| Chain sequence(s) |
A: QVQLQQWGAGLVKPSETLSLTCAVYGGSFSNYYWTWIRQPPGKGLEWIGEINHSGNTNYNPSLKSRVTISVDTSRNQFSLKLNSVTVADTAVYNCARGGGVGATPYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC
B: EIVLTQSPGTLSLSPGERATLSCRAGQSVNSNFLIWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCLHYGSSPTFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC input PDB |
| Selected Chain(s) | A,B |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with all chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:05:53)
[INFO] Main: Simulation completed successfully. (00:05:57)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Q | A | -1.3361 | |
| 2 | V | A | 0.0000 | |
| 3 | Q | A | -0.9379 | |
| 4 | L | A | 0.0000 | |
| 5 | Q | A | -0.6871 | |
| 6 | Q | A | 0.0000 | |
| 7 | W | A | 0.2872 | |
| 8 | G | A | 0.1918 | |
| 9 | A | A | 0.2646 | |
| 10 | G | A | 0.5128 | |
| 11 | L | A | 0.2241 | |
| 12 | V | A | 0.0000 | |
| 13 | K | A | -1.8236 | |
| 14 | P | A | -1.0475 | |
| 15 | S | A | -1.2138 | |
| 16 | E | A | -1.8457 | |
| 17 | T | A | -1.5408 | |
| 18 | L | A | 0.0000 | |
| 19 | S | A | -0.7594 | |
| 20 | L | A | 0.0000 | |
| 21 | T | A | -0.1516 | |
| 22 | C | A | 0.0000 | |
| 23 | A | A | 0.0000 | |
| 24 | V | A | 0.0000 | |
| 25 | Y | A | 0.0768 | |
| 26 | G | A | -0.6034 | |
| 27 | G | A | -0.7629 | |
| 28 | S | A | -0.5722 | |
| 29 | F | A | 0.0000 | |
| 30 | S | A | -0.9272 | |
| 31 | N | A | -0.9346 | |
| 32 | Y | A | 0.0784 | |
| 33 | Y | A | 0.3150 | |
| 34 | W | A | 0.0000 | |
| 35 | T | A | 0.0000 | |
| 36 | W | A | 0.0000 | |
| 37 | I | A | 0.0000 | |
| 38 | R | A | 0.0000 | |
| 39 | Q | A | -0.5386 | |
| 40 | P | A | -0.6903 | |
| 41 | P | A | -0.8391 | |
| 42 | G | A | -1.4965 | |
| 43 | K | A | -2.3547 | |
| 44 | G | A | -1.4947 | |
| 45 | L | A | -0.7307 | |
| 46 | E | A | -0.8093 | |
| 47 | W | A | 0.0000 | |
| 48 | I | A | 0.0000 | |
| 49 | G | A | 0.0000 | |
| 50 | E | A | 0.0000 | |
| 51 | I | A | 0.0000 | |
| 52 | N | A | -0.9414 | |
| 53 | H | A | -1.1955 | |
| 54 | S | A | -1.0640 | |
| 55 | G | A | -1.2186 | |
| 56 | N | A | -1.6285 | |
| 57 | T | A | -0.9573 | |
| 58 | N | A | -1.0101 | |
| 59 | Y | A | -0.7892 | |
| 60 | N | A | -1.0717 | |
| 61 | P | A | -1.1598 | |
| 62 | S | A | -0.8464 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.0686 | |
| 65 | S | A | -1.3939 | |
| 66 | R | A | -1.5230 | |
| 67 | V | A | 0.0000 | |
| 68 | T | A | -1.0284 | |
| 69 | I | A | 0.0000 | |
| 70 | S | A | -0.7243 | |
| 71 | V | A | -0.9618 | |
| 72 | D | A | -1.6610 | |
| 73 | T | A | -1.4751 | |
| 74 | S | A | -1.5137 | |
| 75 | R | A | -2.3082 | |
| 76 | N | A | -1.5509 | |
| 77 | Q | A | -1.2470 | |
| 78 | F | A | 0.0000 | |
| 79 | S | A | -0.4412 | |
| 80 | L | A | 0.0000 | |
| 81 | K | A | -1.4863 | |
| 82 | L | A | 0.0000 | |
| 83 | N | A | -1.6169 | |
| 84 | S | A | -1.4289 | |
| 85 | V | A | 0.0000 | |
| 86 | T | A | 0.1719 | |
| 87 | V | A | 1.4576 | |
| 88 | A | A | 0.8875 | |
| 89 | D | A | 0.0000 | |
| 90 | T | A | 0.8648 | |
| 91 | A | A | 0.0000 | |
| 92 | V | A | 0.8342 | |
| 93 | Y | A | 0.0000 | |
| 94 | N | A | 0.0000 | |
| 95 | C | A | 0.0000 | |
| 96 | A | A | 0.0000 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | 0.0000 | |
| 99 | G | A | 0.4286 | |
| 100 | G | A | 0.6521 | |
| 101 | V | A | 1.3534 | |
| 102 | G | A | 0.2474 | |
| 103 | A | A | 0.0329 | |
| 104 | T | A | 0.0669 | |
| 105 | P | A | 0.0000 | |
| 106 | Y | A | 0.5096 | |
| 107 | F | A | 0.0000 | |
| 108 | D | A | -0.3363 | |
| 109 | Y | A | -0.2508 | |
| 110 | W | A | -0.5693 | |
| 111 | G | A | 0.0000 | |
| 112 | Q | A | -1.3541 | |
| 113 | G | A | -0.4306 | |
| 114 | T | A | 0.5126 | |
| 115 | L | A | 1.1376 | |
| 116 | V | A | 0.0000 | |
| 117 | T | A | 0.0000 | |
| 118 | V | A | 0.0000 | |
| 119 | S | A | -0.2076 | |
| 120 | S | A | -0.6329 | |
| 121 | A | A | -0.5520 | |
| 122 | S | A | -0.6163 | |
| 123 | T | A | -0.6938 | |
| 124 | K | A | -1.1608 | |
| 125 | G | A | -1.3711 | |
| 126 | P | A | 0.0000 | |
| 127 | S | A | -0.4044 | |
| 128 | V | A | 0.0000 | |
| 129 | F | A | 0.0000 | |
| 130 | P | A | -1.2908 | |
| 131 | L | A | 0.0000 | |
| 132 | A | A | -1.2985 | |
| 133 | P | A | 0.0000 | |
| 134 | S | A | -0.9189 | |
| 135 | S | A | -0.6125 | |
| 136 | K | A | -0.6967 | |
| 137 | S | A | 0.0000 | |
| 138 | T | A | -0.5937 | |
| 139 | S | A | -0.6635 | |
| 140 | G | A | -0.8068 | |
| 141 | G | A | -0.8750 | |
| 142 | T | A | -0.6127 | |
| 143 | A | A | 0.0000 | |
| 144 | A | A | 0.0000 | |
| 145 | L | A | 0.0000 | |
| 146 | G | A | 0.0000 | |
| 147 | C | A | 0.0000 | |
| 148 | L | A | 0.0000 | |
| 149 | V | A | 0.0000 | |
| 150 | K | A | 0.0000 | |
| 151 | D | A | -0.3665 | |
| 152 | Y | A | 0.0000 | |
| 153 | F | A | 0.0000 | |
| 154 | P | A | -0.7260 | |
| 155 | E | A | -0.6474 | |
| 156 | P | A | -0.9507 | |
| 157 | V | A | -0.8542 | |
| 158 | T | A | -0.7103 | |
| 159 | V | A | -0.3771 | |
| 160 | S | A | -0.3896 | |
| 161 | W | A | 0.0000 | |
| 162 | N | A | -0.7020 | |
| 163 | S | A | -0.6240 | |
| 164 | G | A | -0.5427 | |
| 165 | A | A | -0.2726 | |
| 166 | L | A | -0.0401 | |
| 167 | T | A | -0.2025 | |
| 168 | S | A | -0.2026 | |
| 169 | G | A | -0.2310 | |
| 170 | V | A | 0.1337 | |
| 171 | H | A | -0.3134 | |
| 172 | T | A | 0.0086 | |
| 173 | F | A | 0.0000 | |
| 174 | P | A | -0.3583 | |
| 175 | A | A | 0.1506 | |
| 176 | V | A | 0.4970 | |
| 177 | L | A | 1.0954 | |
| 178 | Q | A | 0.2830 | |
| 179 | S | A | -0.0479 | |
| 180 | S | A | -0.1763 | |
| 181 | G | A | 0.2332 | |
| 182 | L | A | 0.0880 | |
| 183 | Y | A | 0.3259 | |
| 184 | S | A | 0.0000 | |
| 185 | L | A | 0.0000 | |
| 186 | S | A | 0.0000 | |
| 187 | S | A | 0.0000 | |
| 188 | V | A | 0.0000 | |
| 189 | V | A | 0.0000 | |
| 190 | T | A | -0.1416 | |
| 191 | V | A | 0.0000 | |
| 192 | P | A | -0.6409 | |
| 193 | S | A | -0.5739 | |
| 194 | S | A | -0.6149 | |
| 195 | S | A | -0.6518 | |
| 196 | L | A | -0.8395 | |
| 197 | G | A | -1.0044 | |
| 198 | T | A | -0.8076 | |
| 199 | Q | A | -1.4082 | |
| 200 | T | A | -1.1218 | |
| 201 | Y | A | 0.0000 | |
| 202 | I | A | -1.0462 | |
| 203 | C | A | 0.0000 | |
| 204 | N | A | -1.3222 | |
| 205 | V | A | 0.0000 | |
| 206 | N | A | -2.1945 | |
| 207 | H | A | 0.0000 | |
| 208 | K | A | -2.8622 | |
| 209 | P | A | -1.7065 | |
| 210 | S | A | -1.8668 | |
| 211 | N | A | -2.6525 | |
| 212 | T | A | -2.1627 | |
| 213 | K | A | -2.7051 | |
| 214 | V | A | -1.4189 | |
| 215 | D | A | -2.0205 | |
| 216 | K | A | -1.8806 | |
| 217 | K | A | -2.0847 | |
| 218 | V | A | 0.0000 | |
| 219 | E | A | -2.8092 | |
| 220 | P | A | -1.8726 | |
| 221 | K | A | -2.0783 | |
| 222 | S | A | -0.8721 | |
| 223 | C | A | 0.0655 | |
| 1 | E | B | -1.4865 | |
| 2 | I | B | -0.1036 | |
| 3 | V | B | 0.7964 | |
| 4 | L | B | 0.0000 | |
| 5 | T | B | -0.6583 | |
| 6 | Q | B | 0.0000 | |
| 7 | S | B | -0.6906 | |
| 8 | P | B | -0.4176 | |
| 9 | G | B | -0.7576 | |
| 10 | T | B | -0.3058 | |
| 11 | L | B | -0.0369 | |
| 12 | S | B | -0.2368 | |
| 13 | L | B | -0.5605 | |
| 14 | S | B | -1.0917 | |
| 15 | P | B | -1.5465 | |
| 16 | G | B | -1.8631 | |
| 17 | E | B | -2.3333 | |
| 18 | R | B | -2.9766 | |
| 19 | A | B | 0.0000 | |
| 20 | T | B | -0.5322 | |
| 21 | L | B | 0.0000 | |
| 22 | S | B | -0.9154 | |
| 23 | C | B | 0.0000 | |
| 24 | R | B | -2.1346 | |
| 25 | A | B | 0.0000 | |
| 26 | G | B | -1.1583 | |
| 27 | Q | B | -1.7410 | |
| 28 | S | B | -1.5128 | |
| 29 | V | B | -1.1499 | |
| 30 | N | B | -1.0582 | |
| 31 | S | B | -0.9726 | |
| 32 | N | B | -0.6517 | |
| 33 | F | B | 0.0810 | |
| 34 | L | B | 0.0000 | |
| 35 | I | B | 0.0000 | |
| 36 | W | B | 0.0000 | |
| 37 | Y | B | 0.0000 | |
| 38 | Q | B | 0.0000 | |
| 39 | Q | B | -0.9479 | |
| 40 | K | B | -1.3634 | |
| 41 | P | B | -1.3261 | |
| 42 | G | B | -1.3711 | |
| 43 | Q | B | -2.0476 | |
| 44 | A | B | -1.2223 | |
| 45 | P | B | 0.0000 | |
| 46 | R | B | -1.3782 | |
| 47 | L | B | -0.5262 | |
| 48 | L | B | 0.0000 | |
| 49 | I | B | 0.0000 | |
| 50 | Y | B | 0.0627 | |
| 51 | G | B | -0.3439 | |
| 52 | A | B | 0.0000 | |
| 53 | S | B | -0.6663 | |
| 54 | S | B | -0.6178 | |
| 55 | R | B | -1.1955 | |
| 56 | A | B | 0.0000 | |
| 57 | T | B | -0.4128 | |
| 58 | G | B | -0.7418 | |
| 59 | I | B | -0.8731 | |
| 60 | P | B | -1.2292 | |
| 61 | D | B | -2.1566 | |
| 62 | R | B | -2.0596 | |
| 63 | F | B | 0.0000 | |
| 64 | S | B | -0.8961 | |
| 65 | G | B | 0.0000 | |
| 66 | S | B | -0.8112 | |
| 67 | G | B | -1.3124 | |
| 68 | S | B | -1.4376 | |
| 69 | G | B | -1.5131 | |
| 70 | T | B | -2.1110 | |
| 71 | D | B | -2.7593 | |
| 72 | F | B | 0.0000 | |
| 73 | T | B | -0.8828 | |
| 74 | L | B | 0.0000 | |
| 75 | T | B | -0.7967 | |
| 76 | I | B | 0.0000 | |
| 77 | S | B | -2.2889 | |
| 78 | R | B | -3.1004 | |
| 79 | L | B | 0.0000 | |
| 80 | E | B | -2.3599 | |
| 81 | P | B | -1.4888 | |
| 82 | E | B | -2.1532 | |
| 83 | D | B | 0.0000 | |
| 84 | F | B | -0.4403 | |
| 85 | A | B | 0.0000 | |
| 86 | V | B | -0.0405 | |
| 87 | Y | B | 0.0000 | |
| 88 | Y | B | 0.0000 | |
| 89 | C | B | 0.0000 | |
| 90 | L | B | 0.0000 | |
| 91 | H | B | 0.0000 | |
| 92 | Y | B | 0.0000 | |
| 93 | G | B | -0.4627 | |
| 94 | S | B | -0.5733 | |
| 95 | S | B | -0.6320 | |
| 96 | P | B | 0.0000 | |
| 97 | T | B | -0.0666 | |
| 98 | F | B | 0.1286 | |
| 99 | G | B | 0.0000 | |
| 100 | Q | B | -1.3788 | |
| 101 | G | B | 0.0000 | |
| 102 | T | B | 0.0000 | |
| 103 | R | B | -0.3261 | |
| 104 | L | B | 0.0000 | |
| 105 | E | B | 0.0000 | |
| 106 | I | B | -0.2764 | |
| 107 | K | B | -0.8074 | |
| 108 | R | B | -0.7793 | |
| 109 | T | B | 0.0497 | |
| 110 | V | B | 0.6486 | |
| 111 | A | B | 0.1252 | |
| 112 | A | B | -0.0350 | |
| 113 | P | B | 0.0000 | |
| 114 | S | B | -0.1942 | |
| 115 | V | B | 0.0000 | |
| 116 | F | B | 0.0000 | |
| 117 | I | B | 0.0000 | |
| 118 | F | B | 0.0000 | |
| 119 | P | B | -0.6210 | |
| 120 | P | B | -0.8472 | |
| 121 | S | B | -1.9034 | |
| 122 | D | B | -3.0274 | |
| 123 | E | B | -3.1700 | |
| 124 | Q | B | 0.0000 | |
| 125 | L | B | -2.2707 | |
| 126 | K | B | -2.8488 | |
| 127 | S | B | -1.7619 | |
| 128 | G | B | -1.2119 | |
| 129 | T | B | -1.0042 | |
| 130 | A | B | 0.0000 | |
| 131 | S | B | 0.0000 | |
| 132 | V | B | 0.0000 | |
| 133 | V | B | 0.0000 | |
| 134 | C | B | 0.0000 | |
| 135 | L | B | 0.0000 | |
| 136 | L | B | 0.0000 | |
| 137 | N | B | 0.0000 | |
| 138 | N | B | -0.7566 | |
| 139 | F | B | 0.0000 | |
| 140 | Y | B | 0.0000 | |
| 141 | P | B | -1.4437 | |
| 142 | R | B | -2.6211 | |
| 143 | E | B | -2.9652 | |
| 144 | A | B | -2.0280 | |
| 145 | K | B | -1.9957 | |
| 146 | V | B | -0.9520 | |
| 147 | Q | B | -0.7061 | |
| 148 | W | B | 0.0000 | |
| 149 | K | B | -0.5831 | |
| 150 | V | B | 0.0000 | |
| 151 | D | B | -1.8737 | |
| 152 | N | B | -1.5139 | |
| 153 | A | B | -0.2797 | |
| 154 | L | B | 0.5712 | |
| 155 | Q | B | -0.3535 | |
| 156 | S | B | -0.6706 | |
| 157 | G | B | -1.2168 | |
| 158 | N | B | -1.4595 | |
| 159 | S | B | -1.3638 | |
| 160 | Q | B | -1.3129 | |
| 161 | E | B | -1.4955 | |
| 162 | S | B | -0.6106 | |
| 163 | V | B | -0.6418 | |
| 164 | T | B | -1.1219 | |
| 165 | E | B | -2.2120 | |
| 166 | Q | B | -1.7987 | |
| 167 | D | B | -1.8966 | |
| 168 | S | B | -1.6975 | |
| 169 | K | B | -2.2298 | |
| 170 | D | B | -1.6508 | |
| 171 | S | B | -1.5711 | |
| 172 | T | B | 0.0000 | |
| 173 | Y | B | 0.0000 | |
| 174 | S | B | 0.0000 | |
| 175 | L | B | 0.0000 | |
| 176 | S | B | 0.0000 | |
| 177 | S | B | 0.0000 | |
| 178 | T | B | -0.6413 | |
| 179 | L | B | 0.0000 | |
| 180 | T | B | -0.6026 | |
| 181 | L | B | -0.8102 | |
| 182 | S | B | -1.0509 | |
| 183 | K | B | -2.0997 | |
| 184 | A | B | -1.9278 | |
| 185 | D | B | -2.6084 | |
| 186 | Y | B | 0.0000 | |
| 187 | E | B | -3.7217 | |
| 188 | K | B | -3.7297 | |
| 189 | H | B | -3.0445 | |
| 190 | K | B | -3.3196 | |
| 191 | V | B | -1.4752 | |
| 192 | Y | B | 0.0000 | |
| 193 | A | B | 0.0000 | |
| 194 | C | B | 0.0000 | |
| 195 | E | B | -0.6112 | |
| 196 | V | B | 0.0000 | |
| 197 | T | B | -1.0479 | |
| 198 | H | B | 0.0000 | |
| 199 | Q | B | -1.6268 | |
| 200 | G | B | -0.3706 | |
| 201 | L | B | -0.2065 | |
| 202 | S | B | -0.4501 | |
| 203 | S | B | -0.4010 | |
| 204 | P | B | -0.4340 | |
| 205 | V | B | 0.1472 | |
| 206 | T | B | -0.3155 | |
| 207 | K | B | -0.5585 | |
| 208 | S | B | -0.5538 | |
| 209 | F | B | 0.0000 | |
| 210 | N | B | -1.8607 | |
| 211 | R | B | -2.4882 | |
| 212 | G | B | -1.9414 | |
| 213 | E | B | -2.0733 | |
| 214 | C | B | -0.6426 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine