Chain sequence(s) |
A: MLALFFSLAPLLSQALPLGYTAAPAESFYFWPENISSLQAGEIFRKRELLTLPDIFDFGPNLEKVVQVAYKTRLTDGNDSFSIASIFIPKNPSPELKLYSYQTFEDAVQLDCAPSYALEVGNKSSNYLPVTSNLSAISRELEKGRHCIIPDHEGYISGFFAGRQEGYAGLDGIRAARNYLNGTNETPIGIFGYSGGAQATAWIVDLHDEYAPDLNFVGTVSGGTLVDAWGTFQYIDYPKVYLKGSILIMYTGLFSGYPAQFEVIWPYIEPVIQENMLLLRLAPNDCNQSPILQGYNNSIMAGIHVDLPEFPASKYIFQHESLLANYSVVPVSTPKFPRYMYHGGSDELAKLSLVEQYVDQQWNTGANLTFVVYPGLLHDETAYRGFDAAMDWLDAQLDSGYLPPVNSTHT
input PDB |
Selected Chain(s) | A |
Distance of aggregation | 10 Å |
FoldX usage | Yes |
Dynamic mode | No |
Automated mutations | Yes |
Downloads | Download all the data |
Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00) [WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow to prevent this behavior) (00:00:00) [INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00) [INFO] runJob: Creating pdb object from: input.pdb (00:00:00) [INFO] FoldX: Starting FoldX energy minimalization (00:00:00) [INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:03:42) [INFO] Auto_mut: Residue number 5 from chain A and a score of 3.988 (phenylalanine) selected for automated muatation (00:03:45) [INFO] Auto_mut: Residue number 6 from chain A and a score of 3.645 (phenylalanine) selected for automated muatation (00:03:45) [INFO] Auto_mut: Residue number 4 from chain A and a score of 3.550 (leucine) selected for automated muatation (00:03:45) [INFO] Auto_mut: Residue number 2 from chain A and a score of 2.742 (leucine) selected for automated muatation (00:03:45) [INFO] Auto_mut: Residue number 3 from chain A and a score of 2.534 (alanine) selected for automated muatation (00:03:45) [INFO] Auto_mut: Residue number 8 from chain A and a score of 2.421 (leucine) selected for automated muatation (00:03:45) [INFO] Auto_mut: Mutating residue number 5 from chain A (phenylalanine) into glutamic acid (00:03:45) [INFO] Auto_mut: Mutating residue number 5 from chain A (phenylalanine) into aspartic acid (00:03:45) [INFO] Auto_mut: Mutating residue number 6 from chain A (phenylalanine) into glutamic acid (00:03:45) [INFO] Auto_mut: Mutating residue number 5 from chain A (phenylalanine) into lysine (00:05:24) [INFO] Auto_mut: Mutating residue number 5 from chain A (phenylalanine) into arginine (00:05:27) [INFO] Auto_mut: Mutating residue number 6 from chain A (phenylalanine) into lysine (00:05:28) [INFO] Auto_mut: Mutating residue number 6 from chain A (phenylalanine) into aspartic acid (00:07:06) [INFO] Auto_mut: Mutating residue number 4 from chain A (leucine) into glutamic acid (00:07:09) [INFO] Auto_mut: Mutating residue number 4 from chain A (leucine) into aspartic acid (00:07:12) [INFO] Auto_mut: Mutating residue number 6 from chain A (phenylalanine) into arginine (00:08:41) [INFO] Auto_mut: Mutating residue number 4 from chain A (leucine) into lysine (00:08:53) [INFO] Auto_mut: Mutating residue number 4 from chain A (leucine) into arginine (00:08:56) [INFO] Auto_mut: Mutating residue number 2 from chain A (leucine) into glutamic acid (00:10:20) [INFO] Auto_mut: Mutating residue number 2 from chain A (leucine) into aspartic acid (00:10:37) [INFO] Auto_mut: Mutating residue number 3 from chain A (alanine) into glutamic acid (00:10:41) [INFO] Auto_mut: Mutating residue number 2 from chain A (leucine) into lysine (00:11:58) [INFO] Auto_mut: Mutating residue number 2 from chain A (leucine) into arginine (00:12:22) [INFO] Auto_mut: Mutating residue number 3 from chain A (alanine) into lysine (00:12:25) [INFO] Auto_mut: Mutating residue number 3 from chain A (alanine) into aspartic acid (00:13:39) [INFO] Auto_mut: Mutating residue number 8 from chain A (leucine) into glutamic acid (00:14:04) [INFO] Auto_mut: Mutating residue number 8 from chain A (leucine) into aspartic acid (00:14:11) [INFO] Auto_mut: Mutating residue number 3 from chain A (alanine) into arginine (00:15:17) [INFO] Auto_mut: Mutating residue number 8 from chain A (leucine) into lysine (00:15:47) [INFO] Auto_mut: Mutating residue number 8 from chain A (leucine) into arginine (00:15:54) [INFO] Auto_mut: Effect of mutation residue number 5 from chain A (phenylalanine) into glutamic acid: Energy difference: -0.1527 kcal/mol, Difference in average score from the base case: -0.0200 (00:17:39) [INFO] Auto_mut: Effect of mutation residue number 5 from chain A (phenylalanine) into lysine: Energy difference: -0.0833 kcal/mol, Difference in average score from the base case: -0.0192 (00:17:39) [INFO] Auto_mut: Effect of mutation residue number 5 from chain A (phenylalanine) into aspartic acid: Energy difference: -0.1465 kcal/mol, Difference in average score from the base case: -0.0198 (00:17:39) [INFO] Auto_mut: Effect of mutation residue number 5 from chain A (phenylalanine) into arginine: Energy difference: -0.4197 kcal/mol, Difference in average score from the base case: -0.0202 (00:17:39) [INFO] Auto_mut: Effect of mutation residue number 6 from chain A (phenylalanine) into glutamic acid: Energy difference: -0.0534 kcal/mol, Difference in average score from the base case: -0.0193 (00:17:39) [INFO] Auto_mut: Effect of mutation residue number 6 from chain A (phenylalanine) into lysine: Energy difference: 0.1173 kcal/mol, Difference in average score from the base case: -0.0190 (00:17:39) [INFO] Auto_mut: Effect of mutation residue number 6 from chain A (phenylalanine) into aspartic acid: Energy difference: 0.1541 kcal/mol, Difference in average score from the base case: -0.0191 (00:17:39) [INFO] Auto_mut: Effect of mutation residue number 6 from chain A (phenylalanine) into arginine: Energy difference: -0.3463 kcal/mol, Difference in average score from the base case: -0.0195 (00:17:39) [INFO] Auto_mut: Effect of mutation residue number 4 from chain A (leucine) into glutamic acid: Energy difference: -0.5072 kcal/mol, Difference in average score from the base case: -0.0173 (00:17:39) [INFO] Auto_mut: Effect of mutation residue number 4 from chain A (leucine) into lysine: Energy difference: 0.0379 kcal/mol, Difference in average score from the base case: -0.0170 (00:17:39) [INFO] Auto_mut: Effect of mutation residue number 4 from chain A (leucine) into aspartic acid: Energy difference: -0.0666 kcal/mol, Difference in average score from the base case: -0.0170 (00:17:39) [INFO] Auto_mut: Effect of mutation residue number 4 from chain A (leucine) into arginine: Energy difference: -0.2307 kcal/mol, Difference in average score from the base case: -0.0174 (00:17:39) [INFO] Auto_mut: Effect of mutation residue number 2 from chain A (leucine) into glutamic acid: Energy difference: -0.2174 kcal/mol, Difference in average score from the base case: -0.0142 (00:17:39) [INFO] Auto_mut: Effect of mutation residue number 2 from chain A (leucine) into lysine: Energy difference: 0.0628 kcal/mol, Difference in average score from the base case: -0.0135 (00:17:39) [INFO] Auto_mut: Effect of mutation residue number 2 from chain A (leucine) into aspartic acid: Energy difference: 0.2198 kcal/mol, Difference in average score from the base case: -0.0139 (00:17:39) [INFO] Auto_mut: Effect of mutation residue number 2 from chain A (leucine) into arginine: Energy difference: -0.0013 kcal/mol, Difference in average score from the base case: -0.0135 (00:17:40) [INFO] Auto_mut: Effect of mutation residue number 3 from chain A (alanine) into glutamic acid: Energy difference: -0.8328 kcal/mol, Difference in average score from the base case: -0.0057 (00:17:40) [INFO] Auto_mut: Effect of mutation residue number 3 from chain A (alanine) into lysine: Energy difference: -0.4161 kcal/mol, Difference in average score from the base case: -0.0102 (00:17:40) [INFO] Auto_mut: Effect of mutation residue number 3 from chain A (alanine) into aspartic acid: Energy difference: -0.8556 kcal/mol, Difference in average score from the base case: -0.0061 (00:17:40) [INFO] Auto_mut: Effect of mutation residue number 3 from chain A (alanine) into arginine: Energy difference: -0.3500 kcal/mol, Difference in average score from the base case: -0.0065 (00:17:40) [INFO] Auto_mut: Effect of mutation residue number 8 from chain A (leucine) into glutamic acid: Energy difference: 0.3261 kcal/mol, Difference in average score from the base case: -0.0170 (00:17:40) [INFO] Auto_mut: Effect of mutation residue number 8 from chain A (leucine) into lysine: Energy difference: 0.1171 kcal/mol, Difference in average score from the base case: -0.0165 (00:17:40) [INFO] Auto_mut: Effect of mutation residue number 8 from chain A (leucine) into aspartic acid: Energy difference: 0.1212 kcal/mol, Difference in average score from the base case: -0.0166 (00:17:40) [INFO] Auto_mut: Effect of mutation residue number 8 from chain A (leucine) into arginine: Energy difference: 0.1185 kcal/mol, Difference in average score from the base case: -0.0170 (00:17:40) [INFO] Main: Simulation completed successfully. (00:17:47) |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
1 | M | A | 1.9819 | |
2 | L | A | 2.7423 | |
3 | A | A | 2.5344 | |
4 | L | A | 3.5504 | |
5 | F | A | 3.9883 | |
6 | F | A | 3.6454 | |
7 | S | A | 2.2258 | |
8 | L | A | 2.4211 | |
9 | A | A | 1.4260 | |
10 | P | A | 1.3541 | |
11 | L | A | 2.1429 | |
12 | L | A | 1.8514 | |
13 | S | A | 0.4485 | |
14 | Q | A | -0.3605 | |
15 | A | A | 0.1374 | |
16 | L | A | 0.8438 | |
17 | P | A | 0.4689 | |
18 | L | A | 0.7338 | |
19 | G | A | 0.7573 | |
20 | Y | A | 1.5795 | |
21 | T | A | 1.0300 | |
22 | A | A | 0.4031 | |
23 | A | A | 0.2378 | |
24 | P | A | -0.6658 | |
25 | A | A | -0.7065 | |
26 | E | A | -1.6744 | |
27 | S | A | -0.6111 | |
28 | F | A | 0.0000 | |
29 | Y | A | 0.0000 | |
30 | F | A | 1.0478 | |
31 | W | A | 0.3179 | |
32 | P | A | 0.0000 | |
33 | E | A | -2.1664 | |
34 | N | A | -2.0478 | |
35 | I | A | -1.3557 | |
36 | S | A | -1.4342 | |
37 | S | A | -1.2277 | |
38 | L | A | -1.0089 | |
39 | Q | A | -1.4956 | |
40 | A | A | -0.9510 | |
41 | G | A | 0.0000 | |
42 | E | A | -1.3641 | |
43 | I | A | -0.9808 | |
44 | F | A | -0.9108 | |
45 | R | A | -2.3341 | |
46 | K | A | -2.8658 | |
47 | R | A | -2.1570 | |
48 | E | A | -1.9410 | |
49 | L | A | 0.0791 | |
50 | L | A | 1.1621 | |
51 | T | A | 0.6752 | |
52 | L | A | 0.4526 | |
53 | P | A | -0.1115 | |
54 | D | A | -1.2251 | |
55 | I | A | 0.3322 | |
56 | F | A | 0.0000 | |
57 | D | A | -1.8476 | |
58 | F | A | 0.0000 | |
59 | G | A | -1.4087 | |
60 | P | A | -1.4581 | |
61 | N | A | -2.3522 | |
62 | L | A | -2.1533 | |
63 | E | A | -2.8608 | |
64 | K | A | -1.6214 | |
65 | V | A | 0.0000 | |
66 | V | A | 0.0000 | |
67 | Q | A | 0.0000 | |
68 | V | A | 0.0000 | |
69 | A | A | 0.0000 | |
70 | Y | A | 0.0000 | |
71 | K | A | 0.0000 | |
72 | T | A | 0.0000 | |
73 | R | A | -1.3687 | |
74 | L | A | -1.2094 | |
75 | T | A | -1.2761 | |
76 | D | A | -2.3934 | |
77 | G | A | -1.9404 | |
78 | N | A | -2.3728 | |
79 | D | A | -1.8766 | |
80 | S | A | 0.0000 | |
81 | F | A | 0.0000 | |
82 | S | A | 0.0000 | |
83 | I | A | 0.0000 | |
84 | A | A | 0.0000 | |
85 | S | A | 0.0000 | |
86 | I | A | 0.0000 | |
87 | F | A | 0.0000 | |
88 | I | A | -1.0277 | |
89 | P | A | 0.0000 | |
90 | K | A | -3.2067 | |
91 | N | A | -2.8583 | |
92 | P | A | -2.1892 | |
93 | S | A | -1.7250 | |
94 | P | A | -1.3395 | |
95 | E | A | -1.9357 | |
96 | L | A | -1.1590 | |
97 | K | A | -1.1214 | |
98 | L | A | 0.0000 | |
99 | Y | A | 0.0000 | |
100 | S | A | 0.0000 | |
101 | Y | A | 0.0000 | |
102 | Q | A | 0.0000 | |
103 | T | A | 0.0000 | |
104 | F | A | 0.4572 | |
105 | E | A | 0.0000 | |
106 | D | A | -0.1317 | |
107 | A | A | 0.0000 | |
108 | V | A | 0.0000 | |
109 | Q | A | 0.0000 | |
110 | L | A | 0.0000 | |
111 | D | A | 0.0000 | |
112 | C | A | 0.0000 | |
113 | A | A | 0.0000 | |
114 | P | A | 0.0000 | |
115 | S | A | 0.0000 | |
116 | Y | A | 0.0089 | |
117 | A | A | 0.0000 | |
118 | L | A | 0.0000 | |
119 | E | A | 0.5602 | |
120 | V | A | 1.2201 | |
121 | G | A | -0.1111 | |
122 | N | A | -0.7245 | |
123 | K | A | -1.8301 | |
124 | S | A | 0.0000 | |
125 | S | A | -0.6017 | |
126 | N | A | 0.0000 | |
127 | Y | A | 1.0127 | |
128 | L | A | 1.8054 | |
129 | P | A | 0.0000 | |
130 | V | A | 0.0000 | |
131 | T | A | 0.6019 | |
132 | S | A | 0.5660 | |
133 | N | A | 0.0000 | |
134 | L | A | -0.3745 | |
135 | S | A | -0.4954 | |
136 | A | A | 0.0000 | |
137 | I | A | 0.0000 | |
138 | S | A | -1.2352 | |
139 | R | A | -1.4052 | |
140 | E | A | 0.0000 | |
141 | L | A | 0.0000 | |
142 | E | A | -3.0152 | |
143 | K | A | -2.4744 | |
144 | G | A | 0.0000 | |
145 | R | A | 0.0000 | |
146 | H | A | 0.0000 | |
147 | C | A | 0.0000 | |
148 | I | A | 0.0000 | |
149 | I | A | 0.0000 | |
150 | P | A | 0.0000 | |
151 | D | A | 0.0000 | |
152 | H | A | 0.0000 | |
153 | E | A | 0.0000 | |
154 | G | A | 0.0000 | |
155 | Y | A | 0.6279 | |
156 | I | A | 0.0000 | |
157 | S | A | 0.0000 | |
158 | G | A | 0.0000 | |
159 | F | A | 0.0000 | |
160 | F | A | 0.0000 | |
161 | A | A | 0.0000 | |
162 | G | A | 0.0000 | |
163 | R | A | -0.4338 | |
164 | Q | A | 0.0000 | |
165 | E | A | 0.0000 | |
166 | G | A | 0.0000 | |
167 | Y | A | 0.0448 | |
168 | A | A | 0.0000 | |
169 | G | A | 0.0000 | |
170 | L | A | 0.0000 | |
171 | D | A | 0.0000 | |
172 | G | A | 0.0000 | |
173 | I | A | 0.0000 | |
174 | R | A | -0.8080 | |
175 | A | A | 0.0000 | |
176 | A | A | 0.0000 | |
177 | R | A | 0.0000 | |
178 | N | A | -1.7951 | |
179 | Y | A | -0.8033 | |
180 | L | A | -0.6207 | |
181 | N | A | -1.5334 | |
182 | G | A | -1.6997 | |
183 | T | A | -1.7127 | |
184 | N | A | -2.3303 | |
185 | E | A | -1.7456 | |
186 | T | A | 0.0000 | |
187 | P | A | -0.8647 | |
188 | I | A | 0.0000 | |
189 | G | A | 0.0000 | |
190 | I | A | 0.0000 | |
191 | F | A | 0.0000 | |
192 | G | A | 0.0000 | |
193 | Y | A | 0.0000 | |
194 | S | A | 0.0000 | |
195 | G | A | 0.0000 | |
196 | G | A | 0.0000 | |
197 | A | A | 0.0000 | |
198 | Q | A | 0.0000 | |
199 | A | A | 0.0000 | |
200 | T | A | 0.0000 | |
201 | A | A | 0.0000 | |
202 | W | A | 0.0000 | |
203 | I | A | 0.0000 | |
204 | V | A | 0.0000 | |
205 | D | A | 0.0000 | |
206 | L | A | 0.0000 | |
207 | H | A | 0.0000 | |
208 | D | A | -2.8252 | |
209 | E | A | -2.6148 | |
210 | Y | A | -1.2997 | |
211 | A | A | 0.0000 | |
212 | P | A | -1.7120 | |
213 | D | A | -1.5578 | |
214 | L | A | 0.0000 | |
215 | N | A | 0.0000 | |
216 | F | A | 0.0000 | |
217 | V | A | 0.0000 | |
218 | G | A | 0.0000 | |
219 | T | A | 0.0000 | |
220 | V | A | 0.0000 | |
221 | S | A | 0.0000 | |
222 | G | A | 0.0000 | |
223 | G | A | 0.0000 | |
224 | T | A | 0.0000 | |
225 | L | A | 0.0000 | |
226 | V | A | 0.0000 | |
227 | D | A | 0.0000 | |
228 | A | A | 0.0000 | |
229 | W | A | -0.0494 | |
230 | G | A | -0.1601 | |
231 | T | A | 0.0000 | |
232 | F | A | 0.0000 | |
233 | Q | A | -0.2283 | |
234 | Y | A | 0.0609 | |
235 | I | A | 0.0000 | |
236 | D | A | -0.2426 | |
237 | Y | A | 0.2561 | |
238 | P | A | -0.8297 | |
239 | K | A | -1.4886 | |
240 | V | A | 0.0153 | |
241 | Y | A | 0.9378 | |
242 | L | A | 0.8546 | |
243 | K | A | 0.0000 | |
244 | G | A | 0.0000 | |
245 | S | A | 0.0000 | |
246 | I | A | 0.0000 | |
247 | L | A | 0.0000 | |
248 | I | A | 0.0000 | |
249 | M | A | 0.0000 | |
250 | Y | A | 0.0000 | |
251 | T | A | 0.0000 | |
252 | G | A | 0.0000 | |
253 | L | A | 0.0000 | |
254 | F | A | 0.0000 | |
255 | S | A | 0.0000 | |
256 | G | A | 0.0000 | |
257 | Y | A | 0.0000 | |
258 | P | A | -0.5651 | |
259 | A | A | -0.6133 | |
260 | Q | A | -0.2715 | |
261 | F | A | 0.0000 | |
262 | E | A | -1.1792 | |
263 | V | A | 0.4718 | |
264 | I | A | 0.0000 | |
265 | W | A | -0.1762 | |
266 | P | A | -0.1334 | |
267 | Y | A | 0.2947 | |
268 | I | A | 0.0000 | |
269 | E | A | -0.5601 | |
270 | P | A | -0.2766 | |
271 | V | A | 0.6581 | |
272 | I | A | 0.0000 | |
273 | Q | A | -0.5579 | |
274 | E | A | -1.1891 | |
275 | N | A | -0.2642 | |
276 | M | A | 0.0000 | |
277 | L | A | 0.5984 | |
278 | L | A | 0.9051 | |
279 | L | A | 0.0000 | |
280 | R | A | 0.0000 | |
281 | L | A | 1.3501 | |
282 | A | A | 0.5410 | |
283 | P | A | -0.3906 | |
284 | N | A | -1.0112 | |
285 | D | A | -0.8778 | |
286 | C | A | 0.0000 | |
287 | N | A | 0.0000 | |
288 | Q | A | -0.6722 | |
289 | S | A | -0.4824 | |
290 | P | A | 0.0000 | |
291 | I | A | 0.5681 | |
292 | L | A | 1.0019 | |
293 | Q | A | -0.6099 | |
294 | G | A | -0.4800 | |
295 | Y | A | -0.7977 | |
296 | N | A | -2.1250 | |
297 | N | A | -2.0243 | |
298 | S | A | -0.8734 | |
299 | I | A | 0.0000 | |
300 | M | A | 0.0000 | |
301 | A | A | -0.6897 | |
302 | G | A | -0.3590 | |
303 | I | A | 0.0000 | |
304 | H | A | -1.1446 | |
305 | V | A | -1.2046 | |
306 | D | A | -2.4832 | |
307 | L | A | 0.0000 | |
308 | P | A | -1.4781 | |
309 | E | A | -2.3730 | |
310 | F | A | -1.1173 | |
311 | P | A | -0.6166 | |
312 | A | A | 0.0000 | |
313 | S | A | 0.0000 | |
314 | K | A | -1.0268 | |
315 | Y | A | 0.4581 | |
316 | I | A | 0.0000 | |
317 | F | A | 0.0000 | |
318 | Q | A | 0.3542 | |
319 | H | A | 0.3953 | |
320 | E | A | 0.0000 | |
321 | S | A | 0.0000 | |
322 | L | A | 0.0000 | |
323 | L | A | 0.0000 | |
324 | A | A | -0.2159 | |
325 | N | A | -0.9041 | |
326 | Y | A | 0.1154 | |
327 | S | A | 0.6781 | |
328 | V | A | 1.6949 | |
329 | V | A | 0.9824 | |
330 | P | A | 0.3001 | |
331 | V | A | 0.3301 | |
332 | S | A | -0.6461 | |
333 | T | A | -0.8408 | |
334 | P | A | 0.0000 | |
335 | K | A | -1.8102 | |
336 | F | A | 0.0000 | |
337 | P | A | -0.7304 | |
338 | R | A | 0.0000 | |
339 | Y | A | 0.0000 | |
340 | M | A | 0.0000 | |
341 | Y | A | 0.0000 | |
342 | H | A | 0.0000 | |
343 | G | A | 0.0000 | |
344 | G | A | -0.0425 | |
345 | S | A | -0.1961 | |
346 | D | A | 0.0000 | |
347 | E | A | -0.2691 | |
348 | L | A | 0.0000 | |
349 | A | A | 0.0000 | |
350 | K | A | -0.6371 | |
351 | L | A | -0.3856 | |
352 | S | A | -0.6245 | |
353 | L | A | -0.5657 | |
354 | V | A | 0.0000 | |
355 | E | A | -1.5524 | |
356 | Q | A | -1.4747 | |
357 | Y | A | 0.0000 | |
358 | V | A | 0.0000 | |
359 | D | A | -1.9008 | |
360 | Q | A | -1.4781 | |
361 | Q | A | 0.0000 | |
362 | W | A | -0.8413 | |
363 | N | A | -1.4931 | |
364 | T | A | -1.1278 | |
365 | G | A | -1.2709 | |
366 | A | A | -1.3459 | |
367 | N | A | -1.5993 | |
368 | L | A | 0.0000 | |
369 | T | A | 0.0393 | |
370 | F | A | 0.4127 | |
371 | V | A | 0.9799 | |
372 | V | A | 0.8020 | |
373 | Y | A | 0.1358 | |
374 | P | A | -0.0806 | |
375 | G | A | -0.3878 | |
376 | L | A | -0.4769 | |
377 | L | A | -0.2249 | |
378 | H | A | 0.0000 | |
379 | D | A | -1.9163 | |
380 | E | A | -1.4948 | |
381 | T | A | 0.0000 | |
382 | A | A | -0.7256 | |
383 | Y | A | -0.3468 | |
384 | R | A | -1.6873 | |
385 | G | A | 0.0000 | |
386 | F | A | -0.7741 | |
387 | D | A | -2.1627 | |
388 | A | A | -1.5610 | |
389 | A | A | 0.0000 | |
390 | M | A | 0.0000 | |
391 | D | A | -2.1934 | |
392 | W | A | -0.9613 | |
393 | L | A | 0.0000 | |
394 | D | A | -1.4527 | |
395 | A | A | -1.1812 | |
396 | Q | A | -0.9925 | |
397 | L | A | 0.0000 | |
398 | D | A | -2.1023 | |
399 | S | A | -0.9192 | |
400 | G | A | -0.5008 | |
401 | Y | A | 0.3814 | |
402 | L | A | 1.5516 | |
403 | P | A | 0.6344 | |
404 | P | A | 0.4359 | |
405 | V | A | 1.1753 | |
406 | N | A | -0.7614 | |
407 | S | A | -0.6238 | |
408 | T | A | -0.7700 | |
409 | H | A | -1.2966 | |
410 | T | A | -0.5996 |
Automated mutations analysis
In the automated mutations mode, the server selects aggregation prone resides
and each selected residue is mutated to glutamic acid, lysine, aspartic acid and arginine.
The table below shows 2 best scored mutants for each mutated residue. Protein variants
are ordered according to the mutation effect they had on protein stability
(energetic effect) together with the difference in the average per-residue aggregation score
between the wild type and the mutant (in the table green values indicate a positive change,
grey are neutral, and orange/red mean destabilizing or more aggregation prone mutants).
Summary for all the mutants can be found in this
CSV file.
Mutant |
Energetic effect |
Score comparison |
|||
FR5A | -0.4197 | -0.0202 | View | CSV | PDB |
LE4A | -0.5072 | -0.0173 | View | CSV | PDB |
FR6A | -0.3463 | -0.0195 | View | CSV | PDB |
FE5A | -0.1527 | -0.02 | View | CSV | PDB |
LR4A | -0.2307 | -0.0174 | View | CSV | PDB |
FE6A | -0.0534 | -0.0193 | View | CSV | PDB |
LE2A | -0.2174 | -0.0142 | View | CSV | PDB |
AK3A | -0.4161 | -0.0102 | View | CSV | PDB |
AD3A | -0.8556 | -0.0061 | View | CSV | PDB |
LR2A | -0.0013 | -0.0135 | View | CSV | PDB |
LR8A | 0.1185 | -0.017 | View | CSV | PDB |
LK8A | 0.1171 | -0.0165 | View | CSV | PDB |