| Chain sequence(s) |
A: NNSSSLEVSRNGRSLGEYYRDDHYDYDPRGRRGSRWQEEEDMYNPRMRGGNPDYYDERSGGYRSGPDDRNTYHNVHPIPAYDDQRDDKDNVIRPDQPAPVKPDGDDTGKGDDSSVTPSPENPDDPNNPPSTTETPGNSDGEHKDDEGNVIRPAGKHVVKPDDEKDDKSDNDPIKPNVPSEHHHDGSHDGSDDGSHDGSHPDQPGHHDGLKGTMSQGPYGPDPRGDRSGDEREFRHNQHGRVFDDRRGRGGFDDYNGPDGYGSDYGRRYGDDGREIHYSRSEKSFDDEYHGRGGDDRSFHFSKTNRVIDENMPYPPNGPFRGGDNRSIRSEQIAAMNYEEQFHQGPRGGRMGSANPFNVPPRGGRDDDHTFHSA
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:04:59)
[INFO] Main: Simulation completed successfully. (00:05:03)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | N | A | -1.9720 | |
| 2 | N | A | -2.0759 | |
| 3 | S | A | -1.1488 | |
| 4 | S | A | -0.6841 | |
| 5 | S | A | -0.2825 | |
| 6 | L | A | 0.7675 | |
| 7 | E | A | -0.9245 | |
| 8 | V | A | 0.0016 | |
| 9 | S | A | -1.4160 | |
| 10 | R | A | -2.7553 | |
| 11 | N | A | -2.6651 | |
| 12 | G | A | -2.1934 | |
| 13 | R | A | -2.5073 | |
| 14 | S | A | -1.1338 | |
| 15 | L | A | -0.1281 | |
| 16 | G | A | -0.6263 | |
| 17 | E | A | -1.1382 | |
| 18 | Y | A | 0.4322 | |
| 19 | Y | A | -0.3337 | |
| 20 | R | A | -2.4894 | |
| 21 | D | A | -3.1268 | |
| 22 | D | A | -3.2041 | |
| 23 | H | A | -2.2608 | |
| 24 | Y | A | -0.6694 | |
| 25 | D | A | -1.5251 | |
| 26 | Y | A | -0.5301 | |
| 27 | D | A | -2.4562 | |
| 28 | P | A | -2.2092 | |
| 29 | R | A | -3.2352 | |
| 30 | G | A | -3.1943 | |
| 31 | R | A | -3.7781 | |
| 32 | R | A | -3.5738 | |
| 33 | G | A | -2.4336 | |
| 34 | S | A | -1.8488 | |
| 35 | R | A | -2.3653 | |
| 36 | W | A | -1.4922 | |
| 37 | Q | A | -3.2540 | |
| 38 | E | A | -3.9793 | |
| 39 | E | A | -3.8114 | |
| 40 | E | A | -3.7451 | |
| 41 | D | A | -3.2922 | |
| 42 | M | A | -0.6729 | |
| 43 | Y | A | -0.1620 | |
| 44 | N | A | -1.7623 | |
| 45 | P | A | -1.5991 | |
| 46 | R | A | -2.2307 | |
| 47 | M | A | -1.5348 | |
| 48 | R | A | -2.7713 | |
| 49 | G | A | -1.8824 | |
| 50 | G | A | -1.6599 | |
| 51 | N | A | -2.0207 | |
| 52 | P | A | -1.2845 | |
| 53 | D | A | -1.5317 | |
| 54 | Y | A | 0.0349 | |
| 55 | Y | A | -0.2113 | |
| 56 | D | A | -1.9211 | |
| 57 | E | A | -2.8415 | |
| 58 | R | A | -3.1884 | |
| 59 | S | A | -1.9304 | |
| 60 | G | A | -1.6916 | |
| 61 | G | A | -0.9173 | |
| 62 | Y | A | -0.0585 | |
| 63 | R | A | -1.6812 | |
| 64 | S | A | -1.8245 | |
| 65 | G | A | -1.8475 | |
| 66 | P | A | -1.9855 | |
| 67 | D | A | -3.0725 | |
| 68 | D | A | -3.1380 | |
| 69 | R | A | -3.2858 | |
| 70 | N | A | -2.7157 | |
| 71 | T | A | -1.2537 | |
| 72 | Y | A | 0.0254 | |
| 73 | H | A | -1.2052 | |
| 74 | N | A | -1.0179 | |
| 75 | V | A | 0.9378 | |
| 76 | H | A | -0.2342 | |
| 77 | P | A | 0.5131 | |
| 78 | I | A | 1.9849 | |
| 79 | P | A | 0.6383 | |
| 80 | A | A | 0.3135 | |
| 81 | Y | A | -0.2461 | |
| 82 | D | A | -3.1459 | |
| 83 | D | A | -4.0800 | |
| 84 | Q | A | -4.6926 | |
| 85 | R | A | -5.3615 | |
| 86 | D | A | -5.6520 | |
| 87 | D | A | -5.2880 | |
| 88 | K | A | -4.6324 | |
| 89 | D | A | -3.6139 | |
| 90 | N | A | -2.3034 | |
| 91 | V | A | 0.3011 | |
| 92 | I | A | 0.7686 | |
| 93 | R | A | -1.6242 | |
| 94 | P | A | -1.6221 | |
| 95 | D | A | -2.8427 | |
| 96 | Q | A | -2.4338 | |
| 97 | P | A | -1.1202 | |
| 98 | A | A | -0.3218 | |
| 99 | P | A | -0.1034 | |
| 100 | V | A | 0.4460 | |
| 101 | K | A | -1.5976 | |
| 102 | P | A | -1.9072 | |
| 103 | D | A | -2.9978 | |
| 104 | G | A | -3.0666 | |
| 105 | D | A | -3.4113 | |
| 106 | D | A | -3.4548 | |
| 107 | T | A | -2.2892 | |
| 108 | G | A | -2.4861 | |
| 109 | K | A | -3.1243 | |
| 110 | G | A | -2.8774 | |
| 111 | D | A | -3.4998 | |
| 112 | D | A | -2.9545 | |
| 113 | S | A | -1.2881 | |
| 114 | S | A | -0.2488 | |
| 115 | V | A | 1.2625 | |
| 116 | T | A | 0.4962 | |
| 117 | P | A | -0.2800 | |
| 118 | S | A | -0.8764 | |
| 119 | P | A | -1.6641 | |
| 120 | E | A | -3.1175 | |
| 121 | N | A | -3.1919 | |
| 122 | P | A | -2.6684 | |
| 123 | D | A | -3.5779 | |
| 124 | D | A | -3.8820 | |
| 125 | P | A | -2.5749 | |
| 126 | N | A | -2.8312 | |
| 127 | N | A | -2.5306 | |
| 128 | P | A | -1.3876 | |
| 129 | P | A | -0.9401 | |
| 130 | S | A | -0.8364 | |
| 131 | T | A | -0.7985 | |
| 132 | T | A | -1.1237 | |
| 133 | E | A | -2.0494 | |
| 134 | T | A | -1.3635 | |
| 135 | P | A | -1.2728 | |
| 136 | G | A | -1.6861 | |
| 137 | N | A | -2.2012 | |
| 138 | S | A | -2.1685 | |
| 139 | D | A | -3.0768 | |
| 140 | G | A | -2.8811 | |
| 141 | E | A | -3.6665 | |
| 142 | H | A | -3.7015 | |
| 143 | K | A | -4.3024 | |
| 144 | D | A | -4.5401 | |
| 145 | D | A | -4.4279 | |
| 146 | E | A | -3.6912 | |
| 147 | G | A | -2.0353 | |
| 148 | N | A | -0.9687 | |
| 149 | V | A | 1.2080 | |
| 150 | I | A | 1.4992 | |
| 151 | R | A | -0.6998 | |
| 152 | P | A | -0.7292 | |
| 153 | A | A | -1.0185 | |
| 154 | G | A | -1.6037 | |
| 155 | K | A | -1.7045 | |
| 156 | H | A | -0.7828 | |
| 157 | V | A | 1.1142 | |
| 158 | V | A | 1.0011 | |
| 159 | K | A | -1.2977 | |
| 160 | P | A | -1.9684 | |
| 161 | D | A | -3.7095 | |
| 162 | D | A | -4.5100 | |
| 163 | E | A | -4.7228 | |
| 164 | K | A | -4.8004 | |
| 165 | D | A | -4.6642 | |
| 166 | D | A | -4.4394 | |
| 167 | K | A | -4.0487 | |
| 168 | S | A | -3.2519 | |
| 169 | D | A | -3.7656 | |
| 170 | N | A | -3.1037 | |
| 171 | D | A | -2.7815 | |
| 172 | P | A | -1.1970 | |
| 173 | I | A | 0.1947 | |
| 174 | K | A | -1.2479 | |
| 175 | P | A | -0.7677 | |
| 176 | N | A | -0.8067 | |
| 177 | V | A | 0.4480 | |
| 178 | P | A | -0.4443 | |
| 179 | S | A | -1.2789 | |
| 180 | E | A | -2.6144 | |
| 181 | H | A | -2.8954 | |
| 182 | H | A | -2.9793 | |
| 183 | H | A | -2.9601 | |
| 184 | D | A | -3.0236 | |
| 185 | G | A | -2.2467 | |
| 186 | S | A | -1.9663 | |
| 187 | H | A | -2.4101 | |
| 188 | D | A | -2.6547 | |
| 189 | G | A | -2.1323 | |
| 190 | S | A | -2.2645 | |
| 191 | D | A | -2.9880 | |
| 192 | D | A | -2.9907 | |
| 193 | G | A | -2.0830 | |
| 194 | S | A | -1.7810 | |
| 195 | H | A | -2.1897 | |
| 196 | D | A | -2.6008 | |
| 197 | G | A | -1.8909 | |
| 198 | S | A | -1.4285 | |
| 199 | H | A | -1.7266 | |
| 200 | P | A | -1.9426 | |
| 201 | D | A | -2.8367 | |
| 202 | Q | A | -2.5005 | |
| 203 | P | A | -1.8498 | |
| 204 | G | A | -1.7613 | |
| 205 | H | A | -2.3364 | |
| 206 | H | A | -2.5751 | |
| 207 | D | A | -2.4152 | |
| 208 | G | A | -1.4397 | |
| 209 | L | A | 0.0028 | |
| 210 | K | A | -1.1933 | |
| 211 | G | A | -0.7550 | |
| 212 | T | A | -0.2155 | |
| 213 | M | A | 0.2903 | |
| 214 | S | A | -0.3731 | |
| 215 | Q | A | -1.1725 | |
| 216 | G | A | -0.8659 | |
| 217 | P | A | -0.2625 | |
| 218 | Y | A | 0.4553 | |
| 219 | G | A | -0.5123 | |
| 220 | P | A | -1.3798 | |
| 221 | D | A | -2.5129 | |
| 222 | P | A | -2.4742 | |
| 223 | R | A | -3.3227 | |
| 224 | G | A | -3.0936 | |
| 225 | D | A | -3.4926 | |
| 226 | R | A | -3.4935 | |
| 227 | S | A | -2.5190 | |
| 228 | G | A | -2.8615 | |
| 229 | D | A | -3.9719 | |
| 230 | E | A | -4.0170 | |
| 231 | R | A | -3.9256 | |
| 232 | E | A | -3.1719 | |
| 233 | F | A | -0.9977 | |
| 234 | R | A | -2.6639 | |
| 235 | H | A | -2.6649 | |
| 236 | N | A | -2.9523 | |
| 237 | Q | A | -3.1731 | |
| 238 | H | A | -2.5228 | |
| 239 | G | A | -1.6069 | |
| 240 | R | A | -1.2956 | |
| 241 | V | A | 0.9004 | |
| 242 | F | A | 0.5862 | |
| 243 | D | A | -2.2472 | |
| 244 | D | A | -3.2692 | |
| 245 | R | A | -3.9548 | |
| 246 | R | A | -4.0027 | |
| 247 | G | A | -3.1401 | |
| 248 | R | A | -2.6175 | |
| 249 | G | A | -1.6192 | |
| 250 | G | A | -0.9248 | |
| 251 | F | A | 0.3129 | |
| 252 | D | A | -1.7734 | |
| 253 | D | A | -2.0650 | |
| 254 | Y | A | -0.4905 | |
| 255 | N | A | -1.6131 | |
| 256 | G | A | -1.6145 | |
| 257 | P | A | -1.5554 | |
| 258 | D | A | -1.9590 | |
| 259 | G | A | -0.9292 | |
| 260 | Y | A | 0.4220 | |
| 261 | G | A | -0.3049 | |
| 262 | S | A | -0.7997 | |
| 263 | D | A | -1.7159 | |
| 264 | Y | A | -0.5376 | |
| 265 | G | A | -1.4936 | |
| 266 | R | A | -2.6598 | |
| 267 | R | A | -2.1849 | |
| 268 | Y | A | -0.9028 | |
| 269 | G | A | -1.7176 | |
| 270 | D | A | -2.9483 | |
| 271 | D | A | -3.5153 | |
| 272 | G | A | -3.0382 | |
| 273 | R | A | -3.2679 | |
| 274 | E | A | -2.3530 | |
| 275 | I | A | 0.0676 | |
| 276 | H | A | -0.5684 | |
| 277 | Y | A | 0.4193 | |
| 278 | S | A | -0.8212 | |
| 279 | R | A | -2.5737 | |
| 280 | S | A | -2.3695 | |
| 281 | E | A | -3.1466 | |
| 282 | K | A | -2.6867 | |
| 283 | S | A | -1.2977 | |
| 284 | F | A | -0.3653 | |
| 285 | D | A | -2.2887 | |
| 286 | D | A | -2.8904 | |
| 287 | E | A | -2.5014 | |
| 288 | Y | A | -0.8225 | |
| 289 | H | A | -1.5364 | |
| 290 | G | A | -1.6992 | |
| 291 | R | A | -2.6032 | |
| 292 | G | A | -2.3206 | |
| 293 | G | A | -2.7034 | |
| 294 | D | A | -3.5125 | |
| 295 | D | A | -3.5692 | |
| 296 | R | A | -2.9682 | |
| 297 | S | A | -0.9465 | |
| 298 | F | A | 1.1440 | |
| 299 | H | A | 0.3507 | |
| 300 | F | A | 1.3787 | |
| 301 | S | A | -0.3188 | |
| 302 | K | A | -2.0369 | |
| 303 | T | A | -1.6323 | |
| 304 | N | A | -1.9900 | |
| 305 | R | A | -1.5122 | |
| 306 | V | A | 0.7041 | |
| 307 | I | A | 0.6159 | |
| 308 | D | A | -1.5115 | |
| 309 | E | A | -2.1865 | |
| 310 | N | A | -1.7752 | |
| 311 | M | A | 0.0003 | |
| 312 | P | A | 0.2172 | |
| 313 | Y | A | 0.9179 | |
| 314 | P | A | -0.0526 | |
| 315 | P | A | -0.8385 | |
| 316 | N | A | -1.2751 | |
| 317 | G | A | -1.0264 | |
| 318 | P | A | -0.4382 | |
| 319 | F | A | 0.4115 | |
| 320 | R | A | -1.5797 | |
| 321 | G | A | -1.6395 | |
| 322 | G | A | -2.4140 | |
| 323 | D | A | -3.2923 | |
| 324 | N | A | -3.0171 | |
| 325 | R | A | -3.2918 | |
| 326 | S | A | -2.1262 | |
| 327 | I | A | -0.7509 | |
| 328 | R | A | -2.1320 | |
| 329 | S | A | -1.4447 | |
| 330 | E | A | -1.8298 | |
| 331 | Q | A | -1.0450 | |
| 332 | I | A | 0.8763 | |
| 333 | A | A | -0.2706 | |
| 334 | A | A | -0.3368 | |
| 335 | M | A | -0.0557 | |
| 336 | N | A | -1.0623 | |
| 337 | Y | A | -0.1646 | |
| 338 | E | A | -2.1322 | |
| 339 | E | A | -2.8243 | |
| 340 | Q | A | -2.0562 | |
| 341 | F | A | -0.3630 | |
| 342 | H | A | -1.8165 | |
| 343 | Q | A | -2.0763 | |
| 344 | G | A | -1.6085 | |
| 345 | P | A | -1.7618 | |
| 346 | R | A | -2.7757 | |
| 347 | G | A | -2.0348 | |
| 348 | G | A | -1.8149 | |
| 349 | R | A | -2.0056 | |
| 350 | M | A | -0.3002 | |
| 351 | G | A | -0.7320 | |
| 352 | S | A | -0.7304 | |
| 353 | A | A | -0.4585 | |
| 354 | N | A | -1.0112 | |
| 355 | P | A | -0.0073 | |
| 356 | F | A | 1.2656 | |
| 357 | N | A | -0.0079 | |
| 358 | V | A | 1.0454 | |
| 359 | P | A | -0.1684 | |
| 360 | P | A | -1.1800 | |
| 361 | R | A | -2.3108 | |
| 362 | G | A | -2.3072 | |
| 363 | G | A | -2.7157 | |
| 364 | R | A | -3.9748 | |
| 365 | D | A | -4.3820 | |
| 366 | D | A | -4.3745 | |
| 367 | D | A | -3.6934 | |
| 368 | H | A | -2.2017 | |
| 369 | T | A | -0.5968 | |
| 370 | F | A | 0.9092 | |
| 371 | H | A | -0.2615 | |
| 372 | S | A | -0.1692 | |
| 373 | A | A | -0.0732 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine