| Chain sequence(s) |
A: GAPAANPGPALRSTSEYVTPTDLLYYAETDEITETGHPTADIVVNGAVATPKVSATDWKVFKLTLPDPNTLPLPSPDFLDRSTHIAIWQLKALKIHVGGPLGVGTYGHPNYNAFGDVDNPTEYQHETEDVTQNLSWTPKRLQLYIVGDLPPLGVYTAPAEPAPGLPPGAKPPTKEVSTIIEHGDRADIGFGARDFAALLPDKNDVPDNILNTTTKRPDLEGMKADPWGRRMFDYDEYEQSKNVKNYVRSGPDLYPLPDAPPPSKLYVRPPPSSPYWELPSYNYFTLPDRGEVSESQELFNKPKFFTKTAGKNNGVLWHNQLYVTVLDNTRDTIETKTTQTSTPAINVYDPSNYVTSQTHTRTYKLSLILQLCIIPLTPDTLAEIQRLDPSILVDANLPDIPPVERPDPYAGLKFIEIDLTDKLSSELEKSDLGREYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.4970 | |
| 2 | A | A | -0.2573 | |
| 3 | P | A | -0.5044 | |
| 4 | A | A | -0.4497 | |
| 5 | A | A | -0.7068 | |
| 6 | N | A | -1.5520 | |
| 7 | P | A | -1.1161 | |
| 8 | G | A | -0.9840 | |
| 9 | P | A | -0.6622 | |
| 10 | A | A | -0.1913 | |
| 11 | L | A | -0.2650 | |
| 12 | R | A | -0.9987 | |
| 13 | S | A | -1.2673 | |
| 14 | T | A | 0.0000 | |
| 15 | S | A | -1.6554 | |
| 16 | E | A | -2.1843 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.4843 | |
| 20 | P | A | -0.6293 | |
| 21 | T | A | -0.7954 | |
| 22 | D | A | -1.6438 | |
| 23 | L | A | -0.5284 | |
| 24 | L | A | -0.2141 | |
| 25 | Y | A | -0.0668 | |
| 26 | Y | A | -0.5495 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -1.4668 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.9005 | |
| 31 | E | A | -2.8554 | |
| 32 | I | A | -1.3068 | |
| 33 | T | A | -0.8588 | |
| 34 | E | A | -0.4181 | |
| 35 | T | A | -0.3651 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.8451 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -0.5775 | |
| 40 | A | A | -0.3963 | |
| 41 | D | A | -0.2833 | |
| 42 | I | A | 1.6387 | |
| 43 | V | A | 2.8200 | |
| 44 | V | A | 2.1982 | |
| 45 | N | A | -0.0162 | |
| 46 | G | A | 0.4321 | |
| 47 | A | A | 1.3090 | |
| 48 | V | A | 2.3710 | |
| 49 | A | A | 1.5732 | |
| 50 | T | A | 0.7930 | |
| 51 | P | A | -0.1065 | |
| 52 | K | A | -0.7233 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | T | A | 0.0000 | |
| 57 | D | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | K | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | K | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.1345 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -0.6371 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -0.6970 | |
| 70 | T | A | -0.2859 | |
| 71 | L | A | 0.0296 | |
| 72 | P | A | -0.1288 | |
| 73 | L | A | -0.1020 | |
| 74 | P | A | -0.3495 | |
| 75 | S | A | -0.6974 | |
| 76 | P | A | -1.2996 | |
| 77 | D | A | -2.2703 | |
| 78 | F | A | -1.0350 | |
| 79 | L | A | 0.0000 | |
| 80 | D | A | -2.9900 | |
| 81 | R | A | -2.7919 | |
| 82 | S | A | -1.7829 | |
| 83 | T | A | -1.2300 | |
| 84 | H | A | -1.3169 | |
| 85 | I | A | 0.0000 | |
| 86 | A | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | Q | A | -0.2724 | |
| 90 | L | A | 0.0000 | |
| 91 | K | A | -0.3504 | |
| 92 | A | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | K | A | 0.0000 | |
| 95 | I | A | 0.0000 | |
| 96 | H | A | -1.0486 | |
| 97 | V | A | 0.0000 | |
| 98 | G | A | -0.8175 | |
| 99 | G | A | -0.6471 | |
| 100 | P | A | -0.2625 | |
| 101 | L | A | 0.0159 | |
| 102 | G | A | 0.3307 | |
| 103 | V | A | 0.7977 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | 0.1177 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -0.7712 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | -1.7352 | |
| 110 | N | A | -2.5807 | |
| 111 | Y | A | 0.0000 | |
| 112 | N | A | -1.4996 | |
| 113 | A | A | 0.0000 | |
| 114 | F | A | 0.0000 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.3779 | |
| 117 | V | A | -0.9443 | |
| 118 | D | A | -1.8570 | |
| 119 | N | A | -2.2758 | |
| 120 | P | A | -1.6948 | |
| 121 | T | A | -1.4584 | |
| 122 | E | A | -1.9902 | |
| 123 | Y | A | -0.5472 | |
| 124 | Q | A | -1.0163 | |
| 125 | H | A | -1.4224 | |
| 126 | E | A | -1.9864 | |
| 127 | T | A | -1.7847 | |
| 128 | E | A | -2.9237 | |
| 129 | D | A | -2.9199 | |
| 130 | V | A | -1.6033 | |
| 131 | T | A | -1.7870 | |
| 132 | Q | A | -1.9134 | |
| 133 | N | A | -2.0799 | |
| 134 | L | A | -1.0641 | |
| 135 | S | A | -0.6145 | |
| 136 | W | A | 0.0000 | |
| 137 | T | A | 0.0690 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | -1.3619 | |
| 140 | R | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | L | A | 0.1374 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | L | A | -0.1697 | |
| 153 | G | A | 0.0000 | |
| 154 | V | A | 0.0000 | |
| 155 | Y | A | -1.2885 | |
| 156 | T | A | -1.4820 | |
| 157 | A | A | 0.0000 | |
| 158 | P | A | -1.3663 | |
| 159 | A | A | -1.8280 | |
| 160 | E | A | -2.2204 | |
| 161 | P | A | -1.2500 | |
| 162 | A | A | -0.5413 | |
| 163 | P | A | -0.5305 | |
| 164 | G | A | -0.2994 | |
| 165 | L | A | -0.0189 | |
| 166 | P | A | -0.4737 | |
| 167 | P | A | -0.7083 | |
| 168 | G | A | -0.7760 | |
| 169 | A | A | -0.7369 | |
| 170 | K | A | -1.5346 | |
| 171 | P | A | -1.3315 | |
| 172 | P | A | -1.3267 | |
| 173 | T | A | -1.9271 | |
| 174 | K | A | -2.8778 | |
| 175 | E | A | -2.6033 | |
| 176 | V | A | -1.2178 | |
| 177 | S | A | -0.6919 | |
| 178 | T | A | -0.0321 | |
| 179 | I | A | 0.1649 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | -0.7747 | |
| 182 | H | A | -1.0038 | |
| 183 | G | A | -0.7883 | |
| 184 | D | A | -0.8586 | |
| 185 | R | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | -0.7710 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.7636 | |
| 190 | F | A | -0.1824 | |
| 191 | G | A | -0.6152 | |
| 192 | A | A | -0.9955 | |
| 193 | R | A | -1.2001 | |
| 194 | D | A | -0.6188 | |
| 195 | F | A | 0.0000 | |
| 196 | A | A | -1.0111 | |
| 197 | A | A | -0.4590 | |
| 198 | L | A | -0.6527 | |
| 199 | L | A | -1.0376 | |
| 200 | P | A | -1.3746 | |
| 201 | D | A | -2.0477 | |
| 202 | K | A | -2.8608 | |
| 203 | N | A | -2.1485 | |
| 204 | D | A | -1.2841 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.2195 | |
| 208 | N | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -1.0846 | |
| 211 | N | A | -1.5956 | |
| 212 | T | A | -0.8005 | |
| 213 | T | A | -0.5543 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | R | A | -1.4258 | |
| 217 | P | A | -0.8951 | |
| 218 | D | A | -1.2328 | |
| 219 | L | A | -1.5067 | |
| 220 | E | A | -2.4922 | |
| 221 | G | A | -1.7121 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.4896 | |
| 224 | A | A | -1.5018 | |
| 225 | D | A | -1.2654 | |
| 226 | P | A | -0.6658 | |
| 227 | W | A | -0.3031 | |
| 228 | G | A | 0.0000 | |
| 229 | R | A | 0.0000 | |
| 230 | R | A | -0.4609 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | D | A | -0.8674 | |
| 234 | Y | A | -0.5225 | |
| 235 | D | A | -1.0908 | |
| 236 | E | A | -1.4879 | |
| 237 | Y | A | -1.2598 | |
| 238 | E | A | -2.0541 | |
| 239 | Q | A | -2.1131 | |
| 240 | S | A | -1.9914 | |
| 241 | K | A | -2.3804 | |
| 242 | N | A | -1.9061 | |
| 243 | V | A | -0.6567 | |
| 244 | K | A | -1.4571 | |
| 245 | N | A | -0.8756 | |
| 246 | Y | A | -0.2240 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.2234 | |
| 249 | S | A | -0.9488 | |
| 250 | G | A | -0.7036 | |
| 251 | P | A | -0.2534 | |
| 252 | D | A | 0.3593 | |
| 253 | L | A | 1.0228 | |
| 254 | Y | A | 1.4754 | |
| 255 | P | A | 0.4663 | |
| 256 | L | A | 0.5461 | |
| 257 | P | A | -0.7374 | |
| 258 | D | A | -2.0406 | |
| 259 | A | A | -1.0961 | |
| 260 | P | A | -1.0294 | |
| 261 | P | A | -0.8160 | |
| 262 | P | A | -0.6040 | |
| 263 | S | A | -0.6008 | |
| 264 | K | A | -0.9756 | |
| 265 | L | A | 0.8611 | |
| 266 | Y | A | 0.9046 | |
| 267 | V | A | 1.3477 | |
| 268 | R | A | -0.0521 | |
| 269 | P | A | 0.0184 | |
| 270 | P | A | -0.2184 | |
| 271 | P | A | -0.6095 | |
| 272 | S | A | -0.4143 | |
| 273 | S | A | -0.2347 | |
| 274 | P | A | -0.0031 | |
| 275 | Y | A | 0.5691 | |
| 276 | W | A | -0.1850 | |
| 277 | E | A | -1.1728 | |
| 278 | L | A | 0.0432 | |
| 279 | P | A | -0.3455 | |
| 280 | S | A | 0.0000 | |
| 281 | Y | A | 0.4204 | |
| 282 | N | A | 0.0968 | |
| 283 | Y | A | 1.1079 | |
| 284 | F | A | 0.4597 | |
| 285 | T | A | -0.3520 | |
| 286 | L | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -1.4583 | |
| 289 | R | A | 0.0000 | |
| 290 | G | A | -1.4672 | |
| 291 | E | A | -1.7319 | |
| 292 | V | A | -0.8918 | |
| 293 | S | A | -1.4131 | |
| 294 | E | A | -2.0155 | |
| 295 | S | A | -1.3508 | |
| 296 | Q | A | -1.3124 | |
| 297 | E | A | -1.1334 | |
| 298 | L | A | -0.9051 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.2561 | |
| 301 | K | A | -1.5284 | |
| 302 | P | A | -0.9781 | |
| 303 | K | A | -0.5454 | |
| 304 | F | A | -0.4531 | |
| 305 | F | A | 0.0000 | |
| 306 | T | A | -0.9152 | |
| 307 | K | A | -1.9910 | |
| 308 | T | A | 0.0000 | |
| 309 | A | A | -0.9976 | |
| 310 | G | A | -1.3261 | |
| 311 | K | A | -1.5481 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | -1.2847 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.4046 | |
| 319 | N | A | -0.4979 | |
| 320 | Q | A | -0.4737 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | 0.0551 | |
| 331 | D | A | 0.0000 | |
| 332 | T | A | -0.0204 | |
| 333 | I | A | -0.6703 | |
| 334 | E | A | -1.9851 | |
| 335 | T | A | -1.8825 | |
| 336 | K | A | -2.0471 | |
| 337 | T | A | -0.6461 | |
| 338 | T | A | -0.2635 | |
| 339 | Q | A | -0.4292 | |
| 340 | T | A | -0.1799 | |
| 341 | S | A | -0.4653 | |
| 342 | T | A | -0.3822 | |
| 343 | P | A | -0.4667 | |
| 344 | A | A | -0.1679 | |
| 345 | I | A | 0.2313 | |
| 346 | N | A | -0.0575 | |
| 347 | V | A | 1.6420 | |
| 348 | Y | A | 1.4271 | |
| 349 | D | A | -0.1295 | |
| 350 | P | A | -0.0971 | |
| 351 | S | A | -0.2697 | |
| 352 | N | A | -0.0281 | |
| 353 | Y | A | 0.3417 | |
| 354 | V | A | 1.1967 | |
| 355 | T | A | -0.0612 | |
| 356 | S | A | -1.0145 | |
| 357 | Q | A | -1.6931 | |
| 358 | T | A | -1.2407 | |
| 359 | H | A | 0.0000 | |
| 360 | T | A | -0.4785 | |
| 361 | R | A | 0.0000 | |
| 362 | T | A | -0.7631 | |
| 363 | Y | A | 0.0000 | |
| 364 | K | A | -1.7506 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | L | A | 0.0000 | |
| 370 | Q | A | -0.3498 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | I | A | -0.2322 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.6295 | |
| 376 | L | A | -0.3555 | |
| 377 | T | A | -0.5950 | |
| 378 | P | A | -0.9521 | |
| 379 | D | A | -1.8810 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -0.7140 | |
| 382 | A | A | -1.1710 | |
| 383 | E | A | 0.0000 | |
| 384 | I | A | 0.0000 | |
| 385 | Q | A | -1.9759 | |
| 386 | R | A | -1.7089 | |
| 387 | L | A | -0.8097 | |
| 388 | D | A | -1.0347 | |
| 389 | P | A | -1.0717 | |
| 390 | S | A | -0.3206 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -0.3227 | |
| 394 | D | A | -0.9109 | |
| 395 | A | A | -0.9815 | |
| 396 | N | A | -1.5630 | |
| 397 | L | A | -1.3736 | |
| 398 | P | A | -1.5099 | |
| 399 | D | A | -1.8240 | |
| 400 | I | A | -0.4369 | |
| 401 | P | A | -0.4577 | |
| 402 | P | A | -0.4130 | |
| 403 | V | A | 0.4480 | |
| 404 | E | A | -1.5111 | |
| 405 | R | A | -1.4221 | |
| 406 | P | A | -1.2011 | |
| 407 | D | A | -1.3203 | |
| 408 | P | A | -0.6963 | |
| 409 | Y | A | -0.3799 | |
| 410 | A | A | -0.5967 | |
| 411 | G | A | -0.6758 | |
| 412 | L | A | -0.6186 | |
| 413 | K | A | -1.8405 | |
| 414 | F | A | -1.1253 | |
| 415 | I | A | -1.1122 | |
| 416 | E | A | -2.2214 | |
| 417 | I | A | -1.6885 | |
| 418 | D | A | -2.5397 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.6041 | |
| 421 | D | A | -2.3514 | |
| 422 | K | A | -1.9297 | |
| 423 | L | A | -0.7376 | |
| 424 | S | A | -0.8848 | |
| 425 | S | A | -0.9140 | |
| 426 | E | A | -2.3005 | |
| 427 | L | A | -2.1228 | |
| 428 | E | A | -3.5080 | |
| 429 | K | A | -3.4224 | |
| 430 | S | A | -2.6100 | |
| 431 | D | A | -2.4461 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -3.1946 | |
| 435 | E | A | -2.2570 | |
| 436 | Y | A | -1.3095 | |
| 437 | L | A | -0.9046 | |
| 438 | N | A | -2.1055 | |
| 439 | R | A | -2.3025 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine