Project name: 1348

Chain sequence(s)	H: EVQLLESGGGSVQPGGSLRLSCAASGVTYSHYWLAWFRQAPGKEREGVAAIYTNDGTTYYGDSVKGRFTISLDNSKNTLYLQMSSLTAEDTAVYYCALRGNDGSWFSPLLPYHYNYWGQGTQVTVSS
Selected Chain(s)	H
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with H chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:00:41)
[INFO]       Main:     Simulation completed successfully.                                          (00:00:41)

• Minimal score value: -2.9609
• Maximal score value: 2.3351
• Average score: -0.6864
• Total score value: -87.1697

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-2.0968
2	V	H	0.0000
3	Q	H	-1.3062
4	L	H	0.0000
5	L	H	0.9285
6	E	H	0.1803
7	S	H	-0.2900
8	G	H	-0.8439
9	G	H	-0.8636
11	G	H	-0.6816
12	S	H	-0.6667
13	V	H	-0.7527
14	Q	H	-1.5514
15	P	H	-1.3633
16	G	H	-1.0626
17	G	H	-0.9063
18	S	H	-0.9932
19	L	H	-1.0018
20	R	H	-1.6216
21	L	H	0.0000
22	S	H	0.0000
23	C	H	0.0000
24	A	H	-0.1262
25	A	H	-0.5151
26	S	H	-0.7372
27	G	H	-0.9043
28	V	H	-0.5894
29	T	H	-0.1255
30	Y	H	-0.2770
35	S	H	-1.0081
36	H	H	-1.9678
37	Y	H	0.0000
38	W	H	0.0000
39	L	H	0.0000
40	A	H	0.0000
41	W	H	0.0000
42	F	H	0.0000
43	R	H	0.0000
44	Q	H	-1.5127
45	A	H	-1.4701
46	P	H	-1.1620
47	G	H	-1.5505
48	K	H	-2.5854
49	E	H	-2.9609
50	R	H	-1.7389
51	E	H	-1.2785
52	G	H	-0.5905
53	V	H	0.0000
54	A	H	0.0000
55	A	H	0.0000
56	I	H	0.0000
57	Y	H	-0.5229
58	T	H	-1.2049
59	N	H	-1.9762
62	D	H	-2.3859
63	G	H	-1.4461
64	T	H	-0.5466
65	T	H	-0.1504
66	Y	H	0.1107
67	Y	H	-0.7530
68	G	H	-1.2027
69	D	H	-2.3951
70	S	H	-1.7895
71	V	H	0.0000
72	K	H	-2.5406
74	G	H	-1.6887
75	R	H	-1.3565
76	F	H	0.0000
77	T	H	-0.8901
78	I	H	0.0000
79	S	H	-0.3112
80	L	H	-0.5940
81	D	H	-1.5458
82	N	H	-2.3370
83	S	H	-1.8517
84	K	H	-2.5434
85	N	H	-1.9045
86	T	H	-0.9817
87	L	H	0.0000
88	Y	H	-0.2674
89	L	H	0.0000
90	Q	H	-1.4647
91	M	H	0.0000
92	S	H	-0.9253
93	S	H	-0.8022
94	L	H	0.0000
95	T	H	-1.1291
96	A	H	-1.1609
97	E	H	-1.8676
98	D	H	0.0000
99	T	H	-0.7242
100	A	H	0.0000
101	V	H	-0.2323
102	Y	H	0.0000
103	Y	H	-0.0711
104	C	H	0.0000
105	A	H	0.0000
106	L	H	0.0000
107	R	H	-1.4785
108	G	H	-1.9222
109	N	H	-2.8808
110	D	H	-2.8271
111	G	H	-1.2604
111A	S	H	-0.0514
111B	W	H	1.4733
111C	F	H	2.3351
112D	S	H	1.3966
112C	P	H	0.0000
112B	L	H	0.9594
112A	L	H	0.8412
112	P	H	0.2410
113	Y	H	0.9976
114	H	H	-0.1564
115	Y	H	0.0000
116	N	H	-1.2639
117	Y	H	-0.7621
118	W	H	-0.0874
119	G	H	-0.1410
120	Q	H	-0.8945
121	G	H	-0.4107
122	T	H	-0.5011
123	Q	H	-0.8295
124	V	H	0.0000
125	T	H	-0.7297
126	V	H	0.0000
127	S	H	-0.9803
128	S	H	-0.7913