Project name: 66eb60f4abedb53

Chain sequence(s)	A: VQLVESGGGLVQPGGSLRLSCAASGFTFSDYWMYWVRQAPGKGLEWVSEINTNGLITKYPDSVKGRFTISRDNAKNTLYLQMNSLRPEDTAVYYCARSPSGFNRGQGTLVTVEVQLVESGGGLVQPGNSLRLSCAASGFTFSSFGMSWVRQAPGKGLEWVSSISGSGSDTLYADSVKGRFTISRDNAKTTLYLQMNSLRPEDTAVYYCTIGGSLSRSSQGTLVTVSSVQLVESGGGLVQPGGSLRLSCAASGFTFSDYWMYWVRQAPGKGLEWVSEINTNGLITKYPDSVKGRFTISRDNAKNTLYLQMNSLRPEDTAVYYCARSPSGFNRGQGTLVTV
Selected Chain(s)	A
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:04:35)
[INFO]       Main:     Simulation completed successfully.                                          (00:04:37)

• Minimal score value: -3.1705
• Maximal score value: 1.7668
• Average score: -0.5796
• Total score value: -196.4767

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	V	A	0.9040
3	Q	A	-0.7457
4	L	A	0.0000
5	V	A	0.2848
6	E	A	0.0000
7	S	A	-0.3749
8	G	A	-0.9829
9	G	A	-0.0966
10	G	A	0.6454
11	L	A	1.5881
12	V	A	0.2770
13	Q	A	-1.1331
14	P	A	-1.3844
15	G	A	-1.5140
16	G	A	-1.2040
17	S	A	-1.2738
18	L	A	-1.2994
19	R	A	-2.2854
20	L	A	0.0000
21	S	A	-0.5502
22	C	A	0.0000
23	A	A	-0.3547
24	A	A	0.0000
25	S	A	-0.1798
26	G	A	0.0015
27	F	A	0.0027
28	T	A	-0.7439
29	F	A	0.0000
30	S	A	-1.5752
31	D	A	-1.9191
32	Y	A	-0.7481
33	W	A	-0.3755
34	M	A	0.0000
35	Y	A	-0.1840
36	W	A	0.0000
37	V	A	0.0000
38	R	A	0.0000
39	Q	A	-0.5347
40	A	A	-0.9060
41	P	A	-1.0719
42	G	A	-1.1741
43	K	A	-1.7153
44	G	A	-1.2411
45	L	A	-0.5828
46	E	A	-0.6017
47	W	A	-0.2293
48	V	A	0.0000
49	S	A	0.0000
50	E	A	-0.5401
51	I	A	0.0000
52	N	A	-0.5866
53	T	A	-1.1095
54	N	A	-1.2822
55	G	A	-0.1727
56	L	A	1.2594
57	I	A	1.0545
58	T	A	-0.0834
59	K	A	-1.3719
60	Y	A	-1.5121
61	P	A	0.0000
62	D	A	-2.5559
63	S	A	-1.8672
64	V	A	0.0000
65	K	A	-2.4368
66	G	A	-1.8021
67	R	A	-2.1345
68	F	A	0.0000
69	T	A	-1.1466
70	I	A	0.0000
71	S	A	-0.4703
72	R	A	-1.1425
73	D	A	-1.7311
74	N	A	-2.2779
75	A	A	-1.4946
76	K	A	-2.3005
77	N	A	-1.7840
78	T	A	-1.0038
79	L	A	0.0000
80	Y	A	-0.5697
81	L	A	0.0000
82	Q	A	-1.5492
83	M	A	0.0000
84	N	A	-2.0445
85	S	A	-1.5572
86	L	A	0.0000
87	R	A	-2.8730
88	P	A	-2.0590
89	E	A	-2.5959
90	D	A	-1.6888
91	T	A	-0.5412
92	A	A	0.0000
93	V	A	0.6766
94	Y	A	0.0000
95	Y	A	-0.0364
96	C	A	0.0000
97	A	A	0.0000
98	R	A	-0.5057
99	S	A	-0.0475
100	P	A	-0.0448
101	S	A	0.0703
102	G	A	0.0000
103	F	A	0.9638
104	N	A	-0.7611
105	R	A	-1.0764
106	G	A	-0.8720
107	Q	A	-1.2495
108	G	A	0.0000
109	T	A	0.5409
110	L	A	1.5803
111	V	A	0.0000
112	T	A	0.4561
113	V	A	-0.4840
125	E	A	-1.8964
126	V	A	-0.8640
127	Q	A	-1.0679
128	L	A	0.0000
129	V	A	1.1171
130	E	A	0.0000
131	S	A	-0.0845
132	G	A	-0.5341
133	G	A	0.2988
134	G	A	0.7390
135	L	A	1.4854
136	V	A	-0.1019
137	Q	A	-1.4101
138	P	A	-1.5665
139	G	A	-1.6052
140	N	A	-1.7200
141	S	A	-1.6806
142	L	A	-1.0090
143	R	A	-1.7045
144	L	A	0.0000
145	S	A	-0.1675
146	C	A	0.0000
147	A	A	0.0178
148	A	A	0.0000
149	S	A	-0.7489
150	G	A	-1.2297
151	F	A	-0.1354
152	T	A	-0.0830
153	F	A	0.0000
154	S	A	-0.4388
155	S	A	0.1742
156	F	A	0.9040
157	G	A	-0.0958
158	M	A	0.0000
159	S	A	0.0000
160	W	A	0.0000
161	V	A	0.0000
162	R	A	0.0000
163	Q	A	-0.7997
164	A	A	-1.1478
165	P	A	-1.0044
166	G	A	-1.4712
167	K	A	-2.4008
168	G	A	-1.6240
169	L	A	-1.0310
170	E	A	-1.6114
171	W	A	-0.3827
172	V	A	0.0000
173	S	A	0.0000
174	S	A	0.1346
175	I	A	0.0000
176	S	A	-0.6605
177	G	A	-0.4372
178	S	A	-0.8583
179	G	A	-1.2357
180	S	A	-1.2675
181	D	A	-1.7357
182	T	A	-0.2761
183	L	A	0.8059
184	Y	A	-0.1117
185	A	A	-1.1215
186	D	A	-2.3294
187	S	A	-2.0201
188	V	A	0.0000
189	K	A	-2.5652
190	G	A	-2.0223
191	R	A	-1.9985
192	F	A	0.0000
193	T	A	-0.9145
194	I	A	0.0000
195	S	A	-0.7495
196	R	A	-0.9029
197	D	A	-1.4512
198	N	A	-1.5368
199	A	A	-1.4092
200	K	A	-1.5698
201	T	A	-1.1400
202	T	A	0.0000
203	L	A	0.0000
204	Y	A	-0.4871
205	L	A	0.0000
206	Q	A	-1.6517
207	M	A	0.0000
208	N	A	-2.3027
209	S	A	-1.5840
210	L	A	0.0000
211	R	A	-1.7211
212	P	A	-1.5223
213	E	A	-2.0726
214	D	A	0.0000
215	T	A	-0.2583
216	A	A	0.0000
217	V	A	0.6249
218	Y	A	0.0000
219	Y	A	0.0000
220	C	A	0.0000
221	T	A	0.0000
222	I	A	0.4046
223	G	A	-0.1534
224	G	A	-0.2891
225	S	A	-0.2073
226	L	A	0.0492
227	S	A	-0.4501
228	R	A	-1.3481
229	S	A	-0.8560
230	S	A	-0.8821
231	Q	A	-0.9005
232	G	A	-0.1856
233	T	A	0.5821
234	L	A	1.5864
235	V	A	0.0000
236	T	A	0.4314
237	V	A	0.0000
238	S	A	-0.6041
239	S	A	-0.7260
250	V	A	0.6629
251	Q	A	-0.6065
252	L	A	0.0000
253	V	A	0.2113
254	E	A	0.0000
255	S	A	-0.2265
256	G	A	-0.9508
257	G	A	0.0676
258	G	A	0.9991
259	L	A	1.7668
260	V	A	0.3065
261	Q	A	-0.9803
262	P	A	-1.3943
263	G	A	-1.4621
264	G	A	-1.0637
265	S	A	-1.3565
266	L	A	-1.0047
267	R	A	-1.6930
268	L	A	0.0000
269	S	A	-0.4062
270	C	A	0.0000
271	A	A	-0.1226
272	A	A	0.0000
273	S	A	-0.2053
274	G	A	0.0379
275	F	A	-0.0253
276	T	A	-0.4656
277	F	A	0.0000
278	S	A	-1.4911
279	D	A	-1.6428
280	Y	A	-0.2197
281	W	A	0.1555
282	M	A	0.0000
283	Y	A	0.1272
284	W	A	0.0000
285	V	A	0.0000
286	R	A	0.0000
287	Q	A	-1.1374
288	A	A	-1.4210
289	P	A	-1.3328
290	G	A	-1.5993
291	K	A	-2.5151
292	G	A	-1.7846
293	L	A	-1.0927
294	E	A	-1.9696
295	W	A	-0.7053
296	V	A	0.0000
297	S	A	0.0000
298	E	A	-0.2600
299	I	A	0.0000
300	N	A	0.0346
301	T	A	-0.7304
302	N	A	-1.0208
303	G	A	0.1233
304	L	A	1.5078
305	I	A	1.4024
306	T	A	0.1229
307	K	A	-1.1911
308	Y	A	0.0000
309	P	A	-1.9720
310	D	A	-2.8270
311	S	A	-1.9882
312	V	A	0.0000
313	K	A	-3.1705
314	G	A	-2.3308
315	R	A	-2.4705
316	F	A	0.0000
317	T	A	-1.2954
318	I	A	0.0000
319	S	A	-0.4488
320	R	A	-1.0110
321	D	A	-1.8202
322	N	A	-1.9879
323	A	A	-1.3694
324	K	A	-2.2706
325	N	A	-1.6416
326	T	A	0.0000
327	L	A	0.0000
328	Y	A	-0.5237
329	L	A	0.0000
330	Q	A	-1.5721
331	M	A	0.0000
332	N	A	-1.9880
333	S	A	-1.5939
334	L	A	0.0000
335	R	A	-2.1818
336	P	A	-1.7476
337	E	A	-2.2849
338	D	A	0.0000
339	T	A	-0.2768
340	A	A	0.0000
341	V	A	0.5525
342	Y	A	0.0000
343	Y	A	-0.2042
344	C	A	0.0000
345	A	A	0.0000
346	R	A	0.1575
347	S	A	0.0000
348	P	A	-0.0431
349	S	A	-0.1837
350	G	A	0.0000
351	F	A	0.9459
352	N	A	-0.1998
353	R	A	-1.1531
354	G	A	-0.9253
355	Q	A	-1.1954
356	G	A	0.0000
357	T	A	0.6686
358	L	A	1.6983
359	V	A	0.0000
360	T	A	1.1326
361	V	A	0.4120