| Chain sequence(s) |
A: MHHHHHHGSAEAWYNLGNAYYKQGDYDEAIEYYQKALELDPNNAEAWYNLGNAYYKQGDYDEAIEYYQKALELDPNNAEAWYNLGNAYYKQGDYDEAIEYYQKALELDPNNAEAWYNLGNAYYKQGDYDEAIEYYQKALELDPNNAEAWYNLGNAYYKQGDYDEAIEYYQKALELDPNNGALKWRSKINFRAKVANSKFRKGSISGGGGSMFTLEDFVGDWEQTAAYNLDQVLEQGGVSSLLQNLAVSVTPIQRIVRSGENALKIDIHVIIPYEGLSADQMAQIEEVFKVVYPVDDHHFKVILPYGTLVIDGVTPNMLNYFGRPYEGIAVFDGKKITVTGTLWNGNKIIDERLITPDGSMLFRVTINS
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:08:32)
[INFO] Main: Simulation completed successfully. (00:08:35)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | M | A | 0.1764 | |
| 2 | H | A | -1.3959 | |
| 3 | H | A | -2.1091 | |
| 4 | H | A | -2.5822 | |
| 5 | H | A | -2.7333 | |
| 6 | H | A | -2.4594 | |
| 7 | H | A | -1.8608 | |
| 8 | G | A | -1.2576 | |
| 9 | S | A | -1.2543 | |
| 10 | A | A | 0.0000 | |
| 11 | E | A | -2.1146 | |
| 12 | A | A | -1.3293 | |
| 13 | W | A | -1.1005 | |
| 14 | Y | A | -1.6433 | |
| 15 | N | A | -1.3027 | |
| 16 | L | A | -0.3592 | |
| 17 | G | A | 0.0000 | |
| 18 | N | A | -0.9787 | |
| 19 | A | A | -1.0259 | |
| 20 | Y | A | -1.6209 | |
| 21 | Y | A | -1.8255 | |
| 22 | K | A | -2.3268 | |
| 23 | Q | A | -2.3555 | |
| 24 | G | A | -2.3107 | |
| 25 | D | A | -2.4223 | |
| 26 | Y | A | -2.3712 | |
| 27 | D | A | -2.8282 | |
| 28 | E | A | -2.6746 | |
| 29 | A | A | 0.0000 | |
| 30 | I | A | -1.7749 | |
| 31 | E | A | -2.6294 | |
| 32 | Y | A | -1.6268 | |
| 33 | Y | A | 0.0000 | |
| 34 | Q | A | -2.0401 | |
| 35 | K | A | -2.0163 | |
| 36 | A | A | 0.0000 | |
| 37 | L | A | 0.0000 | |
| 38 | E | A | -2.2303 | |
| 39 | L | A | -1.1577 | |
| 40 | D | A | -2.2655 | |
| 41 | P | A | -1.9166 | |
| 42 | N | A | -2.5016 | |
| 43 | N | A | -2.2563 | |
| 44 | A | A | -2.2045 | |
| 45 | E | A | -2.1880 | |
| 46 | A | A | 0.0000 | |
| 47 | W | A | -1.2263 | |
| 48 | Y | A | 0.0000 | |
| 49 | N | A | -0.4746 | |
| 50 | L | A | 0.0000 | |
| 51 | G | A | 0.0000 | |
| 52 | N | A | -0.5667 | |
| 53 | A | A | 0.0000 | |
| 54 | Y | A | -1.5826 | |
| 55 | Y | A | -1.4734 | |
| 56 | K | A | -1.9771 | |
| 57 | Q | A | -2.0428 | |
| 58 | G | A | -1.9623 | |
| 59 | D | A | -2.2181 | |
| 60 | Y | A | -2.1566 | |
| 61 | D | A | -2.7456 | |
| 62 | E | A | -2.4877 | |
| 63 | A | A | 0.0000 | |
| 64 | I | A | -1.6688 | |
| 65 | E | A | -2.5585 | |
| 66 | Y | A | -1.5729 | |
| 67 | Y | A | 0.0000 | |
| 68 | Q | A | -2.0020 | |
| 69 | K | A | -2.1491 | |
| 70 | A | A | 0.0000 | |
| 71 | L | A | 0.0000 | |
| 72 | E | A | -2.6699 | |
| 73 | L | A | -2.0014 | |
| 74 | D | A | -2.6994 | |
| 75 | P | A | -2.0432 | |
| 76 | N | A | -2.5709 | |
| 77 | N | A | -2.3486 | |
| 78 | A | A | -2.2123 | |
| 79 | E | A | -2.2228 | |
| 80 | A | A | 0.0000 | |
| 81 | W | A | -1.1923 | |
| 82 | Y | A | 0.0000 | |
| 83 | N | A | -0.4418 | |
| 84 | L | A | 0.0000 | |
| 85 | G | A | 0.0000 | |
| 86 | N | A | 0.0000 | |
| 87 | A | A | 0.0000 | |
| 88 | Y | A | -1.4854 | |
| 89 | Y | A | -1.3620 | |
| 90 | K | A | -1.6774 | |
| 91 | Q | A | -1.8381 | |
| 92 | G | A | -1.8943 | |
| 93 | D | A | -2.1408 | |
| 94 | Y | A | -2.1475 | |
| 95 | D | A | -2.7631 | |
| 96 | E | A | -2.4593 | |
| 97 | A | A | 0.0000 | |
| 98 | I | A | -1.6756 | |
| 99 | E | A | -2.5958 | |
| 100 | Y | A | -1.5826 | |
| 101 | Y | A | 0.0000 | |
| 102 | Q | A | -1.9633 | |
| 103 | K | A | -2.1225 | |
| 104 | A | A | 0.0000 | |
| 105 | L | A | 0.0000 | |
| 106 | E | A | -2.6516 | |
| 107 | L | A | -1.9880 | |
| 108 | D | A | -2.7870 | |
| 109 | P | A | -2.0872 | |
| 110 | N | A | -2.6052 | |
| 111 | N | A | -2.3427 | |
| 112 | A | A | -2.1860 | |
| 113 | E | A | -2.1594 | |
| 114 | A | A | 0.0000 | |
| 115 | W | A | -1.1315 | |
| 116 | Y | A | -1.1999 | |
| 117 | N | A | -0.3596 | |
| 118 | L | A | 0.0000 | |
| 119 | G | A | 0.0000 | |
| 120 | N | A | 0.0000 | |
| 121 | A | A | 0.0000 | |
| 122 | Y | A | -1.3518 | |
| 123 | Y | A | -1.4436 | |
| 124 | K | A | -1.8781 | |
| 125 | Q | A | -1.9177 | |
| 126 | G | A | -1.9452 | |
| 127 | D | A | -2.3279 | |
| 128 | Y | A | -2.2115 | |
| 129 | D | A | -2.7377 | |
| 130 | E | A | -2.4229 | |
| 131 | A | A | 0.0000 | |
| 132 | I | A | -1.6627 | |
| 133 | E | A | -2.5719 | |
| 134 | Y | A | -1.5448 | |
| 135 | Y | A | 0.0000 | |
| 136 | Q | A | -1.9922 | |
| 137 | K | A | -2.1382 | |
| 138 | A | A | 0.0000 | |
| 139 | L | A | 0.0000 | |
| 140 | E | A | -2.6540 | |
| 141 | L | A | -2.0350 | |
| 142 | D | A | -2.7013 | |
| 143 | P | A | -2.0522 | |
| 144 | N | A | -2.4218 | |
| 145 | N | A | -1.8773 | |
| 146 | A | A | -1.6849 | |
| 147 | E | A | -1.4191 | |
| 148 | A | A | 0.0000 | |
| 149 | W | A | -0.9625 | |
| 150 | Y | A | -0.7982 | |
| 151 | N | A | -0.2402 | |
| 152 | L | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | N | A | -0.6264 | |
| 155 | A | A | 0.0000 | |
| 156 | Y | A | -1.3963 | |
| 157 | Y | A | -1.3346 | |
| 158 | K | A | -2.1156 | |
| 159 | Q | A | -1.9910 | |
| 160 | G | A | -1.7315 | |
| 161 | D | A | -1.9893 | |
| 162 | Y | A | -1.4151 | |
| 163 | D | A | -2.4131 | |
| 164 | E | A | -2.4662 | |
| 165 | A | A | 0.0000 | |
| 166 | I | A | -1.6442 | |
| 167 | E | A | -2.5908 | |
| 168 | Y | A | -1.5796 | |
| 169 | Y | A | 0.0000 | |
| 170 | Q | A | -2.3569 | |
| 171 | K | A | -2.0680 | |
| 172 | A | A | 0.0000 | |
| 173 | L | A | -2.1900 | |
| 174 | E | A | -2.3997 | |
| 175 | L | A | -1.5464 | |
| 176 | D | A | -2.1301 | |
| 177 | P | A | -1.9263 | |
| 178 | N | A | -2.1131 | |
| 179 | N | A | -1.6052 | |
| 180 | G | A | -1.2369 | |
| 181 | A | A | -0.6799 | |
| 182 | L | A | 0.0000 | |
| 183 | K | A | -1.9060 | |
| 184 | W | A | -0.4923 | |
| 185 | R | A | -1.4750 | |
| 186 | S | A | -1.7801 | |
| 187 | K | A | -2.1822 | |
| 188 | I | A | -1.6888 | |
| 189 | N | A | -2.4804 | |
| 190 | F | A | -1.6450 | |
| 191 | R | A | -2.6094 | |
| 192 | A | A | -2.4762 | |
| 193 | K | A | -2.6441 | |
| 194 | V | A | -1.2678 | |
| 195 | A | A | -1.6589 | |
| 196 | N | A | -1.7187 | |
| 197 | S | A | -1.1001 | |
| 198 | K | A | -1.7326 | |
| 199 | F | A | -0.4749 | |
| 200 | R | A | -2.1562 | |
| 201 | K | A | -2.3467 | |
| 202 | G | A | -1.4120 | |
| 203 | S | A | -0.3866 | |
| 204 | I | A | 0.6997 | |
| 205 | S | A | 0.0148 | |
| 206 | G | A | -0.5402 | |
| 207 | G | A | -0.7745 | |
| 208 | G | A | -0.7123 | |
| 209 | G | A | -0.5538 | |
| 210 | S | A | -0.0379 | |
| 211 | M | A | 0.2391 | |
| 212 | F | A | -0.3074 | |
| 213 | T | A | -0.7063 | |
| 214 | L | A | -1.4341 | |
| 215 | E | A | -2.0714 | |
| 216 | D | A | -1.0152 | |
| 217 | F | A | 0.0000 | |
| 218 | V | A | -1.0640 | |
| 219 | G | A | -1.5129 | |
| 220 | D | A | -2.2151 | |
| 221 | W | A | -1.9102 | |
| 222 | E | A | -2.7789 | |
| 223 | Q | A | -1.4050 | |
| 224 | T | A | -1.4438 | |
| 225 | A | A | -0.0639 | |
| 226 | A | A | 0.2618 | |
| 227 | Y | A | 0.0864 | |
| 228 | N | A | -1.4938 | |
| 229 | L | A | -1.1694 | |
| 230 | D | A | -2.6217 | |
| 231 | Q | A | -2.8262 | |
| 232 | V | A | -1.8397 | |
| 233 | L | A | 0.0000 | |
| 234 | E | A | -3.1824 | |
| 235 | Q | A | -2.5229 | |
| 236 | G | A | 0.0000 | |
| 237 | G | A | -1.4667 | |
| 238 | V | A | 0.0000 | |
| 239 | S | A | -0.8163 | |
| 240 | S | A | -1.0815 | |
| 241 | L | A | -0.5608 | |
| 242 | L | A | 0.0000 | |
| 243 | Q | A | -1.4307 | |
| 244 | N | A | -1.3952 | |
| 245 | L | A | 0.0000 | |
| 246 | A | A | -0.2739 | |
| 247 | V | A | -0.1526 | |
| 248 | S | A | -0.0667 | |
| 249 | V | A | -0.0044 | |
| 250 | T | A | -0.5999 | |
| 251 | P | A | -0.3183 | |
| 252 | I | A | -1.0093 | |
| 253 | Q | A | -1.0960 | |
| 254 | R | A | -1.4973 | |
| 255 | I | A | 0.0000 | |
| 256 | V | A | -1.1549 | |
| 257 | R | A | -2.6145 | |
| 258 | S | A | -1.8256 | |
| 259 | G | A | -2.1470 | |
| 260 | E | A | -2.7476 | |
| 261 | N | A | -2.1835 | |
| 262 | A | A | -1.6901 | |
| 263 | L | A | 0.0000 | |
| 264 | K | A | -1.2704 | |
| 265 | I | A | 0.0000 | |
| 266 | D | A | 0.0000 | |
| 267 | I | A | -0.1185 | |
| 268 | H | A | 0.0000 | |
| 269 | V | A | 0.0000 | |
| 270 | I | A | 1.0627 | |
| 271 | I | A | 0.0000 | |
| 272 | P | A | -0.9872 | |
| 273 | Y | A | -1.2767 | |
| 274 | E | A | -2.2007 | |
| 275 | G | A | -1.1713 | |
| 276 | L | A | -0.7669 | |
| 277 | S | A | -0.9876 | |
| 278 | A | A | -0.9711 | |
| 279 | D | A | -2.1820 | |
| 280 | Q | A | -1.7122 | |
| 281 | M | A | -1.3488 | |
| 282 | A | A | -1.9360 | |
| 283 | Q | A | -2.1580 | |
| 284 | I | A | 0.0000 | |
| 285 | E | A | -3.1530 | |
| 286 | E | A | -3.1059 | |
| 287 | V | A | -1.7699 | |
| 288 | F | A | 0.0000 | |
| 289 | K | A | -2.1240 | |
| 290 | V | A | -0.3889 | |
| 291 | V | A | 0.5714 | |
| 292 | Y | A | 1.4033 | |
| 293 | P | A | 0.1531 | |
| 294 | V | A | 0.5553 | |
| 295 | D | A | -1.9190 | |
| 296 | D | A | -2.8127 | |
| 297 | H | A | -2.2818 | |
| 298 | H | A | -1.1697 | |
| 299 | F | A | 0.0000 | |
| 300 | K | A | 0.6740 | |
| 301 | V | A | 0.0000 | |
| 302 | I | A | 0.3802 | |
| 303 | L | A | 0.0000 | |
| 304 | P | A | -0.3931 | |
| 305 | Y | A | 0.0000 | |
| 306 | G | A | -0.0687 | |
| 307 | T | A | -0.3706 | |
| 308 | L | A | 0.0000 | |
| 309 | V | A | 0.0535 | |
| 310 | I | A | 0.0000 | |
| 311 | D | A | -0.1888 | |
| 312 | G | A | 0.6757 | |
| 313 | V | A | 1.6309 | |
| 314 | T | A | 0.6993 | |
| 315 | P | A | 0.0475 | |
| 316 | N | A | 0.0000 | |
| 317 | M | A | 0.2720 | |
| 318 | L | A | 0.0000 | |
| 319 | N | A | -0.5979 | |
| 320 | Y | A | -0.2417 | |
| 321 | F | A | -0.1358 | |
| 322 | G | A | -1.0851 | |
| 323 | R | A | -0.9595 | |
| 324 | P | A | -0.8230 | |
| 325 | Y | A | 0.0000 | |
| 326 | E | A | -1.4613 | |
| 327 | G | A | 0.0000 | |
| 328 | I | A | 0.7404 | |
| 329 | A | A | 0.0000 | |
| 330 | V | A | 0.7878 | |
| 331 | F | A | -0.3676 | |
| 332 | D | A | -1.1412 | |
| 333 | G | A | 0.0000 | |
| 334 | K | A | -1.8250 | |
| 335 | K | A | -0.8555 | |
| 336 | I | A | 0.0000 | |
| 337 | T | A | -0.0073 | |
| 338 | V | A | 0.0000 | |
| 339 | T | A | -0.1767 | |
| 340 | G | A | -0.7420 | |
| 341 | T | A | -1.2365 | |
| 342 | L | A | 0.0000 | |
| 343 | W | A | -0.6503 | |
| 344 | N | A | -1.0546 | |
| 345 | G | A | -1.1819 | |
| 346 | N | A | -1.6206 | |
| 347 | K | A | -1.7343 | |
| 348 | I | A | 0.0000 | |
| 349 | I | A | -0.2883 | |
| 350 | D | A | 0.0000 | |
| 351 | E | A | 0.0923 | |
| 352 | R | A | 0.0000 | |
| 353 | L | A | 0.2004 | |
| 354 | I | A | 0.0000 | |
| 355 | T | A | -0.5867 | |
| 356 | P | A | -0.9461 | |
| 357 | D | A | -1.9957 | |
| 358 | G | A | -1.2363 | |
| 359 | S | A | -0.6432 | |
| 360 | M | A | 0.2236 | |
| 361 | L | A | 1.3366 | |
| 362 | F | A | 0.7914 | |
| 363 | R | A | -0.1316 | |
| 364 | V | A | 0.0053 | |
| 365 | T | A | -0.6552 | |
| 366 | I | A | 0.0000 | |
| 367 | N | A | -1.9233 | |
| 368 | S | A | -0.9866 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine