| Chain sequence(s) |
A: DIDECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDECKEPDVCKHGQCINTDGSYRCECPFGYILAGNECVDTDECSVGNPCGNGTCKNVIGGFECTCEEGFEPGPMMTCEDINECAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCVDENECQTKPGICENGRCLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNGADIDECKVIHDVCRNGECVNDRGSYHCICKTGYTPDITGTSCV
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:05:10)
[INFO] Main: Simulation completed successfully. (00:05:13)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | D | A | -2.0416 | |
| 2 | I | A | -0.3110 | |
| 3 | D | A | -1.5637 | |
| 4 | E | A | -1.6058 | |
| 5 | C | A | -1.0728 | |
| 6 | V | A | -0.2222 | |
| 7 | E | A | -2.2211 | |
| 8 | E | A | -3.0311 | |
| 9 | P | A | -1.9015 | |
| 10 | E | A | -2.7131 | |
| 11 | I | A | 0.0000 | |
| 12 | C | A | 0.0000 | |
| 13 | A | A | -0.8644 | |
| 14 | L | A | 0.0721 | |
| 15 | G | A | -0.0679 | |
| 16 | T | A | -0.3196 | |
| 17 | C | A | -0.6959 | |
| 18 | S | A | -0.4637 | |
| 19 | N | A | -1.4247 | |
| 20 | T | A | -1.8029 | |
| 21 | E | A | -2.5393 | |
| 22 | G | A | -1.7785 | |
| 23 | S | A | -1.3792 | |
| 24 | F | A | -1.0675 | |
| 25 | K | A | -1.2238 | |
| 26 | C | A | 0.0000 | |
| 27 | L | A | 0.5909 | |
| 28 | C | A | 0.1744 | |
| 29 | P | A | -0.5869 | |
| 30 | E | A | -1.8450 | |
| 31 | G | A | -0.6962 | |
| 32 | F | A | 0.2942 | |
| 33 | S | A | 0.5224 | |
| 34 | L | A | 0.4127 | |
| 35 | S | A | 0.0000 | |
| 36 | S | A | -1.1120 | |
| 37 | S | A | -1.2434 | |
| 38 | G | A | -1.1047 | |
| 39 | R | A | -1.7824 | |
| 40 | R | A | 0.0000 | |
| 41 | C | A | 0.0000 | |
| 42 | Q | A | 0.0000 | |
| 43 | D | A | 0.0000 | |
| 44 | L | A | 1.3639 | |
| 45 | R | A | 0.0827 | |
| 46 | M | A | 0.6061 | |
| 47 | S | A | -0.2677 | |
| 48 | Y | A | -0.2596 | |
| 49 | C | A | 0.0000 | |
| 50 | Y | A | 0.0000 | |
| 51 | A | A | -1.3442 | |
| 52 | K | A | -2.3521 | |
| 53 | F | A | -1.9671 | |
| 54 | E | A | -2.8366 | |
| 55 | G | A | -2.0187 | |
| 56 | G | A | -1.8648 | |
| 57 | K | A | -2.7063 | |
| 58 | C | A | 0.0000 | |
| 59 | S | A | -1.4685 | |
| 60 | S | A | -0.8208 | |
| 61 | P | A | -1.0237 | |
| 62 | K | A | -1.2294 | |
| 63 | S | A | -1.5068 | |
| 64 | R | A | -1.8987 | |
| 65 | N | A | -1.4984 | |
| 66 | H | A | 0.0000 | |
| 67 | S | A | 0.1594 | |
| 68 | K | A | -0.1653 | |
| 69 | Q | A | -0.2850 | |
| 70 | E | A | -0.6196 | |
| 71 | C | A | 0.0000 | |
| 72 | C | A | 0.0000 | |
| 73 | C | A | 0.0000 | |
| 74 | A | A | 0.0000 | |
| 75 | L | A | 0.0000 | |
| 76 | K | A | -2.0932 | |
| 77 | G | A | 0.0000 | |
| 78 | E | A | -1.4152 | |
| 79 | G | A | 0.0000 | |
| 80 | W | A | 0.0000 | |
| 81 | G | A | 0.0000 | |
| 82 | D | A | -1.8916 | |
| 83 | P | A | -1.4586 | |
| 84 | C | A | -1.1292 | |
| 85 | E | A | -1.0039 | |
| 86 | L | A | 0.2428 | |
| 87 | C | A | 0.0000 | |
| 88 | P | A | -1.2081 | |
| 89 | T | A | -2.0250 | |
| 90 | E | A | -3.1743 | |
| 91 | P | A | -2.7813 | |
| 92 | D | A | -3.5087 | |
| 93 | E | A | -3.6221 | |
| 94 | A | A | -2.3022 | |
| 95 | F | A | 0.0000 | |
| 96 | R | A | -3.2961 | |
| 97 | Q | A | -2.0584 | |
| 98 | I | A | 0.0000 | |
| 99 | C | A | 0.0000 | |
| 100 | P | A | -0.6597 | |
| 101 | Y | A | 0.5475 | |
| 102 | G | A | -0.2470 | |
| 103 | S | A | -0.4541 | |
| 104 | G | A | 0.0000 | |
| 105 | I | A | 0.2660 | |
| 106 | I | A | 0.5273 | |
| 107 | V | A | 0.0000 | |
| 108 | G | A | 0.0000 | |
| 109 | P | A | -0.9155 | |
| 110 | D | A | -2.1294 | |
| 111 | D | A | -1.4776 | |
| 112 | S | A | -0.5119 | |
| 113 | A | A | 0.2969 | |
| 114 | V | A | 0.5300 | |
| 115 | D | A | -0.5847 | |
| 116 | M | A | -0.6829 | |
| 117 | D | A | -1.1457 | |
| 118 | E | A | 0.0000 | |
| 119 | C | A | -1.2369 | |
| 120 | K | A | -2.0279 | |
| 121 | E | A | 0.0000 | |
| 122 | P | A | -1.7242 | |
| 123 | D | A | -2.6437 | |
| 124 | V | A | -1.8179 | |
| 125 | C | A | 0.0000 | |
| 126 | K | A | -2.4370 | |
| 127 | H | A | -2.1963 | |
| 128 | G | A | -2.0293 | |
| 129 | Q | A | -2.1625 | |
| 130 | C | A | -1.6543 | |
| 131 | I | A | -0.3566 | |
| 132 | N | A | -1.2327 | |
| 133 | T | A | -1.3435 | |
| 134 | D | A | -1.9571 | |
| 135 | G | A | -0.8875 | |
| 136 | S | A | -1.0465 | |
| 137 | Y | A | -0.8199 | |
| 138 | R | A | -2.0378 | |
| 139 | C | A | -1.9834 | |
| 140 | E | A | -1.8245 | |
| 141 | C | A | -0.3697 | |
| 142 | P | A | 0.5332 | |
| 143 | F | A | 1.9244 | |
| 144 | G | A | 1.5184 | |
| 145 | Y | A | 1.5122 | |
| 146 | I | A | 1.9478 | |
| 147 | L | A | 0.7877 | |
| 148 | A | A | 0.1556 | |
| 149 | G | A | -0.7830 | |
| 150 | N | A | -2.2995 | |
| 151 | E | A | -1.9234 | |
| 152 | C | A | 0.0000 | |
| 153 | V | A | 0.6176 | |
| 154 | D | A | 0.7529 | |
| 155 | T | A | 0.7233 | |
| 156 | D | A | -0.5489 | |
| 157 | E | A | -0.8542 | |
| 158 | C | A | -0.8192 | |
| 159 | S | A | -0.2235 | |
| 160 | V | A | 1.0167 | |
| 161 | G | A | -0.3411 | |
| 162 | N | A | -1.4407 | |
| 163 | P | A | -0.7196 | |
| 164 | C | A | 0.0000 | |
| 165 | G | A | -1.5407 | |
| 166 | N | A | -2.0944 | |
| 167 | G | A | -2.0402 | |
| 168 | T | A | -1.1680 | |
| 169 | C | A | -1.4822 | |
| 170 | K | A | -2.0221 | |
| 171 | N | A | -1.0583 | |
| 172 | V | A | 0.5305 | |
| 173 | I | A | 1.9933 | |
| 174 | G | A | 1.3936 | |
| 175 | G | A | 0.3851 | |
| 176 | F | A | -0.4289 | |
| 177 | E | A | -1.3725 | |
| 178 | C | A | -1.3343 | |
| 179 | T | A | -1.2579 | |
| 180 | C | A | -2.1485 | |
| 181 | E | A | -3.2171 | |
| 182 | E | A | -2.9241 | |
| 183 | G | A | -1.8695 | |
| 184 | F | A | -2.4628 | |
| 185 | E | A | -2.8102 | |
| 186 | P | A | -1.4499 | |
| 187 | G | A | -0.7299 | |
| 188 | P | A | -0.0403 | |
| 189 | M | A | 0.9266 | |
| 190 | M | A | 0.3050 | |
| 191 | T | A | -0.7311 | |
| 192 | C | A | 0.0000 | |
| 193 | E | A | -2.5291 | |
| 194 | D | A | -1.8533 | |
| 195 | I | A | -1.3556 | |
| 196 | N | A | -1.5269 | |
| 197 | E | A | -1.4235 | |
| 198 | C | A | -1.0488 | |
| 199 | A | A | -0.9881 | |
| 200 | Q | A | -1.7945 | |
| 201 | N | A | -1.4107 | |
| 202 | P | A | -0.4563 | |
| 203 | L | A | 1.0155 | |
| 204 | L | A | -0.0681 | |
| 205 | C | A | -0.2811 | |
| 206 | A | A | 0.5922 | |
| 207 | F | A | 1.1317 | |
| 208 | R | A | -1.0445 | |
| 209 | C | A | -0.7828 | |
| 210 | V | A | -0.7436 | |
| 211 | N | A | -0.5189 | |
| 212 | T | A | 0.1218 | |
| 213 | Y | A | 0.8167 | |
| 214 | G | A | -0.7803 | |
| 215 | S | A | -0.4003 | |
| 216 | Y | A | -0.3940 | |
| 217 | E | A | -2.1075 | |
| 218 | C | A | 0.0000 | |
| 219 | K | A | -0.9601 | |
| 220 | C | A | 0.1186 | |
| 221 | P | A | 0.8426 | |
| 222 | V | A | 1.7534 | |
| 223 | G | A | 0.8576 | |
| 224 | Y | A | 0.6742 | |
| 225 | V | A | -0.1829 | |
| 226 | L | A | -1.5347 | |
| 227 | R | A | -2.9399 | |
| 228 | E | A | -3.5777 | |
| 229 | D | A | -3.4661 | |
| 230 | R | A | -3.7875 | |
| 231 | R | A | -2.3860 | |
| 232 | M | A | -1.3369 | |
| 233 | C | A | -1.0665 | |
| 234 | K | A | -1.1746 | |
| 235 | D | A | -0.1723 | |
| 236 | E | A | -0.9435 | |
| 237 | D | A | -2.3397 | |
| 238 | E | A | -2.8224 | |
| 239 | C | A | -2.8052 | |
| 240 | E | A | -3.6055 | |
| 241 | E | A | -3.7996 | |
| 242 | G | A | -3.0501 | |
| 243 | K | A | -3.2401 | |
| 244 | H | A | -2.6666 | |
| 245 | D | A | -2.3298 | |
| 246 | C | A | 0.0000 | |
| 247 | T | A | -2.3141 | |
| 248 | E | A | -3.1876 | |
| 249 | K | A | -2.9786 | |
| 250 | Q | A | -2.6806 | |
| 251 | M | A | 0.0000 | |
| 252 | E | A | -2.3992 | |
| 253 | C | A | -1.7544 | |
| 254 | K | A | -1.2337 | |
| 255 | N | A | -0.7459 | |
| 256 | L | A | 0.9852 | |
| 257 | I | A | 1.7730 | |
| 258 | G | A | 1.0033 | |
| 259 | T | A | 0.7836 | |
| 260 | Y | A | 0.2412 | |
| 261 | M | A | 0.1046 | |
| 262 | C | A | 0.0000 | |
| 263 | I | A | -0.5940 | |
| 264 | C | A | -1.0967 | |
| 265 | G | A | -0.8774 | |
| 266 | P | A | -0.4134 | |
| 267 | G | A | -0.8226 | |
| 268 | Y | A | -0.9508 | |
| 269 | Q | A | -1.5000 | |
| 270 | R | A | -2.9545 | |
| 271 | R | A | -3.1503 | |
| 272 | P | A | -2.4245 | |
| 273 | D | A | -3.2241 | |
| 274 | G | A | -3.0281 | |
| 275 | E | A | -3.6096 | |
| 276 | G | A | 0.0000 | |
| 277 | C | A | -1.9246 | |
| 278 | V | A | -1.0168 | |
| 279 | D | A | -1.5353 | |
| 280 | E | A | -1.9101 | |
| 281 | N | A | -1.8879 | |
| 282 | E | A | -1.6595 | |
| 283 | C | A | -1.5533 | |
| 284 | Q | A | -2.0708 | |
| 285 | T | A | -1.6848 | |
| 286 | K | A | -2.1926 | |
| 287 | P | A | -1.6550 | |
| 288 | G | A | -1.7969 | |
| 289 | I | A | -1.5001 | |
| 290 | C | A | 0.0000 | |
| 291 | E | A | -2.9992 | |
| 292 | N | A | -2.8223 | |
| 293 | G | A | -3.1246 | |
| 294 | R | A | -3.1479 | |
| 295 | C | A | -2.1083 | |
| 296 | L | A | -0.7349 | |
| 297 | N | A | -1.4795 | |
| 298 | T | A | -1.4060 | |
| 299 | R | A | -2.2252 | |
| 300 | G | A | -1.4474 | |
| 301 | S | A | -1.2763 | |
| 302 | Y | A | -1.0627 | |
| 303 | T | A | -1.4858 | |
| 304 | C | A | 0.0000 | |
| 305 | E | A | -3.4010 | |
| 306 | C | A | -2.9286 | |
| 307 | N | A | -3.2150 | |
| 308 | D | A | -2.9395 | |
| 309 | G | A | -2.2035 | |
| 310 | F | A | -1.9808 | |
| 311 | T | A | -1.4277 | |
| 312 | A | A | -1.4702 | |
| 313 | S | A | 0.0000 | |
| 314 | P | A | -1.5661 | |
| 315 | N | A | -2.2489 | |
| 316 | Q | A | -2.5483 | |
| 317 | D | A | -2.1834 | |
| 318 | E | A | -2.6515 | |
| 319 | C | A | -2.0652 | |
| 320 | L | A | -1.2853 | |
| 321 | D | A | -1.6776 | |
| 322 | N | A | -2.3458 | |
| 323 | R | A | -2.4786 | |
| 324 | E | A | -2.6689 | |
| 325 | G | A | -1.7688 | |
| 326 | Y | A | -0.8134 | |
| 327 | C | A | 0.0000 | |
| 328 | F | A | 0.0000 | |
| 329 | T | A | -1.1267 | |
| 330 | E | A | -0.8229 | |
| 331 | V | A | 0.0000 | |
| 332 | L | A | -0.2160 | |
| 333 | Q | A | -1.1143 | |
| 334 | N | A | -1.1592 | |
| 335 | M | A | 0.3939 | |
| 336 | C | A | 0.1309 | |
| 337 | Q | A | 0.3290 | |
| 338 | I | A | 1.3684 | |
| 339 | G | A | -0.0463 | |
| 340 | S | A | -0.6946 | |
| 341 | S | A | 0.0000 | |
| 342 | N | A | -1.6430 | |
| 343 | R | A | -2.0536 | |
| 344 | N | A | -1.9224 | |
| 345 | P | A | -1.7047 | |
| 346 | V | A | 0.0000 | |
| 347 | T | A | -1.5322 | |
| 348 | K | A | -1.0036 | |
| 349 | S | A | 0.0000 | |
| 350 | E | A | -1.1232 | |
| 351 | C | A | 0.0000 | |
| 352 | C | A | 0.0000 | |
| 353 | C | A | 0.0000 | |
| 354 | D | A | -1.5132 | |
| 355 | G | A | -1.2307 | |
| 356 | G | A | -0.9587 | |
| 357 | R | A | -1.4628 | |
| 358 | G | A | 0.0000 | |
| 359 | W | A | 0.0000 | |
| 360 | G | A | 0.0000 | |
| 361 | P | A | -0.9240 | |
| 362 | H | A | -1.0164 | |
| 363 | C | A | -0.5738 | |
| 364 | E | A | -0.5564 | |
| 365 | I | A | 0.2325 | |
| 366 | C | A | 0.0000 | |
| 367 | P | A | 0.2616 | |
| 368 | F | A | 1.0468 | |
| 369 | Q | A | -0.9350 | |
| 370 | G | A | -0.5462 | |
| 371 | T | A | 0.1497 | |
| 372 | V | A | 0.7059 | |
| 373 | A | A | -0.1324 | |
| 374 | F | A | 0.0000 | |
| 375 | K | A | -2.3715 | |
| 376 | K | A | -2.2197 | |
| 377 | L | A | -1.2827 | |
| 378 | C | A | 0.0000 | |
| 379 | P | A | -1.9640 | |
| 380 | H | A | -2.1716 | |
| 381 | G | A | -2.2566 | |
| 382 | R | A | -2.6541 | |
| 383 | G | A | 0.0000 | |
| 384 | F | A | -1.4635 | |
| 385 | M | A | -1.0028 | |
| 386 | T | A | -1.6321 | |
| 387 | N | A | -1.4426 | |
| 388 | G | A | -1.0252 | |
| 389 | A | A | -0.9614 | |
| 390 | D | A | -1.6870 | |
| 391 | I | A | 0.0000 | |
| 392 | D | A | -1.8255 | |
| 393 | E | A | 0.0000 | |
| 394 | C | A | -1.0979 | |
| 395 | K | A | -1.8005 | |
| 396 | V | A | 0.0000 | |
| 397 | I | A | -1.1212 | |
| 398 | H | A | -1.9311 | |
| 399 | D | A | -2.8452 | |
| 400 | V | A | -1.6630 | |
| 401 | C | A | 0.0000 | |
| 402 | R | A | -2.8432 | |
| 403 | N | A | -2.2536 | |
| 404 | G | A | -1.8181 | |
| 405 | E | A | -2.0046 | |
| 406 | C | A | -0.9625 | |
| 407 | V | A | -0.0409 | |
| 408 | N | A | -1.5927 | |
| 409 | D | A | -1.9699 | |
| 410 | R | A | -2.5475 | |
| 411 | G | A | -1.9553 | |
| 412 | S | A | -1.5762 | |
| 413 | Y | A | -0.8896 | |
| 414 | H | A | -0.2501 | |
| 415 | C | A | 0.0000 | |
| 416 | I | A | 0.6338 | |
| 417 | C | A | -0.6312 | |
| 418 | K | A | -1.8743 | |
| 419 | T | A | -0.8435 | |
| 420 | G | A | -0.5080 | |
| 421 | Y | A | 0.1779 | |
| 422 | T | A | 0.6126 | |
| 423 | P | A | 0.6438 | |
| 424 | D | A | 0.8427 | |
| 425 | I | A | 1.6507 | |
| 426 | T | A | 0.5983 | |
| 427 | G | A | 0.4374 | |
| 428 | T | A | 0.0966 | |
| 429 | S | A | -0.2223 | |
| 430 | C | A | 0.0818 | |
| 431 | V | A | 1.1471 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine