Project name: 65e0c387dd7d9ca

Chain sequence(s)	A: LGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQR
Selected Chain(s)	A
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:45)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:47)

• Minimal score value: -3.5618
• Maximal score value: 1.2387
• Average score: -1.0671
• Total score value: -110.9796

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
125	L	A	1.2387
126	G	A	0.2273
127	G	A	-0.2050
128	Y	A	0.6189
129	M	A	0.9569
130	L	A	1.0043
131	G	A	0.0000
132	S	A	-0.3079
133	A	A	-0.3582
134	M	A	-0.4617
135	S	A	-0.5995
136	R	A	-1.1088
137	P	A	-0.8212
138	I	A	-0.6460
139	I	A	-1.1792
140	H	A	-1.5037
141	F	A	-0.9923
142	G	A	-1.0562
143	S	A	-1.2571
144	D	A	-2.3240
145	Y	A	-0.7252
146	E	A	-1.7175
147	D	A	-2.3586
148	R	A	-3.2156
149	Y	A	-1.7626
150	Y	A	0.0000
151	R	A	-3.5618
152	E	A	-3.4566
153	N	A	-2.3217
154	M	A	-2.1471
155	H	A	-2.0543
156	R	A	-1.5144
157	Y	A	0.0000
158	P	A	0.0000
159	N	A	-1.1401
160	Q	A	-0.5143
161	V	A	0.0000
162	Y	A	0.7129
163	Y	A	0.1925
164	R	A	-0.5003
165	P	A	-1.0444
166	M	A	-1.1623
167	D	A	-2.4669
168	E	A	-2.1938
169	Y	A	-0.6208
170	S	A	-1.2885
171	N	A	-1.6330
172	Q	A	-2.4922
173	N	A	-2.9406
174	N	A	-3.0575
175	F	A	0.0000
176	V	A	0.0000
177	H	A	-2.7982
178	D	A	-2.3691
179	C	A	0.0000
180	V	A	0.0000
181	N	A	-1.7489
182	I	A	-0.7345
183	T	A	0.0000
184	I	A	0.0000
185	K	A	-0.9210
186	Q	A	-0.0708
187	H	A	-0.3958
188	T	A	-0.3442
189	V	A	0.6480
190	T	A	-0.0686
191	T	A	-0.9669
192	T	A	-1.2551
193	T	A	-0.9679
194	K	A	-2.2292
195	G	A	-1.9093
196	E	A	-2.0874
197	N	A	-1.8349
198	F	A	-1.0929
199	T	A	-1.2425
200	E	A	-2.0414
201	T	A	-1.3216
202	D	A	0.0000
203	V	A	-1.5325
204	K	A	-2.1258
205	M	A	0.0000
206	M	A	0.0000
207	E	A	-2.2012
208	R	A	-2.3367
209	V	A	0.0000
210	V	A	0.0000
211	E	A	-1.9532
212	Q	A	-1.1355
213	M	A	0.0000
214	C	A	0.0000
215	I	A	-0.6222
216	T	A	-0.9520
217	Q	A	0.0000
218	Y	A	-1.8887
219	E	A	-2.9089
220	R	A	-3.1367
221	E	A	-2.1314
222	S	A	-1.5475
223	Q	A	-2.1832
224	A	A	-1.3365
225	Y	A	-0.3135
226	Y	A	0.1459
227	Q	A	-1.4812
228	R	A	-1.8272