Project name: 57926a8c0a6a9a7

Chain sequence(s)	H: EVQLVESGGGLVQPGGSLRLSCAASGLIFRSYGMSWVRQAPGKGLEWVATINSGGTYTYYPDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCANSYSGAMDYWGQGTLVTVSS; L: DDVLTQTPLSLPVTPGQPASISCRSSQSIVHSNGNTYLEWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSLVPWTFGQGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:46)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:48)

• Minimal score value: -2.6629
• Maximal score value: 1.7609
• Average score: -0.483
• Total score value: -110.6146

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.8609
2	V	H	-0.4014
3	Q	H	-0.5775
4	L	H	0.0000
5	V	H	1.2805
6	E	H	0.0000
7	S	H	-0.0719
8	G	H	-0.6311
9	G	H	0.2021
11	G	H	0.8240
12	L	H	1.3335
13	V	H	0.0000
14	Q	H	-1.4296
15	P	H	-1.4858
16	G	H	-1.4497
17	G	H	-1.1653
18	S	H	-1.0424
19	L	H	-0.8339
20	R	H	-1.7136
21	L	H	0.0000
22	S	H	-0.2310
23	C	H	0.0000
24	A	H	-0.0747
25	A	H	0.0000
26	S	H	-0.4744
27	G	H	-0.6883
28	L	H	0.0000
29	I	H	1.2459
30	F	H	0.0000
35	R	H	-1.9916
36	S	H	-0.3993
37	Y	H	0.1129
38	G	H	-0.1900
39	M	H	0.0000
40	S	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.6087
45	A	H	-0.9948
46	P	H	-0.8055
47	G	H	-1.4646
48	K	H	-2.3479
49	G	H	-1.5803
50	L	H	0.0000
51	E	H	-0.9991
52	W	H	0.0000
53	V	H	0.0000
54	A	H	0.0000
55	T	H	0.0000
56	I	H	0.0000
57	N	H	-0.3503
58	S	H	-0.8360
59	G	H	-1.0366
62	G	H	-0.5834
63	T	H	0.2117
64	Y	H	1.1432
65	T	H	0.7849
66	Y	H	0.8129
67	Y	H	-0.3697
68	P	H	-1.2522
69	D	H	-2.6629
70	S	H	-1.7512
71	V	H	0.0000
72	K	H	-2.5421
74	G	H	-1.7442
75	R	H	-1.4518
76	F	H	0.0000
77	T	H	-0.7586
78	I	H	0.0000
79	S	H	-0.2992
80	R	H	-1.2320
81	D	H	-1.7166
82	N	H	-1.9059
83	S	H	-1.7726
84	K	H	-2.5835
85	N	H	-1.9885
86	T	H	-1.1670
87	L	H	0.0000
88	Y	H	-0.4378
89	L	H	0.0000
90	Q	H	-1.0929
91	M	H	0.0000
92	N	H	-1.3100
93	S	H	-1.2580
94	L	H	0.0000
95	R	H	-2.3315
96	A	H	-1.7267
97	E	H	-2.2222
98	D	H	0.0000
99	T	H	-0.3611
100	A	H	0.0000
101	V	H	0.8659
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	N	H	0.0000
107	S	H	0.6457
108	Y	H	1.2943
109	S	H	0.4722
113	G	H	0.2004
114	A	H	0.0000
115	M	H	0.0000
116	D	H	0.0000
117	Y	H	0.7187
118	W	H	0.1972
119	G	H	0.0000
120	Q	H	-0.9047
121	G	H	0.0419
122	T	H	0.6698
123	L	H	1.5988
124	V	H	0.0000
125	T	H	0.3002
126	V	H	0.0000
127	S	H	-0.5800
128	S	H	-0.5198
1	D	L	-1.2061
2	D	L	0.0000
3	V	L	0.6468
4	L	L	0.0000
5	T	L	-0.4466
6	Q	L	0.0000
7	T	L	-0.1285
8	P	L	0.2821
9	L	L	0.9510
10	S	L	0.0510
11	L	L	-0.0423
12	P	L	-0.7897
13	V	L	0.0000
14	T	L	-1.3926
15	P	L	-1.4071
16	G	L	-1.6109
17	Q	L	-1.9724
18	P	L	-1.5422
19	A	L	0.0000
20	S	L	-0.6862
21	I	L	0.0000
22	S	L	-0.7676
23	C	L	0.0000
24	R	L	-2.2202
25	S	L	0.0000
26	S	L	-0.9417
27	Q	L	-1.4693
28	S	L	-0.8434
29	I	L	0.0000
30	V	L	0.3428
31	H	L	-0.4989
32	S	L	-0.9046
34	N	L	-1.6807
35	G	L	-1.1732
36	N	L	-0.9895
37	T	L	-0.2359
38	Y	L	0.1067
39	L	L	0.0000
40	E	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	L	L	0.0000
44	Q	L	-0.8063
45	K	L	-1.1671
46	P	L	-0.8449
47	G	L	-1.3375
48	Q	L	-1.8734
49	S	L	-1.1587
50	P	L	0.0000
51	Q	L	-0.6688
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	-0.3349
56	K	L	-0.5812
57	V	L	-0.4724
65	S	L	-0.8213
66	N	L	-1.3024
67	R	L	-1.7251
68	F	L	-0.6524
69	S	L	-0.5881
70	G	L	-0.8068
71	V	L	-0.9070
72	P	L	-1.1495
74	D	L	-2.1548
75	R	L	0.0000
76	F	L	0.0000
77	S	L	-1.2390
78	G	L	0.0000
79	S	L	-0.6725
80	G	L	-0.9067
83	S	L	-0.7275
84	G	L	-0.8175
85	T	L	-1.4304
86	D	L	-1.8998
87	F	L	0.0000
88	T	L	-0.8974
89	L	L	0.0000
90	K	L	-1.3169
91	I	L	0.0000
92	S	L	-1.6331
93	R	L	-2.0784
94	V	L	0.0000
95	E	L	-1.5576
96	A	L	-1.1581
97	E	L	-1.6259
98	D	L	0.0000
99	V	L	-0.4774
100	G	L	0.0000
101	V	L	-0.2749
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	F	L	0.0000
106	Q	L	0.0000
107	G	L	0.0000
108	S	L	0.0000
109	L	L	0.9896
114	V	L	1.7609
115	P	L	0.7247
116	W	L	0.7769
117	T	L	0.2260
118	F	L	0.0000
119	G	L	0.0000
120	Q	L	-0.9537
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-0.8018
124	V	L	0.0000
125	E	L	-1.0918
126	I	L	-0.6293
127	K	L	-1.6756