| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFEDIVVNGKVLVPKVSGYQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGSVGHPLFNKLGDTENPTEPVHCGADDRVAFSFDPKQTQLFIVGCEPPTGEHWDLAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYRRCGPDGHPLPRAPPPSPLYVPPPASSPLAVPPPTNYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPKENVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:06)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9473 | |
| 2 | L | A | 1.9687 | |
| 3 | P | A | 0.6582 | |
| 4 | P | A | 0.3718 | |
| 5 | T | A | 0.1249 | |
| 6 | T | A | 0.1235 | |
| 7 | P | A | 0.1874 | |
| 8 | V | A | 1.2426 | |
| 9 | A | A | 0.0693 | |
| 10 | K | A | -1.0891 | |
| 11 | V | A | -0.2630 | |
| 12 | Q | A | -1.4871 | |
| 13 | S | A | -1.5819 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4349 | |
| 16 | E | A | -2.4522 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4536 | |
| 20 | P | A | 0.1283 | |
| 21 | T | A | 0.1646 | |
| 22 | S | A | -0.0945 | |
| 23 | L | A | 0.1016 | |
| 24 | F | A | -0.0183 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.1167 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.6160 | |
| 31 | R | A | -2.5427 | |
| 32 | L | A | -0.7119 | |
| 33 | L | A | 1.2440 | |
| 34 | T | A | 1.4644 | |
| 35 | V | A | 1.9951 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2881 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6882 | |
| 40 | E | A | -2.0090 | |
| 41 | D | A | -0.8495 | |
| 42 | I | A | 1.2081 | |
| 43 | V | A | 2.1678 | |
| 44 | V | A | 1.6893 | |
| 45 | N | A | -0.5040 | |
| 46 | G | A | -0.3530 | |
| 47 | K | A | -0.1297 | |
| 48 | V | A | 2.1886 | |
| 49 | L | A | 2.5266 | |
| 50 | V | A | 1.4493 | |
| 51 | P | A | 0.3195 | |
| 52 | K | A | -0.7377 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1234 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.4620 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2640 | |
| 70 | K | A | -1.8098 | |
| 71 | F | A | -0.6612 | |
| 72 | A | A | -0.5810 | |
| 73 | L | A | -0.8646 | |
| 74 | P | A | -1.2552 | |
| 75 | Q | A | -2.4862 | |
| 76 | K | A | -3.0993 | |
| 77 | D | A | -2.9944 | |
| 78 | F | A | -1.6504 | |
| 79 | Y | A | -1.9243 | |
| 80 | D | A | -2.7634 | |
| 81 | P | A | -2.3464 | |
| 82 | E | A | -3.0721 | |
| 83 | K | A | -3.4433 | |
| 84 | E | A | -2.5107 | |
| 85 | R | A | -1.3181 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6506 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9350 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3089 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.7419 | |
| 99 | G | A | -0.5366 | |
| 100 | P | A | -0.4308 | |
| 101 | L | A | -0.0009 | |
| 102 | G | A | -0.2822 | |
| 103 | K | A | -0.7932 | |
| 104 | G | A | -0.6276 | |
| 105 | S | A | -0.6283 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.1092 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.4472 | |
| 110 | L | A | 0.3388 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.1404 | |
| 113 | K | A | -0.5254 | |
| 114 | L | A | 0.0000 | |
| 115 | G | A | -1.1074 | |
| 116 | D | A | -1.7693 | |
| 117 | T | A | -1.3356 | |
| 118 | E | A | -2.7752 | |
| 119 | N | A | -2.6876 | |
| 120 | P | A | -2.1581 | |
| 121 | T | A | -1.6661 | |
| 122 | E | A | -2.1978 | |
| 123 | P | A | -0.9792 | |
| 124 | V | A | -0.4395 | |
| 125 | H | A | -0.4621 | |
| 126 | C | A | -0.6379 | |
| 127 | G | A | -1.1839 | |
| 128 | A | A | -1.2549 | |
| 129 | D | A | -2.2158 | |
| 130 | D | A | -1.8020 | |
| 131 | R | A | -1.2111 | |
| 132 | V | A | 0.1956 | |
| 133 | A | A | 0.4545 | |
| 134 | F | A | 0.2734 | |
| 135 | S | A | -0.1205 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.8070 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5622 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2153 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1365 | |
| 157 | D | A | 0.3118 | |
| 158 | L | A | 0.8231 | |
| 159 | A | A | 0.2050 | |
| 160 | E | A | -1.4266 | |
| 161 | P | A | -0.1965 | |
| 162 | C | A | 0.1754 | |
| 163 | P | A | -0.1808 | |
| 164 | G | A | -0.0835 | |
| 165 | L | A | 0.5615 | |
| 166 | P | A | -0.1259 | |
| 167 | P | A | -0.3457 | |
| 168 | G | A | -0.4234 | |
| 169 | A | A | -0.0232 | |
| 170 | C | A | 0.6826 | |
| 171 | P | A | 0.5537 | |
| 172 | P | A | 0.8357 | |
| 173 | I | A | 2.0760 | |
| 174 | Q | A | 0.8828 | |
| 175 | L | A | 1.4959 | |
| 176 | V | A | 0.8571 | |
| 177 | N | A | -0.2854 | |
| 178 | S | A | 0.0589 | |
| 179 | V | A | 0.4672 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3833 | |
| 182 | D | A | 0.0897 | |
| 183 | G | A | -0.1614 | |
| 184 | D | A | -0.5793 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | -0.4795 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1064 | |
| 190 | F | A | 0.0121 | |
| 191 | G | A | -0.1618 | |
| 192 | N | A | -0.3428 | |
| 193 | M | A | -0.1809 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.4666 | |
| 197 | E | A | -2.7092 | |
| 198 | L | A | -1.2510 | |
| 199 | Q | A | -2.5698 | |
| 200 | Q | A | -3.3549 | |
| 201 | D | A | -3.6136 | |
| 202 | R | A | -3.3460 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.1720 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3894 | |
| 211 | S | A | -1.9285 | |
| 212 | T | A | -1.4882 | |
| 213 | R | A | -2.2137 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.2180 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3212 | |
| 220 | L | A | 0.5428 | |
| 221 | K | A | -1.2193 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.9394 | |
| 224 | N | A | -1.6687 | |
| 225 | E | A | -1.3030 | |
| 226 | A | A | -0.6395 | |
| 227 | Y | A | -0.4110 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6947 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | -0.1368 | |
| 234 | F | A | 0.0344 | |
| 235 | G | A | -0.8608 | |
| 236 | R | A | -2.5402 | |
| 237 | R | A | -2.6395 | |
| 238 | E | A | -1.9047 | |
| 239 | Q | A | 0.0693 | |
| 240 | V | A | 1.6778 | |
| 241 | Y | A | 1.2927 | |
| 242 | A | A | 0.1589 | |
| 243 | R | A | -1.3820 | |
| 244 | H | A | -1.2599 | |
| 245 | F | A | -0.3019 | |
| 246 | Y | A | 0.0000 | |
| 247 | R | A | 0.0000 | |
| 248 | R | A | -0.5433 | |
| 249 | C | A | -0.8459 | |
| 250 | G | A | -0.8660 | |
| 251 | P | A | -0.8778 | |
| 252 | D | A | -1.3180 | |
| 253 | G | A | -1.2582 | |
| 254 | H | A | -1.4459 | |
| 255 | P | A | -1.3021 | |
| 256 | L | A | -0.1999 | |
| 257 | P | A | -0.8760 | |
| 258 | R | A | -1.4253 | |
| 259 | A | A | -0.7614 | |
| 260 | P | A | -0.7589 | |
| 261 | P | A | -0.2674 | |
| 262 | P | A | -0.1135 | |
| 263 | S | A | 0.2489 | |
| 264 | P | A | 0.6883 | |
| 265 | L | A | 1.6962 | |
| 266 | Y | A | 1.5752 | |
| 267 | V | A | 1.7612 | |
| 268 | P | A | 0.8251 | |
| 269 | P | A | 0.6204 | |
| 270 | P | A | -0.0525 | |
| 271 | A | A | 0.1322 | |
| 272 | S | A | -0.2167 | |
| 273 | S | A | 0.2168 | |
| 274 | P | A | 0.3782 | |
| 275 | L | A | 1.1115 | |
| 276 | A | A | 1.0655 | |
| 277 | V | A | 1.7220 | |
| 278 | P | A | 0.7321 | |
| 279 | P | A | 0.2386 | |
| 280 | P | A | -0.2815 | |
| 281 | T | A | -0.4292 | |
| 282 | N | A | -0.7532 | |
| 283 | Y | A | 0.8886 | |
| 284 | F | A | 0.7338 | |
| 285 | G | A | 0.1095 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.8558 | |
| 291 | L | A | 1.6562 | |
| 292 | V | A | 0.6564 | |
| 293 | S | A | -0.1410 | |
| 294 | S | A | -0.9661 | |
| 295 | D | A | -1.8370 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.0737 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6140 | |
| 301 | R | A | -1.7831 | |
| 302 | P | A | -0.9143 | |
| 303 | F | A | -0.1587 | |
| 304 | W | A | -0.5065 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0822 | |
| 307 | R | A | -2.9220 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.7754 | |
| 310 | G | A | -1.4114 | |
| 311 | N | A | -1.3623 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.8994 | |
| 319 | N | A | -0.8865 | |
| 320 | E | A | -1.0510 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3700 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.2149 | |
| 333 | N | A | 0.3692 | |
| 334 | F | A | 1.4552 | |
| 335 | T | A | 0.7413 | |
| 336 | I | A | 0.4092 | |
| 337 | S | A | -0.9681 | |
| 338 | Q | A | -1.7552 | |
| 339 | Q | A | -1.3615 | |
| 340 | L | A | 0.6103 | |
| 341 | C | A | 0.1747 | |
| 342 | T | A | -0.5044 | |
| 343 | P | A | -1.1459 | |
| 344 | K | A | -2.3105 | |
| 345 | E | A | -2.5978 | |
| 346 | N | A | -1.5435 | |
| 347 | V | A | 0.4391 | |
| 348 | Y | A | 0.8208 | |
| 349 | D | A | -0.2413 | |
| 350 | P | A | -0.4170 | |
| 351 | S | A | -0.3341 | |
| 352 | C | A | -0.3565 | |
| 353 | F | A | -0.8566 | |
| 354 | K | A | -1.7988 | |
| 355 | N | A | -1.7589 | |
| 356 | Y | A | -0.1118 | |
| 357 | L | A | 0.5643 | |
| 358 | R | A | 0.8964 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.4812 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0058 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -1.8854 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6477 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.2795 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3260 | |
| 376 | L | A | -1.7529 | |
| 377 | D | A | -2.0207 | |
| 378 | P | A | -1.0567 | |
| 379 | G | A | -1.0180 | |
| 380 | V | A | -0.9326 | |
| 381 | L | A | -0.5415 | |
| 382 | A | A | -0.6611 | |
| 383 | H | A | -0.8293 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4032 | |
| 386 | T | A | -0.5615 | |
| 387 | M | A | -0.3130 | |
| 388 | N | A | -0.8757 | |
| 389 | P | A | -1.2651 | |
| 390 | T | A | -1.5258 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.5174 | |
| 393 | E | A | -2.8936 | |
| 394 | N | A | -2.5967 | |
| 395 | W | A | -1.5072 | |
| 396 | N | A | -1.2124 | |
| 397 | L | A | -0.2231 | |
| 398 | G | A | 0.5274 | |
| 399 | F | A | 2.4091 | |
| 400 | V | A | 1.8331 | |
| 401 | P | A | 0.0519 | |
| 402 | P | A | -1.9122 | |
| 403 | K | A | -3.4106 | |
| 404 | E | A | -3.8808 | |
| 405 | R | A | -4.1654 | |
| 406 | E | A | -3.8768 | |
| 407 | D | A | -2.8934 | |
| 408 | P | A | -1.7760 | |
| 409 | Y | A | -0.9775 | |
| 410 | K | A | -2.0996 | |
| 411 | G | A | -0.6281 | |
| 412 | L | A | 0.6777 | |
| 413 | I | A | 1.5898 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3917 | |
| 416 | E | A | -1.6568 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.8518 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.9074 | |
| 421 | E | A | -2.5306 | |
| 422 | R | A | -2.1117 | |
| 423 | F | A | -1.0475 | |
| 424 | S | A | -1.3294 | |
| 425 | Q | A | -1.8148 | |
| 426 | D | A | -2.8816 | |
| 427 | L | A | -1.9820 | |
| 428 | D | A | -2.7647 | |
| 429 | Q | A | -2.6043 | |
| 430 | F | A | -1.4380 | |
| 431 | A | A | -0.8963 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.5670 | |
| 435 | K | A | -0.7123 | |
| 436 | F | A | 0.1544 | |
| 437 | L | A | 1.0382 | |
| 438 | Y | A | 0.8299 | |
| 439 | Q | A | -0.2618 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine