| Chain sequence(s) |
A: GPLPLAPEPPLLPTTEYVTPTDLYYIAETDLLTEVGHPTKDIVVNGKVVVPRVSAYDWLVFKLTLPDPNKLPLPSDDFIDFSTEILIWQLRAFYIGVFGPLGVGEYGHPNFNRLGNVDNPTEVQHCGPDDTVAYSWTPKLKQLYIIGDRPPLAKYTARAPPAPGLPPGAIPPLTEVTTVIQHGDRADIGFGARDFAALDPAKNNVPDIIRDTTTKVPDYEGMKAEPTGRRMFTHDEYEKSYDKEKYRLCGPDLVPLPDKPPPSKLYKKPPPESPYAVRPPYNLFTVPDRGEITEEDLLFNKPIILEKTAGLNQGVLWHNQLYITVLDNTRDEIETIETQISTPEENVYNPENYVTSKRYTREYKLSIVVQLCRIPLTPETLERLARLDPRILVEAELPDVPPVERPDPLAGLKFREIDLTDKLSSDLSKYDLGRYFLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.2124 | |
| 2 | P | A | 0.4263 | |
| 3 | L | A | 1.5925 | |
| 4 | P | A | 1.0704 | |
| 5 | L | A | 1.4649 | |
| 6 | A | A | 0.3182 | |
| 7 | P | A | -0.8584 | |
| 8 | E | A | -1.8213 | |
| 9 | P | A | -1.0885 | |
| 10 | P | A | -0.4393 | |
| 11 | L | A | 0.3786 | |
| 12 | L | A | 0.7834 | |
| 13 | P | A | 0.1168 | |
| 14 | T | A | 0.0000 | |
| 15 | T | A | -0.7818 | |
| 16 | E | A | -1.5284 | |
| 17 | Y | A | -0.9731 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.6470 | |
| 20 | P | A | -0.7053 | |
| 21 | T | A | 0.0000 | |
| 22 | D | A | -1.6091 | |
| 23 | L | A | -0.4271 | |
| 24 | Y | A | -0.0569 | |
| 25 | Y | A | 0.1424 | |
| 26 | I | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -0.9446 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.3082 | |
| 31 | L | A | 0.4285 | |
| 32 | L | A | 0.1344 | |
| 33 | T | A | 0.2150 | |
| 34 | E | A | 0.2217 | |
| 35 | V | A | 0.9471 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -1.2147 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -1.5128 | |
| 40 | K | A | -2.0997 | |
| 41 | D | A | -0.8781 | |
| 42 | I | A | 1.1889 | |
| 43 | V | A | 2.2002 | |
| 44 | V | A | 1.7439 | |
| 45 | N | A | -0.5056 | |
| 46 | G | A | -0.3516 | |
| 47 | K | A | -0.1272 | |
| 48 | V | A | 1.8778 | |
| 49 | V | A | 2.4862 | |
| 50 | V | A | 1.3588 | |
| 51 | P | A | 0.0818 | |
| 52 | R | A | -1.0518 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | D | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | L | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | K | A | -1.4609 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.2920 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | -1.2643 | |
| 67 | D | A | -1.2843 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.1074 | |
| 70 | K | A | -1.8765 | |
| 71 | L | A | -0.8096 | |
| 72 | P | A | -0.6713 | |
| 73 | L | A | -0.6725 | |
| 74 | P | A | -0.7027 | |
| 75 | S | A | -1.5452 | |
| 76 | D | A | -2.8834 | |
| 77 | D | A | -2.7990 | |
| 78 | F | A | -1.4147 | |
| 79 | I | A | 0.0000 | |
| 80 | D | A | -1.8686 | |
| 81 | F | A | 0.0510 | |
| 82 | S | A | -0.2359 | |
| 83 | T | A | -0.4373 | |
| 84 | E | A | -0.5876 | |
| 85 | I | A | 0.0000 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | Q | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.7183 | |
| 92 | A | A | 0.0000 | |
| 93 | F | A | 0.0000 | |
| 94 | Y | A | -0.5080 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | 0.0000 | |
| 97 | V | A | 0.0000 | |
| 98 | F | A | 0.4732 | |
| 99 | G | A | -0.3085 | |
| 100 | P | A | -0.1063 | |
| 101 | L | A | 0.2910 | |
| 102 | G | A | 0.2680 | |
| 103 | V | A | 0.3124 | |
| 104 | G | A | 0.0000 | |
| 105 | E | A | -1.5845 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -0.9008 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | -0.8358 | |
| 110 | N | A | -1.8832 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.1223 | |
| 113 | R | A | -0.5009 | |
| 114 | L | A | -0.3193 | |
| 115 | G | A | -0.9327 | |
| 116 | N | A | -1.5689 | |
| 117 | V | A | -1.2017 | |
| 118 | D | A | -2.6650 | |
| 119 | N | A | -2.6149 | |
| 120 | P | A | -1.8144 | |
| 121 | T | A | -1.5306 | |
| 122 | E | A | -1.9961 | |
| 123 | V | A | -0.2485 | |
| 124 | Q | A | -0.3522 | |
| 125 | H | A | -0.3543 | |
| 126 | C | A | -0.4639 | |
| 127 | G | A | -1.0573 | |
| 128 | P | A | -1.3310 | |
| 129 | D | A | -2.2891 | |
| 130 | D | A | -1.7160 | |
| 131 | T | A | -1.2663 | |
| 132 | V | A | -0.3843 | |
| 133 | A | A | -0.2355 | |
| 134 | Y | A | -0.1169 | |
| 135 | S | A | -0.5348 | |
| 136 | W | A | 0.0000 | |
| 137 | T | A | -0.6466 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | L | A | 0.0000 | |
| 141 | K | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | R | A | -0.3706 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | L | A | -0.1153 | |
| 153 | A | A | 0.0000 | |
| 154 | K | A | -0.6939 | |
| 155 | Y | A | -0.8605 | |
| 156 | T | A | -1.0760 | |
| 157 | A | A | -1.1607 | |
| 158 | R | A | -1.4770 | |
| 159 | A | A | -0.7741 | |
| 160 | P | A | -0.6306 | |
| 161 | P | A | -0.2386 | |
| 162 | A | A | -0.2008 | |
| 163 | P | A | -0.3699 | |
| 164 | G | A | -0.3365 | |
| 165 | L | A | 0.4490 | |
| 166 | P | A | -0.0311 | |
| 167 | P | A | -0.2186 | |
| 168 | G | A | 0.2041 | |
| 169 | A | A | 0.9513 | |
| 170 | I | A | 2.1230 | |
| 171 | P | A | 0.7898 | |
| 172 | P | A | 0.5099 | |
| 173 | L | A | 0.5780 | |
| 174 | T | A | -0.6793 | |
| 175 | E | A | -1.7548 | |
| 176 | V | A | -0.8110 | |
| 177 | T | A | -0.3612 | |
| 178 | T | A | -0.0643 | |
| 179 | V | A | -0.0355 | |
| 180 | I | A | 0.0000 | |
| 181 | Q | A | -0.7748 | |
| 182 | H | A | -1.0758 | |
| 183 | G | A | -0.7385 | |
| 184 | D | A | -0.6240 | |
| 185 | R | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.3162 | |
| 190 | F | A | -0.1079 | |
| 191 | G | A | -0.3007 | |
| 192 | A | A | -0.6658 | |
| 193 | R | A | -1.1700 | |
| 194 | D | A | -1.1727 | |
| 195 | F | A | 0.0000 | |
| 196 | A | A | -1.2037 | |
| 197 | A | A | -0.8960 | |
| 198 | L | A | -0.5400 | |
| 199 | D | A | 0.0000 | |
| 200 | P | A | -0.8472 | |
| 201 | A | A | -0.8575 | |
| 202 | K | A | -2.1723 | |
| 203 | N | A | -1.6363 | |
| 204 | N | A | -1.1818 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.8174 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | R | A | -1.9137 | |
| 211 | D | A | -1.9474 | |
| 212 | T | A | -1.1248 | |
| 213 | T | A | -0.7467 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | 0.1000 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | -0.8945 | |
| 219 | Y | A | -1.3505 | |
| 220 | E | A | -2.4300 | |
| 221 | G | A | -1.6543 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.4999 | |
| 224 | A | A | -1.5418 | |
| 225 | E | A | -1.2187 | |
| 226 | P | A | -0.4258 | |
| 227 | T | A | -0.0994 | |
| 228 | G | A | 0.0000 | |
| 229 | R | A | 0.0000 | |
| 230 | R | A | -0.5600 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | T | A | -0.6670 | |
| 234 | H | A | -0.9255 | |
| 235 | D | A | -1.3347 | |
| 236 | E | A | -1.3494 | |
| 237 | Y | A | -0.8816 | |
| 238 | E | A | -1.5274 | |
| 239 | K | A | -1.1797 | |
| 240 | S | A | -1.0524 | |
| 241 | Y | A | -0.6545 | |
| 242 | D | A | -2.1591 | |
| 243 | K | A | -2.2798 | |
| 244 | E | A | -2.2543 | |
| 245 | K | A | -1.7971 | |
| 246 | Y | A | 0.0000 | |
| 247 | R | A | 0.2467 | |
| 248 | L | A | 0.2389 | |
| 249 | C | A | -0.2463 | |
| 250 | G | A | 0.0236 | |
| 251 | P | A | 0.3431 | |
| 252 | D | A | 1.0775 | |
| 253 | L | A | 2.3966 | |
| 254 | V | A | 2.4398 | |
| 255 | P | A | 0.8505 | |
| 256 | L | A | 0.4699 | |
| 257 | P | A | -1.2050 | |
| 258 | D | A | -3.1147 | |
| 259 | K | A | -2.8017 | |
| 260 | P | A | -1.8830 | |
| 261 | P | A | -1.8851 | |
| 262 | P | A | -2.1490 | |
| 263 | S | A | -1.5299 | |
| 264 | K | A | -1.2446 | |
| 265 | L | A | 0.5336 | |
| 266 | Y | A | -0.8312 | |
| 267 | K | A | -2.4737 | |
| 268 | K | A | -2.2425 | |
| 269 | P | A | -1.1282 | |
| 270 | P | A | -1.3264 | |
| 271 | P | A | -1.0448 | |
| 272 | E | A | -1.7136 | |
| 273 | S | A | -0.6321 | |
| 274 | P | A | -0.0102 | |
| 275 | Y | A | 1.1022 | |
| 276 | A | A | 0.4478 | |
| 277 | V | A | 1.4723 | |
| 278 | R | A | 0.6421 | |
| 279 | P | A | 0.4833 | |
| 280 | P | A | 0.0000 | |
| 281 | Y | A | 1.6705 | |
| 282 | N | A | 1.0028 | |
| 283 | L | A | 1.4188 | |
| 284 | F | A | 0.4014 | |
| 285 | T | A | -0.6113 | |
| 286 | V | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | 0.0000 | |
| 289 | R | A | 0.0000 | |
| 290 | G | A | -1.1407 | |
| 291 | E | A | -1.7037 | |
| 292 | I | A | -1.1460 | |
| 293 | T | A | -1.8184 | |
| 294 | E | A | -2.5986 | |
| 295 | E | A | -2.7477 | |
| 296 | D | A | -1.9554 | |
| 297 | L | A | -1.1250 | |
| 298 | L | A | -0.9316 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.1222 | |
| 301 | K | A | -1.7082 | |
| 302 | P | A | -0.6879 | |
| 303 | I | A | 0.0119 | |
| 304 | I | A | -0.5116 | |
| 305 | L | A | 0.0000 | |
| 306 | E | A | -2.5944 | |
| 307 | K | A | -2.5863 | |
| 308 | T | A | 0.0000 | |
| 309 | A | A | -0.6801 | |
| 310 | G | A | -0.6241 | |
| 311 | L | A | 0.1831 | |
| 312 | N | A | 0.0000 | |
| 313 | Q | A | -0.8249 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.7504 | |
| 319 | N | A | -0.6730 | |
| 320 | Q | A | -0.7056 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | I | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.0418 | |
| 331 | D | A | 0.0000 | |
| 332 | E | A | -1.4198 | |
| 333 | I | A | -1.3744 | |
| 334 | E | A | -1.9652 | |
| 335 | T | A | -1.2029 | |
| 336 | I | A | -0.3015 | |
| 337 | E | A | -1.1573 | |
| 338 | T | A | -0.1421 | |
| 339 | Q | A | -0.2633 | |
| 340 | I | A | 1.3776 | |
| 341 | S | A | 0.1740 | |
| 342 | T | A | -0.5479 | |
| 343 | P | A | -1.2963 | |
| 344 | E | A | -2.4008 | |
| 345 | E | A | -2.6217 | |
| 346 | N | A | -1.5204 | |
| 347 | V | A | 0.4940 | |
| 348 | Y | A | 0.7113 | |
| 349 | N | A | -0.5684 | |
| 350 | P | A | -0.9122 | |
| 351 | E | A | -1.4721 | |
| 352 | N | A | -0.7231 | |
| 353 | Y | A | 0.1313 | |
| 354 | V | A | 0.8076 | |
| 355 | T | A | -0.1805 | |
| 356 | S | A | -0.6266 | |
| 357 | K | A | -1.5369 | |
| 358 | R | A | -1.0179 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -0.1642 | |
| 361 | R | A | 0.0000 | |
| 362 | E | A | 0.0693 | |
| 363 | Y | A | 0.0000 | |
| 364 | K | A | -0.4130 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | I | A | 0.0000 | |
| 368 | V | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | R | A | -0.4793 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.4723 | |
| 376 | L | A | -0.2828 | |
| 377 | T | A | -0.9016 | |
| 378 | P | A | -1.4884 | |
| 379 | E | A | -2.4332 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -1.2241 | |
| 382 | E | A | -2.5691 | |
| 383 | R | A | -1.5456 | |
| 384 | L | A | 0.0000 | |
| 385 | A | A | -0.8785 | |
| 386 | R | A | -1.3021 | |
| 387 | L | A | -0.5392 | |
| 388 | D | A | 0.0000 | |
| 389 | P | A | -0.9083 | |
| 390 | R | A | -1.0981 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -0.7412 | |
| 394 | E | A | -1.8593 | |
| 395 | A | A | -1.4394 | |
| 396 | E | A | -2.2151 | |
| 397 | L | A | -1.0185 | |
| 398 | P | A | -1.2691 | |
| 399 | D | A | -1.8905 | |
| 400 | V | A | -0.8303 | |
| 401 | P | A | -0.5879 | |
| 402 | P | A | -1.1498 | |
| 403 | V | A | -0.9910 | |
| 404 | E | A | -2.8126 | |
| 405 | R | A | -3.0899 | |
| 406 | P | A | -2.1018 | |
| 407 | D | A | -1.9402 | |
| 408 | P | A | -1.0325 | |
| 409 | L | A | -0.5093 | |
| 410 | A | A | -0.6638 | |
| 411 | G | A | -0.7345 | |
| 412 | L | A | -0.5904 | |
| 413 | K | A | -1.9519 | |
| 414 | F | A | -1.4242 | |
| 415 | R | A | -1.7504 | |
| 416 | E | A | -2.6436 | |
| 417 | I | A | 0.0000 | |
| 418 | D | A | -2.7308 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.6493 | |
| 421 | D | A | -2.3431 | |
| 422 | K | A | -1.9151 | |
| 423 | L | A | -0.7037 | |
| 424 | S | A | -0.7816 | |
| 425 | S | A | -0.5114 | |
| 426 | D | A | -1.3265 | |
| 427 | L | A | 0.0000 | |
| 428 | S | A | -1.8402 | |
| 429 | K | A | -2.6002 | |
| 430 | Y | A | -1.9736 | |
| 431 | D | A | -2.4186 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.2860 | |
| 435 | Y | A | -0.7065 | |
| 436 | F | A | -0.3585 | |
| 437 | L | A | 0.0848 | |
| 438 | N | A | -1.5486 | |
| 439 | R | A | -1.8797 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine