.0380
210	K	H	-2.5476
211	V	H	0.0000
212	E	H	-2.5034
213	P	H	-1.2296