| Chain sequence(s) |
A: MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 5 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:06:59)
[INFO] Main: Simulation completed successfully. (00:07:02)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | M | A | 0.7259 | |
| 2 | E | A | -1.9595 | |
| 3 | E | A | -2.1944 | |
| 4 | P | A | -0.7942 | |
| 5 | Q | A | -1.2825 | |
| 6 | S | A | -0.7503 | |
| 7 | D | A | -1.8724 | |
| 8 | P | A | -0.6075 | |
| 9 | S | A | 0.0645 | |
| 10 | V | A | 1.4004 | |
| 11 | E | A | -1.5405 | |
| 12 | P | A | -0.6254 | |
| 13 | P | A | -0.0221 | |
| 14 | L | A | 1.4807 | |
| 15 | S | A | -0.0532 | |
| 16 | Q | A | -1.5434 | |
| 17 | E | A | -2.0411 | |
| 18 | T | A | -0.1949 | |
| 19 | F | A | 0.9033 | |
| 20 | S | A | -0.3479 | |
| 21 | D | A | -1.6993 | |
| 22 | L | A | 0.5844 | |
| 23 | W | A | 1.0086 | |
| 24 | K | A | -1.2109 | |
| 25 | L | A | 1.5211 | |
| 26 | L | A | 1.7807 | |
| 27 | P | A | -0.3030 | |
| 28 | E | A | -2.0911 | |
| 29 | N | A | -1.8299 | |
| 30 | N | A | -1.1889 | |
| 31 | V | A | 1.8267 | |
| 32 | L | A | 1.8315 | |
| 33 | S | A | 0.0298 | |
| 34 | P | A | -0.0194 | |
| 35 | L | A | 1.4349 | |
| 36 | P | A | 0.1177 | |
| 37 | S | A | -0.4697 | |
| 38 | Q | A | -1.2217 | |
| 39 | A | A | -0.0320 | |
| 40 | M | A | 0.7438 | |
| 41 | D | A | -1.9617 | |
| 42 | D | A | -1.8777 | |
| 43 | L | A | 1.4356 | |
| 44 | M | A | 1.6338 | |
| 45 | L | A | 1.7002 | |
| 46 | S | A | 0.0274 | |
| 47 | P | A | -0.6124 | |
| 48 | D | A | -2.1487 | |
| 49 | D | A | -1.7500 | |
| 50 | I | A | 1.3779 | |
| 51 | E | A | -1.6772 | |
| 52 | Q | A | -1.3097 | |
| 53 | W | A | 1.3287 | |
| 54 | F | A | 2.1442 | |
| 55 | T | A | -0.0416 | |
| 56 | E | A | -2.1620 | |
| 57 | D | A | -2.1690 | |
| 58 | P | A | -0.6562 | |
| 59 | G | A | -0.5592 | |
| 60 | P | A | -0.6758 | |
| 61 | D | A | -2.1682 | |
| 62 | E | A | -2.1346 | |
| 63 | A | A | -0.3262 | |
| 64 | P | A | -0.5682 | |
| 65 | R | A | -1.7027 | |
| 66 | M | A | 0.6680 | |
| 67 | P | A | -0.3409 | |
| 68 | E | A | -1.8557 | |
| 69 | A | A | -0.2536 | |
| 70 | A | A | 0.0092 | |
| 71 | P | A | -0.2959 | |
| 72 | P | A | 0.0089 | |
| 73 | V | A | 1.7374 | |
| 74 | A | A | 0.3297 | |
| 75 | P | A | -0.2336 | |
| 76 | A | A | -0.0335 | |
| 77 | P | A | -0.2338 | |
| 78 | A | A | 0.0225 | |
| 79 | A | A | 0.0232 | |
| 80 | P | A | -0.2574 | |
| 81 | T | A | -0.1630 | |
| 82 | P | A | -0.2568 | |
| 83 | A | A | 0.0222 | |
| 84 | A | A | 0.0233 | |
| 85 | P | A | -0.2337 | |
| 86 | A | A | -0.0341 | |
| 87 | P | A | -0.2338 | |
| 88 | A | A | -0.0338 | |
| 89 | P | A | -0.2834 | |
| 90 | S | A | -0.1273 | |
| 91 | W | A | 0.6473 | |
| 92 | P | A | 0.2086 | |
| 93 | L | A | 1.5096 | |
| 94 | S | A | 0.0000 | |
| 95 | S | A | -0.2437 | |
| 96 | S | A | -0.1213 | |
| 97 | V | A | 0.4513 | |
| 98 | P | A | 0.0124 | |
| 99 | S | A | -0.3573 | |
| 100 | Q | A | -1.5134 | |
| 101 | K | A | -1.9196 | |
| 102 | T | A | -0.2516 | |
| 103 | Y | A | 0.4248 | |
| 104 | Q | A | -1.0686 | |
| 105 | G | A | -0.3708 | |
| 106 | S | A | -0.1926 | |
| 107 | Y | A | 0.1882 | |
| 108 | G | A | -0.1485 | |
| 109 | F | A | 0.0000 | |
| 110 | R | A | -0.6438 | |
| 111 | L | A | 0.0508 | |
| 112 | G | A | -0.0015 | |
| 113 | F | A | 0.5376 | |
| 114 | L | A | 1.1985 | |
| 115 | H | A | -0.7602 | |
| 116 | S | A | -0.3386 | |
| 117 | G | A | -0.4821 | |
| 118 | T | A | -0.0880 | |
| 119 | A | A | -0.2487 | |
| 120 | K | A | -1.7281 | |
| 121 | S | A | -0.4721 | |
| 122 | V | A | 0.2032 | |
| 123 | T | A | 0.0228 | |
| 124 | C | A | 0.0927 | |
| 125 | T | A | 0.0000 | |
| 126 | Y | A | 0.1620 | |
| 127 | S | A | 0.0000 | |
| 128 | P | A | -0.3237 | |
| 129 | A | A | 0.0743 | |
| 130 | L | A | 0.2118 | |
| 131 | N | A | -0.7488 | |
| 132 | K | A | 0.0000 | |
| 133 | M | A | 0.0000 | |
| 134 | F | A | 0.0000 | |
| 135 | C | A | 0.0000 | |
| 136 | Q | A | -0.1965 | |
| 137 | L | A | 0.4340 | |
| 138 | A | A | -0.0425 | |
| 139 | K | A | -0.8594 | |
| 140 | T | A | -0.1809 | |
| 141 | C | A | 0.0000 | |
| 142 | P | A | -0.1150 | |
| 143 | V | A | 0.0000 | |
| 144 | Q | A | -0.2070 | |
| 145 | L | A | 0.0000 | |
| 146 | W | A | 0.3330 | |
| 147 | V | A | -0.0573 | |
| 148 | D | A | -1.7887 | |
| 149 | S | A | -0.5464 | |
| 150 | T | A | -0.1095 | |
| 151 | P | A | 0.0000 | |
| 152 | P | A | -0.1601 | |
| 153 | P | A | -0.3563 | |
| 154 | G | A | -0.5156 | |
| 155 | T | A | 0.0000 | |
| 156 | R | A | -0.2703 | |
| 157 | V | A | 0.0000 | |
| 158 | R | A | -0.2856 | |
| 159 | A | A | 0.0000 | |
| 160 | M | A | 0.1138 | |
| 161 | A | A | 0.0267 | |
| 162 | I | A | 0.0000 | |
| 163 | Y | A | 0.0000 | |
| 164 | K | A | -1.2228 | |
| 165 | Q | A | -0.9915 | |
| 166 | S | A | -0.5639 | |
| 167 | Q | A | -1.2647 | |
| 168 | H | A | -0.2878 | |
| 169 | M | A | 0.4359 | |
| 170 | T | A | 0.0034 | |
| 171 | E | A | -0.3315 | |
| 172 | V | A | 0.0000 | |
| 173 | V | A | 0.0000 | |
| 174 | R | A | -0.2307 | |
| 175 | R | A | 0.0000 | |
| 176 | C | A | 0.0000 | |
| 177 | P | A | -0.3364 | |
| 178 | H | A | -1.0388 | |
| 179 | H | A | -0.4531 | |
| 180 | E | A | -1.1665 | |
| 181 | R | A | -1.8789 | |
| 182 | C | A | 0.1988 | |
| 183 | S | A | -0.3398 | |
| 184 | D | A | -1.3647 | |
| 185 | S | A | -0.6596 | |
| 186 | D | A | -1.8895 | |
| 187 | G | A | -0.6271 | |
| 188 | L | A | 0.7802 | |
| 189 | A | A | 0.0000 | |
| 190 | P | A | -0.0870 | |
| 191 | P | A | -0.1784 | |
| 192 | Q | A | -0.2715 | |
| 193 | H | A | 0.0000 | |
| 194 | L | A | 0.0000 | |
| 195 | I | A | 0.0000 | |
| 196 | R | A | 0.0000 | |
| 197 | V | A | -0.0534 | |
| 198 | E | A | -1.2850 | |
| 199 | G | A | -0.7300 | |
| 200 | N | A | -0.0308 | |
| 201 | L | A | 1.1800 | |
| 202 | R | A | -1.5695 | |
| 203 | V | A | 0.0000 | |
| 204 | E | A | -1.1725 | |
| 205 | Y | A | 0.0805 | |
| 206 | L | A | 0.3941 | |
| 207 | D | A | -1.6535 | |
| 208 | D | A | -1.5760 | |
| 209 | R | A | -2.2606 | |
| 210 | N | A | -1.6078 | |
| 211 | T | A | -0.0961 | |
| 212 | F | A | 0.6945 | |
| 213 | R | A | 0.0000 | |
| 214 | H | A | -0.2846 | |
| 215 | S | A | -0.0267 | |
| 216 | V | A | 0.0000 | |
| 217 | V | A | 0.0000 | |
| 218 | V | A | 0.0000 | |
| 219 | P | A | -0.0411 | |
| 220 | Y | A | -0.1909 | |
| 221 | E | A | -1.6107 | |
| 222 | P | A | -0.5522 | |
| 223 | P | A | -0.4415 | |
| 224 | E | A | -1.5120 | |
| 225 | V | A | 1.3606 | |
| 226 | G | A | -0.1587 | |
| 227 | S | A | -0.4759 | |
| 228 | D | A | -1.7881 | |
| 229 | C | A | -0.2471 | |
| 230 | T | A | -0.0075 | |
| 231 | T | A | -0.0655 | |
| 232 | I | A | 0.0000 | |
| 233 | H | A | -0.4468 | |
| 234 | Y | A | 0.0000 | |
| 235 | N | A | -0.1266 | |
| 236 | Y | A | 0.0000 | |
| 237 | M | A | 0.0000 | |
| 238 | C | A | 0.0000 | |
| 239 | N | A | -0.2627 | |
| 240 | S | A | -0.0998 | |
| 241 | S | A | -0.5336 | |
| 242 | C | A | 0.0000 | |
| 243 | M | A | 0.8772 | |
| 244 | G | A | -0.1393 | |
| 245 | G | A | 0.0000 | |
| 246 | M | A | 0.0000 | |
| 247 | N | A | -1.2515 | |
| 248 | R | A | -2.0982 | |
| 249 | R | A | -0.6184 | |
| 250 | P | A | -0.1099 | |
| 251 | I | A | 0.0000 | |
| 252 | L | A | 0.0000 | |
| 253 | T | A | 0.0000 | |
| 254 | I | A | 0.0000 | |
| 255 | I | A | 0.0000 | |
| 256 | T | A | 0.0000 | |
| 257 | L | A | 0.0000 | |
| 258 | E | A | 0.0000 | |
| 259 | D | A | -0.3379 | |
| 260 | S | A | -0.3513 | |
| 261 | S | A | -0.3235 | |
| 262 | G | A | -0.6740 | |
| 263 | N | A | -1.2247 | |
| 264 | L | A | 0.4709 | |
| 265 | L | A | 0.3542 | |
| 266 | G | A | 0.0000 | |
| 267 | R | A | -0.1876 | |
| 268 | N | A | -0.2269 | |
| 269 | S | A | 0.0000 | |
| 270 | F | A | 0.0000 | |
| 271 | E | A | -0.1801 | |
| 272 | V | A | 0.0000 | |
| 273 | R | A | -0.6505 | |
| 274 | V | A | 0.0000 | |
| 275 | C | A | 0.0000 | |
| 276 | A | A | 0.0771 | |
| 277 | C | A | 0.1147 | |
| 278 | P | A | 0.0000 | |
| 279 | G | A | 0.0000 | |
| 280 | R | A | -1.7144 | |
| 281 | D | A | 0.0000 | |
| 282 | R | A | -0.4047 | |
| 283 | R | A | -1.2483 | |
| 284 | T | A | -0.3346 | |
| 285 | E | A | -0.3884 | |
| 286 | E | A | -0.4557 | |
| 287 | E | A | -0.5402 | |
| 288 | N | A | -0.2015 | |
| 289 | L | A | 0.5704 | |
| 290 | R | A | -1.4079 | |
| 291 | K | A | -0.7574 | |
| 292 | K | A | -1.1093 | |
| 293 | G | A | -0.8690 | |
| 294 | E | A | -1.3846 | |
| 295 | P | A | -0.5116 | |
| 296 | H | A | -1.0610 | |
| 297 | H | A | -1.4785 | |
| 298 | E | A | -1.7202 | |
| 299 | L | A | 1.1725 | |
| 300 | P | A | -0.0245 | |
| 301 | P | A | -0.3900 | |
| 302 | G | A | -0.5552 | |
| 303 | S | A | -0.3136 | |
| 304 | T | A | -0.4234 | |
| 305 | K | A | -2.0860 | |
| 306 | R | A | -2.1773 | |
| 307 | A | A | 0.0979 | |
| 308 | L | A | 1.5175 | |
| 309 | P | A | -0.2191 | |
| 310 | N | A | -1.5506 | |
| 311 | N | A | -1.5193 | |
| 312 | T | A | -0.3871 | |
| 313 | S | A | -0.2693 | |
| 314 | S | A | -0.2948 | |
| 315 | S | A | -0.3032 | |
| 316 | P | A | -0.5147 | |
| 317 | Q | A | -1.2902 | |
| 318 | P | A | -0.7847 | |
| 319 | K | A | -2.0531 | |
| 320 | K | A | -2.3158 | |
| 321 | K | A | -2.0555 | |
| 322 | P | A | -0.3767 | |
| 323 | L | A | 0.6451 | |
| 324 | D | A | -1.6406 | |
| 325 | G | A | -0.8318 | |
| 326 | E | A | -1.6109 | |
| 327 | Y | A | 1.3372 | |
| 328 | F | A | 2.1685 | |
| 329 | T | A | 0.5195 | |
| 330 | L | A | 1.0872 | |
| 331 | Q | A | -0.8776 | |
| 332 | I | A | -0.0921 | |
| 333 | R | A | -1.8447 | |
| 334 | G | A | -1.1280 | |
| 335 | R | A | -2.2537 | |
| 336 | E | A | -2.4855 | |
| 337 | R | A | -1.9521 | |
| 338 | F | A | 0.8412 | |
| 339 | E | A | 0.0911 | |
| 340 | M | A | 0.7002 | |
| 341 | F | A | 0.5167 | |
| 342 | R | A | -0.9301 | |
| 343 | E | A | -1.7833 | |
| 344 | L | A | 0.3436 | |
| 345 | N | A | -1.3720 | |
| 346 | E | A | -1.6794 | |
| 347 | A | A | 0.0152 | |
| 348 | L | A | 1.1784 | |
| 349 | E | A | -0.8545 | |
| 350 | L | A | 0.9965 | |
| 351 | K | A | -1.7286 | |
| 352 | D | A | -2.0017 | |
| 353 | A | A | -0.3468 | |
| 354 | Q | A | -1.1864 | |
| 355 | A | A | -0.2384 | |
| 356 | G | A | -0.7546 | |
| 357 | K | A | -2.1098 | |
| 358 | E | A | -2.1722 | |
| 359 | P | A | -0.6692 | |
| 360 | G | A | -0.5977 | |
| 361 | G | A | -0.5910 | |
| 362 | S | A | -0.6405 | |
| 363 | R | A | -1.8726 | |
| 364 | A | A | -0.4679 | |
| 365 | H | A | -1.0186 | |
| 366 | S | A | -0.4351 | |
| 367 | S | A | -0.4351 | |
| 368 | H | A | -0.7505 | |
| 369 | L | A | 1.0614 | |
| 370 | K | A | -1.4591 | |
| 371 | S | A | -0.8392 | |
| 372 | K | A | -2.0525 | |
| 373 | K | A | -2.0994 | |
| 374 | G | A | -1.0583 | |
| 375 | Q | A | -1.3448 | |
| 376 | S | A | -0.4405 | |
| 377 | T | A | -0.1581 | |
| 378 | S | A | -0.5654 | |
| 379 | R | A | -2.0829 | |
| 380 | H | A | -1.6997 | |
| 381 | K | A | -2.2130 | |
| 382 | K | A | -1.7383 | |
| 383 | L | A | 1.4308 | |
| 384 | M | A | 1.6889 | |
| 385 | F | A | 1.8284 | |
| 386 | K | A | -1.3625 | |
| 387 | T | A | -0.7130 | |
| 388 | E | A | -1.9175 | |
| 389 | G | A | -0.8455 | |
| 390 | P | A | -0.6633 | |
| 391 | D | A | -1.8788 | |
| 392 | S | A | -0.9381 | |
| 393 | D | A | -1.8316 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine