| Chain sequence(s) |
A: GPAHLDPSPALRPTTEYVTPTDLLYVAETDLITETGHPTKDIVVNGKVLLPQVSATQFKVFKLTLPDPNTLPLPSEDFLDPSTERLIWRLLMYKIHKYGPLGKGTYGHANFNALGDVSNPTTYVTGTSDNTKNLSWTPKLKQSYIIGDEPPTGKYTAKAEPKPGLPPGAIPPLKTVSTTIEHGDVADIGFGAKDYKALEPSKDNVPDIIRDTKTVEFDYEGMKADPYGDKMFDSFKKEKSSDSKKYVLDGPDLIPLPSSPPPSPLYVPPPPSSPYAVLPPYNYFTLPDAGEITEADELFNKPIILEKTPGLNNGVLWGNRLYITVLDNSRDEIEEIRTRISTPAPDVYDPANYVTSYRYTREYKLSLIVQLCKVPLTPETLAEIARRDPRILVDWNLPFIPPVEEADPYAGKKFIEIDLTDKLSSDLEKYELGRFYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.7344 | |
| 2 | P | A | -0.4905 | |
| 3 | A | A | -0.4752 | |
| 4 | H | A | -0.9528 | |
| 5 | L | A | 0.0665 | |
| 6 | D | A | -1.5480 | |
| 7 | P | A | -0.9822 | |
| 8 | S | A | -0.6107 | |
| 9 | P | A | -0.6232 | |
| 10 | A | A | -0.0969 | |
| 11 | L | A | -0.0483 | |
| 12 | R | A | -0.8430 | |
| 13 | P | A | -0.6384 | |
| 14 | T | A | 0.0000 | |
| 15 | T | A | -1.0697 | |
| 16 | E | A | -1.9429 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.5894 | |
| 20 | P | A | -0.6754 | |
| 21 | T | A | -0.8705 | |
| 22 | D | A | -1.5936 | |
| 23 | L | A | -0.4897 | |
| 24 | L | A | -0.1692 | |
| 25 | Y | A | -0.1132 | |
| 26 | V | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -1.0273 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.2824 | |
| 31 | L | A | 0.4480 | |
| 32 | I | A | 0.1597 | |
| 33 | T | A | -0.1460 | |
| 34 | E | A | -0.5169 | |
| 35 | T | A | -0.4801 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.8821 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -1.3740 | |
| 40 | K | A | -2.3851 | |
| 41 | D | A | -0.7601 | |
| 42 | I | A | 1.2593 | |
| 43 | V | A | 2.2843 | |
| 44 | V | A | 1.5976 | |
| 45 | N | A | -0.5667 | |
| 46 | G | A | -0.3872 | |
| 47 | K | A | -0.1263 | |
| 48 | V | A | 2.1901 | |
| 49 | L | A | 2.5051 | |
| 50 | L | A | 1.1351 | |
| 51 | P | A | -0.0796 | |
| 52 | Q | A | -1.1189 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | T | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | F | A | 0.0000 | |
| 59 | K | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | K | A | -1.2953 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.5781 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.2030 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -0.6847 | |
| 70 | T | A | -0.3227 | |
| 71 | L | A | 0.0215 | |
| 72 | P | A | -0.1130 | |
| 73 | L | A | -0.1715 | |
| 74 | P | A | -0.5281 | |
| 75 | S | A | -1.4130 | |
| 76 | E | A | -2.7607 | |
| 77 | D | A | -2.7789 | |
| 78 | F | A | -1.4379 | |
| 79 | L | A | 0.0000 | |
| 80 | D | A | -2.2207 | |
| 81 | P | A | -1.1926 | |
| 82 | S | A | -0.9098 | |
| 83 | T | A | -0.8683 | |
| 84 | E | A | -1.1815 | |
| 85 | R | A | -0.8856 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | -0.3886 | |
| 90 | L | A | 0.0000 | |
| 91 | L | A | -0.1824 | |
| 92 | M | A | 0.0000 | |
| 93 | Y | A | 0.0000 | |
| 94 | K | A | 0.0000 | |
| 95 | I | A | 0.0000 | |
| 96 | H | A | -0.4451 | |
| 97 | K | A | 0.0000 | |
| 98 | Y | A | 0.2043 | |
| 99 | G | A | -0.5571 | |
| 100 | P | A | -0.7630 | |
| 101 | L | A | -0.6204 | |
| 102 | G | A | -1.0772 | |
| 103 | K | A | -1.6583 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.5908 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -0.8343 | |
| 108 | H | A | 0.0000 | |
| 109 | A | A | -1.6861 | |
| 110 | N | A | -2.7442 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.6020 | |
| 113 | A | A | 0.0000 | |
| 114 | L | A | 0.0000 | |
| 115 | G | A | -0.4020 | |
| 116 | D | A | -0.8949 | |
| 117 | V | A | -0.2856 | |
| 118 | S | A | -1.2756 | |
| 119 | N | A | -1.6971 | |
| 120 | P | A | -0.6496 | |
| 121 | T | A | -0.3959 | |
| 122 | T | A | 0.0950 | |
| 123 | Y | A | 1.2541 | |
| 124 | V | A | 0.9185 | |
| 125 | T | A | 0.7489 | |
| 126 | G | A | -0.5630 | |
| 127 | T | A | -0.8753 | |
| 128 | S | A | -1.2273 | |
| 129 | D | A | -2.4397 | |
| 130 | N | A | -1.7549 | |
| 131 | T | A | -2.2166 | |
| 132 | K | A | -2.7098 | |
| 133 | N | A | -2.3128 | |
| 134 | L | A | -1.1728 | |
| 135 | S | A | -0.6850 | |
| 136 | W | A | 0.0000 | |
| 137 | T | A | -0.6885 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | -1.1982 | |
| 140 | L | A | 0.0000 | |
| 141 | K | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | S | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | E | A | -0.5720 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | -0.5093 | |
| 153 | G | A | 0.0000 | |
| 154 | K | A | -0.7799 | |
| 155 | Y | A | -0.8498 | |
| 156 | T | A | -0.6216 | |
| 157 | A | A | 0.0000 | |
| 158 | K | A | -1.0589 | |
| 159 | A | A | -1.5711 | |
| 160 | E | A | -2.5804 | |
| 161 | P | A | -1.9317 | |
| 162 | K | A | -2.2828 | |
| 163 | P | A | -1.3294 | |
| 164 | G | A | -0.6433 | |
| 165 | L | A | 0.3320 | |
| 166 | P | A | 0.1070 | |
| 167 | P | A | -0.1472 | |
| 168 | G | A | 0.2578 | |
| 169 | A | A | 1.1548 | |
| 170 | I | A | 2.2873 | |
| 171 | P | A | 0.4021 | |
| 172 | P | A | -0.1545 | |
| 173 | L | A | 0.2863 | |
| 174 | K | A | -1.1984 | |
| 175 | T | A | -0.5842 | |
| 176 | V | A | -0.2981 | |
| 177 | S | A | -0.5335 | |
| 178 | T | A | -0.3190 | |
| 179 | T | A | -0.5827 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | -1.2256 | |
| 182 | H | A | -0.9622 | |
| 183 | G | A | -0.6521 | |
| 184 | D | A | -0.8886 | |
| 185 | V | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.5344 | |
| 190 | F | A | -0.0520 | |
| 191 | G | A | -0.4064 | |
| 192 | A | A | -0.7427 | |
| 193 | K | A | -1.2038 | |
| 194 | D | A | -1.7488 | |
| 195 | Y | A | 0.0000 | |
| 196 | K | A | -3.0061 | |
| 197 | A | A | -1.7214 | |
| 198 | L | A | -0.8770 | |
| 199 | E | A | -1.6863 | |
| 200 | P | A | -1.5542 | |
| 201 | S | A | -1.3774 | |
| 202 | K | A | -2.6206 | |
| 203 | D | A | -1.8789 | |
| 204 | N | A | -1.1740 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -2.1755 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | R | A | -2.6653 | |
| 211 | D | A | -3.0892 | |
| 212 | T | A | -2.0265 | |
| 213 | K | A | -1.7508 | |
| 214 | T | A | 0.0000 | |
| 215 | V | A | 0.0000 | |
| 216 | E | A | -1.1088 | |
| 217 | F | A | 0.0000 | |
| 218 | D | A | -1.3822 | |
| 219 | Y | A | -1.7556 | |
| 220 | E | A | -2.5694 | |
| 221 | G | A | -1.8868 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.6368 | |
| 224 | A | A | -1.5900 | |
| 225 | D | A | -1.2968 | |
| 226 | P | A | -0.5854 | |
| 227 | Y | A | -0.3228 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.7775 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | D | A | -0.5418 | |
| 234 | S | A | -0.0998 | |
| 235 | F | A | 0.0907 | |
| 236 | K | A | -1.3869 | |
| 237 | K | A | -1.8637 | |
| 238 | E | A | -2.2518 | |
| 239 | K | A | -2.0326 | |
| 240 | S | A | -1.7155 | |
| 241 | S | A | -1.6846 | |
| 242 | D | A | -2.2271 | |
| 243 | S | A | -1.7042 | |
| 244 | K | A | -2.2396 | |
| 245 | K | A | -1.5489 | |
| 246 | Y | A | -0.3546 | |
| 247 | V | A | 0.0000 | |
| 248 | L | A | -0.0759 | |
| 249 | D | A | -0.9095 | |
| 250 | G | A | -0.4497 | |
| 251 | P | A | 0.0433 | |
| 252 | D | A | 0.9545 | |
| 253 | L | A | 2.4566 | |
| 254 | I | A | 2.6018 | |
| 255 | P | A | 1.1967 | |
| 256 | L | A | 1.2921 | |
| 257 | P | A | 0.4305 | |
| 258 | S | A | -0.1953 | |
| 259 | S | A | -0.2387 | |
| 260 | P | A | -0.4110 | |
| 261 | P | A | -0.0932 | |
| 262 | P | A | 0.0494 | |
| 263 | S | A | 0.5762 | |
| 264 | P | A | 0.7398 | |
| 265 | L | A | 1.8969 | |
| 266 | Y | A | 1.8189 | |
| 267 | V | A | 1.9752 | |
| 268 | P | A | 1.2123 | |
| 269 | P | A | 0.7108 | |
| 270 | P | A | -0.1610 | |
| 271 | P | A | -0.1253 | |
| 272 | S | A | -0.3212 | |
| 273 | S | A | 0.2483 | |
| 274 | P | A | 0.6752 | |
| 275 | Y | A | 1.8291 | |
| 276 | A | A | 1.3229 | |
| 277 | V | A | 2.4543 | |
| 278 | L | A | 2.0724 | |
| 279 | P | A | 1.0399 | |
| 280 | P | A | 0.3794 | |
| 281 | Y | A | 0.6673 | |
| 282 | N | A | 0.6069 | |
| 283 | Y | A | 1.2826 | |
| 284 | F | A | 0.5935 | |
| 285 | T | A | -0.6803 | |
| 286 | L | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -1.6747 | |
| 289 | A | A | 0.0000 | |
| 290 | G | A | -1.6552 | |
| 291 | E | A | -2.0323 | |
| 292 | I | A | -1.3853 | |
| 293 | T | A | -1.3862 | |
| 294 | E | A | -2.0064 | |
| 295 | A | A | -1.2077 | |
| 296 | D | A | -1.4101 | |
| 297 | E | A | -1.4018 | |
| 298 | L | A | -0.8965 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.2501 | |
| 301 | K | A | -1.6888 | |
| 302 | P | A | -0.5018 | |
| 303 | I | A | 0.1694 | |
| 304 | I | A | 0.0785 | |
| 305 | L | A | 0.0000 | |
| 306 | E | A | -2.4294 | |
| 307 | K | A | -2.6175 | |
| 308 | T | A | 0.0000 | |
| 309 | P | A | -1.0898 | |
| 310 | G | A | -0.8333 | |
| 311 | L | A | -0.3060 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | -0.9540 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | G | A | -1.0177 | |
| 319 | N | A | -1.0207 | |
| 320 | R | A | -1.1280 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | I | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | S | A | 0.0000 | |
| 330 | R | A | -0.7432 | |
| 331 | D | A | 0.0000 | |
| 332 | E | A | -2.5535 | |
| 333 | I | A | 0.0000 | |
| 334 | E | A | -2.4549 | |
| 335 | E | A | -2.3395 | |
| 336 | I | A | -0.5483 | |
| 337 | R | A | -1.0387 | |
| 338 | T | A | -0.2891 | |
| 339 | R | A | -0.1994 | |
| 340 | I | A | 1.5720 | |
| 341 | S | A | 0.4807 | |
| 342 | T | A | -0.0154 | |
| 343 | P | A | -0.4257 | |
| 344 | A | A | -0.1447 | |
| 345 | P | A | -0.4271 | |
| 346 | D | A | -0.8068 | |
| 347 | V | A | 1.2913 | |
| 348 | Y | A | 1.2911 | |
| 349 | D | A | -0.1734 | |
| 350 | P | A | -0.2446 | |
| 351 | A | A | 0.2057 | |
| 352 | N | A | 0.5706 | |
| 353 | Y | A | 0.6847 | |
| 354 | V | A | 1.2532 | |
| 355 | T | A | -0.0705 | |
| 356 | S | A | -0.2619 | |
| 357 | Y | A | -0.5975 | |
| 358 | R | A | -1.1380 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -0.8637 | |
| 361 | R | A | 0.0000 | |
| 362 | E | A | -0.1952 | |
| 363 | Y | A | 0.0000 | |
| 364 | K | A | -0.4076 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | Q | A | -0.3322 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.6517 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -0.7217 | |
| 376 | L | A | -0.4706 | |
| 377 | T | A | -0.7024 | |
| 378 | P | A | -1.0562 | |
| 379 | E | A | -1.9082 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -0.6541 | |
| 382 | A | A | -0.9628 | |
| 383 | E | A | 0.0000 | |
| 384 | I | A | 0.0000 | |
| 385 | A | A | -0.9405 | |
| 386 | R | A | -1.4410 | |
| 387 | R | A | -0.9455 | |
| 388 | D | A | -0.9442 | |
| 389 | P | A | -0.7667 | |
| 390 | R | A | -1.1722 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -0.8991 | |
| 394 | D | A | -2.0033 | |
| 395 | W | A | -1.4491 | |
| 396 | N | A | -1.4497 | |
| 397 | L | A | 0.0000 | |
| 398 | P | A | 0.4281 | |
| 399 | F | A | 1.7432 | |
| 400 | I | A | 0.8883 | |
| 401 | P | A | 0.3442 | |
| 402 | P | A | -0.3313 | |
| 403 | V | A | 0.0045 | |
| 404 | E | A | -1.7581 | |
| 405 | E | A | -1.7702 | |
| 406 | A | A | -1.1181 | |
| 407 | D | A | -1.2826 | |
| 408 | P | A | -0.7359 | |
| 409 | Y | A | -0.7772 | |
| 410 | A | A | -0.8274 | |
| 411 | G | A | -1.2856 | |
| 412 | K | A | -1.8474 | |
| 413 | K | A | -2.4472 | |
| 414 | F | A | -1.4216 | |
| 415 | I | A | -1.1211 | |
| 416 | E | A | -2.2621 | |
| 417 | I | A | -1.7874 | |
| 418 | D | A | -2.7014 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.8557 | |
| 421 | D | A | -2.6090 | |
| 422 | K | A | -2.4372 | |
| 423 | L | A | -0.9759 | |
| 424 | S | A | -1.1215 | |
| 425 | S | A | -0.7809 | |
| 426 | D | A | -1.8767 | |
| 427 | L | A | 0.0000 | |
| 428 | E | A | -3.2963 | |
| 429 | K | A | -3.3270 | |
| 430 | Y | A | -2.2870 | |
| 431 | E | A | -2.4698 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.2043 | |
| 435 | F | A | -0.2368 | |
| 436 | Y | A | -0.0934 | |
| 437 | L | A | -0.1647 | |
| 438 | N | A | -1.5713 | |
| 439 | R | A | -1.8308 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine