| Chain sequence(s) |
A: GPLPLNPGPALRSTREYVTPTDLLFIAETDLITETGHPEADIVENGEIKIPRVSAYQWRVFKLTLPDPNKMPLPSEDFVDPATERLIWRLLAFKIEVFGELGTGSYGHPNFNALGNVDNPTSYLHPSSDDTQNLSWRPKRLQEYIIGDEPPLGKYTTKAAPAPGLPPGAEPPTTTVTTVIEHGDMADIGFGAKDFKALEPRKNNVPDIILNTTTKVPDYAGMRAEPYGRRMFTSDRRESSRDVKKYVLNGPVLNPLPSSPPPSKLYTKPPPSSPYYVLPPYNYFTLPDEGEITEEDLLFNRPVWLERTAGLNDGVLWGNRLYITVLDNTRAAIETIKTRIATPPIDVYNPEYYKESKRYTAEYKLSLILQLCRIPLTPETLAELARLDPSILVNWNLPDIPPVTRPDPLAGKKFIEIDLTDKLSRDLEKYELGREYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:06)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.2137 | |
| 2 | P | A | 0.4326 | |
| 3 | L | A | 1.3975 | |
| 4 | P | A | 0.6753 | |
| 5 | L | A | 1.0421 | |
| 6 | N | A | -0.6561 | |
| 7 | P | A | -0.7139 | |
| 8 | G | A | -0.7438 | |
| 9 | P | A | -0.5930 | |
| 10 | A | A | -0.0290 | |
| 11 | L | A | 0.2390 | |
| 12 | R | A | -0.7590 | |
| 13 | S | A | -1.0079 | |
| 14 | T | A | 0.0000 | |
| 15 | R | A | -2.2577 | |
| 16 | E | A | -2.5343 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.8868 | |
| 20 | P | A | -0.9219 | |
| 21 | T | A | -0.9832 | |
| 22 | D | A | -1.7127 | |
| 23 | L | A | -1.0064 | |
| 24 | L | A | -0.7386 | |
| 25 | F | A | 0.0000 | |
| 26 | I | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -1.0662 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.3482 | |
| 31 | L | A | 0.4125 | |
| 32 | I | A | 0.2467 | |
| 33 | T | A | -0.1236 | |
| 34 | E | A | -0.5518 | |
| 35 | T | A | -0.4535 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -1.0941 | |
| 38 | P | A | 0.0000 | |
| 39 | E | A | -0.7818 | |
| 40 | A | A | -0.1929 | |
| 41 | D | A | -0.5559 | |
| 42 | I | A | 0.4559 | |
| 43 | V | A | 0.3888 | |
| 44 | E | A | -1.8859 | |
| 45 | N | A | -2.3036 | |
| 46 | G | A | -1.6350 | |
| 47 | E | A | -1.7919 | |
| 48 | I | A | 0.2904 | |
| 49 | K | A | -1.2396 | |
| 50 | I | A | -0.2631 | |
| 51 | P | A | -0.3262 | |
| 52 | R | A | -0.7043 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | K | A | -1.3512 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.4728 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.4162 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.5903 | |
| 70 | K | A | -2.0338 | |
| 71 | M | A | -0.9389 | |
| 72 | P | A | -0.6219 | |
| 73 | L | A | -0.5463 | |
| 74 | P | A | -0.6313 | |
| 75 | S | A | -1.4911 | |
| 76 | E | A | -2.8403 | |
| 77 | D | A | -2.9171 | |
| 78 | F | A | -1.5905 | |
| 79 | V | A | 0.0000 | |
| 80 | D | A | -2.4021 | |
| 81 | P | A | -1.3600 | |
| 82 | A | A | -0.6697 | |
| 83 | T | A | -0.7736 | |
| 84 | E | A | -1.2222 | |
| 85 | R | A | -0.9731 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | -0.3884 | |
| 90 | L | A | 0.0000 | |
| 91 | L | A | -0.2751 | |
| 92 | A | A | 0.0000 | |
| 93 | F | A | 0.0000 | |
| 94 | K | A | 0.0000 | |
| 95 | I | A | 0.0000 | |
| 96 | E | A | -0.5853 | |
| 97 | V | A | 0.0000 | |
| 98 | F | A | 0.1315 | |
| 99 | G | A | -0.9659 | |
| 100 | E | A | -1.6226 | |
| 101 | L | A | -0.6089 | |
| 102 | G | A | -0.2938 | |
| 103 | T | A | -0.4380 | |
| 104 | G | A | 0.0000 | |
| 105 | S | A | -0.3756 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -1.0581 | |
| 108 | H | A | -1.5951 | |
| 109 | P | A | -1.7765 | |
| 110 | N | A | -2.6201 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | A | A | 0.0000 | |
| 114 | L | A | 0.0000 | |
| 115 | G | A | 0.0000 | |
| 116 | N | A | -1.4495 | |
| 117 | V | A | -1.2637 | |
| 118 | D | A | -2.7352 | |
| 119 | N | A | -2.5088 | |
| 120 | P | A | -1.3218 | |
| 121 | T | A | -0.7338 | |
| 122 | S | A | -0.3398 | |
| 123 | Y | A | 0.2769 | |
| 124 | L | A | -0.0364 | |
| 125 | H | A | -0.6125 | |
| 126 | P | A | -1.1145 | |
| 127 | S | A | -1.3065 | |
| 128 | S | A | -1.3315 | |
| 129 | D | A | -2.3766 | |
| 130 | D | A | -1.7797 | |
| 131 | T | A | -1.8107 | |
| 132 | Q | A | -1.9373 | |
| 133 | N | A | -2.1102 | |
| 134 | L | A | 0.0000 | |
| 135 | S | A | -0.8174 | |
| 136 | W | A | 0.0000 | |
| 137 | R | A | -0.8318 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | R | A | -1.2250 | |
| 141 | L | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | E | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | E | A | -0.6073 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | L | A | -0.0259 | |
| 153 | G | A | 0.0000 | |
| 154 | K | A | -0.5415 | |
| 155 | Y | A | -0.4357 | |
| 156 | T | A | -0.5942 | |
| 157 | T | A | -1.0053 | |
| 158 | K | A | -1.4155 | |
| 159 | A | A | -0.6042 | |
| 160 | A | A | -0.3795 | |
| 161 | P | A | -0.6177 | |
| 162 | A | A | -0.1631 | |
| 163 | P | A | -0.3465 | |
| 164 | G | A | -0.3802 | |
| 165 | L | A | -0.1772 | |
| 166 | P | A | -0.5586 | |
| 167 | P | A | -0.7490 | |
| 168 | G | A | -0.7730 | |
| 169 | A | A | -0.8984 | |
| 170 | E | A | -1.8863 | |
| 171 | P | A | -1.3281 | |
| 172 | P | A | -0.8980 | |
| 173 | T | A | -0.7699 | |
| 174 | T | A | -0.3430 | |
| 175 | T | A | -0.2729 | |
| 176 | V | A | -0.0192 | |
| 177 | T | A | -0.0337 | |
| 178 | T | A | 0.0038 | |
| 179 | V | A | -0.3421 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | -1.0764 | |
| 182 | H | A | -0.9263 | |
| 183 | G | A | -0.6658 | |
| 184 | D | A | -0.7002 | |
| 185 | M | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | -0.2859 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.5084 | |
| 190 | F | A | -0.0654 | |
| 191 | G | A | -0.3022 | |
| 192 | A | A | -0.5476 | |
| 193 | K | A | -1.2469 | |
| 194 | D | A | -1.5012 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -2.9968 | |
| 197 | A | A | -1.5099 | |
| 198 | L | A | -1.4493 | |
| 199 | E | A | -2.0780 | |
| 200 | P | A | -2.1443 | |
| 201 | R | A | -2.8712 | |
| 202 | K | A | -3.4285 | |
| 203 | N | A | -2.2682 | |
| 204 | N | A | -1.3729 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.3291 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -1.8196 | |
| 211 | N | A | -2.3955 | |
| 212 | T | A | -1.3693 | |
| 213 | T | A | -1.0831 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | -0.0709 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | -0.4278 | |
| 219 | Y | A | -0.5700 | |
| 220 | A | A | -0.6770 | |
| 221 | G | A | -0.8784 | |
| 222 | M | A | 0.0000 | |
| 223 | R | A | -2.0774 | |
| 224 | A | A | -1.1453 | |
| 225 | E | A | -1.1882 | |
| 226 | P | A | -0.6038 | |
| 227 | Y | A | -0.3054 | |
| 228 | G | A | 0.0000 | |
| 229 | R | A | -0.6670 | |
| 230 | R | A | -0.7419 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | T | A | -0.6836 | |
| 234 | S | A | -0.6237 | |
| 235 | D | A | -1.4116 | |
| 236 | R | A | -1.7990 | |
| 237 | R | A | -1.8112 | |
| 238 | E | A | -1.5524 | |
| 239 | S | A | -1.4316 | |
| 240 | S | A | -1.7797 | |
| 241 | R | A | -2.9364 | |
| 242 | D | A | -2.5259 | |
| 243 | V | A | -1.1146 | |
| 244 | K | A | -1.8110 | |
| 245 | K | A | -1.6414 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | L | A | -0.0142 | |
| 249 | N | A | -0.6867 | |
| 250 | G | A | -0.2099 | |
| 251 | P | A | 0.0565 | |
| 252 | V | A | 0.7387 | |
| 253 | L | A | 0.8247 | |
| 254 | N | A | -0.4856 | |
| 255 | P | A | -0.0404 | |
| 256 | L | A | 0.6648 | |
| 257 | P | A | -0.3062 | |
| 258 | S | A | -0.4432 | |
| 259 | S | A | -0.8404 | |
| 260 | P | A | -0.9097 | |
| 261 | P | A | -0.9889 | |
| 262 | P | A | -0.9912 | |
| 263 | S | A | -0.7885 | |
| 264 | K | A | -1.0467 | |
| 265 | L | A | 0.8527 | |
| 266 | Y | A | 0.1554 | |
| 267 | T | A | -0.6249 | |
| 268 | K | A | -0.7877 | |
| 269 | P | A | -0.2015 | |
| 270 | P | A | -0.3702 | |
| 271 | P | A | -0.1394 | |
| 272 | S | A | -0.2403 | |
| 273 | S | A | 0.1825 | |
| 274 | P | A | 0.5443 | |
| 275 | Y | A | 1.3813 | |
| 276 | Y | A | 1.4682 | |
| 277 | V | A | 2.2338 | |
| 278 | L | A | 1.5905 | |
| 279 | P | A | 0.7092 | |
| 280 | P | A | 0.1930 | |
| 281 | Y | A | 0.4060 | |
| 282 | N | A | -0.2918 | |
| 283 | Y | A | 0.7838 | |
| 284 | F | A | 0.1595 | |
| 285 | T | A | -0.7522 | |
| 286 | L | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | 0.0000 | |
| 289 | E | A | 0.0000 | |
| 290 | G | A | 0.0000 | |
| 291 | E | A | -1.9801 | |
| 292 | I | A | -1.3575 | |
| 293 | T | A | -1.8847 | |
| 294 | E | A | -2.7269 | |
| 295 | E | A | -2.9345 | |
| 296 | D | A | -2.2902 | |
| 297 | L | A | -1.5045 | |
| 298 | L | A | 0.0000 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.0958 | |
| 301 | R | A | -1.2676 | |
| 302 | P | A | -0.6552 | |
| 303 | V | A | 0.0105 | |
| 304 | W | A | -0.2014 | |
| 305 | L | A | -1.0258 | |
| 306 | E | A | -2.5277 | |
| 307 | R | A | -2.6469 | |
| 308 | T | A | -1.3195 | |
| 309 | A | A | -0.8981 | |
| 310 | G | A | -0.7781 | |
| 311 | L | A | -0.4292 | |
| 312 | N | A | 0.0000 | |
| 313 | D | A | -1.1626 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | G | A | -1.0196 | |
| 319 | N | A | -0.9434 | |
| 320 | R | A | -1.3417 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | I | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.4268 | |
| 331 | A | A | 0.0000 | |
| 332 | A | A | -0.6155 | |
| 333 | I | A | -0.7158 | |
| 334 | E | A | -2.0108 | |
| 335 | T | A | -1.5685 | |
| 336 | I | A | -0.9832 | |
| 337 | K | A | -2.5949 | |
| 338 | T | A | -1.8180 | |
| 339 | R | A | -1.8179 | |
| 340 | I | A | 0.4370 | |
| 341 | A | A | 0.0854 | |
| 342 | T | A | 0.2947 | |
| 343 | P | A | 0.4538 | |
| 344 | P | A | 0.9379 | |
| 345 | I | A | 1.7184 | |
| 346 | D | A | 0.2711 | |
| 347 | V | A | 1.9274 | |
| 348 | Y | A | 1.5103 | |
| 349 | N | A | -0.0453 | |
| 350 | P | A | -1.2276 | |
| 351 | E | A | -1.8098 | |
| 352 | Y | A | -0.8404 | |
| 353 | Y | A | -1.6481 | |
| 354 | K | A | -2.9487 | |
| 355 | E | A | -3.4178 | |
| 356 | S | A | -2.0159 | |
| 357 | K | A | -1.8801 | |
| 358 | R | A | -1.1315 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -0.5704 | |
| 361 | A | A | 0.0000 | |
| 362 | E | A | -0.1208 | |
| 363 | Y | A | 0.0000 | |
| 364 | K | A | -0.4718 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | L | A | 0.0000 | |
| 370 | Q | A | -0.4531 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | R | A | -0.8418 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.7174 | |
| 376 | L | A | -0.3587 | |
| 377 | T | A | -0.6496 | |
| 378 | P | A | -0.9761 | |
| 379 | E | A | -1.7929 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -0.4109 | |
| 382 | A | A | -0.7550 | |
| 383 | E | A | 0.0000 | |
| 384 | L | A | 0.0000 | |
| 385 | A | A | -0.7450 | |
| 386 | R | A | -1.1774 | |
| 387 | L | A | -0.5650 | |
| 388 | D | A | -0.6917 | |
| 389 | P | A | -0.5907 | |
| 390 | S | A | -0.6638 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -0.7636 | |
| 394 | N | A | -1.3104 | |
| 395 | W | A | -1.1252 | |
| 396 | N | A | -1.7411 | |
| 397 | L | A | -1.1244 | |
| 398 | P | A | -1.2232 | |
| 399 | D | A | -1.8768 | |
| 400 | I | A | -0.6716 | |
| 401 | P | A | -0.2663 | |
| 402 | P | A | -0.1865 | |
| 403 | V | A | 0.9693 | |
| 404 | T | A | -0.3955 | |
| 405 | R | A | -1.8400 | |
| 406 | P | A | -1.5055 | |
| 407 | D | A | -1.8179 | |
| 408 | P | A | -1.1662 | |
| 409 | L | A | -0.8733 | |
| 410 | A | A | -1.0175 | |
| 411 | G | A | -1.3135 | |
| 412 | K | A | -1.8642 | |
| 413 | K | A | -2.4240 | |
| 414 | F | A | -1.4074 | |
| 415 | I | A | -1.1273 | |
| 416 | E | A | -2.2677 | |
| 417 | I | A | -1.8072 | |
| 418 | D | A | -2.7560 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.8789 | |
| 421 | D | A | -2.7006 | |
| 422 | K | A | -2.6669 | |
| 423 | L | A | -1.4703 | |
| 424 | S | A | -1.8003 | |
| 425 | R | A | -2.5271 | |
| 426 | D | A | -2.7052 | |
| 427 | L | A | 0.0000 | |
| 428 | E | A | -3.6636 | |
| 429 | K | A | -3.3756 | |
| 430 | Y | A | -2.2703 | |
| 431 | E | A | -2.3736 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.9766 | |
| 435 | E | A | -2.0589 | |
| 436 | Y | A | -1.1161 | |
| 437 | L | A | -0.7907 | |
| 438 | N | A | -2.2139 | |
| 439 | R | A | -2.2926 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine