| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIVKNGKVVVPKVSGYQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTVGHPLWNKLGDTENPTAPLHEGPDDRVAFSYDPKQTQLFIVGCEPPTGEHWDIAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYRRCGPEGHPLPDAPPPSPLYVKPPPTSPYAVRPSTDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLSTPAINVYDPANFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9543 | |
| 2 | L | A | 1.9795 | |
| 3 | P | A | 0.6548 | |
| 4 | P | A | 0.3504 | |
| 5 | T | A | 0.1044 | |
| 6 | T | A | 0.1283 | |
| 7 | P | A | 0.1697 | |
| 8 | V | A | 1.2138 | |
| 9 | A | A | 0.0256 | |
| 10 | K | A | -1.1614 | |
| 11 | V | A | -0.4174 | |
| 12 | Q | A | -1.5435 | |
| 13 | S | A | -1.6068 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4104 | |
| 16 | E | A | -2.4366 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4597 | |
| 20 | P | A | 0.1311 | |
| 21 | T | A | 0.1629 | |
| 22 | S | A | -0.0960 | |
| 23 | L | A | 0.1074 | |
| 24 | F | A | -0.0186 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.1624 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.7549 | |
| 31 | R | A | -2.6134 | |
| 32 | L | A | -0.7508 | |
| 33 | L | A | 1.2352 | |
| 34 | T | A | 1.4696 | |
| 35 | V | A | 2.0104 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2294 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6234 | |
| 40 | K | A | -1.6406 | |
| 41 | D | A | -0.9381 | |
| 42 | I | A | 0.8256 | |
| 43 | V | A | 1.0186 | |
| 44 | K | A | -1.1904 | |
| 45 | N | A | -1.9288 | |
| 46 | G | A | -1.2324 | |
| 47 | K | A | -0.9476 | |
| 48 | V | A | 1.4990 | |
| 49 | V | A | 2.0638 | |
| 50 | V | A | 1.2954 | |
| 51 | P | A | 0.4806 | |
| 52 | K | A | -0.6247 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1374 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.4805 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2587 | |
| 70 | K | A | -1.8079 | |
| 71 | F | A | -0.6712 | |
| 72 | A | A | -0.6022 | |
| 73 | L | A | -0.9430 | |
| 74 | P | A | -1.2659 | |
| 75 | Q | A | -2.4798 | |
| 76 | K | A | -3.0967 | |
| 77 | D | A | -2.9851 | |
| 78 | F | A | -1.6417 | |
| 79 | Y | A | -1.9027 | |
| 80 | D | A | -2.7479 | |
| 81 | P | A | -2.3541 | |
| 82 | E | A | -3.0729 | |
| 83 | K | A | -3.4369 | |
| 84 | E | A | -2.4996 | |
| 85 | R | A | -1.3082 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6650 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9544 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3506 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6736 | |
| 99 | G | A | -0.5451 | |
| 100 | P | A | -0.4290 | |
| 101 | L | A | -0.0015 | |
| 102 | G | A | -0.2376 | |
| 103 | K | A | -0.6465 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.4436 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.1534 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.4298 | |
| 110 | L | A | 0.2969 | |
| 111 | W | A | 0.0000 | |
| 112 | N | A | -1.0506 | |
| 113 | K | A | -0.5289 | |
| 114 | L | A | -0.9522 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.3278 | |
| 117 | T | A | -1.2172 | |
| 118 | E | A | -2.7229 | |
| 119 | N | A | -2.4078 | |
| 120 | P | A | -1.4785 | |
| 121 | T | A | -0.7285 | |
| 122 | A | A | -0.3067 | |
| 123 | P | A | 0.1071 | |
| 124 | L | A | -0.1951 | |
| 125 | H | A | -1.2663 | |
| 126 | E | A | -2.3140 | |
| 127 | G | A | -1.9753 | |
| 128 | P | A | -1.7308 | |
| 129 | D | A | -2.5124 | |
| 130 | D | A | -2.0455 | |
| 131 | R | A | -1.1118 | |
| 132 | V | A | 0.2586 | |
| 133 | A | A | 0.4542 | |
| 134 | F | A | 0.2875 | |
| 135 | S | A | -0.0684 | |
| 136 | Y | A | 0.0000 | |
| 137 | D | A | -0.6812 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5754 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2674 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1122 | |
| 157 | D | A | 0.3514 | |
| 158 | I | A | 0.8361 | |
| 159 | A | A | 0.1094 | |
| 160 | E | A | -1.4809 | |
| 161 | P | A | -0.2503 | |
| 162 | C | A | 0.1778 | |
| 163 | P | A | -0.1694 | |
| 164 | G | A | -0.0669 | |
| 165 | L | A | 0.6057 | |
| 166 | P | A | -0.1021 | |
| 167 | P | A | -0.3350 | |
| 168 | G | A | -0.4157 | |
| 169 | A | A | -0.0098 | |
| 170 | C | A | 0.7576 | |
| 171 | P | A | 0.5552 | |
| 172 | P | A | 0.7828 | |
| 173 | I | A | 2.0371 | |
| 174 | Q | A | 0.8509 | |
| 175 | L | A | 1.4365 | |
| 176 | V | A | 0.8202 | |
| 177 | N | A | -0.3437 | |
| 178 | S | A | -0.0129 | |
| 179 | V | A | 0.3539 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3597 | |
| 182 | D | A | 0.0738 | |
| 183 | G | A | -0.1558 | |
| 184 | D | A | -0.5604 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1751 | |
| 190 | F | A | 0.0688 | |
| 191 | G | A | -0.1026 | |
| 192 | N | A | -0.2778 | |
| 193 | M | A | -0.1485 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.3937 | |
| 197 | E | A | -2.5990 | |
| 198 | L | A | -1.2069 | |
| 199 | Q | A | -2.5335 | |
| 200 | Q | A | -3.3368 | |
| 201 | D | A | -3.6002 | |
| 202 | R | A | -3.3373 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.2039 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3787 | |
| 211 | S | A | -1.9014 | |
| 212 | T | A | -1.4569 | |
| 213 | R | A | -2.1166 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1722 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.2503 | |
| 220 | L | A | 0.4323 | |
| 221 | K | A | -1.4435 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -1.0047 | |
| 224 | N | A | -1.7396 | |
| 225 | E | A | -1.3560 | |
| 226 | A | A | -0.6768 | |
| 227 | Y | A | -0.4478 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.7246 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | -0.1369 | |
| 234 | F | A | 0.0370 | |
| 235 | G | A | -0.9251 | |
| 236 | R | A | -2.6933 | |
| 237 | R | A | -2.9641 | |
| 238 | E | A | -2.1473 | |
| 239 | Q | A | -0.0959 | |
| 240 | V | A | 1.5996 | |
| 241 | Y | A | 1.2631 | |
| 242 | A | A | 0.1505 | |
| 243 | R | A | -1.3487 | |
| 244 | H | A | -1.2408 | |
| 245 | F | A | -0.3135 | |
| 246 | Y | A | 0.0000 | |
| 247 | R | A | 0.0000 | |
| 248 | R | A | -0.4953 | |
| 249 | C | A | -1.2960 | |
| 250 | G | A | -1.0209 | |
| 251 | P | A | -1.0412 | |
| 252 | E | A | -1.3112 | |
| 253 | G | A | -1.2567 | |
| 254 | H | A | -1.4610 | |
| 255 | P | A | -1.3765 | |
| 256 | L | A | -0.4767 | |
| 257 | P | A | -0.9180 | |
| 258 | D | A | -1.8153 | |
| 259 | A | A | -0.7665 | |
| 260 | P | A | -0.9706 | |
| 261 | P | A | -0.6710 | |
| 262 | P | A | -0.1907 | |
| 263 | S | A | -0.0128 | |
| 264 | P | A | 0.6843 | |
| 265 | L | A | 1.5188 | |
| 266 | Y | A | 1.0874 | |
| 267 | V | A | 0.9316 | |
| 268 | K | A | -1.0312 | |
| 269 | P | A | -0.2460 | |
| 270 | P | A | -0.4886 | |
| 271 | P | A | -0.2823 | |
| 272 | T | A | -0.1708 | |
| 273 | S | A | 0.1595 | |
| 274 | P | A | 0.4357 | |
| 275 | Y | A | 1.1514 | |
| 276 | A | A | 0.6729 | |
| 277 | V | A | 1.5445 | |
| 278 | R | A | 0.1320 | |
| 279 | P | A | -0.2570 | |
| 280 | S | A | 0.0000 | |
| 281 | T | A | -0.5088 | |
| 282 | D | A | -0.8382 | |
| 283 | Y | A | 0.8908 | |
| 284 | F | A | 0.6995 | |
| 285 | G | A | 0.0938 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.8568 | |
| 291 | L | A | 1.6605 | |
| 292 | V | A | 0.6644 | |
| 293 | S | A | -0.1544 | |
| 294 | S | A | -0.9696 | |
| 295 | D | A | -1.8388 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1397 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6132 | |
| 301 | R | A | -1.8521 | |
| 302 | P | A | -0.9603 | |
| 303 | F | A | -0.1783 | |
| 304 | W | A | -0.5179 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0830 | |
| 307 | R | A | -2.9243 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.7830 | |
| 310 | G | A | -1.4178 | |
| 311 | N | A | -1.3918 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.9823 | |
| 319 | N | A | -0.9015 | |
| 320 | E | A | -1.0608 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3440 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.1516 | |
| 333 | N | A | 0.4101 | |
| 334 | F | A | 1.4334 | |
| 335 | T | A | 0.7143 | |
| 336 | I | A | 0.3326 | |
| 337 | S | A | -1.0060 | |
| 338 | Q | A | -1.6802 | |
| 339 | Q | A | -1.0733 | |
| 340 | L | A | 0.5415 | |
| 341 | S | A | 0.2399 | |
| 342 | T | A | 0.0108 | |
| 343 | P | A | -0.2437 | |
| 344 | A | A | 0.0880 | |
| 345 | I | A | 0.5981 | |
| 346 | N | A | 0.0208 | |
| 347 | V | A | 1.6881 | |
| 348 | Y | A | 1.5157 | |
| 349 | D | A | -0.0198 | |
| 350 | P | A | -0.6041 | |
| 351 | A | A | -0.3054 | |
| 352 | N | A | -0.1728 | |
| 353 | F | A | -0.7895 | |
| 354 | K | A | -1.8989 | |
| 355 | N | A | -1.7948 | |
| 356 | Y | A | -0.1610 | |
| 357 | L | A | 0.5523 | |
| 358 | R | A | 0.8922 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.4717 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | 0.0149 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -1.9060 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6716 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.2768 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3171 | |
| 376 | L | A | -1.7487 | |
| 377 | D | A | -2.0138 | |
| 378 | P | A | -1.0545 | |
| 379 | G | A | -1.0166 | |
| 380 | V | A | -0.9284 | |
| 381 | L | A | -0.5406 | |
| 382 | A | A | -0.6616 | |
| 383 | H | A | -0.8540 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4107 | |
| 386 | T | A | -0.5804 | |
| 387 | M | A | -0.3359 | |
| 388 | N | A | -0.8754 | |
| 389 | P | A | -1.3048 | |
| 390 | T | A | -1.6458 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.5919 | |
| 393 | E | A | -3.2197 | |
| 394 | N | A | -2.8907 | |
| 395 | W | A | -1.5826 | |
| 396 | N | A | -1.1751 | |
| 397 | L | A | -0.2451 | |
| 398 | G | A | 0.5352 | |
| 399 | F | A | 2.4372 | |
| 400 | V | A | 2.0574 | |
| 401 | P | A | 0.0726 | |
| 402 | P | A | -1.9810 | |
| 403 | K | A | -3.5893 | |
| 404 | E | A | -4.1510 | |
| 405 | R | A | -4.7549 | |
| 406 | E | A | -4.1606 | |
| 407 | D | A | -3.0380 | |
| 408 | P | A | -1.8598 | |
| 409 | Y | A | -0.9897 | |
| 410 | K | A | -2.0991 | |
| 411 | G | A | -0.6338 | |
| 412 | L | A | 0.6516 | |
| 413 | I | A | 1.5711 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3927 | |
| 416 | E | A | -1.6666 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.8440 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.8813 | |
| 421 | E | A | -2.4859 | |
| 422 | R | A | -2.0383 | |
| 423 | F | A | -0.9963 | |
| 424 | S | A | -1.2901 | |
| 425 | Q | A | -1.7470 | |
| 426 | D | A | -2.9599 | |
| 427 | L | A | -2.1841 | |
| 428 | D | A | -3.0858 | |
| 429 | Q | A | -2.7733 | |
| 430 | F | A | -1.6486 | |
| 431 | A | A | -1.1450 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.2697 | |
| 435 | K | A | -1.1027 | |
| 436 | F | A | -0.0963 | |
| 437 | L | A | 0.7935 | |
| 438 | Y | A | 0.6326 | |
| 439 | Q | A | -0.3767 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine