Project name: 1347

Chain sequence(s)	H: EVQLLESGGGSVQPGGSLRLSCAASGVTYSHYWLGWFRQAPGKEREGVAAIYTNDGTTYYGDSVKGRFTISRDNSKNTLYLQMSSLRPEDTAVYYCALRGNDGSWFSPLQPYHYNYWGQGTQVTVSS
Selected Chain(s)	H
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with H chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:00:46)
[INFO]       Main:     Simulation completed successfully.                                          (00:00:46)

• Minimal score value: -2.7976
• Maximal score value: 1.2
• Average score: -0.7565
• Total score value: -96.0719

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-2.1473
2	V	H	0.0000
3	Q	H	-1.3327
4	L	H	0.0000
5	L	H	0.8517
6	E	H	0.0204
7	S	H	-0.6858
8	G	H	-1.2352
9	G	H	-1.0552
11	G	H	-0.7503
12	S	H	-0.6676
13	V	H	-0.8621
14	Q	H	-1.7537
15	P	H	-1.7969
16	G	H	-1.3262
17	G	H	-1.0213
18	S	H	-1.0975
19	L	H	-1.0559
20	R	H	-2.1326
21	L	H	0.0000
22	S	H	-0.4847
23	C	H	0.0000
24	A	H	-0.1733
25	A	H	-0.4670
26	S	H	-0.9891
27	G	H	-1.1063
28	V	H	-0.4270
29	T	H	0.0204
30	Y	H	0.5064
35	S	H	-0.5777
36	H	H	-1.6154
37	Y	H	0.0000
38	W	H	0.0000
39	L	H	0.0000
40	G	H	0.0000
41	W	H	0.0000
42	F	H	0.0000
43	R	H	0.0000
44	Q	H	-1.5637
45	A	H	-1.4837
46	P	H	-1.0600
47	G	H	-1.4723
48	K	H	-2.2819
49	E	H	-2.7976
50	R	H	-1.9513
51	E	H	-1.5056
52	G	H	-0.8576
53	V	H	0.0000
54	A	H	0.0000
55	A	H	0.0000
56	I	H	0.0000
57	Y	H	0.0000
58	T	H	-1.3727
59	N	H	-1.9617
62	D	H	-2.4638
63	G	H	-1.4393
64	T	H	-0.6483
65	T	H	0.0016
66	Y	H	0.2444
67	Y	H	-0.5381
68	G	H	-1.1758
69	D	H	-2.3372
70	S	H	-1.7421
71	V	H	0.0000
72	K	H	-2.4520
74	G	H	-1.6124
75	R	H	-1.2876
76	F	H	0.0000
77	T	H	-0.7913
78	I	H	0.0000
79	S	H	-0.5507
80	R	H	-1.1731
81	D	H	-1.8381
82	N	H	-2.3419
83	S	H	-1.8882
84	K	H	-2.5387
85	N	H	-1.8889
86	T	H	-1.0951
87	L	H	0.0000
88	Y	H	-0.6169
89	L	H	0.0000
90	Q	H	-1.4041
91	M	H	0.0000
92	S	H	-1.0270
93	S	H	-1.0452
94	L	H	0.0000
95	R	H	-2.4106
96	P	H	-2.0119
97	E	H	-2.3772
98	D	H	0.0000
99	T	H	-1.0990
100	A	H	0.0000
101	V	H	-0.3017
102	Y	H	0.0000
103	Y	H	-0.1109
104	C	H	0.0000
105	A	H	0.0000
106	L	H	0.0000
107	R	H	0.0000
108	G	H	-1.3963
109	N	H	-2.6414
110	D	H	-2.6918
111	G	H	-1.2499
111A	S	H	0.0002
111B	W	H	1.0874
111C	F	H	1.2000
112D	S	H	0.6012
112C	P	H	0.0000
112B	L	H	0.2888
112A	Q	H	-0.3791
112	P	H	-0.0842
113	Y	H	0.7849
114	H	H	-0.4750
115	Y	H	0.0000
116	N	H	-0.8506
117	Y	H	-0.3903
118	W	H	0.0131
119	G	H	-0.1573
120	Q	H	-1.0214
121	G	H	-0.5149
122	T	H	-0.5980
123	Q	H	-1.0317
124	V	H	0.0000
125	T	H	-0.9121
126	V	H	0.0000
127	S	H	-1.1429
128	S	H	-0.8795