Project name: 62b73499167eb15

Chain sequence(s)	A: QVQLVESGGGLVQAGGSLRLSCAASGSTFSRYALAWYRQTPGKQREWVATITSGGVTSYVDSVKGRFTVSRDNAANTVYLQMISLKPEDTAVYYCKAPEILSPWGQGTQVTVSSGGGGSGGGGSGGGGSQVQLVESGGGLVQPGGSLRLSCAASGFTRDAYAIGWFRQAPGKEREGVSCISASGSRTNYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAIYYCAATEFGTGYVCYGGLEGNEFSFWGQGTQVTVSS
Selected Chain(s)	A
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:03:52)
[INFO]       Main:     Simulation completed successfully.                                          (00:03:54)

• Minimal score value: -3.706
• Maximal score value: 1.602
• Average score: -0.7729
• Total score value: -199.4059

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	A	-1.1710
2	V	A	-0.2171
3	Q	A	-0.6199
4	L	A	0.0000
5	V	A	0.0638
6	E	A	0.0000
7	S	A	-0.5958
8	G	A	-0.9510
9	G	A	-0.6537
10	G	A	-0.3584
11	L	A	-0.0279
12	V	A	-0.5236
13	Q	A	-1.6096
14	A	A	-1.5303
15	G	A	-1.0090
16	G	A	-0.5765
17	S	A	-0.5504
18	L	A	-0.7451
19	R	A	-1.9251
20	L	A	0.0000
21	S	A	-0.5358
22	C	A	0.0000
23	A	A	-0.1604
24	A	A	-0.2725
25	S	A	-0.5439
26	G	A	-0.6835
27	S	A	-0.8010
28	T	A	-0.7815
29	F	A	0.0000
30	S	A	-1.5875
31	R	A	-2.2319
32	Y	A	-1.1710
33	A	A	-0.6437
34	L	A	0.0000
35	A	A	0.0000
36	W	A	0.0000
37	Y	A	-0.3825
38	R	A	-1.0539
39	Q	A	-1.6814
40	T	A	-1.7953
41	P	A	-1.3011
42	G	A	-1.7960
43	K	A	-3.0073
44	Q	A	-2.8019
45	R	A	-2.1861
46	E	A	-1.8588
47	W	A	-0.4347
48	V	A	0.0000
49	A	A	0.0000
50	T	A	0.2497
51	I	A	0.0000
52	T	A	-0.0436
53	S	A	-0.9113
54	G	A	-0.5208
55	G	A	0.0806
56	V	A	1.3736
57	T	A	0.5736
58	S	A	-0.1127
59	Y	A	-0.7995
60	V	A	-1.1330
61	D	A	-2.3377
62	S	A	-1.6838
63	V	A	0.0000
64	K	A	-2.5622
65	G	A	-1.5351
66	R	A	-0.9190
67	F	A	0.0000
68	T	A	-0.7195
69	V	A	0.0000
70	S	A	-0.4153
71	R	A	-1.1061
72	D	A	-1.5354
73	N	A	-1.8345
74	A	A	-0.7973
75	A	A	-0.7286
76	N	A	-1.2923
77	T	A	-0.7184
78	V	A	0.0000
79	Y	A	-0.6338
80	L	A	0.0000
81	Q	A	-1.0552
82	M	A	0.0000
83	I	A	0.0968
84	S	A	-0.3532
85	L	A	0.0000
86	K	A	-1.8377
87	P	A	-1.7695
88	E	A	-2.2241
89	D	A	0.0000
90	T	A	-0.8685
91	A	A	0.0000
92	V	A	-0.1536
93	Y	A	0.0000
94	Y	A	-0.1606
95	C	A	0.0000
96	K	A	-0.0547
97	A	A	0.0000
98	P	A	-0.6565
99	E	A	-1.5663
100	I	A	0.1592
101	L	A	1.2890
102	S	A	0.0000
103	P	A	0.1621
104	W	A	0.3490
105	G	A	0.0000
106	Q	A	-0.7526
107	G	A	0.0000
108	T	A	0.0000
109	Q	A	-0.5659
110	V	A	0.0000
111	T	A	-0.5782
112	V	A	0.0000
113	S	A	-1.1094
114	S	A	-1.3791
115	G	A	-1.3642
116	G	A	-1.2543
117	G	A	-1.1833
118	G	A	-1.1770
119	S	A	-1.0422
120	G	A	-1.1285
121	G	A	-1.1510
122	G	A	-1.1522
123	G	A	-1.1417
124	S	A	-0.9319
125	G	A	-1.1298
126	G	A	-1.1534
127	G	A	-1.2612
128	G	A	-1.2280
129	S	A	-1.1939
130	Q	A	-1.4688
131	V	A	-0.4477
132	Q	A	-0.5797
133	L	A	0.0000
134	V	A	-0.0495
135	E	A	0.0000
136	S	A	-0.5321
137	G	A	-1.0074
138	G	A	-0.5522
139	G	A	-0.2706
140	L	A	0.1605
141	V	A	-0.3657
142	Q	A	-1.3365
143	P	A	-1.5540
144	G	A	-1.3293
145	G	A	-0.9469
146	S	A	-1.1277
147	L	A	-0.9997
148	R	A	-2.0840
149	L	A	0.0000
150	S	A	-0.5718
151	C	A	0.0000
152	A	A	-0.4506
153	A	A	0.0000
154	S	A	-0.9190
155	G	A	-0.8876
156	F	A	-1.1485
157	T	A	-1.4100
158	R	A	-2.9912
159	D	A	-2.7241
160	A	A	-1.3220
161	Y	A	0.0000
162	A	A	0.0000
163	I	A	0.0000
164	G	A	0.0000
165	W	A	0.0000
166	F	A	0.0000
167	R	A	0.0000
168	Q	A	-1.9730
169	A	A	-1.9072
170	P	A	-1.3975
171	G	A	-1.9701
172	K	A	-3.3928
173	E	A	-3.7060
174	R	A	-3.3092
175	E	A	-2.7445
176	G	A	-1.6929
177	V	A	0.0000
178	S	A	0.0000
179	C	A	0.0000
180	I	A	0.0000
181	S	A	-0.7083
182	A	A	-1.2363
183	S	A	-1.0219
184	G	A	-1.4316
185	S	A	-1.3364
186	R	A	-1.9242
187	T	A	-0.9248
188	N	A	-0.8276
189	Y	A	-1.0529
190	A	A	-1.5805
191	D	A	-2.5241
192	S	A	-1.8492
193	V	A	0.0000
194	K	A	-2.6801
195	G	A	-1.7766
196	R	A	-1.4743
197	F	A	0.0000
198	T	A	-0.9007
199	I	A	0.0000
200	S	A	-0.7160
201	R	A	-1.0422
202	D	A	-1.5085
203	N	A	-2.1836
204	A	A	-1.7122
205	K	A	-2.3567
206	N	A	-2.0682
207	T	A	-1.0418
208	V	A	0.0000
209	Y	A	-0.6606
210	L	A	0.0000
211	Q	A	-1.2850
212	M	A	0.0000
213	N	A	-1.3915
214	S	A	-1.1958
215	L	A	0.0000
216	K	A	-2.2451
217	P	A	-1.8581
218	E	A	-2.3226
219	D	A	0.0000
220	T	A	-0.8319
221	A	A	0.0000
222	I	A	-0.1062
223	Y	A	0.0000
224	Y	A	-0.3106
225	C	A	0.0000
226	A	A	0.0000
227	A	A	0.0000
228	T	A	0.0000
229	E	A	-1.2060
230	F	A	0.7210
231	G	A	-0.0552
232	T	A	-0.0285
233	G	A	0.5051
234	Y	A	1.6020
235	V	A	0.0000
236	C	A	0.1259
237	Y	A	1.1401
238	G	A	0.1195
239	G	A	-0.5703
240	L	A	-1.2638
241	E	A	-2.7947
242	G	A	-2.1606
243	N	A	-2.1951
244	E	A	-1.7595
245	F	A	0.0000
246	S	A	-0.4254
247	F	A	0.4688
248	W	A	0.3714
249	G	A	-0.2517
250	Q	A	-1.0687
251	G	A	0.0000
252	T	A	0.0000
253	Q	A	-0.2858
254	V	A	0.0000
255	T	A	-0.4933
256	V	A	0.0000
257	S	A	-0.8876
258	S	A	-0.6218