| Chain sequence(s) |
A: GPLPTNPEPPLRSTDEYVTPTDLLYIAETDLITKTGNPEKDIVKNGKVVEEKVSAYQWKVFKLTLPDPNKLPLPTADAIDPATEIRIWRLLAYKIKVFGPLGKGTVGHKNFNRLGDVDNPTAPVHDTSNVTQNYSFEPVLKQMYIVGDEPPLGVYTAPAAPAPGLPPGAIPPLTEVKTTIEDGDNADIGFGAKDFKALEPSKDDVPDNIKDTTTKVPDLEGMKAEPYGRRMFDYDYYEQSRDVKKFRRAGPMLIPPPSAGPPSPLYTKPPPTSPYAIPPSYDYFTIPDRGEITEEQKLFNKPRFFEKTEGLNNGILWGNQLYITVLDNTRAEIETIKTQKSTPLINVYDPSNYVESKRYTEKYKLELIVQLCTIPLTPETLALIERLDRRILVEANLPFVPPIEYPDPYAGKKFIEIDLTNKLSSNLEESELGREYLNK
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.2067 | |
| 2 | P | A | 0.1732 | |
| 3 | L | A | 0.9794 | |
| 4 | P | A | -0.0595 | |
| 5 | T | A | -0.7540 | |
| 6 | N | A | -1.7836 | |
| 7 | P | A | -1.9232 | |
| 8 | E | A | -2.5135 | |
| 9 | P | A | -1.7234 | |
| 10 | P | A | -0.7869 | |
| 11 | L | A | -0.2875 | |
| 12 | R | A | -1.0363 | |
| 13 | S | A | -1.1443 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.5951 | |
| 16 | E | A | -2.6306 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.8080 | |
| 20 | P | A | -0.8660 | |
| 21 | T | A | -1.0328 | |
| 22 | D | A | -1.7418 | |
| 23 | L | A | -0.6208 | |
| 24 | L | A | -0.1511 | |
| 25 | Y | A | -0.0360 | |
| 26 | I | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -0.9374 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.2577 | |
| 31 | L | A | 0.4478 | |
| 32 | I | A | 0.1552 | |
| 33 | T | A | -0.2244 | |
| 34 | K | A | -0.8368 | |
| 35 | T | A | -1.0218 | |
| 36 | G | A | 0.0000 | |
| 37 | N | A | -2.3798 | |
| 38 | P | A | 0.0000 | |
| 39 | E | A | -2.0564 | |
| 40 | K | A | -2.5891 | |
| 41 | D | A | -1.9623 | |
| 42 | I | A | -0.0305 | |
| 43 | V | A | 0.5266 | |
| 44 | K | A | -1.3456 | |
| 45 | N | A | -1.9703 | |
| 46 | G | A | -1.3085 | |
| 47 | K | A | -1.1199 | |
| 48 | V | A | 0.6554 | |
| 49 | V | A | 1.2229 | |
| 50 | E | A | -0.5541 | |
| 51 | E | A | -1.9244 | |
| 52 | K | A | -2.2114 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | K | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | K | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.2099 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.4146 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.6138 | |
| 70 | K | A | -1.9834 | |
| 71 | L | A | -0.9063 | |
| 72 | P | A | -0.6520 | |
| 73 | L | A | -0.3597 | |
| 74 | P | A | -0.4414 | |
| 75 | T | A | -0.3519 | |
| 76 | A | A | -0.3876 | |
| 77 | D | A | -1.1570 | |
| 78 | A | A | -0.6644 | |
| 79 | I | A | -0.8990 | |
| 80 | D | A | -1.8861 | |
| 81 | P | A | -1.2528 | |
| 82 | A | A | -0.7979 | |
| 83 | T | A | -0.8280 | |
| 84 | E | A | -1.1054 | |
| 85 | I | A | 0.0000 | |
| 86 | R | A | -0.7850 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | -0.2809 | |
| 90 | L | A | 0.0000 | |
| 91 | L | A | -0.3178 | |
| 92 | A | A | 0.0000 | |
| 93 | Y | A | 0.0000 | |
| 94 | K | A | 0.0000 | |
| 95 | I | A | 0.0000 | |
| 96 | K | A | -0.4746 | |
| 97 | V | A | 0.0000 | |
| 98 | F | A | 0.3872 | |
| 99 | G | A | -0.4533 | |
| 100 | P | A | -0.5560 | |
| 101 | L | A | -0.6053 | |
| 102 | G | A | -1.3360 | |
| 103 | K | A | -2.2987 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.8293 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | -1.0296 | |
| 108 | H | A | 0.0000 | |
| 109 | K | A | -2.9902 | |
| 110 | N | A | -2.9097 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.6500 | |
| 113 | R | A | -1.1038 | |
| 114 | L | A | 0.0000 | |
| 115 | G | A | -0.7071 | |
| 116 | D | A | -1.5267 | |
| 117 | V | A | -1.3092 | |
| 118 | D | A | -2.8293 | |
| 119 | N | A | -2.4744 | |
| 120 | P | A | -1.2815 | |
| 121 | T | A | -0.6271 | |
| 122 | A | A | -0.1578 | |
| 123 | P | A | 0.3929 | |
| 124 | V | A | 0.3485 | |
| 125 | H | A | 0.0181 | |
| 126 | D | A | -0.7869 | |
| 127 | T | A | -0.5886 | |
| 128 | S | A | -0.9921 | |
| 129 | N | A | -1.6487 | |
| 130 | V | A | -1.0095 | |
| 131 | T | A | -1.7847 | |
| 132 | Q | A | -2.3845 | |
| 133 | N | A | -2.7364 | |
| 134 | Y | A | -1.4563 | |
| 135 | S | A | -0.8894 | |
| 136 | F | A | 0.0000 | |
| 137 | E | A | -0.6481 | |
| 138 | P | A | 0.0000 | |
| 139 | V | A | 0.0000 | |
| 140 | L | A | 0.0000 | |
| 141 | K | A | -0.6849 | |
| 142 | Q | A | 0.0000 | |
| 143 | M | A | 0.2457 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | E | A | 0.0000 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | L | A | -0.1824 | |
| 153 | G | A | 0.0000 | |
| 154 | V | A | -0.6065 | |
| 155 | Y | A | -0.7312 | |
| 156 | T | A | -0.5749 | |
| 157 | A | A | 0.0000 | |
| 158 | P | A | 0.4848 | |
| 159 | A | A | 0.1682 | |
| 160 | A | A | 0.0654 | |
| 161 | P | A | -0.1179 | |
| 162 | A | A | -0.1847 | |
| 163 | P | A | -0.3720 | |
| 164 | G | A | -0.3855 | |
| 165 | L | A | 0.3904 | |
| 166 | P | A | -0.0669 | |
| 167 | P | A | -0.2221 | |
| 168 | G | A | 0.1746 | |
| 169 | A | A | 0.9418 | |
| 170 | I | A | 2.3344 | |
| 171 | P | A | 1.2346 | |
| 172 | P | A | 0.9636 | |
| 173 | L | A | 1.3182 | |
| 174 | T | A | -0.3128 | |
| 175 | E | A | -1.6775 | |
| 176 | V | A | -1.1378 | |
| 177 | K | A | -1.7768 | |
| 178 | T | A | -0.8646 | |
| 179 | T | A | -0.6559 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | -1.0687 | |
| 182 | D | A | 0.0000 | |
| 183 | G | A | -0.8070 | |
| 184 | D | A | -0.6146 | |
| 185 | N | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | -0.2182 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.6760 | |
| 190 | F | A | -0.0786 | |
| 191 | G | A | -0.2719 | |
| 192 | A | A | -0.3348 | |
| 193 | K | A | -0.6206 | |
| 194 | D | A | -1.1581 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -2.8083 | |
| 197 | A | A | -1.3134 | |
| 198 | L | A | -0.3954 | |
| 199 | E | A | -1.6772 | |
| 200 | P | A | -1.6628 | |
| 201 | S | A | -1.7317 | |
| 202 | K | A | -2.9604 | |
| 203 | D | A | -2.2497 | |
| 204 | D | A | -1.3281 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.7783 | |
| 208 | N | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | K | A | -2.4203 | |
| 211 | D | A | -2.6868 | |
| 212 | T | A | -1.4560 | |
| 213 | T | A | -0.9370 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | 0.2905 | |
| 217 | P | A | -0.1361 | |
| 218 | D | A | -0.9184 | |
| 219 | L | A | -1.0909 | |
| 220 | E | A | -2.3602 | |
| 221 | G | A | -1.6857 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.5851 | |
| 224 | A | A | -1.5628 | |
| 225 | E | A | -1.3122 | |
| 226 | P | A | -0.6962 | |
| 227 | Y | A | -0.4458 | |
| 228 | G | A | 0.0000 | |
| 229 | R | A | -0.5297 | |
| 230 | R | A | -0.6639 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | D | A | -0.9551 | |
| 234 | Y | A | 0.0448 | |
| 235 | D | A | 0.1030 | |
| 236 | Y | A | 0.6360 | |
| 237 | Y | A | -0.3238 | |
| 238 | E | A | -1.7130 | |
| 239 | Q | A | -1.9779 | |
| 240 | S | A | -2.2934 | |
| 241 | R | A | -2.8014 | |
| 242 | D | A | -2.7595 | |
| 243 | V | A | -1.4281 | |
| 244 | K | A | -2.2243 | |
| 245 | K | A | -2.1161 | |
| 246 | F | A | 0.0000 | |
| 247 | R | A | -0.2780 | |
| 248 | R | A | 0.0000 | |
| 249 | A | A | -0.6062 | |
| 250 | G | A | -0.4523 | |
| 251 | P | A | 0.2772 | |
| 252 | M | A | 1.4155 | |
| 253 | L | A | 2.7606 | |
| 254 | I | A | 2.7430 | |
| 255 | P | A | 1.1588 | |
| 256 | P | A | 0.6307 | |
| 257 | P | A | 0.0100 | |
| 258 | S | A | -0.2618 | |
| 259 | A | A | -0.6073 | |
| 260 | G | A | -0.8873 | |
| 261 | P | A | -0.8403 | |
| 262 | P | A | -0.5502 | |
| 263 | S | A | -0.0078 | |
| 264 | P | A | 0.5528 | |
| 265 | L | A | 1.6268 | |
| 266 | Y | A | 0.7376 | |
| 267 | T | A | -0.4897 | |
| 268 | K | A | -1.5427 | |
| 269 | P | A | -0.5539 | |
| 270 | P | A | -0.7144 | |
| 271 | P | A | -0.2480 | |
| 272 | T | A | -0.1860 | |
| 273 | S | A | 0.1387 | |
| 274 | P | A | 0.5668 | |
| 275 | Y | A | 1.3359 | |
| 276 | A | A | 0.8621 | |
| 277 | I | A | 1.8874 | |
| 278 | P | A | 0.8777 | |
| 279 | P | A | 0.4141 | |
| 280 | S | A | 0.0000 | |
| 281 | Y | A | 0.6694 | |
| 282 | D | A | -0.0709 | |
| 283 | Y | A | 0.7868 | |
| 284 | F | A | 0.0255 | |
| 285 | T | A | -1.0071 | |
| 286 | I | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | 0.0000 | |
| 289 | R | A | 0.0000 | |
| 290 | G | A | 0.0000 | |
| 291 | E | A | -1.9688 | |
| 292 | I | A | -1.6009 | |
| 293 | T | A | -1.9061 | |
| 294 | E | A | -2.7777 | |
| 295 | E | A | -2.9145 | |
| 296 | Q | A | -2.1864 | |
| 297 | K | A | -1.5814 | |
| 298 | L | A | 0.0000 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.2294 | |
| 301 | K | A | -1.5625 | |
| 302 | P | A | -0.9848 | |
| 303 | R | A | -0.4781 | |
| 304 | F | A | -0.5606 | |
| 305 | F | A | -1.0521 | |
| 306 | E | A | -2.4156 | |
| 307 | K | A | -3.0491 | |
| 308 | T | A | 0.0000 | |
| 309 | E | A | -2.5256 | |
| 310 | G | A | -1.5049 | |
| 311 | L | A | -0.8114 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | I | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | G | A | -0.8789 | |
| 319 | N | A | -0.8183 | |
| 320 | Q | A | -0.6707 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | I | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.9545 | |
| 331 | A | A | 0.0000 | |
| 332 | E | A | -2.8129 | |
| 333 | I | A | -2.1621 | |
| 334 | E | A | -2.7774 | |
| 335 | T | A | -2.1297 | |
| 336 | I | A | -1.2085 | |
| 337 | K | A | -2.1083 | |
| 338 | T | A | -1.2341 | |
| 339 | Q | A | -1.3449 | |
| 340 | K | A | -1.7421 | |
| 341 | S | A | -0.9603 | |
| 342 | T | A | -0.1754 | |
| 343 | P | A | 0.1399 | |
| 344 | L | A | 1.2234 | |
| 345 | I | A | 0.8763 | |
| 346 | N | A | 0.3500 | |
| 347 | V | A | 1.8413 | |
| 348 | Y | A | 1.4308 | |
| 349 | D | A | -0.1400 | |
| 350 | P | A | -0.5109 | |
| 351 | S | A | -0.5847 | |
| 352 | N | A | -0.7530 | |
| 353 | Y | A | -0.8601 | |
| 354 | V | A | -0.3567 | |
| 355 | E | A | -1.8091 | |
| 356 | S | A | -1.8496 | |
| 357 | K | A | -2.5654 | |
| 358 | R | A | -2.3801 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -1.0674 | |
| 361 | E | A | 0.0000 | |
| 362 | K | A | -0.3536 | |
| 363 | Y | A | 0.0000 | |
| 364 | K | A | -0.5067 | |
| 365 | L | A | 0.0000 | |
| 366 | E | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | Q | A | -0.3391 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | T | A | 0.0000 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.6632 | |
| 376 | L | A | -0.3494 | |
| 377 | T | A | -0.6313 | |
| 378 | P | A | -0.8962 | |
| 379 | E | A | -1.7143 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -0.9737 | |
| 382 | A | A | -1.3547 | |
| 383 | L | A | 0.0000 | |
| 384 | I | A | 0.0000 | |
| 385 | E | A | -2.6164 | |
| 386 | R | A | -2.1311 | |
| 387 | L | A | -1.1906 | |
| 388 | D | A | -1.6338 | |
| 389 | R | A | -2.4114 | |
| 390 | R | A | -1.8739 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -1.4045 | |
| 394 | E | A | -2.5011 | |
| 395 | A | A | -1.6589 | |
| 396 | N | A | -1.6239 | |
| 397 | L | A | 0.0000 | |
| 398 | P | A | 0.4040 | |
| 399 | F | A | 1.7134 | |
| 400 | V | A | 0.6384 | |
| 401 | P | A | 0.2724 | |
| 402 | P | A | -0.2924 | |
| 403 | I | A | 0.0834 | |
| 404 | E | A | -1.5680 | |
| 405 | Y | A | -1.0860 | |
| 406 | P | A | -1.0898 | |
| 407 | D | A | -1.8123 | |
| 408 | P | A | -0.9512 | |
| 409 | Y | A | -1.0662 | |
| 410 | A | A | -1.1819 | |
| 411 | G | A | -1.4114 | |
| 412 | K | A | -2.0257 | |
| 413 | K | A | -2.4552 | |
| 414 | F | A | -1.3788 | |
| 415 | I | A | -1.1017 | |
| 416 | E | A | -2.2330 | |
| 417 | I | A | -1.7287 | |
| 418 | D | A | -2.4669 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.3802 | |
| 421 | N | A | -1.8060 | |
| 422 | K | A | -1.6672 | |
| 423 | L | A | -0.5726 | |
| 424 | S | A | -0.7683 | |
| 425 | S | A | -0.7447 | |
| 426 | N | A | -1.8574 | |
| 427 | L | A | -1.8550 | |
| 428 | E | A | -3.2965 | |
| 429 | E | A | -3.3398 | |
| 430 | S | A | 0.0000 | |
| 431 | E | A | -2.1163 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.8473 | |
| 435 | E | A | -1.8434 | |
| 436 | Y | A | -0.9927 | |
| 437 | L | A | -0.5423 | |
| 438 | N | A | -1.8473 | |
| 439 | K | A | -2.0226 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine