| Chain sequence(s) |
A: GLPALNPAPALRSTAEYVTPTDLLFVAQTDLLTETGNPTADIVVNGKVLVPKVSAYDWRVFKLTLPDPNTLPLPSPDFLDRSTEILIWRLRALYIKKFGDLGTGTVGHPNFNRLGNVDNPTKPLHPGPDDDVNYSWTPVRLQAFIVGDEPPLGKYTAPAAPAPGLPPGAEPPTTVVRDVIQHGDRADIGYGARDYAALLPDKDDVPDDILDTTTKVPDWEGMAAEPTGRRMFISDRRTSSSNSENFVRDGPELHPIPDAPPPSPLYVRPPPSSPYAVPPPTDYFTLPDRGAITEADLLFNRPVWIEQTPGLNQGILWHNQLYVTVLDNTRATIETIKTKISTPAINVYDPSNYVTSKRYSESYQLELVVQLCKIPLTPEVLAELARLDPRILVDARLPEIPPVERPDPYAGLKFREIDLTNKLSTDLEKYPLGRAYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | 0.2035 | |
| 2 | L | A | 1.4580 | |
| 3 | P | A | 0.6028 | |
| 4 | A | A | 0.6230 | |
| 5 | L | A | 1.0826 | |
| 6 | N | A | -0.7145 | |
| 7 | P | A | -0.4778 | |
| 8 | A | A | -0.2312 | |
| 9 | P | A | -0.4697 | |
| 10 | A | A | -0.1390 | |
| 11 | L | A | -0.2046 | |
| 12 | R | A | -0.9231 | |
| 13 | S | A | -0.7051 | |
| 14 | T | A | 0.0000 | |
| 15 | A | A | -1.0673 | |
| 16 | E | A | -1.9276 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.5673 | |
| 20 | P | A | -0.6559 | |
| 21 | T | A | -0.8518 | |
| 22 | D | A | -1.5687 | |
| 23 | L | A | -0.4042 | |
| 24 | L | A | -0.1400 | |
| 25 | F | A | -0.0405 | |
| 26 | V | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | Q | A | -0.5539 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.1884 | |
| 31 | L | A | 0.6333 | |
| 32 | L | A | 0.0000 | |
| 33 | T | A | 0.0625 | |
| 34 | E | A | -0.2743 | |
| 35 | T | A | -0.4166 | |
| 36 | G | A | 0.0000 | |
| 37 | N | A | -0.9752 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -0.7305 | |
| 40 | A | A | -0.5296 | |
| 41 | D | A | -0.0301 | |
| 42 | I | A | 1.8418 | |
| 43 | V | A | 2.5327 | |
| 44 | V | A | 1.7009 | |
| 45 | N | A | -0.5494 | |
| 46 | G | A | -0.3580 | |
| 47 | K | A | -0.1345 | |
| 48 | V | A | 2.1194 | |
| 49 | L | A | 2.4989 | |
| 50 | V | A | 1.3965 | |
| 51 | P | A | 0.2292 | |
| 52 | K | A | -0.6008 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | D | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | K | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.2195 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -0.6606 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -0.8211 | |
| 70 | T | A | -0.1399 | |
| 71 | L | A | 0.0653 | |
| 72 | P | A | -0.0620 | |
| 73 | L | A | -0.0668 | |
| 74 | P | A | -0.3339 | |
| 75 | S | A | -0.7309 | |
| 76 | P | A | -1.2864 | |
| 77 | D | A | -2.3173 | |
| 78 | F | A | -1.2506 | |
| 79 | L | A | 0.0000 | |
| 80 | D | A | -3.0629 | |
| 81 | R | A | -2.9947 | |
| 82 | S | A | -1.7423 | |
| 83 | T | A | -1.4152 | |
| 84 | E | A | -1.6378 | |
| 85 | I | A | 0.0000 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | -0.3430 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6381 | |
| 92 | A | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | Y | A | -0.4063 | |
| 95 | I | A | 0.0000 | |
| 96 | K | A | -0.2797 | |
| 97 | K | A | 0.0000 | |
| 98 | F | A | 0.5041 | |
| 99 | G | A | -0.7998 | |
| 100 | D | A | -1.5842 | |
| 101 | L | A | -0.6260 | |
| 102 | G | A | -0.3241 | |
| 103 | T | A | -0.1356 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.0973 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | -0.7521 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | -1.4893 | |
| 110 | N | A | -2.5203 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | R | A | -1.0508 | |
| 114 | L | A | -0.7088 | |
| 115 | G | A | 0.0000 | |
| 116 | N | A | -1.2109 | |
| 117 | V | A | -1.1033 | |
| 118 | D | A | -2.3838 | |
| 119 | N | A | -2.4186 | |
| 120 | P | A | -1.7658 | |
| 121 | T | A | -1.4853 | |
| 122 | K | A | -1.9229 | |
| 123 | P | A | -0.6301 | |
| 124 | L | A | -0.4007 | |
| 125 | H | A | -0.5703 | |
| 126 | P | A | -1.0829 | |
| 127 | G | A | -1.2336 | |
| 128 | P | A | -1.5058 | |
| 129 | D | A | -2.5889 | |
| 130 | D | A | -2.0625 | |
| 131 | D | A | -2.0758 | |
| 132 | V | A | -1.2980 | |
| 133 | N | A | -1.6534 | |
| 134 | Y | A | -0.8186 | |
| 135 | S | A | -0.4693 | |
| 136 | W | A | 0.0000 | |
| 137 | T | A | -0.3769 | |
| 138 | P | A | 0.0000 | |
| 139 | V | A | 0.0000 | |
| 140 | R | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | A | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | E | A | -0.2452 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | L | A | -0.3830 | |
| 153 | G | A | 0.0000 | |
| 154 | K | A | -0.5958 | |
| 155 | Y | A | -0.2337 | |
| 156 | T | A | 0.0674 | |
| 157 | A | A | 0.0000 | |
| 158 | P | A | -0.2277 | |
| 159 | A | A | 0.0970 | |
| 160 | A | A | -0.1594 | |
| 161 | P | A | -0.4424 | |
| 162 | A | A | -0.1235 | |
| 163 | P | A | -0.3128 | |
| 164 | G | A | -0.3049 | |
| 165 | L | A | -0.0617 | |
| 166 | P | A | -0.4931 | |
| 167 | P | A | -0.7179 | |
| 168 | G | A | -0.7775 | |
| 169 | A | A | -0.8563 | |
| 170 | E | A | -1.7242 | |
| 171 | P | A | -1.1068 | |
| 172 | P | A | -0.6302 | |
| 173 | T | A | -0.1298 | |
| 174 | T | A | 0.5373 | |
| 175 | V | A | 1.1258 | |
| 176 | V | A | -0.0359 | |
| 177 | R | A | -1.5388 | |
| 178 | D | A | -1.1552 | |
| 179 | V | A | -0.5888 | |
| 180 | I | A | 0.0000 | |
| 181 | Q | A | -0.8426 | |
| 182 | H | A | -1.0332 | |
| 183 | G | A | -0.7924 | |
| 184 | D | A | -0.6524 | |
| 185 | R | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | -0.4740 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.4985 | |
| 190 | Y | A | -0.2514 | |
| 191 | G | A | -0.3899 | |
| 192 | A | A | -0.3495 | |
| 193 | R | A | -0.5720 | |
| 194 | D | A | -0.7670 | |
| 195 | Y | A | 0.0000 | |
| 196 | A | A | -1.2113 | |
| 197 | A | A | -0.4757 | |
| 198 | L | A | -0.7115 | |
| 199 | L | A | -1.1696 | |
| 200 | P | A | -1.5712 | |
| 201 | D | A | -2.4260 | |
| 202 | K | A | -3.0802 | |
| 203 | D | A | -2.1432 | |
| 204 | D | A | -1.4028 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.3849 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -1.6105 | |
| 211 | D | A | -2.1021 | |
| 212 | T | A | -1.1253 | |
| 213 | T | A | -0.7591 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | 0.0037 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | W | A | -0.7400 | |
| 220 | E | A | -1.8803 | |
| 221 | G | A | -1.3526 | |
| 222 | M | A | 0.0000 | |
| 223 | A | A | -0.7984 | |
| 224 | A | A | -0.7515 | |
| 225 | E | A | -0.7635 | |
| 226 | P | A | -0.3825 | |
| 227 | T | A | -0.1659 | |
| 228 | G | A | 0.0000 | |
| 229 | R | A | 0.0000 | |
| 230 | R | A | -0.2382 | |
| 231 | M | A | 0.0189 | |
| 232 | F | A | 0.0000 | |
| 233 | I | A | 0.0114 | |
| 234 | S | A | -0.6787 | |
| 235 | D | A | -1.9355 | |
| 236 | R | A | -2.6098 | |
| 237 | R | A | -1.8906 | |
| 238 | T | A | -0.9667 | |
| 239 | S | A | -0.5722 | |
| 240 | S | A | -0.8964 | |
| 241 | S | A | -1.1649 | |
| 242 | N | A | -1.6308 | |
| 243 | S | A | -1.3745 | |
| 244 | E | A | -1.5939 | |
| 245 | N | A | -1.1167 | |
| 246 | F | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | 0.0000 | |
| 249 | D | A | -1.3079 | |
| 250 | G | A | -0.9932 | |
| 251 | P | A | -0.6505 | |
| 252 | E | A | -0.5046 | |
| 253 | L | A | 0.4025 | |
| 254 | H | A | -0.5646 | |
| 255 | P | A | -0.7570 | |
| 256 | I | A | 0.1933 | |
| 257 | P | A | -0.8008 | |
| 258 | D | A | -1.6015 | |
| 259 | A | A | -0.7966 | |
| 260 | P | A | -0.9092 | |
| 261 | P | A | -0.4929 | |
| 262 | P | A | -0.1084 | |
| 263 | S | A | 0.0420 | |
| 264 | P | A | 0.7018 | |
| 265 | L | A | 1.5992 | |
| 266 | Y | A | 1.2980 | |
| 267 | V | A | 1.4000 | |
| 268 | R | A | -0.2201 | |
| 269 | P | A | 0.0968 | |
| 270 | P | A | -0.2454 | |
| 271 | P | A | -0.2684 | |
| 272 | S | A | -0.3224 | |
| 273 | S | A | 0.1097 | |
| 274 | P | A | 0.2296 | |
| 275 | Y | A | 1.0631 | |
| 276 | A | A | 0.8439 | |
| 277 | V | A | 1.5343 | |
| 278 | P | A | 0.5271 | |
| 279 | P | A | 0.1924 | |
| 280 | P | A | 0.0000 | |
| 281 | T | A | -0.5338 | |
| 282 | D | A | -1.1871 | |
| 283 | Y | A | 0.5676 | |
| 284 | F | A | 0.2753 | |
| 285 | T | A | -0.2787 | |
| 286 | L | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -1.1862 | |
| 289 | R | A | -0.8207 | |
| 290 | G | A | -0.6100 | |
| 291 | A | A | -0.1335 | |
| 292 | I | A | -0.2415 | |
| 293 | T | A | -0.8847 | |
| 294 | E | A | -1.8399 | |
| 295 | A | A | -1.1211 | |
| 296 | D | A | -1.2790 | |
| 297 | L | A | -0.9774 | |
| 298 | L | A | -1.2292 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.0797 | |
| 301 | R | A | -1.6557 | |
| 302 | P | A | -0.7089 | |
| 303 | V | A | -0.2010 | |
| 304 | W | A | -0.5238 | |
| 305 | I | A | 0.0000 | |
| 306 | E | A | -2.2632 | |
| 307 | Q | A | -2.0136 | |
| 308 | T | A | 0.0000 | |
| 309 | P | A | -0.4212 | |
| 310 | G | A | -0.2665 | |
| 311 | L | A | -0.2404 | |
| 312 | N | A | 0.0000 | |
| 313 | Q | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | I | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.6942 | |
| 319 | N | A | -0.6683 | |
| 320 | Q | A | -0.6357 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3854 | |
| 331 | A | A | 0.0000 | |
| 332 | T | A | -0.6109 | |
| 333 | I | A | -0.7697 | |
| 334 | E | A | -1.9385 | |
| 335 | T | A | -1.2541 | |
| 336 | I | A | -0.2891 | |
| 337 | K | A | -1.2033 | |
| 338 | T | A | -0.4320 | |
| 339 | K | A | -0.8002 | |
| 340 | I | A | 1.2345 | |
| 341 | S | A | 0.1904 | |
| 342 | T | A | -0.1698 | |
| 343 | P | A | -0.5286 | |
| 344 | A | A | -0.1882 | |
| 345 | I | A | 0.2150 | |
| 346 | N | A | -0.0108 | |
| 347 | V | A | 1.6641 | |
| 348 | Y | A | 1.4473 | |
| 349 | D | A | -0.0933 | |
| 350 | P | A | -0.3956 | |
| 351 | S | A | -0.0836 | |
| 352 | N | A | 0.1165 | |
| 353 | Y | A | 0.3328 | |
| 354 | V | A | 1.2635 | |
| 355 | T | A | -0.1770 | |
| 356 | S | A | -0.8290 | |
| 357 | K | A | -2.0462 | |
| 358 | R | A | -1.4586 | |
| 359 | Y | A | 0.0000 | |
| 360 | S | A | -0.4736 | |
| 361 | E | A | 0.0000 | |
| 362 | S | A | 0.3909 | |
| 363 | Y | A | 0.0000 | |
| 364 | Q | A | -0.0621 | |
| 365 | L | A | 0.0000 | |
| 366 | E | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | V | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.6121 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.8395 | |
| 376 | L | A | -0.5381 | |
| 377 | T | A | -0.6413 | |
| 378 | P | A | -0.9711 | |
| 379 | E | A | -1.7904 | |
| 380 | V | A | 0.0000 | |
| 381 | L | A | -0.3831 | |
| 382 | A | A | -0.7723 | |
| 383 | E | A | 0.0000 | |
| 384 | L | A | 0.0000 | |
| 385 | A | A | -0.5611 | |
| 386 | R | A | -1.3440 | |
| 387 | L | A | -0.4719 | |
| 388 | D | A | 0.0000 | |
| 389 | P | A | -0.7238 | |
| 390 | R | A | -1.1093 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -0.6057 | |
| 393 | V | A | -1.1896 | |
| 394 | D | A | -1.6809 | |
| 395 | A | A | -1.3832 | |
| 396 | R | A | -2.3214 | |
| 397 | L | A | -1.6481 | |
| 398 | P | A | -1.4417 | |
| 399 | E | A | -1.9519 | |
| 400 | I | A | -0.6745 | |
| 401 | P | A | -0.4870 | |
| 402 | P | A | -0.7358 | |
| 403 | V | A | 0.2120 | |
| 404 | E | A | -2.1393 | |
| 405 | R | A | -2.4951 | |
| 406 | P | A | -1.8045 | |
| 407 | D | A | -1.7468 | |
| 408 | P | A | -0.8908 | |
| 409 | Y | A | -0.4401 | |
| 410 | A | A | -0.5988 | |
| 411 | G | A | -0.6538 | |
| 412 | L | A | -0.4715 | |
| 413 | K | A | -1.8900 | |
| 414 | F | A | -1.3641 | |
| 415 | R | A | -1.7174 | |
| 416 | E | A | -2.5762 | |
| 417 | I | A | 0.0000 | |
| 418 | D | A | -2.5927 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.3672 | |
| 421 | N | A | -1.7753 | |
| 422 | K | A | -1.5212 | |
| 423 | L | A | -0.5153 | |
| 424 | S | A | -0.9675 | |
| 425 | T | A | -0.8991 | |
| 426 | D | A | -2.3860 | |
| 427 | L | A | 0.0000 | |
| 428 | E | A | -3.3683 | |
| 429 | K | A | -3.1358 | |
| 430 | Y | A | -1.8382 | |
| 431 | P | A | -1.1760 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.4938 | |
| 435 | A | A | -1.2886 | |
| 436 | Y | A | -0.8054 | |
| 437 | L | A | -0.5649 | |
| 438 | N | A | -2.0074 | |
| 439 | R | A | -2.1413 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine