Project name: EGFR

Chain sequence(s)	A: DIQMTQSPSSVSASVGDRVTITCRASQGINTWLAWYQQKPGKAPKLLIYAASSLKSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQANSFPLTFGGGTKVEIKGGGGSGGGGSGGGGSQVQLVQSGAEVKKPGASVKVSCKASGYTFTSYGFSWVRQAPGQGLEWMGWISASNGNTYYAQKLQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARVYADYADYWGQGTLVTVSS
Selected Chain(s)	A
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:13)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:14)

• Minimal score value: -3.1266
• Maximal score value: 1.3696
• Average score: -0.6509
• Total score value: -155.5644

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	D	A	-2.1587
2	I	A	-1.6135
3	Q	A	-2.1712
4	M	A	0.0000
5	T	A	-1.3271
6	Q	A	-0.9113
7	S	A	-0.7406
8	P	A	-0.5910
9	S	A	-0.7768
10	S	A	-0.8960
11	V	A	-0.6634
12	S	A	-1.1365
13	A	A	0.0000
14	S	A	-0.9727
15	V	A	-0.0162
16	G	A	-0.7437
17	D	A	-1.5815
18	R	A	-2.2426
19	V	A	0.0000
20	T	A	-0.6193
21	I	A	0.0000
22	T	A	-0.8682
23	C	A	0.0000
24	R	A	-2.7921
25	A	A	0.0000
26	S	A	-1.9995
27	Q	A	-2.4660
28	G	A	-1.8819
29	I	A	0.0000
30	N	A	-1.7762
31	T	A	-0.8028
32	W	A	-0.0982
33	L	A	0.0000
34	A	A	0.0000
35	W	A	0.0000
36	Y	A	0.0000
37	Q	A	0.0000
38	Q	A	0.0000
39	K	A	-1.8324
40	P	A	-1.2472
41	G	A	-1.6925
42	K	A	-2.6466
43	A	A	-1.6262
44	P	A	0.0000
45	K	A	-1.3251
46	L	A	0.0000
47	L	A	0.0000
48	I	A	0.0000
49	Y	A	0.3636
50	A	A	0.0671
51	A	A	0.0000
52	S	A	-0.2787
53	S	A	0.0422
54	L	A	0.2300
55	K	A	-0.3260
56	S	A	-0.4269
57	G	A	-0.5336
58	V	A	-0.3476
59	P	A	-0.3743
60	S	A	-0.4462
61	R	A	-0.7719
62	F	A	0.0000
63	S	A	-0.3187
64	G	A	-0.2662
65	S	A	-0.6704
66	G	A	-1.2128
67	S	A	-1.3457
68	G	A	-1.6753
69	T	A	-1.9891
70	D	A	-2.1598
71	F	A	0.0000
72	T	A	-0.7544
73	L	A	0.0000
74	T	A	-0.6055
75	I	A	0.0000
76	S	A	-1.2942
77	S	A	-1.1069
78	L	A	0.0000
79	Q	A	-0.7361
80	P	A	-1.3206
81	E	A	-1.9499
82	D	A	0.0000
83	F	A	-0.6054
84	A	A	0.0000
85	T	A	-0.8097
86	Y	A	0.0000
87	Y	A	0.0000
88	C	A	0.0000
89	Q	A	0.0000
90	Q	A	0.0000
91	A	A	-0.0645
92	N	A	-0.7703
93	S	A	-0.1868
94	F	A	0.7204
95	P	A	0.0983
96	L	A	0.0000
97	T	A	-0.5407
98	F	A	-0.2453
99	G	A	0.0000
100	G	A	-1.0895
101	G	A	0.0000
102	T	A	0.0000
103	K	A	-1.5040
104	V	A	0.0000
105	E	A	-1.5100
106	I	A	-1.3366
107	K	A	-2.0491
108	G	A	-1.5959
109	G	A	-1.5005
110	G	A	-1.3269
111	G	A	-1.4214
112	S	A	-1.2433
113	G	A	-1.6036
114	G	A	-1.4566
115	G	A	-1.4391
116	G	A	-1.3842
117	S	A	-1.0432
118	G	A	-1.1685
119	G	A	-1.3306
120	G	A	-1.3087
121	G	A	-1.3724
122	S	A	-1.3890
123	Q	A	-1.8473
124	V	A	-1.0620
125	Q	A	-1.2415
126	L	A	0.0000
127	V	A	0.1699
128	Q	A	0.0000
129	S	A	-0.5739
130	G	A	-0.5536
131	A	A	0.1105
132	E	A	-0.3698
133	V	A	0.7735
134	K	A	-1.0906
135	K	A	-2.1794
136	P	A	-2.3214
137	G	A	-1.7282
138	A	A	-1.4343
139	S	A	-1.6231
140	V	A	0.0000
141	K	A	-1.9882
142	V	A	0.0000
143	S	A	-0.4828
144	C	A	0.0000
145	K	A	-0.8952
146	A	A	0.0000
147	S	A	-0.8449
148	G	A	-0.9585
149	Y	A	-0.3154
150	T	A	-0.0951
151	F	A	0.0000
152	T	A	-0.4497
153	S	A	0.0516
154	Y	A	0.5031
155	G	A	0.0000
156	F	A	0.0000
157	S	A	0.0000
158	W	A	0.0000
159	V	A	0.0000
160	R	A	0.0000
161	Q	A	-0.5039
162	A	A	-0.8893
163	P	A	-1.0365
164	G	A	-1.2220
165	Q	A	-1.7522
166	G	A	-1.1268
167	L	A	0.0000
168	E	A	-0.6413
169	W	A	0.0000
170	M	A	0.0000
171	G	A	0.0000
172	W	A	0.4303
173	I	A	0.0000
174	S	A	0.0000
175	A	A	0.0000
176	S	A	-1.1435
177	N	A	-1.9341
178	G	A	-1.6862
179	N	A	-1.6522
180	T	A	-0.3190
181	Y	A	0.7705
182	Y	A	-0.1098
183	A	A	0.0000
184	Q	A	-2.5207
185	K	A	-2.6880
186	L	A	0.0000
187	Q	A	-2.2653
188	G	A	-1.7270
189	R	A	-1.5485
190	V	A	0.0000
191	T	A	-0.7111
192	M	A	0.0000
193	T	A	-0.3162
194	T	A	-0.6700
195	D	A	-0.8736
196	T	A	-0.5736
197	S	A	-0.4887
198	T	A	-0.6197
199	S	A	-0.6694
200	T	A	0.0000
201	A	A	0.0000
202	Y	A	-0.3539
203	M	A	0.0000
204	E	A	-1.1618
205	L	A	0.0000
206	R	A	-1.8738
207	S	A	-1.6266
208	L	A	0.0000
209	R	A	-3.1266
210	S	A	-2.3821
211	D	A	-2.5262
212	D	A	0.0000
213	T	A	-0.7297
214	A	A	0.0000
215	V	A	0.5772
216	Y	A	0.0000
217	Y	A	0.0000
218	C	A	0.0000
219	A	A	0.0000
220	R	A	0.0000
221	V	A	0.0000
222	Y	A	1.3696
223	A	A	0.6882
224	D	A	0.3390
225	Y	A	0.6151
226	A	A	0.0000
227	D	A	0.0437
228	Y	A	-0.1094
229	W	A	-0.4721
230	G	A	0.0000
231	Q	A	-1.3530
232	G	A	-0.5147
233	T	A	0.0000
234	L	A	0.9167
235	V	A	0.0000
236	T	A	-0.1843
237	V	A	0.0000
238	S	A	-1.0789
239	S	A	-0.7847