Project name: 5395e5fc9e01ebb

Chain sequence(s)	H: QVQLQESGPGLVKPSETLSLTCTVSGGSFSSHFWSWIRQPPGKGLEWIGYILYTGGTSFNPSLKSRVSMSVGTSKNQFSLKLSSVTAADTAVYYCARARSGITFTGIIVPGSFDIWGQGTMVTVSS; L: EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:42)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:45)

• Minimal score value: -3.301
• Maximal score value: 2.537
• Average score: -0.487
• Total score value: -113.9478

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.5337
2	V	H	-1.1729
3	Q	H	-1.7269
4	L	H	0.0000
5	Q	H	-1.5941
6	E	H	0.0000
7	S	H	-0.6628
8	G	H	-0.5061
9	P	H	-0.1260
11	G	H	0.1623
12	L	H	0.6936
13	V	H	0.0000
14	K	H	-1.6224
15	P	H	-1.2040
16	S	H	-1.2134
17	E	H	-1.6051
18	T	H	-1.2920
19	L	H	0.0000
20	S	H	-1.0046
21	L	H	0.0000
22	T	H	-0.6370
23	C	H	0.0000
24	T	H	-1.0510
25	V	H	0.0000
26	S	H	-1.3273
27	G	H	-1.2305
28	G	H	-0.9902
29	S	H	-0.4949
30	F	H	0.0000
35	S	H	-0.2229
36	S	H	-0.3293
37	H	H	-0.2615
38	F	H	0.0000
39	W	H	0.0000
40	S	H	0.0000
41	W	H	0.0000
42	I	H	0.0000
43	R	H	0.0000
44	Q	H	-0.7044
45	P	H	-0.8390
46	P	H	-0.9473
47	G	H	-1.4674
48	K	H	-2.3791
49	G	H	-1.6094
50	L	H	0.0000
51	E	H	-0.8054
52	W	H	0.0000
53	I	H	0.0000
54	G	H	0.0000
55	Y	H	0.1465
56	I	H	0.0000
57	L	H	0.3146
58	Y	H	0.3573
59	T	H	0.0003
63	G	H	-0.1981
64	G	H	-0.2376
65	T	H	-0.0788
66	S	H	-0.2851
67	F	H	-0.5825
68	N	H	-0.8021
69	P	H	-1.0493
70	S	H	-0.9204
71	L	H	0.0000
72	K	H	-2.0818
74	S	H	-1.3309
75	R	H	-1.4063
76	V	H	0.0000
77	S	H	-1.1795
78	M	H	0.0000
79	S	H	-0.3913
80	V	H	-0.1267
81	G	H	-0.7569
82	T	H	-0.8496
83	S	H	-1.1625
84	K	H	-2.0250
85	N	H	-1.2852
86	Q	H	-1.0325
87	F	H	0.0000
88	S	H	-0.5914
89	L	H	0.0000
90	K	H	-1.7737
91	L	H	0.0000
92	S	H	-1.0788
93	S	H	-0.9437
94	V	H	0.0000
95	T	H	-0.5175
96	A	H	-0.2115
97	A	H	0.0564
98	D	H	0.0000
99	T	H	0.1950
100	A	H	0.0000
101	V	H	0.3123
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	-0.4262
107	A	H	0.0000
108	R	H	-0.1913
109	S	H	0.7299
110	G	H	1.0890
111	I	H	2.5370
111A	T	H	2.0527
111B	F	H	2.4560
111C	T	H	1.7131
112D	G	H	1.3092
112C	I	H	2.0075
112B	I	H	2.0077
112A	V	H	1.5073
112	P	H	0.8171
113	G	H	0.0000
114	S	H	0.0000
115	F	H	0.0000
116	D	H	-0.4468
117	I	H	-0.5041
118	W	H	-0.7179
119	G	H	0.0000
120	Q	H	-1.7035
121	G	H	0.0000
122	T	H	-0.2537
123	M	H	0.4662
124	V	H	0.0000
125	T	H	0.2270
126	V	H	0.0000
127	S	H	-0.4540
128	S	H	-0.6316
1	E	L	-1.6424
2	I	L	0.0000
3	V	L	0.6041
4	L	L	0.0000
5	T	L	-0.8047
6	Q	L	0.0000
7	S	L	-0.9579
8	P	L	-0.6013
9	G	L	-1.0312
10	T	L	-0.9108
11	L	L	-0.6464
12	S	L	-0.8173
13	L	L	-1.0612
14	S	L	-1.5834
15	P	L	-1.7075
16	G	L	-1.9046
17	E	L	-2.5565
18	R	L	-3.0364
19	A	L	0.0000
20	T	L	-0.6293
21	L	L	0.0000
22	S	L	-0.9186
23	C	L	0.0000
24	R	L	-2.3665
25	A	L	0.0000
26	S	L	-1.0497
27	Q	L	-1.7839
28	S	L	-1.4304
29	V	L	0.0000
30	S	L	-0.6332
36	S	L	-0.3115
37	S	L	-0.4856
38	Y	L	0.1381
39	L	L	0.0000
40	A	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	Q	L	0.0000
45	K	L	-1.0461
46	P	L	-0.7882
47	G	L	-1.3029
48	Q	L	-1.7826
49	A	L	-1.1199
50	P	L	0.0000
51	R	L	-0.8784
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	-0.0061
56	G	L	-0.2333
57	A	L	0.0000
65	S	L	-0.5821
66	S	L	-0.5723
67	R	L	-1.2175
68	A	L	-0.6041
69	T	L	-0.4863
70	G	L	-0.7483
71	I	L	-0.8302
72	P	L	-1.1934
74	D	L	-2.3484
75	R	L	-1.9836
76	F	L	0.0000
77	S	L	-0.9200
78	G	L	-0.5024
79	S	L	-0.6813
80	G	L	-1.0834
83	S	L	-1.0908
84	G	L	-1.2805
85	T	L	-1.8031
86	D	L	-2.1976
87	F	L	0.0000
88	T	L	-0.7773
89	L	L	0.0000
90	T	L	-0.8506
91	I	L	0.0000
92	S	L	-2.4115
93	R	L	-3.3010
94	L	L	0.0000
95	E	L	-1.6016
96	P	L	-1.1817
97	E	L	-1.3896
98	D	L	0.0000
99	F	L	-0.3287
100	A	L	0.0000
101	V	L	-0.5976
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	Y	L	0.0000
108	G	L	-0.0335
109	S	L	-0.6594
114	S	L	-0.6317
115	P	L	0.0000
116	W	L	0.0000
117	T	L	-0.2122
118	F	L	0.0000
119	G	L	0.0000
120	Q	L	-1.5631
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.4374
124	V	L	0.0000
125	E	L	-1.0976
126	I	L	-1.1012
127	K	L	-1.7308