Project name: 26.A10E9

Chain sequence(s)	H: QVQLQQPGAELVKPGASVKLSCKASGYTFTNYWIHWVKQRPGRGLEWIGRIIPNSGDTNYNERFKIKAILTAAKSSSTAYIQLNNLTSEDSAVYFCARPDYWGQGTTLTVSS; L: DIQMTQSPSSLSASLGERVSFTCRASQEISNYLSWVQQKPNGTIKRLINAAAILDSGVPKRFSGSRSGSDYSLTISSLESEDFADYYCLQYANYPWTFGGGTKLEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:16)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:17)

• Minimal score value: -3.0664
• Maximal score value: 1.964
• Average score: -0.6512
• Total score value: -142.6188

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.5070
2	V	H	-1.0115
3	Q	H	-1.8527
4	L	H	0.0000
5	Q	H	-2.1253
6	Q	H	0.0000
7	P	H	-1.0152
8	G	H	-0.9716
9	A	H	-0.1481
11	E	H	-0.2334
12	L	H	0.8622
13	V	H	-0.2259
14	K	H	-1.7512
15	P	H	-1.5390
16	G	H	-1.4930
17	A	H	-1.2502
18	S	H	-1.3968
19	V	H	0.0000
20	K	H	-1.3737
21	L	H	0.0000
22	S	H	-0.7265
23	C	H	0.0000
24	K	H	-1.4668
25	A	H	0.0000
26	S	H	-1.2470
27	G	H	-1.0273
28	Y	H	-0.5103
29	T	H	-0.3456
30	F	H	0.0000
35	T	H	-1.2120
36	N	H	-1.1030
37	Y	H	0.0416
38	W	H	0.0268
39	I	H	0.0000
40	H	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	K	H	0.0000
44	Q	H	-1.0542
45	R	H	-1.7578
46	P	H	-1.3037
47	G	H	-1.6835
48	R	H	-2.6325
49	G	H	-1.7154
50	L	H	0.0000
51	E	H	-1.1961
52	W	H	0.0000
53	I	H	0.0000
54	G	H	0.0000
55	R	H	-0.4366
56	I	H	0.0000
57	I	H	-0.7754
58	P	H	0.0000
59	N	H	-2.0980
62	S	H	-1.6514
63	G	H	-1.8261
64	D	H	-2.2242
65	T	H	-0.9010
66	N	H	-1.0396
67	Y	H	-0.7881
68	N	H	0.0000
69	E	H	-3.0664
70	R	H	-2.8376
71	F	H	0.0000
72	K	H	-1.6273
74	I	H	0.8011
75	K	H	-0.2925
76	A	H	0.0000
77	I	H	1.2316
78	L	H	0.0000
79	T	H	-0.2195
80	A	H	-0.8925
81	A	H	-1.0778
82	K	H	-2.0576
83	S	H	-1.0242
84	S	H	-0.8400
85	S	H	-0.9394
86	T	H	0.0000
87	A	H	0.0000
88	Y	H	-0.0328
89	I	H	0.0000
90	Q	H	-0.4336
91	L	H	0.0000
92	N	H	-0.7740
93	N	H	-1.8800
94	L	H	0.0000
95	T	H	-1.4672
96	S	H	-1.3160
97	E	H	-1.9120
98	D	H	0.0000
99	S	H	-0.6532
100	A	H	0.0000
101	V	H	-0.0595
102	Y	H	0.0000
103	F	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	0.0000
107	P	H	0.0644
116	D	H	-0.2225
117	Y	H	0.3844
118	W	H	-0.2325
119	G	H	0.0000
120	Q	H	-1.6418
121	G	H	0.0000
122	T	H	0.0000
123	T	H	-0.1384
124	L	H	0.0000
125	T	H	-0.1029
126	V	H	0.0000
127	S	H	-0.6301
128	S	H	-0.7843
1	D	L	-2.3926
2	I	L	-1.8566
3	Q	L	-2.1460
4	M	L	0.0000
5	T	L	-1.2959
6	Q	L	-1.0650
7	S	L	-0.7256
8	P	L	-0.5830
9	S	L	-0.8865
10	S	L	-0.9314
11	L	L	-0.3424
12	S	L	-0.3824
13	A	L	0.0000
14	S	L	-0.5047
15	L	L	-0.1213
16	G	L	-1.1730
17	E	L	-1.7754
18	R	L	-2.3130
19	V	L	0.0000
20	S	L	-0.6619
21	F	L	0.0000
22	T	L	-0.8529
23	C	L	0.0000
24	R	L	-2.8582
25	A	L	0.0000
26	S	L	-2.1982
27	Q	L	-2.7969
28	E	L	-2.7392
29	I	L	0.0000
36	S	L	-0.8008
37	N	L	-0.5791
38	Y	L	0.5088
39	L	L	0.0000
40	S	L	0.0000
41	W	L	0.0000
42	V	L	0.0000
43	Q	L	0.0000
44	Q	L	0.0000
45	K	L	-1.4197
46	P	L	-1.1727
47	N	L	-1.7072
48	G	L	-1.1868
49	T	L	-1.0752
50	I	L	-0.7216
51	K	L	-0.8565
52	R	L	-0.6739
53	L	L	0.0000
54	I	L	0.0000
55	N	L	0.4700
56	A	L	0.7210
57	A	L	0.0000
65	A	L	0.7696
66	I	L	1.9640
67	L	L	0.6322
68	D	L	-0.2958
69	S	L	-0.4696
70	G	L	-0.8300
71	V	L	0.0000
72	P	L	-1.1318
74	K	L	-1.9506
75	R	L	-1.5414
76	F	L	0.0000
77	S	L	-0.2545
78	G	L	0.0470
79	S	L	-0.5469
80	R	L	-1.5349
83	S	L	-1.2130
84	G	L	-1.3807
85	S	L	-2.0037
86	D	L	-1.8608
87	Y	L	0.0000
88	S	L	-0.7924
89	L	L	0.0000
90	T	L	-0.6695
91	I	L	0.0000
92	S	L	-1.6316
93	S	L	-1.4306
94	L	L	0.0000
95	E	L	-1.8557
96	S	L	-1.1694
97	E	L	-2.1159
98	D	L	0.0000
99	F	L	-0.6936
100	A	L	0.0000
101	D	L	-1.4882
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	L	L	0.0000
106	Q	L	0.0000
107	Y	L	0.3932
108	A	L	-0.2779
109	N	L	-0.8919
114	Y	L	-0.3874
115	P	L	-0.8961
116	W	L	-0.3028
117	T	L	-0.6153
118	F	L	-0.2514
119	G	L	0.0000
120	G	L	-1.3075
121	G	L	-1.2888
122	T	L	0.0000
123	K	L	-1.8792
124	L	L	0.0000
125	E	L	-0.3452
126	I	L	1.0911
127	K	L	-0.7558