Project name: 61546050a6a4540

Chain sequence(s)	H: EVQLVESGGGLVQPGGSLRLSCAASGFTFSVYYMNWVRQAPGKGLEWVSDINNEGGTTYYADSVKGRFTISRDNSKNSLYLQMNSLRAEDTAVYYCARDAGYSNHVPIFDSWGQGTLVTVSS; L: QAVVTQEPSLTVSPGGTVTLTCGLKSGSVTSDNFPTWYQQTPGQAPRLLIYNTNTRHSGVPDRFSGSILGNKAALTITGAQADDEAEYFCALFISNPSVEFGGGTQLTVL
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:00:59)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:00)

• Minimal score value: -2.5617
• Maximal score value: 1.529
• Average score: -0.514
• Total score value: -119.2479

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.7573
2	V	H	-0.6433
3	Q	H	-0.6373
4	L	H	0.0000
5	V	H	1.1839
6	E	H	0.4485
7	S	H	-0.1270
8	G	H	-0.5816
9	G	H	0.2255
11	G	H	0.7258
12	L	H	1.4294
13	V	H	0.0403
14	Q	H	-1.3001
15	P	H	-1.5806
16	G	H	-1.4842
17	G	H	-1.0527
18	S	H	-1.1902
19	L	H	-0.6976
20	R	H	-1.5424
21	L	H	0.0000
22	S	H	-0.2608
23	C	H	0.0000
24	A	H	-0.0972
25	A	H	0.0000
26	S	H	-0.5336
27	G	H	-0.8815
28	F	H	-0.0796
29	T	H	0.3473
30	F	H	0.0000
35	S	H	-0.2664
36	V	H	1.3448
37	Y	H	0.7664
38	Y	H	-0.0117
39	M	H	0.0000
40	N	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.6215
45	A	H	-1.0210
46	P	H	-0.8251
47	G	H	-1.4487
48	K	H	-2.2510
49	G	H	-1.4555
50	L	H	0.0000
51	E	H	-0.9396
52	W	H	0.0000
53	V	H	0.0000
54	S	H	0.0000
55	D	H	0.0000
56	I	H	0.0000
57	N	H	-0.7938
58	N	H	-0.7927
59	E	H	-2.0869
62	G	H	-1.5973
63	G	H	-1.2306
64	T	H	-0.6176
65	T	H	-0.0791
66	Y	H	-0.2192
67	Y	H	-0.8276
68	A	H	-1.3703
69	D	H	-2.5617
70	S	H	-1.7288
71	V	H	0.0000
72	K	H	-2.5230
74	G	H	-1.7808
75	R	H	-1.7967
76	F	H	0.0000
77	T	H	-0.8923
78	I	H	0.0000
79	S	H	-0.7383
80	R	H	-1.3499
81	D	H	-1.7561
82	N	H	-1.8351
83	S	H	-1.5983
84	K	H	-2.4652
85	N	H	-1.9689
86	S	H	-1.0997
87	L	H	0.0000
88	Y	H	-0.4697
89	L	H	0.0000
90	Q	H	-1.3549
91	M	H	0.0000
92	N	H	-1.7838
93	S	H	-1.4121
94	L	H	0.0000
95	R	H	-2.1438
96	A	H	-1.5949
97	E	H	-2.1641
98	D	H	0.0000
99	T	H	-0.3239
100	A	H	0.0000
101	V	H	0.7158
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	0.0000
107	D	H	0.0000
108	A	H	0.1448
109	G	H	0.2523
110	Y	H	0.6813
111	S	H	-0.5475
111A	N	H	-1.6508
112A	H	H	-1.5196
112	V	H	0.0000
113	P	H	-0.2891
114	I	H	0.0000
115	F	H	0.0000
116	D	H	-0.4701
117	S	H	-0.2636
118	W	H	-0.3662
119	G	H	0.0000
120	Q	H	-1.0696
121	G	H	-0.1035
122	T	H	0.5541
123	L	H	1.5290
124	V	H	0.0000
125	T	H	0.3920
126	V	H	0.0000
127	S	H	-0.7161
128	S	H	-0.6882
1	Q	L	-1.1596
2	A	L	-0.2631
3	V	L	0.7880
4	V	L	0.0000
5	T	L	-0.2583
6	Q	L	0.0000
7	E	L	-0.7970
8	P	L	-0.8374
9	S	L	-0.7062
11	L	L	-0.0801
12	T	L	0.2826
13	V	L	0.3174
14	S	L	0.1368
15	P	L	-0.4385
16	G	L	-0.9074
17	G	L	-0.5981
18	T	L	-0.2787
19	V	L	0.0716
20	T	L	0.0209
21	L	L	0.0000
22	T	L	-0.0252
23	C	L	0.0000
24	G	L	0.0000
25	L	L	-0.6944
26	K	L	-1.4363
27	S	L	-1.0495
28	G	L	-1.4045
29	S	L	-1.2686
30	V	L	0.0000
31	T	L	-0.9141
35	S	L	-1.1340
36	D	L	-1.7904
37	N	L	-0.7382
38	F	L	-0.6083
39	P	L	0.0000
40	T	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	Q	L	-1.1805
45	T	L	-1.3458
46	P	L	-1.0326
47	G	L	-1.3365
48	Q	L	-1.9479
49	A	L	-1.3838
50	P	L	0.0000
51	R	L	-1.2888
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	-0.5692
56	N	L	-1.1102
57	T	L	-0.9951
65	N	L	-1.5578
66	T	L	-1.2351
67	R	L	-1.7403
68	H	L	-1.1389
69	S	L	-0.7402
70	G	L	-0.9127
71	V	L	-1.0227
72	P	L	-1.2415
74	D	L	-2.1223
75	R	L	-1.2263
76	F	L	0.0000
77	S	L	-1.1062
78	G	L	0.0000
79	S	L	-0.0989
80	I	L	0.4903
83	L	L	1.0192
84	G	L	-0.4082
85	N	L	-1.4091
86	K	L	-0.8012
87	A	L	0.0000
88	A	L	0.0000
89	L	L	0.0000
90	T	L	-0.0979
91	I	L	0.0000
92	T	L	-0.7258
93	G	L	-0.9233
94	A	L	0.0000
95	Q	L	-1.3552
96	A	L	-0.9398
97	D	L	-1.6545
98	D	L	0.0000
99	E	L	-1.1144
100	A	L	0.0000
101	E	L	-1.0887
102	Y	L	0.0000
103	F	L	0.0000
104	C	L	0.0000
105	A	L	0.0000
106	L	L	0.0000
107	F	L	-0.1239
108	I	L	-0.0608
109	S	L	-0.5710
113	N	L	-0.8874
114	P	L	-0.4090
115	S	L	-0.5216
116	V	L	0.0000
117	E	L	-0.0192
118	F	L	0.0000
119	G	L	0.0000
120	G	L	-0.8798
121	G	L	0.0000
122	T	L	0.0000
123	Q	L	-1.2176
124	L	L	0.0000
125	T	L	0.0295
126	V	L	0.2794
127	L	L	1.3937