Project name: 61bb0a8d2db2b3a

Chain sequence(s)	H: QVQLVQSGPELKKPGASVKVSCKASGYTFTDYVIHWVKQATGQGLEWIGEIYPGSGSAYSNAKFKDRVTMTADKSSNTAYMELSSLTSDDTAVYFCARRGNGTGFAYWGQGTLVTVSS; L: DIVLTQSPASLAVSLGQRATITCKAGQSVDYDGDSYMNWYQQKPGQPPKLLIYVASNLESGIPARFSGSGSGTDFTLNIHPVEENDAATYYCQQSYKDPLTFGQGTKLEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:59)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:00)

• Minimal score value: -3.2021
• Maximal score value: 0.8033
• Average score: -0.6523
• Total score value: -149.3787

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.4152
2	V	H	-0.7031
3	Q	H	-1.3195
4	L	H	0.0000
5	V	H	0.0613
6	Q	H	0.0000
7	S	H	-0.6110
8	G	H	-0.6845
9	P	H	-0.2245
11	E	H	-0.1921
12	L	H	0.6766
13	K	H	-0.7816
14	K	H	-1.9037
15	P	H	-1.3008
16	G	H	-1.1566
17	A	H	-0.8234
18	S	H	-1.0813
19	V	H	0.0000
20	K	H	-1.6581
21	V	H	0.0000
22	S	H	-0.4816
23	C	H	0.0000
24	K	H	-1.0519
25	A	H	0.0000
26	S	H	-0.9614
27	G	H	-0.9733
28	Y	H	-0.6055
29	T	H	-0.6263
30	F	H	0.0000
35	T	H	-1.0009
36	D	H	-1.4005
37	Y	H	-0.4660
38	V	H	0.0292
39	I	H	0.0000
40	H	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	K	H	0.0000
44	Q	H	-0.5185
45	A	H	-0.8497
46	T	H	-0.5892
47	G	H	-1.1591
48	Q	H	-1.8053
49	G	H	-1.3257
50	L	H	0.0000
51	E	H	-0.7766
52	W	H	0.0000
53	I	H	0.0000
54	G	H	0.0000
55	E	H	0.0000
56	I	H	0.0000
57	Y	H	0.4191
58	P	H	0.0000
59	G	H	-0.8146
62	S	H	-0.5995
63	G	H	-0.4606
64	S	H	0.1776
65	A	H	0.6952
66	Y	H	0.8033
67	S	H	-0.8524
68	N	H	-1.7478
69	A	H	-2.0756
70	K	H	-2.5871
71	F	H	0.0000
72	K	H	-3.0617
74	D	H	-3.2021
75	R	H	-2.2669
76	V	H	0.0000
77	T	H	-0.8486
78	M	H	0.0403
79	T	H	-0.1968
80	A	H	-0.7245
81	D	H	-1.4043
82	K	H	-1.6066
83	S	H	-1.0065
84	S	H	-1.0223
85	N	H	-1.3221
86	T	H	0.0000
87	A	H	0.0000
88	Y	H	-0.4444
89	M	H	0.0000
90	E	H	-1.0834
91	L	H	0.0000
92	S	H	-1.0608
93	S	H	-1.0118
94	L	H	0.0000
95	T	H	-1.2843
96	S	H	-1.4796
97	D	H	-1.9104
98	D	H	0.0000
99	T	H	-0.4614
100	A	H	0.0000
101	V	H	0.2993
102	Y	H	0.0000
103	F	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	0.0000
107	R	H	-0.3904
108	G	H	0.0000
109	N	H	-1.4754
110	G	H	-0.6282
113	T	H	-0.4567
114	G	H	0.0000
115	F	H	0.0000
116	A	H	0.0000
117	Y	H	0.1208
118	W	H	-0.2214
119	G	H	0.0000
120	Q	H	-1.2668
121	G	H	-0.5707
122	T	H	0.0000
123	L	H	0.3981
124	V	H	0.0000
125	T	H	-0.0916
126	V	H	0.0000
127	S	H	-0.6791
128	S	H	-0.8413
1	D	L	-2.1276
2	I	L	0.0000
3	V	L	0.6866
4	L	L	0.0000
5	T	L	-0.4190
6	Q	L	0.0000
7	S	L	-0.4555
8	P	L	-0.3351
9	A	L	-0.5943
10	S	L	-0.8813
11	L	L	-0.6412
12	A	L	-0.9537
13	V	L	0.0000
14	S	L	-1.7783
15	L	L	-1.3436
16	G	L	-1.8885
17	Q	L	-2.6839
18	R	L	-2.9662
19	A	L	0.0000
20	T	L	-0.7451
21	I	L	0.0000
22	T	L	-0.6217
23	C	L	0.0000
24	K	L	-1.4886
25	A	L	0.0000
26	G	L	-1.0893
27	Q	L	-1.7324
28	S	L	-1.0537
29	V	L	0.0000
30	D	L	-0.8332
31	Y	L	-0.1734
34	D	L	-1.7745
35	G	L	-1.4948
36	D	L	-1.3109
37	S	L	0.0000
38	Y	L	0.0633
39	M	L	0.0000
40	N	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	-0.7934
44	Q	L	-1.0889
45	K	L	-1.3591
46	P	L	-1.0391
47	G	L	-1.2978
48	Q	L	-1.8546
49	P	L	-1.1981
50	P	L	0.0000
51	K	L	-0.8863
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.2802
56	V	L	-0.1731
57	A	L	0.0000
65	S	L	-0.5419
66	N	L	-0.4032
67	L	L	0.2324
68	E	L	0.0000
69	S	L	-0.3073
70	G	L	-0.3883
71	I	L	-0.0992
72	P	L	-0.1380
74	A	L	-0.1998
75	R	L	-1.0075
76	F	L	0.0000
77	S	L	-0.5442
78	G	L	-0.4249
79	S	L	-0.8177
80	G	L	-1.0318
83	S	L	-1.2083
84	G	L	-1.1477
85	T	L	-1.6377
86	D	L	-1.9975
87	F	L	0.0000
88	T	L	-0.7261
89	L	L	0.0000
90	N	L	-1.1318
91	I	L	0.0000
92	H	L	-2.4941
93	P	L	-2.1056
94	V	L	0.0000
95	E	L	-2.5039
96	E	L	-3.1325
97	N	L	-2.4623
98	D	L	0.0000
99	A	L	-1.7444
100	A	L	0.0000
101	T	L	-1.1464
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	S	L	0.0000
108	Y	L	-0.2780
109	K	L	-1.9500
114	D	L	-2.4625
115	P	L	-1.9583
116	L	L	0.0000
117	T	L	-0.5390
118	F	L	0.0740
119	G	L	0.0000
120	Q	L	-1.2194
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.7451
124	L	L	0.0000
125	E	L	-2.2055
126	I	L	-1.9408
127	K	L	-2.1145