| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFEDIVVNGKVLVPKVSGWQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTVGHPLFNKLGDTENPTSPVHPTADDRVAYSFDPKQTQLFIVGCEPPTGEHWDIAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFFVRSGPVGHPLPSSPPPSPLYTPPPPSSPFAVLPPYDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPEDNVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9439 | |
| 2 | L | A | 1.9634 | |
| 3 | P | A | 0.8369 | |
| 4 | P | A | 0.3710 | |
| 5 | T | A | 0.1226 | |
| 6 | T | A | 0.1303 | |
| 7 | P | A | 0.1773 | |
| 8 | V | A | 1.2106 | |
| 9 | A | A | 0.0757 | |
| 10 | K | A | -1.0479 | |
| 11 | V | A | -0.2053 | |
| 12 | Q | A | -1.4365 | |
| 13 | S | A | -1.5710 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4242 | |
| 16 | E | A | -2.4436 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4591 | |
| 20 | P | A | 0.1291 | |
| 21 | T | A | 0.1818 | |
| 22 | S | A | -0.0926 | |
| 23 | L | A | 0.1240 | |
| 24 | F | A | -0.0232 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2869 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.8960 | |
| 31 | R | A | -2.6800 | |
| 32 | L | A | -0.7978 | |
| 33 | L | A | 1.1522 | |
| 34 | T | A | 1.3579 | |
| 35 | V | A | 1.8044 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2679 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6834 | |
| 40 | E | A | -1.7878 | |
| 41 | D | A | -0.7596 | |
| 42 | I | A | 1.2654 | |
| 43 | V | A | 2.2144 | |
| 44 | V | A | 1.6398 | |
| 45 | N | A | -0.5531 | |
| 46 | G | A | -0.3720 | |
| 47 | K | A | -0.1397 | |
| 48 | V | A | 2.0136 | |
| 49 | L | A | 2.5343 | |
| 50 | V | A | 1.4301 | |
| 51 | P | A | 0.3120 | |
| 52 | K | A | -0.7321 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | W | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1238 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.3777 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2634 | |
| 70 | K | A | -1.7838 | |
| 71 | F | A | -0.6331 | |
| 72 | A | A | -0.5773 | |
| 73 | L | A | -0.8658 | |
| 74 | P | A | -1.2727 | |
| 75 | Q | A | -2.5054 | |
| 76 | K | A | -3.1075 | |
| 77 | D | A | -2.9891 | |
| 78 | F | A | -1.6506 | |
| 79 | Y | A | -1.8880 | |
| 80 | D | A | -2.6844 | |
| 81 | P | A | -2.3024 | |
| 82 | E | A | -3.0489 | |
| 83 | K | A | -3.3900 | |
| 84 | E | A | -2.4567 | |
| 85 | R | A | -1.2941 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6750 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9618 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3568 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6974 | |
| 99 | G | A | -0.5370 | |
| 100 | P | A | -0.3998 | |
| 101 | L | A | 0.0502 | |
| 102 | G | A | -0.1940 | |
| 103 | K | A | -0.5576 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.3458 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.1537 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.3928 | |
| 110 | L | A | 0.3423 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.1196 | |
| 113 | K | A | -0.6719 | |
| 114 | L | A | -0.9105 | |
| 115 | G | A | -0.8213 | |
| 116 | D | A | -1.2731 | |
| 117 | T | A | -0.8547 | |
| 118 | E | A | -1.7503 | |
| 119 | N | A | -1.9634 | |
| 120 | P | A | -1.4174 | |
| 121 | T | A | -0.7953 | |
| 122 | S | A | -0.6721 | |
| 123 | P | A | -0.0926 | |
| 124 | V | A | -0.1893 | |
| 125 | H | A | -0.5439 | |
| 126 | P | A | -1.0980 | |
| 127 | T | A | -1.0836 | |
| 128 | A | A | -1.0701 | |
| 129 | D | A | -2.0722 | |
| 130 | D | A | -1.5727 | |
| 131 | R | A | -1.0115 | |
| 132 | V | A | 0.2576 | |
| 133 | A | A | 0.4189 | |
| 134 | Y | A | 0.2394 | |
| 135 | S | A | -0.0569 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | 0.0000 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | -0.2052 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5666 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2201 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1066 | |
| 157 | D | A | 0.2772 | |
| 158 | I | A | 0.8311 | |
| 159 | A | A | 0.1167 | |
| 160 | E | A | -1.4807 | |
| 161 | P | A | -0.2275 | |
| 162 | C | A | 0.1897 | |
| 163 | P | A | -0.1637 | |
| 164 | G | A | -0.0645 | |
| 165 | L | A | 0.6155 | |
| 166 | P | A | -0.0993 | |
| 167 | P | A | -0.3334 | |
| 168 | G | A | -0.4177 | |
| 169 | A | A | -0.0203 | |
| 170 | C | A | 0.7409 | |
| 171 | P | A | 0.5491 | |
| 172 | P | A | 0.7860 | |
| 173 | I | A | 2.0384 | |
| 174 | Q | A | 0.8352 | |
| 175 | L | A | 1.4367 | |
| 176 | V | A | 0.8259 | |
| 177 | N | A | -0.3146 | |
| 178 | S | A | 0.0204 | |
| 179 | V | A | 0.4299 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3851 | |
| 182 | D | A | 0.0857 | |
| 183 | G | A | -0.1593 | |
| 184 | D | A | -0.5468 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1329 | |
| 190 | F | A | 0.0648 | |
| 191 | G | A | -0.1032 | |
| 192 | N | A | -0.2759 | |
| 193 | M | A | -0.1454 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.3976 | |
| 197 | E | A | -2.6274 | |
| 198 | L | A | -1.2270 | |
| 199 | Q | A | -2.5439 | |
| 200 | Q | A | -3.3121 | |
| 201 | D | A | -3.6011 | |
| 202 | R | A | -3.3308 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.1584 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3559 | |
| 211 | S | A | -1.8996 | |
| 212 | T | A | -1.4549 | |
| 213 | R | A | -2.1377 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1700 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3580 | |
| 220 | L | A | 0.6123 | |
| 221 | K | A | -1.0973 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.8843 | |
| 224 | N | A | -1.4907 | |
| 225 | E | A | -1.2318 | |
| 226 | A | A | -0.6120 | |
| 227 | Y | A | -0.4101 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6796 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | -0.1559 | |
| 234 | F | A | 0.0076 | |
| 235 | G | A | -0.9212 | |
| 236 | R | A | -2.6520 | |
| 237 | R | A | -2.8950 | |
| 238 | E | A | -2.1496 | |
| 239 | Q | A | -0.2113 | |
| 240 | V | A | 1.4673 | |
| 241 | Y | A | 1.2563 | |
| 242 | A | A | 0.4227 | |
| 243 | R | A | -0.5417 | |
| 244 | H | A | -0.6097 | |
| 245 | F | A | 0.1403 | |
| 246 | F | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.5613 | |
| 249 | S | A | -0.9375 | |
| 250 | G | A | -0.9814 | |
| 251 | P | A | -0.6273 | |
| 252 | V | A | -0.5505 | |
| 253 | G | A | -0.9192 | |
| 254 | H | A | -1.1342 | |
| 255 | P | A | -0.5004 | |
| 256 | L | A | 0.4170 | |
| 257 | P | A | -0.0650 | |
| 258 | S | A | -0.1928 | |
| 259 | S | A | -0.2610 | |
| 260 | P | A | -0.5966 | |
| 261 | P | A | -0.4694 | |
| 262 | P | A | -0.3430 | |
| 263 | S | A | 0.1246 | |
| 264 | P | A | 0.4292 | |
| 265 | L | A | 1.5155 | |
| 266 | Y | A | 0.8847 | |
| 267 | T | A | 0.0981 | |
| 268 | P | A | 0.2363 | |
| 269 | P | A | 0.2788 | |
| 270 | P | A | -0.3486 | |
| 271 | P | A | -0.1052 | |
| 272 | S | A | -0.2909 | |
| 273 | S | A | 0.2740 | |
| 274 | P | A | 0.5605 | |
| 275 | F | A | 1.7493 | |
| 276 | A | A | 1.3750 | |
| 277 | V | A | 2.3135 | |
| 278 | L | A | 1.8562 | |
| 279 | P | A | 0.6606 | |
| 280 | P | A | 0.0000 | |
| 281 | Y | A | 0.2719 | |
| 282 | D | A | -0.3787 | |
| 283 | Y | A | 1.0662 | |
| 284 | F | A | 0.7995 | |
| 285 | G | A | 0.3547 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9847 | |
| 291 | L | A | 1.6066 | |
| 292 | V | A | 0.6226 | |
| 293 | S | A | -0.1602 | |
| 294 | S | A | -0.9636 | |
| 295 | D | A | -1.8434 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1103 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6406 | |
| 301 | R | A | -1.8432 | |
| 302 | P | A | -0.9493 | |
| 303 | F | A | -0.2226 | |
| 304 | W | A | -0.5706 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0890 | |
| 307 | R | A | -2.9290 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.6617 | |
| 310 | G | A | -1.4211 | |
| 311 | N | A | -1.3596 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.8134 | |
| 319 | N | A | -0.9219 | |
| 320 | E | A | -1.0295 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3269 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.0398 | |
| 333 | N | A | 0.5990 | |
| 334 | F | A | 1.7979 | |
| 335 | T | A | 0.8944 | |
| 336 | I | A | 0.4555 | |
| 337 | S | A | -0.9608 | |
| 338 | Q | A | -1.7560 | |
| 339 | Q | A | -1.3844 | |
| 340 | L | A | 0.6488 | |
| 341 | C | A | 0.2660 | |
| 342 | T | A | -0.3574 | |
| 343 | P | A | -0.9965 | |
| 344 | E | A | -2.4809 | |
| 345 | D | A | -2.5557 | |
| 346 | N | A | -1.6295 | |
| 347 | V | A | 0.4486 | |
| 348 | Y | A | 0.9047 | |
| 349 | D | A | -0.2859 | |
| 350 | P | A | -0.4019 | |
| 351 | S | A | -0.3235 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.8105 | |
| 354 | K | A | -1.7951 | |
| 355 | N | A | -1.7712 | |
| 356 | Y | A | -0.0869 | |
| 357 | L | A | 0.6515 | |
| 358 | R | A | 0.9721 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.3822 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0819 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -2.0402 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6887 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.3044 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3041 | |
| 376 | L | A | -1.6951 | |
| 377 | D | A | -1.9616 | |
| 378 | P | A | -1.0245 | |
| 379 | G | A | -1.0062 | |
| 380 | V | A | -0.9290 | |
| 381 | L | A | -0.5244 | |
| 382 | A | A | -0.6508 | |
| 383 | H | A | -0.8106 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4069 | |
| 386 | T | A | -0.5547 | |
| 387 | M | A | -0.3017 | |
| 388 | N | A | -0.8612 | |
| 389 | P | A | -1.2406 | |
| 390 | T | A | -1.4375 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.4241 | |
| 393 | E | A | -2.7462 | |
| 394 | N | A | -2.3524 | |
| 395 | W | A | -1.3439 | |
| 396 | N | A | -1.0662 | |
| 397 | L | A | -0.1654 | |
| 398 | G | A | 0.5391 | |
| 399 | F | A | 2.4201 | |
| 400 | V | A | 1.8328 | |
| 401 | P | A | 0.0547 | |
| 402 | P | A | -1.8424 | |
| 403 | K | A | -3.3197 | |
| 404 | E | A | -3.7860 | |
| 405 | R | A | -3.9283 | |
| 406 | E | A | -3.8053 | |
| 407 | D | A | -2.8850 | |
| 408 | P | A | -1.7691 | |
| 409 | Y | A | -0.9875 | |
| 410 | K | A | -2.1190 | |
| 411 | G | A | -0.6374 | |
| 412 | L | A | 0.6765 | |
| 413 | I | A | 1.5909 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3846 | |
| 416 | E | A | -1.6682 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9391 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0411 | |
| 421 | E | A | -2.7763 | |
| 422 | R | A | -2.6255 | |
| 423 | F | A | -1.2751 | |
| 424 | S | A | -1.4611 | |
| 425 | Q | A | -1.8629 | |
| 426 | D | A | -2.8905 | |
| 427 | L | A | -1.9832 | |
| 428 | D | A | -2.7815 | |
| 429 | Q | A | -2.6183 | |
| 430 | F | A | -1.4280 | |
| 431 | A | A | -0.8993 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.5825 | |
| 435 | K | A | -0.7100 | |
| 436 | F | A | 0.1385 | |
| 437 | L | A | 1.0267 | |
| 438 | Y | A | 0.8249 | |
| 439 | Q | A | -0.2746 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine