| Chain sequence(s) |
A: GGFGNQGGFGNSRGGGAGLGNNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSG
C: GGFGNQGGFGNSRGGGAGLGNNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSG B: GGFGNQGGFGNSRGGGAGLGNNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSG E: GGFGNQGGFGNSRGGGAGLGNNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSG D: GGFGNQGGFGNSRGGGAGLGNNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSG input PDB |
| Selected Chain(s) | A,C,B,E,D |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with all chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:01:50)
[INFO] Main: Simulation completed successfully. (00:01:53)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 281 | G | A | -1.2635 | |
| 282 | G | A | -1.0307 | |
| 283 | F | A | 0.0000 | |
| 284 | G | A | -1.0621 | |
| 285 | N | A | 0.0000 | |
| 286 | Q | A | -1.6928 | |
| 287 | G | A | 0.0000 | |
| 288 | G | A | -0.8721 | |
| 289 | F | A | 0.0000 | |
| 290 | G | A | -1.3595 | |
| 291 | N | A | 0.0000 | |
| 292 | S | A | 0.0000 | |
| 293 | R | A | -3.6332 | |
| 294 | G | A | -2.6272 | |
| 295 | G | A | -1.7502 | |
| 296 | G | A | 0.0000 | |
| 297 | A | A | 0.1284 | |
| 298 | G | A | 0.6627 | |
| 299 | L | A | 1.4085 | |
| 300 | G | A | 0.0000 | |
| 301 | N | A | 0.0000 | |
| 302 | N | A | 0.0000 | |
| 303 | Q | A | 0.0000 | |
| 304 | G | A | 0.0000 | |
| 305 | S | A | 0.0000 | |
| 306 | N | A | 0.0000 | |
| 307 | M | A | 0.0000 | |
| 308 | G | A | 0.0000 | |
| 309 | G | A | 0.0000 | |
| 310 | G | A | 0.0000 | |
| 311 | M | A | 0.0000 | |
| 312 | N | A | 0.0000 | |
| 313 | F | A | 1.5385 | |
| 314 | G | A | 0.9748 | |
| 315 | A | A | 0.4780 | |
| 316 | F | A | 0.0000 | |
| 317 | S | A | -0.2998 | |
| 318 | I | A | 0.0000 | |
| 319 | N | A | -1.1357 | |
| 320 | P | A | 0.0000 | |
| 321 | A | A | -0.0741 | |
| 322 | M | A | 0.0000 | |
| 323 | M | A | 0.6974 | |
| 324 | A | A | 0.0000 | |
| 325 | A | A | 0.1380 | |
| 326 | A | A | -0.1705 | |
| 327 | Q | A | -0.4837 | |
| 328 | A | A | 0.0000 | |
| 329 | A | A | 0.0000 | |
| 330 | L | A | 0.0000 | |
| 331 | Q | A | 0.0000 | |
| 332 | S | A | 0.0000 | |
| 333 | S | A | 0.0000 | |
| 334 | W | A | 0.0000 | |
| 335 | G | A | 0.0000 | |
| 336 | M | A | 0.0000 | |
| 337 | M | A | 0.0000 | |
| 338 | G | A | 0.0000 | |
| 339 | M | A | 0.0000 | |
| 340 | L | A | 0.0000 | |
| 341 | A | A | 0.0000 | |
| 342 | S | A | 0.0000 | |
| 343 | Q | A | 0.0000 | |
| 344 | Q | A | -1.6208 | |
| 345 | N | A | 0.0000 | |
| 346 | Q | A | -2.0522 | |
| 347 | S | A | -1.5450 | |
| 348 | G | A | -1.2077 | |
| 349 | P | A | 0.0000 | |
| 350 | S | A | -1.0062 | |
| 351 | G | A | -1.0784 | |
| 281 | G | B | -1.2954 | |
| 282 | G | B | -1.0454 | |
| 283 | F | B | -0.3003 | |
| 284 | G | B | 0.0000 | |
| 285 | N | B | 0.0000 | |
| 286 | Q | B | -1.6454 | |
| 287 | G | B | 0.0000 | |
| 288 | G | B | -0.9241 | |
| 289 | F | B | 0.0000 | |
| 290 | G | B | 0.0000 | |
| 291 | N | B | 0.0000 | |
| 292 | S | B | 0.0000 | |
| 293 | R | B | -3.7450 | |
| 294 | G | B | -2.5595 | |
| 295 | G | B | -1.6075 | |
| 296 | G | B | 0.0000 | |
| 297 | A | B | 0.1921 | |
| 298 | G | B | 0.6432 | |
| 299 | L | B | 1.2836 | |
| 300 | G | B | 0.0000 | |
| 301 | N | B | 0.0000 | |
| 302 | N | B | 0.0000 | |
| 303 | Q | B | 0.0000 | |
| 304 | G | B | 0.0000 | |
| 305 | S | B | -0.1081 | |
| 306 | N | B | 0.0000 | |
| 307 | M | B | 0.0000 | |
| 308 | G | B | 0.0000 | |
| 309 | G | B | 0.0000 | |
| 310 | G | B | 0.0000 | |
| 311 | M | B | 0.0000 | |
| 312 | N | B | 0.0000 | |
| 313 | F | B | 2.0559 | |
| 314 | G | B | 1.0465 | |
| 315 | A | B | 0.4233 | |
| 316 | F | B | 0.0000 | |
| 317 | S | B | -0.3987 | |
| 318 | I | B | 0.0000 | |
| 319 | N | B | -1.2719 | |
| 320 | P | B | 0.0000 | |
| 321 | A | B | -0.0989 | |
| 322 | M | B | 0.0000 | |
| 323 | M | B | 0.6322 | |
| 324 | A | B | 0.0000 | |
| 325 | A | B | 0.0483 | |
| 326 | A | B | -0.2225 | |
| 327 | Q | B | -0.6988 | |
| 328 | A | B | 0.0000 | |
| 329 | A | B | 0.0000 | |
| 330 | L | B | 0.0000 | |
| 331 | Q | B | 0.0000 | |
| 332 | S | B | 0.0000 | |
| 333 | S | B | 0.0000 | |
| 334 | W | B | 0.0000 | |
| 335 | G | B | 0.0000 | |
| 336 | M | B | 0.0000 | |
| 337 | M | B | 0.0000 | |
| 338 | G | B | 0.0000 | |
| 339 | M | B | 0.0000 | |
| 340 | L | B | 0.0000 | |
| 341 | A | B | 0.0000 | |
| 342 | S | B | 0.0000 | |
| 343 | Q | B | 0.0000 | |
| 344 | Q | B | -1.0343 | |
| 345 | N | B | 0.0000 | |
| 346 | Q | B | -1.7484 | |
| 347 | S | B | 0.0000 | |
| 348 | G | B | -1.0366 | |
| 349 | P | B | 0.0000 | |
| 350 | S | B | -0.9476 | |
| 351 | G | B | -1.1124 | |
| 281 | G | C | -1.0941 | |
| 282 | G | C | -0.8667 | |
| 283 | F | C | -0.3979 | |
| 284 | G | C | -0.9180 | |
| 285 | N | C | -1.3254 | |
| 286 | Q | C | -1.8786 | |
| 287 | G | C | -1.1253 | |
| 288 | G | C | -0.8909 | |
| 289 | F | C | -0.2841 | |
| 290 | G | C | -1.0443 | |
| 291 | N | C | -1.3662 | |
| 292 | S | C | -2.2103 | |
| 293 | R | C | -3.0890 | |
| 294 | G | C | -2.4427 | |
| 295 | G | C | -1.5569 | |
| 296 | G | C | -1.3704 | |
| 297 | A | C | -0.0522 | |
| 298 | G | C | 0.5425 | |
| 299 | L | C | 1.5548 | |
| 300 | G | C | 0.0000 | |
| 301 | N | C | -0.1844 | |
| 302 | N | C | -0.7994 | |
| 303 | Q | C | -0.6475 | |
| 304 | G | C | 0.0000 | |
| 305 | S | C | -0.0218 | |
| 306 | N | C | -0.1573 | |
| 307 | M | C | 0.2198 | |
| 308 | G | C | -0.0858 | |
| 309 | G | C | -0.4556 | |
| 310 | G | C | -0.5248 | |
| 311 | M | C | 0.2793 | |
| 312 | N | C | 0.3568 | |
| 313 | F | C | 1.9107 | |
| 314 | G | C | 0.8762 | |
| 315 | A | C | 0.5306 | |
| 316 | F | C | 0.5192 | |
| 317 | S | C | -0.1216 | |
| 318 | I | C | -0.4079 | |
| 319 | N | C | -1.2908 | |
| 320 | P | C | -0.6189 | |
| 321 | A | C | 0.0299 | |
| 322 | M | C | 0.7445 | |
| 323 | M | C | 0.8492 | |
| 324 | A | C | 0.4682 | |
| 325 | A | C | 0.1675 | |
| 326 | A | C | -0.1230 | |
| 327 | Q | C | -0.4451 | |
| 328 | A | C | 0.0589 | |
| 329 | A | C | 0.1686 | |
| 330 | L | C | 0.0131 | |
| 331 | Q | C | -0.7144 | |
| 332 | S | C | -0.0756 | |
| 333 | S | C | 0.1061 | |
| 334 | W | C | 0.3592 | |
| 335 | G | C | 0.0000 | |
| 336 | M | C | 0.3917 | |
| 337 | M | C | 0.3868 | |
| 338 | G | C | 0.2988 | |
| 339 | M | C | 0.4219 | |
| 340 | L | C | 0.1214 | |
| 341 | A | C | -0.0004 | |
| 342 | S | C | -0.4931 | |
| 343 | Q | C | -1.2821 | |
| 344 | Q | C | -2.2244 | |
| 345 | N | C | -2.3086 | |
| 346 | Q | C | -2.3874 | |
| 347 | S | C | -1.4516 | |
| 348 | G | C | -1.2850 | |
| 349 | P | C | -0.7961 | |
| 350 | S | C | -0.8987 | |
| 351 | G | C | -0.8800 | |
| 281 | G | D | -1.1901 | |
| 282 | G | D | -0.7948 | |
| 283 | F | D | 0.0000 | |
| 284 | G | D | -1.0412 | |
| 285 | N | D | 0.0000 | |
| 286 | Q | D | -1.9162 | |
| 287 | G | D | 0.0000 | |
| 288 | G | D | -0.9853 | |
| 289 | F | D | 0.0000 | |
| 290 | G | D | -1.4997 | |
| 291 | N | D | 0.0000 | |
| 292 | S | D | 0.0000 | |
| 293 | R | D | -3.7122 | |
| 294 | G | D | -2.4551 | |
| 295 | G | D | -1.6985 | |
| 296 | G | D | 0.0000 | |
| 297 | A | D | 0.1697 | |
| 298 | G | D | 0.5158 | |
| 299 | L | D | 1.2742 | |
| 300 | G | D | 0.0000 | |
| 301 | N | D | 0.0000 | |
| 302 | N | D | 0.0000 | |
| 303 | Q | D | 0.0000 | |
| 304 | G | D | 0.0000 | |
| 305 | S | D | 0.0000 | |
| 306 | N | D | 0.0000 | |
| 307 | M | D | 0.0000 | |
| 308 | G | D | 0.0000 | |
| 309 | G | D | 0.0000 | |
| 310 | G | D | 0.0000 | |
| 311 | M | D | 0.0000 | |
| 312 | N | D | 0.0000 | |
| 313 | F | D | 2.0854 | |
| 314 | G | D | 1.2992 | |
| 315 | A | D | 0.6268 | |
| 316 | F | D | 0.0000 | |
| 317 | S | D | -0.3596 | |
| 318 | I | D | 0.0000 | |
| 319 | N | D | -1.2224 | |
| 320 | P | D | 0.0000 | |
| 321 | A | D | -0.1004 | |
| 322 | M | D | 0.0000 | |
| 323 | M | D | 0.7773 | |
| 324 | A | D | 0.0000 | |
| 325 | A | D | 0.0423 | |
| 326 | A | D | -0.4996 | |
| 327 | Q | D | -0.9192 | |
| 328 | A | D | 0.0000 | |
| 329 | A | D | 0.0000 | |
| 330 | L | D | 0.0000 | |
| 331 | Q | D | 0.0000 | |
| 332 | S | D | 0.0000 | |
| 333 | S | D | 0.0000 | |
| 334 | W | D | 0.0000 | |
| 335 | G | D | 0.0000 | |
| 336 | M | D | 0.0000 | |
| 337 | M | D | 0.0000 | |
| 338 | G | D | 0.0000 | |
| 339 | M | D | 0.0000 | |
| 340 | L | D | 0.0000 | |
| 341 | A | D | 0.0000 | |
| 342 | S | D | 0.0000 | |
| 343 | Q | D | 0.0000 | |
| 344 | Q | D | -1.1649 | |
| 345 | N | D | 0.0000 | |
| 346 | Q | D | -1.8910 | |
| 347 | S | D | 0.0000 | |
| 348 | G | D | -1.1338 | |
| 349 | P | D | 0.0000 | |
| 350 | S | D | -0.9160 | |
| 351 | G | D | -1.1002 | |
| 281 | G | E | -1.0531 | |
| 282 | G | E | -0.5220 | |
| 283 | F | E | 0.2130 | |
| 284 | G | E | -0.8513 | |
| 285 | N | E | -1.0038 | |
| 286 | Q | E | -1.9022 | |
| 287 | G | E | -1.0612 | |
| 288 | G | E | -0.9449 | |
| 289 | F | E | -0.5622 | |
| 290 | G | E | -1.2540 | |
| 291 | N | E | -1.5684 | |
| 292 | S | E | -2.0667 | |
| 293 | R | E | -3.2638 | |
| 294 | G | E | -2.2094 | |
| 295 | G | E | -1.7303 | |
| 296 | G | E | -1.0353 | |
| 297 | A | E | -0.0589 | |
| 298 | G | E | 0.2671 | |
| 299 | L | E | 1.4197 | |
| 300 | G | E | 0.1138 | |
| 301 | N | E | -0.4636 | |
| 302 | N | E | -1.3728 | |
| 303 | Q | E | -1.1921 | |
| 304 | G | E | -0.8558 | |
| 305 | S | E | -0.5540 | |
| 306 | N | E | -0.7679 | |
| 307 | M | E | 0.0000 | |
| 308 | G | E | -0.2222 | |
| 309 | G | E | -0.3221 | |
| 310 | G | E | 0.0000 | |
| 311 | M | E | 0.8908 | |
| 312 | N | E | 1.2299 | |
| 313 | F | E | 2.3443 | |
| 314 | G | E | 0.9965 | |
| 315 | A | E | 0.5910 | |
| 316 | F | E | 0.4036 | |
| 317 | S | E | -0.2200 | |
| 318 | I | E | -0.2607 | |
| 319 | N | E | -1.3183 | |
| 320 | P | E | -0.4503 | |
| 321 | A | E | 0.1550 | |
| 322 | M | E | 0.8227 | |
| 323 | M | E | 1.2706 | |
| 324 | A | E | 0.0000 | |
| 325 | A | E | -0.0221 | |
| 326 | A | E | -0.6119 | |
| 327 | Q | E | -1.2248 | |
| 328 | A | E | -0.4791 | |
| 329 | A | E | 0.0000 | |
| 330 | L | E | -0.4140 | |
| 331 | Q | E | -1.2862 | |
| 332 | S | E | -0.5355 | |
| 333 | S | E | -0.2258 | |
| 334 | W | E | 0.1813 | |
| 335 | G | E | 0.0748 | |
| 336 | M | E | 0.3262 | |
| 337 | M | E | 0.0403 | |
| 338 | G | E | -0.1916 | |
| 339 | M | E | 0.1560 | |
| 340 | L | E | -0.1968 | |
| 341 | A | E | 0.0043 | |
| 342 | S | E | -0.1274 | |
| 343 | Q | E | -0.7184 | |
| 344 | Q | E | -1.4423 | |
| 345 | N | E | -1.8939 | |
| 346 | Q | E | -2.1204 | |
| 347 | S | E | -1.5316 | |
| 348 | G | E | -1.0954 | |
| 349 | P | E | -0.7631 | |
| 350 | S | E | -0.8503 | |
| 351 | G | E | -1.0641 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine