| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIVVNGKVLVPKVSGYQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTIGHPLFNKLGDTENPTAPVHEGADDRVNYSFDPKQTQLFIVGCEPPTGEHWDLAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFFRRSGPDGHPLPAEPPPSPLYVPPPPDSPYAVPPSTNYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLSTPAPNVYDPSYFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9430 | |
| 2 | L | A | 1.9648 | |
| 3 | P | A | 0.8322 | |
| 4 | P | A | 0.3744 | |
| 5 | T | A | 0.1259 | |
| 6 | T | A | 0.1341 | |
| 7 | P | A | 0.1752 | |
| 8 | V | A | 1.2059 | |
| 9 | A | A | 0.0836 | |
| 10 | K | A | -1.0267 | |
| 11 | V | A | -0.1799 | |
| 12 | Q | A | -1.4129 | |
| 13 | S | A | -1.5625 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4271 | |
| 16 | E | A | -2.4432 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4559 | |
| 20 | P | A | 0.1253 | |
| 21 | T | A | 0.1776 | |
| 22 | S | A | -0.0970 | |
| 23 | L | A | 0.1120 | |
| 24 | F | A | -0.0293 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.3062 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.9120 | |
| 31 | R | A | -2.6986 | |
| 32 | L | A | -0.8107 | |
| 33 | L | A | 1.1447 | |
| 34 | T | A | 1.3538 | |
| 35 | V | A | 1.7980 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2613 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6276 | |
| 40 | K | A | -1.6805 | |
| 41 | D | A | -0.7300 | |
| 42 | I | A | 1.2672 | |
| 43 | V | A | 2.2287 | |
| 44 | V | A | 1.6583 | |
| 45 | N | A | -0.5377 | |
| 46 | G | A | -0.3644 | |
| 47 | K | A | -0.1299 | |
| 48 | V | A | 2.0234 | |
| 49 | L | A | 2.5290 | |
| 50 | V | A | 1.4263 | |
| 51 | P | A | 0.3152 | |
| 52 | K | A | -0.7011 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1455 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.3826 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2695 | |
| 70 | K | A | -1.7907 | |
| 71 | F | A | -0.6418 | |
| 72 | A | A | -0.5728 | |
| 73 | L | A | -0.8578 | |
| 74 | P | A | -1.2685 | |
| 75 | Q | A | -2.5004 | |
| 76 | K | A | -3.1059 | |
| 77 | D | A | -2.9924 | |
| 78 | F | A | -1.6559 | |
| 79 | Y | A | -1.8890 | |
| 80 | D | A | -2.6849 | |
| 81 | P | A | -2.3081 | |
| 82 | E | A | -3.0469 | |
| 83 | K | A | -3.3940 | |
| 84 | E | A | -2.4570 | |
| 85 | R | A | -1.2903 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6440 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9748 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3729 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6966 | |
| 99 | G | A | -0.5290 | |
| 100 | P | A | -0.3827 | |
| 101 | L | A | 0.0880 | |
| 102 | G | A | -0.1755 | |
| 103 | K | A | -0.5794 | |
| 104 | G | A | -0.4391 | |
| 105 | T | A | -0.4496 | |
| 106 | I | A | 0.0000 | |
| 107 | G | A | -0.1160 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | -0.1782 | |
| 110 | L | A | -0.1349 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.2943 | |
| 113 | K | A | -0.6673 | |
| 114 | L | A | -1.1538 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.1077 | |
| 117 | T | A | -0.7492 | |
| 118 | E | A | -1.7189 | |
| 119 | N | A | -1.9283 | |
| 120 | P | A | -1.2580 | |
| 121 | T | A | -0.6237 | |
| 122 | A | A | -0.2741 | |
| 123 | P | A | -0.1254 | |
| 124 | V | A | -0.3505 | |
| 125 | H | A | -1.6219 | |
| 126 | E | A | -2.6049 | |
| 127 | G | A | -2.1747 | |
| 128 | A | A | -1.5888 | |
| 129 | D | A | -2.4790 | |
| 130 | D | A | -2.0820 | |
| 131 | R | A | -1.4055 | |
| 132 | V | A | -0.4813 | |
| 133 | N | A | -0.9290 | |
| 134 | Y | A | -0.4260 | |
| 135 | S | A | -0.3857 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.5378 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5601 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.1911 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1393 | |
| 157 | D | A | 0.3150 | |
| 158 | L | A | 0.7896 | |
| 159 | A | A | 0.1572 | |
| 160 | E | A | -1.4604 | |
| 161 | P | A | -0.2167 | |
| 162 | C | A | 0.1904 | |
| 163 | P | A | -0.1691 | |
| 164 | G | A | -0.0767 | |
| 165 | L | A | 0.5879 | |
| 166 | P | A | -0.1196 | |
| 167 | P | A | -0.3425 | |
| 168 | G | A | -0.4226 | |
| 169 | A | A | -0.0207 | |
| 170 | C | A | 0.6518 | |
| 171 | P | A | 0.5116 | |
| 172 | P | A | 0.8194 | |
| 173 | I | A | 1.9413 | |
| 174 | Q | A | 0.8239 | |
| 175 | L | A | 1.4780 | |
| 176 | V | A | 0.8550 | |
| 177 | N | A | -0.2929 | |
| 178 | S | A | 0.0290 | |
| 179 | V | A | 0.4301 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3818 | |
| 182 | D | A | 0.0782 | |
| 183 | G | A | -0.1569 | |
| 184 | D | A | -0.5353 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1172 | |
| 190 | F | A | 0.0539 | |
| 191 | G | A | -0.1067 | |
| 192 | N | A | -0.2609 | |
| 193 | M | A | -0.1232 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.4137 | |
| 197 | E | A | -2.6148 | |
| 198 | L | A | -1.2373 | |
| 199 | Q | A | -2.5659 | |
| 200 | Q | A | -3.3370 | |
| 201 | D | A | -3.5872 | |
| 202 | R | A | -3.3427 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.2192 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3553 | |
| 211 | S | A | -1.8852 | |
| 212 | T | A | -1.4247 | |
| 213 | R | A | -2.0670 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1573 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3485 | |
| 220 | L | A | 0.6178 | |
| 221 | K | A | -1.0896 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.8078 | |
| 224 | N | A | -1.4849 | |
| 225 | E | A | -1.2262 | |
| 226 | A | A | -0.6054 | |
| 227 | Y | A | -0.3669 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6565 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | 0.0724 | |
| 234 | F | A | 0.2663 | |
| 235 | G | A | -0.8211 | |
| 236 | R | A | -2.6207 | |
| 237 | R | A | -2.9058 | |
| 238 | E | A | -2.1767 | |
| 239 | Q | A | -0.2140 | |
| 240 | V | A | 1.3636 | |
| 241 | Y | A | 1.1220 | |
| 242 | A | A | 0.1392 | |
| 243 | R | A | -1.1611 | |
| 244 | H | A | -1.0101 | |
| 245 | F | A | 0.0428 | |
| 246 | F | A | 0.0000 | |
| 247 | R | A | 0.0000 | |
| 248 | R | A | -0.5545 | |
| 249 | S | A | -1.3915 | |
| 250 | G | A | -1.1803 | |
| 251 | P | A | -1.0951 | |
| 252 | D | A | -1.2567 | |
| 253 | G | A | -1.2118 | |
| 254 | H | A | -1.3749 | |
| 255 | P | A | -0.7094 | |
| 256 | L | A | 0.3946 | |
| 257 | P | A | -0.0620 | |
| 258 | A | A | 0.0447 | |
| 259 | E | A | -0.4521 | |
| 260 | P | A | -0.5939 | |
| 261 | P | A | -0.1478 | |
| 262 | P | A | -0.0620 | |
| 263 | S | A | 0.3678 | |
| 264 | P | A | 0.5964 | |
| 265 | L | A | 1.8142 | |
| 266 | Y | A | 1.6700 | |
| 267 | V | A | 1.8391 | |
| 268 | P | A | 1.0052 | |
| 269 | P | A | 0.3543 | |
| 270 | P | A | -0.6693 | |
| 271 | P | A | -0.9138 | |
| 272 | D | A | -1.7363 | |
| 273 | S | A | -0.6260 | |
| 274 | P | A | -0.0671 | |
| 275 | Y | A | 0.9572 | |
| 276 | A | A | 0.5777 | |
| 277 | V | A | 1.7983 | |
| 278 | P | A | 1.0839 | |
| 279 | P | A | 0.1058 | |
| 280 | S | A | 0.0000 | |
| 281 | T | A | -0.2223 | |
| 282 | N | A | -0.4369 | |
| 283 | Y | A | 1.0700 | |
| 284 | F | A | 0.8178 | |
| 285 | G | A | 0.2200 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.8939 | |
| 291 | L | A | 1.6149 | |
| 292 | V | A | 0.6471 | |
| 293 | S | A | -0.1522 | |
| 294 | S | A | -0.9543 | |
| 295 | D | A | -1.8433 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1155 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6425 | |
| 301 | R | A | -1.8595 | |
| 302 | P | A | -0.9774 | |
| 303 | F | A | -0.1880 | |
| 304 | W | A | -0.5557 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0789 | |
| 307 | R | A | -2.8341 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.2670 | |
| 310 | G | A | -1.2338 | |
| 311 | N | A | -1.2835 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.7723 | |
| 319 | N | A | -0.9091 | |
| 320 | E | A | -1.0259 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3191 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.0672 | |
| 333 | N | A | 0.5509 | |
| 334 | F | A | 1.7297 | |
| 335 | T | A | 0.8528 | |
| 336 | I | A | 0.3845 | |
| 337 | S | A | -0.9840 | |
| 338 | Q | A | -1.7576 | |
| 339 | Q | A | -1.2993 | |
| 340 | L | A | 0.5565 | |
| 341 | S | A | 0.2366 | |
| 342 | T | A | -0.1570 | |
| 343 | P | A | -0.4632 | |
| 344 | A | A | -0.0251 | |
| 345 | P | A | 0.1885 | |
| 346 | N | A | -0.2571 | |
| 347 | V | A | 1.6714 | |
| 348 | Y | A | 1.6346 | |
| 349 | D | A | 0.3623 | |
| 350 | P | A | -0.3641 | |
| 351 | S | A | -0.0935 | |
| 352 | Y | A | 0.5040 | |
| 353 | F | A | -0.7088 | |
| 354 | K | A | -1.8825 | |
| 355 | N | A | -1.8595 | |
| 356 | Y | A | -0.1588 | |
| 357 | L | A | 0.6315 | |
| 358 | R | A | 0.9550 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.3711 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0905 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -2.0814 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6973 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.3048 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3160 | |
| 376 | L | A | -1.7130 | |
| 377 | D | A | -1.9972 | |
| 378 | P | A | -1.0408 | |
| 379 | G | A | -1.0141 | |
| 380 | V | A | -0.9328 | |
| 381 | L | A | -0.5295 | |
| 382 | A | A | -0.6521 | |
| 383 | H | A | -0.8050 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.3964 | |
| 386 | T | A | -0.5443 | |
| 387 | M | A | -0.2955 | |
| 388 | N | A | -0.8599 | |
| 389 | P | A | -1.2287 | |
| 390 | T | A | -1.4094 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.4045 | |
| 393 | E | A | -2.7306 | |
| 394 | N | A | -2.2924 | |
| 395 | W | A | -1.3274 | |
| 396 | N | A | -1.0847 | |
| 397 | L | A | -0.2103 | |
| 398 | G | A | 0.5248 | |
| 399 | F | A | 2.4139 | |
| 400 | V | A | 1.8220 | |
| 401 | P | A | 0.0458 | |
| 402 | P | A | -1.7665 | |
| 403 | K | A | -3.2941 | |
| 404 | E | A | -3.7338 | |
| 405 | R | A | -3.8202 | |
| 406 | E | A | -3.7515 | |
| 407 | D | A | -2.8676 | |
| 408 | P | A | -1.7623 | |
| 409 | Y | A | -0.9949 | |
| 410 | K | A | -2.1159 | |
| 411 | G | A | -0.6412 | |
| 412 | L | A | 0.6697 | |
| 413 | I | A | 1.5847 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3929 | |
| 416 | E | A | -1.6939 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9541 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0601 | |
| 421 | E | A | -2.7937 | |
| 422 | R | A | -2.5914 | |
| 423 | F | A | -1.2913 | |
| 424 | S | A | -1.4759 | |
| 425 | Q | A | -1.7631 | |
| 426 | D | A | -2.9037 | |
| 427 | L | A | -1.9859 | |
| 428 | D | A | -2.7799 | |
| 429 | Q | A | -2.6231 | |
| 430 | F | A | -1.4223 | |
| 431 | A | A | -0.8879 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.5476 | |
| 435 | K | A | -0.6900 | |
| 436 | F | A | 0.1583 | |
| 437 | L | A | 1.0396 | |
| 438 | Y | A | 0.8365 | |
| 439 | Q | A | -0.2700 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine