| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIVVNGKVLVPKVSGYQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTVGHPLFNKLGDTENPTAPQHCGADDRVAFSFDPKQTQLFIVGCEPPTGEHWDLAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYRRCGPDGVPLPAAPPPSPLYKKPPPSSPYAVPPPTDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPPVNVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:07)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9485 | |
| 2 | L | A | 1.9709 | |
| 3 | P | A | 0.6559 | |
| 4 | P | A | 0.3487 | |
| 5 | T | A | 0.1108 | |
| 6 | T | A | 0.1358 | |
| 7 | P | A | 0.1918 | |
| 8 | V | A | 1.2250 | |
| 9 | A | A | 0.0309 | |
| 10 | K | A | -1.1672 | |
| 11 | V | A | -0.4151 | |
| 12 | Q | A | -1.5321 | |
| 13 | S | A | -1.6065 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4306 | |
| 16 | E | A | -2.4440 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4525 | |
| 20 | P | A | 0.1048 | |
| 21 | T | A | 0.1143 | |
| 22 | S | A | -0.1689 | |
| 23 | L | A | 0.0000 | |
| 24 | F | A | -0.0863 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2748 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.8752 | |
| 31 | R | A | -2.6401 | |
| 32 | L | A | -0.7675 | |
| 33 | L | A | 1.1816 | |
| 34 | T | A | 1.5573 | |
| 35 | V | A | 1.8297 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2575 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6423 | |
| 40 | K | A | -1.6912 | |
| 41 | D | A | -0.7442 | |
| 42 | I | A | 1.2645 | |
| 43 | V | A | 2.2148 | |
| 44 | V | A | 1.6574 | |
| 45 | N | A | -0.5215 | |
| 46 | G | A | -0.3583 | |
| 47 | K | A | -0.1208 | |
| 48 | V | A | 2.0352 | |
| 49 | L | A | 2.5434 | |
| 50 | V | A | 1.4683 | |
| 51 | P | A | 0.3485 | |
| 52 | K | A | -0.6862 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1598 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.4654 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2997 | |
| 70 | K | A | -1.8149 | |
| 71 | F | A | -0.6706 | |
| 72 | A | A | -0.5861 | |
| 73 | L | A | -0.8783 | |
| 74 | P | A | -1.2681 | |
| 75 | Q | A | -2.4708 | |
| 76 | K | A | -3.0883 | |
| 77 | D | A | -2.9792 | |
| 78 | F | A | -1.6356 | |
| 79 | Y | A | -1.8861 | |
| 80 | D | A | -2.7292 | |
| 81 | P | A | -2.4108 | |
| 82 | E | A | -3.0725 | |
| 83 | K | A | -3.4418 | |
| 84 | E | A | -2.5035 | |
| 85 | R | A | -1.3180 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6279 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9812 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3147 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6676 | |
| 99 | G | A | -0.5403 | |
| 100 | P | A | -0.4138 | |
| 101 | L | A | 0.0213 | |
| 102 | G | A | -0.2344 | |
| 103 | K | A | -0.6535 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.4442 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.1455 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.4349 | |
| 110 | L | A | 0.3007 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.0849 | |
| 113 | K | A | -0.3279 | |
| 114 | L | A | -0.9492 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.5140 | |
| 117 | T | A | -1.3676 | |
| 118 | E | A | -2.5751 | |
| 119 | N | A | -2.4205 | |
| 120 | P | A | -1.7074 | |
| 121 | T | A | -0.8959 | |
| 122 | A | A | -0.6523 | |
| 123 | P | A | -0.5593 | |
| 124 | Q | A | -1.1036 | |
| 125 | H | A | -1.0060 | |
| 126 | C | A | -1.1507 | |
| 127 | G | A | -1.4197 | |
| 128 | A | A | -1.2956 | |
| 129 | D | A | -2.1674 | |
| 130 | D | A | -1.7678 | |
| 131 | R | A | -1.1122 | |
| 132 | V | A | 0.2370 | |
| 133 | A | A | 0.4505 | |
| 134 | F | A | 0.2738 | |
| 135 | S | A | -0.0741 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.6778 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5680 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2364 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1522 | |
| 157 | D | A | 0.3304 | |
| 158 | L | A | 0.8354 | |
| 159 | A | A | 0.1802 | |
| 160 | E | A | -1.4527 | |
| 161 | P | A | -0.2392 | |
| 162 | C | A | 0.1742 | |
| 163 | P | A | -0.1657 | |
| 164 | G | A | -0.0691 | |
| 165 | L | A | 0.5967 | |
| 166 | P | A | -0.1079 | |
| 167 | P | A | -0.3387 | |
| 168 | G | A | -0.4199 | |
| 169 | A | A | 0.2971 | |
| 170 | C | A | 1.0104 | |
| 171 | P | A | 0.5216 | |
| 172 | P | A | 0.7711 | |
| 173 | I | A | 1.9719 | |
| 174 | Q | A | 0.8462 | |
| 175 | L | A | 1.5059 | |
| 176 | V | A | 0.8586 | |
| 177 | N | A | -0.3354 | |
| 178 | S | A | 0.0066 | |
| 179 | V | A | 0.3723 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3641 | |
| 182 | D | A | 0.0663 | |
| 183 | G | A | -0.1574 | |
| 184 | D | A | -0.5906 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | -0.4793 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.0993 | |
| 190 | F | A | 0.0140 | |
| 191 | G | A | -0.1622 | |
| 192 | N | A | -0.3358 | |
| 193 | M | A | -0.1701 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.4203 | |
| 197 | E | A | -2.6193 | |
| 198 | L | A | -1.2359 | |
| 199 | Q | A | -2.5568 | |
| 200 | Q | A | -3.3313 | |
| 201 | D | A | -3.5908 | |
| 202 | R | A | -3.3367 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.1844 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3802 | |
| 211 | S | A | -1.9104 | |
| 212 | T | A | -1.4925 | |
| 213 | R | A | -2.2065 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.2116 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.2716 | |
| 220 | L | A | 0.4646 | |
| 221 | K | A | -1.3799 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.9878 | |
| 224 | N | A | -1.7158 | |
| 225 | E | A | -1.3308 | |
| 226 | A | A | -0.6711 | |
| 227 | Y | A | -0.4559 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.7247 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | -0.1431 | |
| 234 | F | A | 0.0311 | |
| 235 | G | A | -0.9425 | |
| 236 | R | A | -2.7269 | |
| 237 | R | A | -3.0407 | |
| 238 | E | A | -2.2132 | |
| 239 | Q | A | -0.1912 | |
| 240 | V | A | 1.5523 | |
| 241 | Y | A | 1.2463 | |
| 242 | A | A | 0.1369 | |
| 243 | R | A | -1.1893 | |
| 244 | H | A | -1.2560 | |
| 245 | F | A | -0.3307 | |
| 246 | Y | A | 0.0000 | |
| 247 | R | A | 0.0000 | |
| 248 | R | A | -0.5731 | |
| 249 | C | A | -1.0007 | |
| 250 | G | A | -0.9363 | |
| 251 | P | A | -0.5084 | |
| 252 | D | A | -0.3678 | |
| 253 | G | A | 0.0647 | |
| 254 | V | A | 1.3038 | |
| 255 | P | A | 0.3774 | |
| 256 | L | A | 0.8698 | |
| 257 | P | A | 0.4579 | |
| 258 | A | A | -0.2506 | |
| 259 | A | A | -0.6415 | |
| 260 | P | A | -0.9584 | |
| 261 | P | A | -1.1465 | |
| 262 | P | A | -0.8495 | |
| 263 | S | A | -0.5644 | |
| 264 | P | A | 0.1531 | |
| 265 | L | A | 1.0649 | |
| 266 | Y | A | -0.2602 | |
| 267 | K | A | -2.2890 | |
| 268 | K | A | -2.2233 | |
| 269 | P | A | -1.0465 | |
| 270 | P | A | -0.9524 | |
| 271 | P | A | -0.3627 | |
| 272 | S | A | -0.3494 | |
| 273 | S | A | 0.1510 | |
| 274 | P | A | 0.1661 | |
| 275 | Y | A | 0.8622 | |
| 276 | A | A | 0.7372 | |
| 277 | V | A | 1.6464 | |
| 278 | P | A | 0.6892 | |
| 279 | P | A | -0.0384 | |
| 280 | P | A | -0.2092 | |
| 281 | T | A | -0.2091 | |
| 282 | D | A | -0.7136 | |
| 283 | Y | A | 0.8026 | |
| 284 | F | A | 0.6420 | |
| 285 | G | A | 0.0718 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9329 | |
| 291 | L | A | 1.6247 | |
| 292 | V | A | 0.6244 | |
| 293 | S | A | -0.1543 | |
| 294 | S | A | -0.9726 | |
| 295 | D | A | -1.8451 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1710 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6629 | |
| 301 | R | A | -1.9679 | |
| 302 | P | A | -1.0276 | |
| 303 | F | A | -0.2005 | |
| 304 | W | A | -0.5215 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0778 | |
| 307 | R | A | -2.9202 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.7751 | |
| 310 | G | A | -1.4099 | |
| 311 | N | A | -1.3871 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.8911 | |
| 319 | N | A | -0.8902 | |
| 320 | E | A | -1.0549 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3551 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.0941 | |
| 333 | N | A | 0.5463 | |
| 334 | F | A | 1.7537 | |
| 335 | T | A | 0.8957 | |
| 336 | I | A | 0.4888 | |
| 337 | S | A | -0.8054 | |
| 338 | Q | A | -1.4558 | |
| 339 | Q | A | -0.7990 | |
| 340 | L | A | 0.8674 | |
| 341 | C | A | 0.5187 | |
| 342 | T | A | 0.2183 | |
| 343 | P | A | -0.1957 | |
| 344 | P | A | 0.1714 | |
| 345 | V | A | 0.7449 | |
| 346 | N | A | 0.0456 | |
| 347 | V | A | 1.7620 | |
| 348 | Y | A | 1.5996 | |
| 349 | D | A | 0.1371 | |
| 350 | P | A | -0.3116 | |
| 351 | S | A | -0.2492 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.4956 | |
| 354 | K | A | -1.6385 | |
| 355 | N | A | -1.6796 | |
| 356 | Y | A | -0.0426 | |
| 357 | L | A | 0.6653 | |
| 358 | R | A | 0.9592 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.3655 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0177 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -1.9148 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6574 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.3129 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3441 | |
| 376 | L | A | -1.7587 | |
| 377 | D | A | -2.0448 | |
| 378 | P | A | -1.0662 | |
| 379 | G | A | -1.0194 | |
| 380 | V | A | -0.9327 | |
| 381 | L | A | -0.5343 | |
| 382 | A | A | -0.6544 | |
| 383 | H | A | -0.8458 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.3924 | |
| 386 | T | A | -0.5727 | |
| 387 | M | A | -0.3286 | |
| 388 | N | A | -0.8638 | |
| 389 | P | A | -1.2603 | |
| 390 | T | A | -1.5117 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.5253 | |
| 393 | E | A | -2.9094 | |
| 394 | N | A | -2.6097 | |
| 395 | W | A | -1.5295 | |
| 396 | N | A | -1.4433 | |
| 397 | L | A | -0.2638 | |
| 398 | G | A | 0.4883 | |
| 399 | F | A | 2.4096 | |
| 400 | V | A | 1.8396 | |
| 401 | P | A | 0.0303 | |
| 402 | P | A | -1.8630 | |
| 403 | K | A | -3.4786 | |
| 404 | E | A | -3.8000 | |
| 405 | R | A | -4.0168 | |
| 406 | E | A | -3.8028 | |
| 407 | D | A | -2.8729 | |
| 408 | P | A | -1.7621 | |
| 409 | Y | A | -0.9937 | |
| 410 | K | A | -2.0976 | |
| 411 | G | A | -0.6397 | |
| 412 | L | A | 0.6561 | |
| 413 | I | A | 1.5673 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.4272 | |
| 416 | E | A | -1.7339 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9598 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0778 | |
| 421 | E | A | -2.8004 | |
| 422 | R | A | -2.6014 | |
| 423 | F | A | -1.3033 | |
| 424 | S | A | -1.4583 | |
| 425 | Q | A | -1.7676 | |
| 426 | D | A | -2.8805 | |
| 427 | L | A | -1.9668 | |
| 428 | D | A | -2.7582 | |
| 429 | Q | A | -2.5994 | |
| 430 | F | A | -1.4119 | |
| 431 | A | A | -0.8684 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.4923 | |
| 435 | K | A | -0.6721 | |
| 436 | F | A | 0.1818 | |
| 437 | L | A | 1.0569 | |
| 438 | Y | A | 0.8504 | |
| 439 | Q | A | -0.2513 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine