| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFADIVKNGKVVVPKVSGYQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTVGHPLFNKFGDTENPTAPQHCGPDDRVAFSFDPKQTQLFIVGCEPPTGEHWDIAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFHVRCGPDGHPLPSAPPPSPLYVPPPASSPYAVRPPTDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLSTPPINVYNPSYFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9414 | |
| 2 | L | A | 1.9621 | |
| 3 | P | A | 0.8298 | |
| 4 | P | A | 0.3719 | |
| 5 | T | A | 0.1220 | |
| 6 | T | A | 0.1256 | |
| 7 | P | A | 0.1756 | |
| 8 | V | A | 1.2136 | |
| 9 | A | A | 0.0864 | |
| 10 | K | A | -1.0285 | |
| 11 | V | A | -0.1692 | |
| 12 | Q | A | -1.4043 | |
| 13 | S | A | -1.5524 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4211 | |
| 16 | E | A | -2.4394 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4594 | |
| 20 | P | A | 0.1303 | |
| 21 | T | A | 0.1857 | |
| 22 | S | A | -0.0892 | |
| 23 | L | A | 0.1411 | |
| 24 | F | A | -0.0126 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2899 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.9002 | |
| 31 | R | A | -2.6835 | |
| 32 | L | A | -0.7994 | |
| 33 | L | A | 1.1573 | |
| 34 | T | A | 1.3631 | |
| 35 | V | A | 1.8088 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | 0.2617 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | 0.2240 | |
| 40 | A | A | 0.0990 | |
| 41 | D | A | -0.0802 | |
| 42 | I | A | 1.5301 | |
| 43 | V | A | 1.3531 | |
| 44 | K | A | -1.1098 | |
| 45 | N | A | -1.9247 | |
| 46 | G | A | -1.1911 | |
| 47 | K | A | -0.9464 | |
| 48 | V | A | 1.6614 | |
| 49 | V | A | 2.0800 | |
| 50 | V | A | 1.5397 | |
| 51 | P | A | 0.7894 | |
| 52 | K | A | -0.0242 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1602 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.3951 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2651 | |
| 70 | K | A | -1.7843 | |
| 71 | F | A | -0.6297 | |
| 72 | A | A | -0.5683 | |
| 73 | L | A | -0.8510 | |
| 74 | P | A | -1.1990 | |
| 75 | Q | A | -2.5073 | |
| 76 | K | A | -3.1094 | |
| 77 | D | A | -2.9948 | |
| 78 | F | A | -1.6517 | |
| 79 | Y | A | -1.8990 | |
| 80 | D | A | -2.7026 | |
| 81 | P | A | -2.3688 | |
| 82 | E | A | -3.0561 | |
| 83 | K | A | -3.3964 | |
| 84 | E | A | -2.4594 | |
| 85 | R | A | -1.2960 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6707 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9565 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3503 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6988 | |
| 99 | G | A | -0.5386 | |
| 100 | P | A | -0.4060 | |
| 101 | L | A | 0.0409 | |
| 102 | G | A | -0.1874 | |
| 103 | K | A | -0.5700 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.4121 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.1436 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.4356 | |
| 110 | L | A | 0.3110 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.0889 | |
| 113 | K | A | -0.2298 | |
| 114 | F | A | -0.9720 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.4925 | |
| 117 | T | A | -0.9330 | |
| 118 | E | A | -1.8126 | |
| 119 | N | A | -2.0122 | |
| 120 | P | A | -1.5757 | |
| 121 | T | A | -0.8701 | |
| 122 | A | A | -0.6502 | |
| 123 | P | A | -0.5496 | |
| 124 | Q | A | -1.3246 | |
| 125 | H | A | -1.1752 | |
| 126 | C | A | -1.1485 | |
| 127 | G | A | -1.3854 | |
| 128 | P | A | -1.4959 | |
| 129 | D | A | -2.2390 | |
| 130 | D | A | -1.7531 | |
| 131 | R | A | -1.0963 | |
| 132 | V | A | 0.2987 | |
| 133 | A | A | 0.4780 | |
| 134 | F | A | 0.2959 | |
| 135 | S | A | -0.0592 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.4429 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | -0.2467 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5640 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2184 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1035 | |
| 157 | D | A | 0.2753 | |
| 158 | I | A | 0.8238 | |
| 159 | A | A | 0.1109 | |
| 160 | E | A | -1.4831 | |
| 161 | P | A | -0.2302 | |
| 162 | C | A | 0.1860 | |
| 163 | P | A | -0.1724 | |
| 164 | G | A | -0.0796 | |
| 165 | L | A | 0.5887 | |
| 166 | P | A | -0.1140 | |
| 167 | P | A | -0.3388 | |
| 168 | G | A | -0.4216 | |
| 169 | A | A | -0.0257 | |
| 170 | C | A | 0.7399 | |
| 171 | P | A | 0.5520 | |
| 172 | P | A | 0.8777 | |
| 173 | I | A | 2.0471 | |
| 174 | Q | A | 0.8448 | |
| 175 | L | A | 1.4282 | |
| 176 | V | A | 0.8177 | |
| 177 | N | A | -0.3160 | |
| 178 | S | A | 0.0152 | |
| 179 | V | A | 0.4224 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3775 | |
| 182 | D | A | 0.0746 | |
| 183 | G | A | -0.1574 | |
| 184 | D | A | -0.5441 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.0999 | |
| 190 | F | A | 0.0624 | |
| 191 | G | A | -0.1078 | |
| 192 | N | A | -0.2745 | |
| 193 | M | A | -0.1407 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.4006 | |
| 197 | E | A | -2.6371 | |
| 198 | L | A | -1.2336 | |
| 199 | Q | A | -2.5593 | |
| 200 | Q | A | -3.3144 | |
| 201 | D | A | -3.5848 | |
| 202 | R | A | -3.3396 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.4615 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3680 | |
| 211 | S | A | -1.7147 | |
| 212 | T | A | -1.4572 | |
| 213 | R | A | -2.1182 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1639 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3460 | |
| 220 | L | A | 0.6125 | |
| 221 | K | A | -1.0956 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.8081 | |
| 224 | N | A | -1.5686 | |
| 225 | E | A | -1.2290 | |
| 226 | A | A | -0.6019 | |
| 227 | Y | A | -0.3559 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6524 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | 0.0835 | |
| 234 | F | A | 0.2660 | |
| 235 | G | A | -0.8246 | |
| 236 | R | A | -2.6140 | |
| 237 | R | A | -2.9122 | |
| 238 | E | A | -2.1741 | |
| 239 | Q | A | -0.2451 | |
| 240 | V | A | 1.3663 | |
| 241 | Y | A | 1.0957 | |
| 242 | A | A | 0.2504 | |
| 243 | R | A | -0.8808 | |
| 244 | H | A | -0.9397 | |
| 245 | F | A | 0.1041 | |
| 246 | H | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.7113 | |
| 249 | C | A | -0.9635 | |
| 250 | G | A | -1.0147 | |
| 251 | P | A | -1.0008 | |
| 252 | D | A | -1.5389 | |
| 253 | G | A | -1.3337 | |
| 254 | H | A | -1.4620 | |
| 255 | P | A | -1.0955 | |
| 256 | L | A | 0.1675 | |
| 257 | P | A | -0.0413 | |
| 258 | S | A | -0.0954 | |
| 259 | A | A | 0.1992 | |
| 260 | P | A | -0.3174 | |
| 261 | P | A | -0.0267 | |
| 262 | P | A | 0.0656 | |
| 263 | S | A | 0.5344 | |
| 264 | P | A | 0.6909 | |
| 265 | L | A | 1.8928 | |
| 266 | Y | A | 1.7434 | |
| 267 | V | A | 1.9388 | |
| 268 | P | A | 0.8385 | |
| 269 | P | A | 0.5472 | |
| 270 | P | A | -0.0263 | |
| 271 | A | A | 0.1757 | |
| 272 | S | A | 0.0157 | |
| 273 | S | A | 0.3152 | |
| 274 | P | A | 0.2097 | |
| 275 | Y | A | 1.0048 | |
| 276 | A | A | 0.9914 | |
| 277 | V | A | 1.3841 | |
| 278 | R | A | 0.0647 | |
| 279 | P | A | -0.5674 | |
| 280 | P | A | -0.6843 | |
| 281 | T | A | -0.6576 | |
| 282 | D | A | -1.1152 | |
| 283 | Y | A | 0.7610 | |
| 284 | F | A | 0.6737 | |
| 285 | G | A | 0.3014 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9066 | |
| 291 | L | A | 1.6075 | |
| 292 | V | A | 0.6268 | |
| 293 | S | A | -0.1623 | |
| 294 | S | A | -0.9643 | |
| 295 | D | A | -1.8429 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1054 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6221 | |
| 301 | R | A | -1.8154 | |
| 302 | P | A | -0.9655 | |
| 303 | F | A | -0.1880 | |
| 304 | W | A | -0.5692 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0880 | |
| 307 | R | A | -2.8299 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.3630 | |
| 310 | G | A | -1.2154 | |
| 311 | N | A | -1.2707 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.8262 | |
| 319 | N | A | -0.8563 | |
| 320 | E | A | -1.0408 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3286 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.0678 | |
| 333 | N | A | 0.5289 | |
| 334 | F | A | 1.6954 | |
| 335 | T | A | 0.8381 | |
| 336 | I | A | 0.3853 | |
| 337 | S | A | -0.8076 | |
| 338 | Q | A | -1.4209 | |
| 339 | Q | A | -0.5996 | |
| 340 | L | A | 0.9026 | |
| 341 | S | A | 0.3873 | |
| 342 | T | A | -0.0763 | |
| 343 | P | A | -0.3987 | |
| 344 | P | A | -0.3591 | |
| 345 | I | A | 0.6889 | |
| 346 | N | A | -0.0325 | |
| 347 | V | A | 1.8599 | |
| 348 | Y | A | 1.8500 | |
| 349 | N | A | 0.6101 | |
| 350 | P | A | -0.1748 | |
| 351 | S | A | 0.0922 | |
| 352 | Y | A | 0.8818 | |
| 353 | F | A | -0.2437 | |
| 354 | K | A | -1.6482 | |
| 355 | N | A | -1.7573 | |
| 356 | Y | A | -0.1554 | |
| 357 | L | A | 0.6116 | |
| 358 | R | A | 0.9318 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.3700 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0784 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -2.0458 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6887 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.3029 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3104 | |
| 376 | L | A | -1.7022 | |
| 377 | D | A | -1.9784 | |
| 378 | P | A | -1.0324 | |
| 379 | G | A | -1.0110 | |
| 380 | V | A | -0.9296 | |
| 381 | L | A | -0.5302 | |
| 382 | A | A | -0.6537 | |
| 383 | H | A | -0.8053 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4072 | |
| 386 | T | A | -0.5504 | |
| 387 | M | A | -0.2969 | |
| 388 | N | A | -0.8592 | |
| 389 | P | A | -1.2443 | |
| 390 | T | A | -1.4468 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.4508 | |
| 393 | E | A | -2.7886 | |
| 394 | N | A | -2.3875 | |
| 395 | W | A | -1.3938 | |
| 396 | N | A | -1.1364 | |
| 397 | L | A | -0.1843 | |
| 398 | G | A | 0.5106 | |
| 399 | F | A | 2.4087 | |
| 400 | V | A | 1.8106 | |
| 401 | P | A | 0.0384 | |
| 402 | P | A | -1.8520 | |
| 403 | K | A | -3.3165 | |
| 404 | E | A | -3.7639 | |
| 405 | R | A | -3.8997 | |
| 406 | E | A | -3.7776 | |
| 407 | D | A | -2.8646 | |
| 408 | P | A | -1.7593 | |
| 409 | Y | A | -0.9845 | |
| 410 | K | A | -2.1193 | |
| 411 | G | A | -0.6326 | |
| 412 | L | A | 0.6739 | |
| 413 | I | A | 1.5820 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.4059 | |
| 416 | E | A | -1.7169 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9597 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0552 | |
| 421 | E | A | -2.7851 | |
| 422 | R | A | -2.6333 | |
| 423 | F | A | -1.2677 | |
| 424 | S | A | -1.4394 | |
| 425 | Q | A | -1.7943 | |
| 426 | D | A | -2.9475 | |
| 427 | L | A | -2.1585 | |
| 428 | D | A | -3.0415 | |
| 429 | Q | A | -2.7549 | |
| 430 | F | A | -1.6181 | |
| 431 | A | A | -1.1450 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.2948 | |
| 435 | K | A | -1.0936 | |
| 436 | F | A | -0.1116 | |
| 437 | L | A | 0.7798 | |
| 438 | Y | A | 0.6234 | |
| 439 | Q | A | -0.3913 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine