| Chain sequence(s) |
A: GPLPANPEPPLRSTDEYVTPTDLLYIAETDLITETGNPTADITVDGKVVVPRVSAYQYDVFLLTLPDPNTLPLPSADFLNPETEIRIWRLLAFKIHKYGPLGTGTYGHPNFNAFGDVDNPTEYQHETADDRVALSFTPVLKQEYVIGDEPPIGRYTDLAEPAPGLPPGALPPTRVVRTLIQHGDMADIGFGAKDYAALEPRKDDVPEIIRDTKTIVLDYDGMRAEPTGRRMFTSNSYTSSSNSRTLRLDGPDPVPLPDAGPPPALYVPPPPSSPTAVPPSTRLFTLPDRGEITESDLLFNKPIFLTQTEGLNNGILWGNRLYITVLDNTRANIATNTTKISTPANNVYDPSNYVTSKTYTRQYKLSLIIQLAKIPLTPETLEYLSRLDPRFLVDAKLPDIPPVERPDPYAGLKFKEIDLTNKLSTNLSDSELGQAYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.2089 | |
| 2 | P | A | 0.1956 | |
| 3 | L | A | 0.9891 | |
| 4 | P | A | 0.0011 | |
| 5 | A | A | -0.6340 | |
| 6 | N | A | -1.6825 | |
| 7 | P | A | -1.8673 | |
| 8 | E | A | -2.3200 | |
| 9 | P | A | -1.3373 | |
| 10 | P | A | -0.6904 | |
| 11 | L | A | 0.0779 | |
| 12 | R | A | -0.9866 | |
| 13 | S | A | -1.1932 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.8700 | |
| 16 | E | A | -2.8070 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.9190 | |
| 20 | P | A | -0.9128 | |
| 21 | T | A | 0.0000 | |
| 22 | D | A | -1.6434 | |
| 23 | L | A | -0.5108 | |
| 24 | L | A | -0.2070 | |
| 25 | Y | A | -0.1301 | |
| 26 | I | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -0.9631 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.2801 | |
| 31 | L | A | 0.5105 | |
| 32 | I | A | 0.2031 | |
| 33 | T | A | -0.0254 | |
| 34 | E | A | -0.2575 | |
| 35 | T | A | -0.2824 | |
| 36 | G | A | 0.0000 | |
| 37 | N | A | -0.7191 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -0.6948 | |
| 40 | A | A | -0.4954 | |
| 41 | D | A | -0.3618 | |
| 42 | I | A | 1.3217 | |
| 43 | T | A | 0.9981 | |
| 44 | V | A | 1.1038 | |
| 45 | D | A | -1.2849 | |
| 46 | G | A | -0.9441 | |
| 47 | K | A | -0.6989 | |
| 48 | V | A | 1.4779 | |
| 49 | V | A | 2.2208 | |
| 50 | V | A | 1.5393 | |
| 51 | P | A | 0.1836 | |
| 52 | R | A | -0.3545 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | Y | A | 0.0000 | |
| 59 | D | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | L | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.3181 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -0.6439 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -0.8360 | |
| 70 | T | A | -0.2052 | |
| 71 | L | A | 0.0290 | |
| 72 | P | A | -0.0457 | |
| 73 | L | A | 0.0399 | |
| 74 | P | A | -0.2890 | |
| 75 | S | A | -0.6382 | |
| 76 | A | A | -0.9052 | |
| 77 | D | A | -1.8280 | |
| 78 | F | A | -0.8560 | |
| 79 | L | A | 0.0000 | |
| 80 | N | A | -2.1161 | |
| 81 | P | A | -1.7776 | |
| 82 | E | A | -2.4160 | |
| 83 | T | A | -1.5373 | |
| 84 | E | A | -1.4257 | |
| 85 | I | A | 0.0000 | |
| 86 | R | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | -0.3315 | |
| 90 | L | A | 0.0000 | |
| 91 | L | A | 0.0000 | |
| 92 | A | A | 0.0000 | |
| 93 | F | A | 0.0000 | |
| 94 | K | A | 0.0000 | |
| 95 | I | A | 0.0000 | |
| 96 | H | A | -0.3514 | |
| 97 | K | A | 0.0000 | |
| 98 | Y | A | 0.3753 | |
| 99 | G | A | -0.2186 | |
| 100 | P | A | -0.1304 | |
| 101 | L | A | 0.1431 | |
| 102 | G | A | 0.0375 | |
| 103 | T | A | -0.2452 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.1742 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -0.4981 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | -0.6313 | |
| 110 | N | A | -1.4495 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | A | A | 0.0000 | |
| 114 | F | A | -0.6542 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.7087 | |
| 117 | V | A | -1.3954 | |
| 118 | D | A | -2.9104 | |
| 119 | N | A | -2.7107 | |
| 120 | P | A | -1.9745 | |
| 121 | T | A | -1.5803 | |
| 122 | E | A | -2.1169 | |
| 123 | Y | A | -0.8046 | |
| 124 | Q | A | -1.3172 | |
| 125 | H | A | -1.4608 | |
| 126 | E | A | -1.8441 | |
| 127 | T | A | -1.5117 | |
| 128 | A | A | -1.2588 | |
| 129 | D | A | -2.3883 | |
| 130 | D | A | -1.8289 | |
| 131 | R | A | -1.5703 | |
| 132 | V | A | -0.1428 | |
| 133 | A | A | -0.0495 | |
| 134 | L | A | -0.0146 | |
| 135 | S | A | -0.1730 | |
| 136 | F | A | 0.0000 | |
| 137 | T | A | -0.5373 | |
| 138 | P | A | 0.0000 | |
| 139 | V | A | 0.0000 | |
| 140 | L | A | 0.0000 | |
| 141 | K | A | -0.2134 | |
| 142 | Q | A | 0.0000 | |
| 143 | E | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | V | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | E | A | 0.0000 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | I | A | -0.4189 | |
| 153 | G | A | 0.0000 | |
| 154 | R | A | -1.1321 | |
| 155 | Y | A | 0.0000 | |
| 156 | T | A | -0.3118 | |
| 157 | D | A | -0.4686 | |
| 158 | L | A | 0.1270 | |
| 159 | A | A | -0.8707 | |
| 160 | E | A | -2.0201 | |
| 161 | P | A | -0.7970 | |
| 162 | A | A | -0.5249 | |
| 163 | P | A | -0.5191 | |
| 164 | G | A | -0.2622 | |
| 165 | L | A | 0.5285 | |
| 166 | P | A | -0.0082 | |
| 167 | P | A | -0.2461 | |
| 168 | G | A | -0.0773 | |
| 169 | A | A | 0.7824 | |
| 170 | L | A | 1.5888 | |
| 171 | P | A | 0.5564 | |
| 172 | P | A | -0.2115 | |
| 173 | T | A | -0.3153 | |
| 174 | R | A | -0.9237 | |
| 175 | V | A | 0.5083 | |
| 176 | V | A | -0.5036 | |
| 177 | R | A | -1.7397 | |
| 178 | T | A | -0.7110 | |
| 179 | L | A | -0.1241 | |
| 180 | I | A | 0.0000 | |
| 181 | Q | A | -0.8311 | |
| 182 | H | A | -1.1495 | |
| 183 | G | A | -0.7846 | |
| 184 | D | A | -0.8543 | |
| 185 | M | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | -0.3879 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.4889 | |
| 190 | F | A | -0.0205 | |
| 191 | G | A | -0.2567 | |
| 192 | A | A | -0.4207 | |
| 193 | K | A | -0.6002 | |
| 194 | D | A | 0.0000 | |
| 195 | Y | A | 0.0000 | |
| 196 | A | A | -1.2018 | |
| 197 | A | A | -0.2563 | |
| 198 | L | A | -0.2901 | |
| 199 | E | A | -1.2793 | |
| 200 | P | A | -1.4790 | |
| 201 | R | A | -2.0047 | |
| 202 | K | A | -2.6006 | |
| 203 | D | A | 0.0000 | |
| 204 | D | A | -1.3004 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | E | A | -1.5341 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | R | A | -2.1900 | |
| 211 | D | A | -2.1357 | |
| 212 | T | A | -1.4795 | |
| 213 | K | A | -1.6805 | |
| 214 | T | A | 0.0000 | |
| 215 | I | A | 0.0000 | |
| 216 | V | A | -0.1648 | |
| 217 | L | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | Y | A | -1.3355 | |
| 220 | D | A | -2.3843 | |
| 221 | G | A | -1.8801 | |
| 222 | M | A | 0.0000 | |
| 223 | R | A | -2.9695 | |
| 224 | A | A | -1.6106 | |
| 225 | E | A | -1.3186 | |
| 226 | P | A | -0.6221 | |
| 227 | T | A | -0.4536 | |
| 228 | G | A | 0.0000 | |
| 229 | R | A | 0.0000 | |
| 230 | R | A | -0.5202 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | T | A | -0.9741 | |
| 234 | S | A | -0.5931 | |
| 235 | N | A | -0.6417 | |
| 236 | S | A | -0.3178 | |
| 237 | Y | A | -0.0184 | |
| 238 | T | A | -0.1850 | |
| 239 | S | A | -0.5894 | |
| 240 | S | A | -1.1850 | |
| 241 | S | A | -1.5936 | |
| 242 | N | A | -2.1261 | |
| 243 | S | A | -1.9921 | |
| 244 | R | A | -2.7468 | |
| 245 | T | A | -1.4228 | |
| 246 | L | A | 0.0000 | |
| 247 | R | A | 0.0000 | |
| 248 | L | A | 0.0104 | |
| 249 | D | A | -0.9378 | |
| 250 | G | A | -0.7715 | |
| 251 | P | A | -0.5020 | |
| 252 | D | A | -0.3153 | |
| 253 | P | A | 0.4668 | |
| 254 | V | A | 1.3180 | |
| 255 | P | A | -0.0252 | |
| 256 | L | A | -0.0450 | |
| 257 | P | A | -0.7514 | |
| 258 | D | A | -1.6751 | |
| 259 | A | A | -0.5410 | |
| 260 | G | A | 0.0000 | |
| 261 | P | A | 0.3577 | |
| 262 | P | A | 0.2771 | |
| 263 | P | A | 0.7100 | |
| 264 | A | A | 1.0745 | |
| 265 | L | A | 1.9673 | |
| 266 | Y | A | 1.8382 | |
| 267 | V | A | 2.0257 | |
| 268 | P | A | 0.8804 | |
| 269 | P | A | 0.2504 | |
| 270 | P | A | -0.3923 | |
| 271 | P | A | -0.3384 | |
| 272 | S | A | -0.3179 | |
| 273 | S | A | -0.1345 | |
| 274 | P | A | -0.3239 | |
| 275 | T | A | 0.2016 | |
| 276 | A | A | 0.4959 | |
| 277 | V | A | 1.4300 | |
| 278 | P | A | 0.5573 | |
| 279 | P | A | -0.1898 | |
| 280 | S | A | -0.1790 | |
| 281 | T | A | 0.1537 | |
| 282 | R | A | 0.3871 | |
| 283 | L | A | 1.5230 | |
| 284 | F | A | 0.5506 | |
| 285 | T | A | -0.7218 | |
| 286 | L | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -1.7101 | |
| 289 | R | A | -1.3316 | |
| 290 | G | A | -1.5551 | |
| 291 | E | A | -1.9718 | |
| 292 | I | A | -1.0691 | |
| 293 | T | A | -1.3875 | |
| 294 | E | A | -1.9196 | |
| 295 | S | A | -1.3149 | |
| 296 | D | A | -1.3143 | |
| 297 | L | A | -0.7984 | |
| 298 | L | A | -0.5999 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.0219 | |
| 301 | K | A | -1.2630 | |
| 302 | P | A | -0.6935 | |
| 303 | I | A | 0.2578 | |
| 304 | F | A | 0.1654 | |
| 305 | L | A | 0.0000 | |
| 306 | T | A | -0.4921 | |
| 307 | Q | A | -1.6891 | |
| 308 | T | A | 0.0000 | |
| 309 | E | A | -2.2217 | |
| 310 | G | A | -1.3979 | |
| 311 | L | A | -0.6363 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | I | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | G | A | -0.7762 | |
| 319 | N | A | -0.8104 | |
| 320 | R | A | -0.9613 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | I | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | 0.0000 | |
| 331 | A | A | 0.0000 | |
| 332 | N | A | -0.3378 | |
| 333 | I | A | -0.3448 | |
| 334 | A | A | -0.6090 | |
| 335 | T | A | -0.8436 | |
| 336 | N | A | -0.9014 | |
| 337 | T | A | -0.3523 | |
| 338 | T | A | -0.1371 | |
| 339 | K | A | -0.4792 | |
| 340 | I | A | 1.3925 | |
| 341 | S | A | 0.2966 | |
| 342 | T | A | -0.3605 | |
| 343 | P | A | -0.3637 | |
| 344 | A | A | -0.6134 | |
| 345 | N | A | -1.1023 | |
| 346 | N | A | -0.8143 | |
| 347 | V | A | 1.1054 | |
| 348 | Y | A | 1.1926 | |
| 349 | D | A | -0.1070 | |
| 350 | P | A | 0.0322 | |
| 351 | S | A | -0.0358 | |
| 352 | N | A | 0.3789 | |
| 353 | Y | A | 0.5729 | |
| 354 | V | A | 1.1901 | |
| 355 | T | A | -0.2305 | |
| 356 | S | A | -0.7763 | |
| 357 | K | A | -1.6755 | |
| 358 | T | A | -0.8978 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -0.2596 | |
| 361 | R | A | 0.0000 | |
| 362 | Q | A | 0.0316 | |
| 363 | Y | A | 0.0000 | |
| 364 | K | A | -0.4295 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | I | A | 0.0000 | |
| 370 | Q | A | -0.4090 | |
| 371 | L | A | 0.0000 | |
| 372 | A | A | 0.0000 | |
| 373 | K | A | -0.5574 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.8053 | |
| 376 | L | A | -0.9678 | |
| 377 | T | A | -0.9550 | |
| 378 | P | A | -1.5073 | |
| 379 | E | A | -2.4354 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -1.3174 | |
| 382 | E | A | -2.6173 | |
| 383 | Y | A | 0.0000 | |
| 384 | L | A | 0.0000 | |
| 385 | S | A | -1.1769 | |
| 386 | R | A | -1.6013 | |
| 387 | L | A | -0.5713 | |
| 388 | D | A | 0.0000 | |
| 389 | P | A | -0.9720 | |
| 390 | R | A | -1.1391 | |
| 391 | F | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -1.0480 | |
| 394 | D | A | -1.5093 | |
| 395 | A | A | -1.3823 | |
| 396 | K | A | -2.2267 | |
| 397 | L | A | 0.0000 | |
| 398 | P | A | -1.6962 | |
| 399 | D | A | -1.9406 | |
| 400 | I | A | -0.5260 | |
| 401 | P | A | -0.5655 | |
| 402 | P | A | -0.8901 | |
| 403 | V | A | -0.0996 | |
| 404 | E | A | -2.2072 | |
| 405 | R | A | -2.6127 | |
| 406 | P | A | -1.7543 | |
| 407 | D | A | -1.6307 | |
| 408 | P | A | -0.8510 | |
| 409 | Y | A | -0.3940 | |
| 410 | A | A | -0.5839 | |
| 411 | G | A | -0.7026 | |
| 412 | L | A | -0.6019 | |
| 413 | K | A | -2.0253 | |
| 414 | F | A | -1.4573 | |
| 415 | K | A | -1.8505 | |
| 416 | E | A | -2.5717 | |
| 417 | I | A | -1.9062 | |
| 418 | D | A | -2.6101 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.4354 | |
| 421 | N | A | -1.9685 | |
| 422 | K | A | -2.0009 | |
| 423 | L | A | -0.7153 | |
| 424 | S | A | -0.8784 | |
| 425 | T | A | -0.5466 | |
| 426 | N | A | -1.4996 | |
| 427 | L | A | 0.0000 | |
| 428 | S | A | -1.8526 | |
| 429 | D | A | -2.7370 | |
| 430 | S | A | 0.0000 | |
| 431 | E | A | -2.5735 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | Q | A | -2.1542 | |
| 435 | A | A | -1.3346 | |
| 436 | Y | A | -0.4991 | |
| 437 | L | A | 0.0688 | |
| 438 | N | A | -1.6362 | |
| 439 | R | A | -1.9729 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine