Project name: 58061fd856c78e5

Chain sequence(s)	A: VQLTESGGGLFSSSGDSITLTCKASGRTFSSAYDIAWFAQKPGEPRRFVAAISWSGNSTYYAEEWRGLVQISRDNSANTAYLKIVIDPDKDGWLEAKERAWIEATYFCAARKPMYRVDISKGQNYDYWGAGTVVTT; D: DTQIFEDPREFLSHLEEYLRQVGGSEEYWLSQIQNHMNGPAKKWWEFKQGSVKNWVEFKKEFLQYS
Selected Chain(s)	A,D
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:02)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:03:22)
[INFO]       Main:     Simulation completed successfully.                                          (00:03:24)

• Minimal score value: -3.5855
• Maximal score value: 1.6164
• Average score: -0.882
• Total score value: -176.4045

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
4	V	A	-0.0621
5	Q	A	-0.8063
6	L	A	0.0000
7	T	A	-0.6183
8	E	A	0.0000
9	S	A	-0.2522
10	G	A	-0.2765
11	G	A	0.4252
12	G	A	0.8461
13	L	A	1.5463
14	F	A	0.0000
15	S	A	-0.2189
16	S	A	-0.6937
17	G	A	-1.3800
18	D	A	-2.1971
19	S	A	-1.2946
20	I	A	-0.7850
21	T	A	-0.7819
22	L	A	0.0000
23	T	A	-0.5267
24	C	A	0.0000
25	K	A	-1.1766
26	A	A	-1.0691
27	S	A	-1.0278
28	G	A	-1.2457
29	R	A	-2.0379
30	T	A	-0.7640
31	F	A	0.0000
32	S	A	-0.7242
33	A	A	0.0000
34	Y	A	0.0000
35	D	A	0.0000
36	I	A	0.0000
37	A	A	0.0000
38	W	A	0.0000
39	F	A	0.0000
40	A	A	0.0000
41	Q	A	-2.2597
42	K	A	-1.7903
43	P	A	-1.5489
44	G	A	-1.8381
45	E	A	-3.0976
46	P	A	-2.7093
47	R	A	-3.4093
48	R	A	-3.2406
49	F	A	0.0000
50	V	A	0.0000
51	A	A	0.0000
52	A	A	0.0000
53	I	A	0.0000
54	S	A	0.0000
55	W	A	-0.3533
56	S	A	-0.7453
57	G	A	-1.0587
58	N	A	-1.4590
59	S	A	-0.6944
60	T	A	-0.1678
61	Y	A	0.3024
62	Y	A	-0.7912
63	A	A	-1.8724
64	E	A	-2.9380
65	E	A	-2.0548
66	W	A	0.0000
67	R	A	-2.8288
68	G	A	-1.9997
69	L	A	-1.5284
70	V	A	0.0000
71	Q	A	-1.7408
72	I	A	0.0000
73	S	A	-0.9936
74	R	A	-0.8690
75	D	A	-1.2837
76	N	A	-1.2405
77	S	A	-0.9307
78	A	A	-0.8887
79	N	A	-1.2646
80	T	A	-0.8263
81	A	A	0.0000
82	Y	A	-0.5984
83	L	A	0.0000
84	K	A	-1.7601
85	I	A	0.0000
86	V	A	-1.1930
87	I	A	0.0000
88	D	A	-2.0115
89	P	A	-2.3683
90	D	A	-3.2189
91	K	A	-3.5855
92	D	A	-3.0802
93	G	A	-1.5730
94	W	A	-0.1789
95	L	A	-0.9252
96	E	A	-0.8619
97	A	A	-0.9288
98	K	A	-1.9336
99	E	A	-1.4826
100	R	A	-1.2095
101	A	A	-0.8531
102	W	A	-0.5641
103	I	A	0.0000
104	E	A	-0.1668
105	A	A	0.0000
106	T	A	0.1512
107	Y	A	0.0000
108	F	A	0.0000
109	C	A	0.0000
110	A	A	0.0000
111	A	A	0.0000
112	R	A	0.0000
113	K	A	-0.8724
114	P	A	0.0000
115	M	A	-0.8254
116	Y	A	-1.1108
117	R	A	-1.8782
118	V	A	0.0000
119	D	A	0.0000
120	I	A	0.0000
121	S	A	-1.1841
122	K	A	-1.9354
123	G	A	-1.8473
124	Q	A	-1.8518
125	N	A	-1.4599
126	Y	A	0.0000
127	D	A	-1.5431
128	Y	A	-0.4683
129	W	A	0.0688
130	G	A	0.0000
131	A	A	0.1203
132	G	A	0.3024
133	T	A	0.5941
134	V	A	1.6164
135	V	A	0.0000
136	T	A	0.6613
137	T	A	0.0889
8	D	D	-2.3257
9	T	D	-1.4144
10	Q	D	-1.5262
11	I	D	-0.7075
12	F	D	-0.5605
13	E	D	-1.3264
14	D	D	-2.5895
15	P	D	-2.1643
16	R	D	-2.6356
17	E	D	-1.9896
18	F	D	0.0000
19	L	D	0.0000
20	S	D	-0.8741
21	H	D	0.0000
22	L	D	0.0000
23	E	D	-1.3810
24	E	D	-0.9825
25	Y	D	0.0000
26	L	D	0.0000
27	R	D	-2.2667
28	Q	D	-0.9924
29	V	D	0.5871
30	G	D	-0.7185
31	G	D	-1.1437
32	S	D	-1.8076
33	E	D	-2.9802
34	E	D	-2.4215
35	Y	D	-0.6979
36	W	D	0.0000
37	L	D	-0.8104
38	S	D	-0.5821
39	Q	D	-0.8485
40	I	D	0.0000
41	Q	D	-2.3937
42	N	D	-2.0272
43	H	D	0.0000
44	M	D	0.0000
45	N	D	-1.9832
46	G	D	-1.6160
47	P	D	-1.5322
48	A	D	0.0000
49	K	D	-2.7405
50	K	D	-2.6355
51	W	D	-1.1366
52	W	D	0.0000
53	E	D	-2.1830
54	F	D	0.0894
55	K	D	-0.7613
56	Q	D	-1.4850
57	G	D	-1.1278
58	S	D	-1.0674
59	V	D	0.0000
60	K	D	-2.1472
61	N	D	-1.6867
62	W	D	0.0000
63	V	D	0.2200
64	E	D	-1.5393
65	F	D	0.0000
66	K	D	-1.5776
67	K	D	-2.2829
68	E	D	-1.9443
69	F	D	0.0000
70	L	D	-1.6438
71	Q	D	-1.5697
72	Y	D	-0.4548
73	S	D	-0.9097