| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIVKDGKVVVPKVSGWQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTVGHPLFNKLGDTENPTTPQHDTADVRVAFSFDPKQTQLFIVGCEPPTGEHWDRAAPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYVRAGPDGVPLPAAPPPSPLYTPPPPTSPYAVLPPTDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPLPNVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9417 | |
| 2 | L | A | 1.9635 | |
| 3 | P | A | 0.6581 | |
| 4 | P | A | 0.3610 | |
| 5 | T | A | 0.1184 | |
| 6 | T | A | 0.1356 | |
| 7 | P | A | 0.1803 | |
| 8 | V | A | 1.2454 | |
| 9 | A | A | 0.0906 | |
| 10 | K | A | -1.0143 | |
| 11 | V | A | -0.1352 | |
| 12 | Q | A | -1.3864 | |
| 13 | S | A | -1.5495 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4399 | |
| 16 | E | A | -2.4478 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4551 | |
| 20 | P | A | 0.1028 | |
| 21 | T | A | 0.1094 | |
| 22 | S | A | -0.1725 | |
| 23 | L | A | 0.0000 | |
| 24 | F | A | -0.1101 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2920 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.8957 | |
| 31 | R | A | -2.6790 | |
| 32 | L | A | -0.8001 | |
| 33 | L | A | 1.1575 | |
| 34 | T | A | 1.3701 | |
| 35 | V | A | 1.8477 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2169 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6234 | |
| 40 | K | A | -1.6385 | |
| 41 | D | A | -0.9433 | |
| 42 | I | A | 0.8033 | |
| 43 | V | A | 0.8735 | |
| 44 | K | A | -1.4331 | |
| 45 | D | A | -2.4469 | |
| 46 | G | A | -1.4895 | |
| 47 | K | A | -1.1440 | |
| 48 | V | A | 1.3328 | |
| 49 | V | A | 1.9457 | |
| 50 | V | A | 1.2520 | |
| 51 | P | A | 0.4305 | |
| 52 | K | A | -0.6412 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | W | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1757 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.4098 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2791 | |
| 70 | K | A | -1.8007 | |
| 71 | F | A | -0.6540 | |
| 72 | A | A | -0.5755 | |
| 73 | L | A | -0.8725 | |
| 74 | P | A | -1.2797 | |
| 75 | Q | A | -2.4939 | |
| 76 | K | A | -3.0994 | |
| 77 | D | A | -2.9860 | |
| 78 | F | A | -1.6657 | |
| 79 | Y | A | -1.8870 | |
| 80 | D | A | -2.6809 | |
| 81 | P | A | -2.2966 | |
| 82 | E | A | -3.0393 | |
| 83 | K | A | -3.3898 | |
| 84 | E | A | -2.4513 | |
| 85 | R | A | -1.2828 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6407 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9779 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3584 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6863 | |
| 99 | G | A | -0.5276 | |
| 100 | P | A | -0.3807 | |
| 101 | L | A | 0.0900 | |
| 102 | G | A | -0.1887 | |
| 103 | K | A | -0.5946 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.3548 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.1758 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.4097 | |
| 110 | L | A | 0.3669 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -0.9495 | |
| 113 | K | A | -0.2805 | |
| 114 | L | A | -0.9263 | |
| 115 | G | A | -0.7976 | |
| 116 | D | A | -1.2081 | |
| 117 | T | A | -0.8995 | |
| 118 | E | A | -1.7659 | |
| 119 | N | A | -1.9902 | |
| 120 | P | A | -1.4637 | |
| 121 | T | A | -0.8116 | |
| 122 | T | A | -0.6284 | |
| 123 | P | A | -0.3843 | |
| 124 | Q | A | -0.6376 | |
| 125 | H | A | -0.8862 | |
| 126 | D | A | -2.0173 | |
| 127 | T | A | -1.2417 | |
| 128 | A | A | -1.2400 | |
| 129 | D | A | -1.9404 | |
| 130 | V | A | -1.1200 | |
| 131 | R | A | -0.6868 | |
| 132 | V | A | 0.4307 | |
| 133 | A | A | 0.4387 | |
| 134 | F | A | 0.2792 | |
| 135 | S | A | -0.0250 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | 0.0000 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | -0.2342 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5679 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2473 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 0.8215 | |
| 157 | D | A | -0.2132 | |
| 158 | R | A | -0.3936 | |
| 159 | A | A | 0.3134 | |
| 160 | A | A | 0.0636 | |
| 161 | P | A | 0.4214 | |
| 162 | C | A | 0.5916 | |
| 163 | P | A | 0.0309 | |
| 164 | G | A | -0.1471 | |
| 165 | L | A | 0.4437 | |
| 166 | P | A | -0.1873 | |
| 167 | P | A | -0.3743 | |
| 168 | G | A | -0.4427 | |
| 169 | A | A | 0.2654 | |
| 170 | C | A | 0.9240 | |
| 171 | P | A | 0.4384 | |
| 172 | P | A | 0.8326 | |
| 173 | I | A | 1.7537 | |
| 174 | Q | A | 0.7114 | |
| 175 | L | A | 1.2497 | |
| 176 | V | A | 0.6579 | |
| 177 | N | A | -0.3581 | |
| 178 | S | A | -0.0276 | |
| 179 | V | A | 0.3345 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3591 | |
| 182 | D | A | 0.0630 | |
| 183 | G | A | -0.1575 | |
| 184 | D | A | -0.5467 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1273 | |
| 190 | F | A | 0.0616 | |
| 191 | G | A | -0.1087 | |
| 192 | N | A | -0.2700 | |
| 193 | M | A | -0.3028 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.3886 | |
| 197 | E | A | -2.7632 | |
| 198 | L | A | -1.4865 | |
| 199 | Q | A | -2.4891 | |
| 200 | Q | A | -3.2568 | |
| 201 | D | A | -3.5360 | |
| 202 | R | A | -3.3001 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.2225 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3023 | |
| 211 | S | A | -1.8402 | |
| 212 | T | A | -1.4001 | |
| 213 | R | A | -2.0528 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1612 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.2640 | |
| 220 | L | A | 0.4881 | |
| 221 | K | A | -1.3448 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.8880 | |
| 224 | N | A | -1.5727 | |
| 225 | E | A | -1.2960 | |
| 226 | A | A | -0.5960 | |
| 227 | Y | A | -0.3604 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6871 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | 0.0796 | |
| 234 | F | A | 0.2705 | |
| 235 | G | A | -0.8186 | |
| 236 | R | A | -2.6123 | |
| 237 | R | A | -2.9194 | |
| 238 | E | A | -2.2034 | |
| 239 | Q | A | -0.2524 | |
| 240 | V | A | 1.4340 | |
| 241 | Y | A | 1.2219 | |
| 242 | A | A | 0.3930 | |
| 243 | R | A | -0.5873 | |
| 244 | H | A | -0.7602 | |
| 245 | F | A | 0.1465 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.8198 | |
| 249 | A | A | -1.2198 | |
| 250 | G | A | -1.1767 | |
| 251 | P | A | -0.7702 | |
| 252 | D | A | -0.3725 | |
| 253 | G | A | 0.0849 | |
| 254 | V | A | 1.3363 | |
| 255 | P | A | 0.5011 | |
| 256 | L | A | 1.0845 | |
| 257 | P | A | 0.4957 | |
| 258 | A | A | 0.1524 | |
| 259 | A | A | 0.0401 | |
| 260 | P | A | -0.4975 | |
| 261 | P | A | -0.4133 | |
| 262 | P | A | -0.3264 | |
| 263 | S | A | 0.0974 | |
| 264 | P | A | 0.3996 | |
| 265 | L | A | 1.5380 | |
| 266 | Y | A | 0.8452 | |
| 267 | T | A | 0.0806 | |
| 268 | P | A | 0.2376 | |
| 269 | P | A | 0.2196 | |
| 270 | P | A | -0.3453 | |
| 271 | P | A | -0.0738 | |
| 272 | T | A | -0.0185 | |
| 273 | S | A | 0.2462 | |
| 274 | P | A | 0.4414 | |
| 275 | Y | A | 1.4362 | |
| 276 | A | A | 1.2506 | |
| 277 | V | A | 2.1924 | |
| 278 | L | A | 1.6267 | |
| 279 | P | A | 0.1624 | |
| 280 | P | A | -0.2628 | |
| 281 | T | A | -0.0991 | |
| 282 | D | A | -0.8016 | |
| 283 | Y | A | 0.7403 | |
| 284 | F | A | 0.6452 | |
| 285 | G | A | 0.3296 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9808 | |
| 291 | L | A | 1.5998 | |
| 292 | V | A | 0.6213 | |
| 293 | S | A | -0.1502 | |
| 294 | S | A | -0.9524 | |
| 295 | D | A | -1.8440 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1155 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6414 | |
| 301 | R | A | -1.8806 | |
| 302 | P | A | -0.9646 | |
| 303 | F | A | -0.1919 | |
| 304 | W | A | -0.5644 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0816 | |
| 307 | R | A | -2.8341 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.2569 | |
| 310 | G | A | -1.2245 | |
| 311 | N | A | -1.2673 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.7864 | |
| 319 | N | A | -0.8528 | |
| 320 | E | A | -1.0413 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3216 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.0604 | |
| 333 | N | A | 0.5740 | |
| 334 | F | A | 1.7536 | |
| 335 | T | A | 0.8776 | |
| 336 | I | A | 0.4553 | |
| 337 | S | A | -0.9688 | |
| 338 | Q | A | -1.7753 | |
| 339 | Q | A | -1.2934 | |
| 340 | L | A | 0.5937 | |
| 341 | C | A | 0.4051 | |
| 342 | T | A | 0.2300 | |
| 343 | P | A | -0.0693 | |
| 344 | L | A | 0.5935 | |
| 345 | P | A | 0.3067 | |
| 346 | N | A | -0.1489 | |
| 347 | V | A | 1.6318 | |
| 348 | Y | A | 1.5284 | |
| 349 | D | A | 0.1721 | |
| 350 | P | A | -0.3926 | |
| 351 | S | A | -0.3471 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.8259 | |
| 354 | K | A | -1.8519 | |
| 355 | N | A | -1.7949 | |
| 356 | Y | A | -0.0943 | |
| 357 | L | A | 0.6552 | |
| 358 | R | A | 0.9970 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.3904 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0769 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -2.0361 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6866 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.3015 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3089 | |
| 376 | L | A | -1.7047 | |
| 377 | D | A | -1.9883 | |
| 378 | P | A | -1.0373 | |
| 379 | G | A | -1.0093 | |
| 380 | V | A | -0.9256 | |
| 381 | L | A | -0.5262 | |
| 382 | A | A | -0.6502 | |
| 383 | H | A | -0.7976 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.3931 | |
| 386 | T | A | -0.5403 | |
| 387 | M | A | -0.2896 | |
| 388 | N | A | -0.8591 | |
| 389 | P | A | -1.2311 | |
| 390 | T | A | -1.4063 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.3811 | |
| 393 | E | A | -2.7039 | |
| 394 | N | A | -2.4360 | |
| 395 | W | A | -1.2917 | |
| 396 | N | A | -0.9939 | |
| 397 | L | A | -0.1210 | |
| 398 | G | A | 0.5759 | |
| 399 | F | A | 2.4299 | |
| 400 | V | A | 1.8443 | |
| 401 | P | A | 0.0655 | |
| 402 | P | A | -1.8039 | |
| 403 | K | A | -3.2949 | |
| 404 | E | A | -3.8163 | |
| 405 | R | A | -3.8367 | |
| 406 | E | A | -3.7549 | |
| 407 | D | A | -2.8600 | |
| 408 | P | A | -1.7538 | |
| 409 | Y | A | -0.9945 | |
| 410 | K | A | -2.1112 | |
| 411 | G | A | -0.6358 | |
| 412 | L | A | 0.6608 | |
| 413 | I | A | 1.5757 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.4020 | |
| 416 | E | A | -1.7127 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9624 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0604 | |
| 421 | E | A | -2.7799 | |
| 422 | R | A | -2.5589 | |
| 423 | F | A | -1.2776 | |
| 424 | S | A | -1.4678 | |
| 425 | Q | A | -1.7915 | |
| 426 | D | A | -2.9028 | |
| 427 | L | A | -1.9902 | |
| 428 | D | A | -2.7791 | |
| 429 | Q | A | -2.6187 | |
| 430 | F | A | -1.4131 | |
| 431 | A | A | -0.8858 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.5513 | |
| 435 | K | A | -0.6948 | |
| 436 | F | A | 0.1546 | |
| 437 | L | A | 1.0368 | |
| 438 | Y | A | 0.8327 | |
| 439 | Q | A | -0.2730 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine