| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIIVDGKVLVPKVSGWQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTVGHPLFNKLGDTENPTAPVHEGPDDRVAFSFDPKQTQLFIVGCEPPTGEHWDLAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYVRSGPEGHPLPDAPPPSPLYVPPPADSPFAVRPSTDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTLPENVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9414 | |
| 2 | L | A | 1.9629 | |
| 3 | P | A | 0.8382 | |
| 4 | P | A | 0.3761 | |
| 5 | T | A | 0.1237 | |
| 6 | T | A | 0.1306 | |
| 7 | P | A | 0.1835 | |
| 8 | V | A | 1.2120 | |
| 9 | A | A | 0.0959 | |
| 10 | K | A | -1.0086 | |
| 11 | V | A | -0.1398 | |
| 12 | Q | A | -1.3842 | |
| 13 | S | A | -1.5370 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4062 | |
| 16 | E | A | -2.4302 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4614 | |
| 20 | P | A | 0.1306 | |
| 21 | T | A | 0.1823 | |
| 22 | S | A | -0.0929 | |
| 23 | L | A | 0.0972 | |
| 24 | F | A | -0.0278 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2891 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.9065 | |
| 31 | R | A | -2.6914 | |
| 32 | L | A | -0.8059 | |
| 33 | L | A | 1.1495 | |
| 34 | T | A | 1.3560 | |
| 35 | V | A | 1.7968 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2173 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.5867 | |
| 40 | K | A | -1.5404 | |
| 41 | D | A | -0.4482 | |
| 42 | I | A | 1.5076 | |
| 43 | I | A | 2.4758 | |
| 44 | V | A | 1.6092 | |
| 45 | D | A | -0.9590 | |
| 46 | G | A | -0.5269 | |
| 47 | K | A | -0.1850 | |
| 48 | V | A | 2.0573 | |
| 49 | L | A | 2.5697 | |
| 50 | V | A | 1.5370 | |
| 51 | P | A | 0.4323 | |
| 52 | K | A | -0.6278 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | W | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1358 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.3802 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2629 | |
| 70 | K | A | -1.7813 | |
| 71 | F | A | -0.6245 | |
| 72 | A | A | -0.5702 | |
| 73 | L | A | -0.8594 | |
| 74 | P | A | -1.2081 | |
| 75 | Q | A | -2.5084 | |
| 76 | K | A | -3.1125 | |
| 77 | D | A | -2.9952 | |
| 78 | F | A | -1.6752 | |
| 79 | Y | A | -1.8947 | |
| 80 | D | A | -2.6983 | |
| 81 | P | A | -2.3109 | |
| 82 | E | A | -3.0562 | |
| 83 | K | A | -3.4017 | |
| 84 | E | A | -2.4653 | |
| 85 | R | A | -1.2941 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6559 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9682 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3744 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6967 | |
| 99 | G | A | -0.5202 | |
| 100 | P | A | -0.3724 | |
| 101 | L | A | 0.1090 | |
| 102 | G | A | -0.1726 | |
| 103 | K | A | -0.5937 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.4292 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.1528 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.4268 | |
| 110 | L | A | 0.3205 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.1210 | |
| 113 | K | A | -0.4861 | |
| 114 | L | A | -1.2115 | |
| 115 | G | A | -0.8513 | |
| 116 | D | A | -1.1490 | |
| 117 | T | A | -0.7724 | |
| 118 | E | A | -1.6899 | |
| 119 | N | A | -1.9118 | |
| 120 | P | A | -1.3076 | |
| 121 | T | A | -0.6543 | |
| 122 | A | A | -0.4030 | |
| 123 | P | A | -0.0829 | |
| 124 | V | A | -0.3663 | |
| 125 | H | A | -1.3226 | |
| 126 | E | A | -2.4315 | |
| 127 | G | A | -2.0865 | |
| 128 | P | A | -1.7651 | |
| 129 | D | A | -2.5224 | |
| 130 | D | A | -2.0437 | |
| 131 | R | A | -1.0935 | |
| 132 | V | A | 0.2693 | |
| 133 | A | A | 0.4517 | |
| 134 | F | A | 0.2870 | |
| 135 | S | A | -0.0654 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.6539 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5604 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.1994 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1409 | |
| 157 | D | A | 0.3091 | |
| 158 | L | A | 0.7986 | |
| 159 | A | A | 0.1720 | |
| 160 | E | A | -1.4561 | |
| 161 | P | A | -0.2123 | |
| 162 | C | A | 0.1864 | |
| 163 | P | A | -0.1624 | |
| 164 | G | A | -0.0664 | |
| 165 | L | A | 0.6084 | |
| 166 | P | A | -0.1055 | |
| 167 | P | A | -0.3365 | |
| 168 | G | A | -0.4211 | |
| 169 | A | A | -0.0236 | |
| 170 | C | A | 0.6483 | |
| 171 | P | A | 0.5120 | |
| 172 | P | A | 0.8372 | |
| 173 | I | A | 1.9724 | |
| 174 | Q | A | 0.8322 | |
| 175 | L | A | 1.4767 | |
| 176 | V | A | 0.8515 | |
| 177 | N | A | -0.2940 | |
| 178 | S | A | 0.0313 | |
| 179 | V | A | 0.4324 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3765 | |
| 182 | D | A | 0.0693 | |
| 183 | G | A | -0.1644 | |
| 184 | D | A | -0.5451 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1319 | |
| 190 | F | A | 0.0626 | |
| 191 | G | A | -0.1033 | |
| 192 | N | A | -0.2636 | |
| 193 | M | A | -0.1333 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.4409 | |
| 197 | E | A | -2.6870 | |
| 198 | L | A | -1.2703 | |
| 199 | Q | A | -2.5876 | |
| 200 | Q | A | -3.3346 | |
| 201 | D | A | -3.5942 | |
| 202 | R | A | -3.3418 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.2253 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3542 | |
| 211 | S | A | -1.8959 | |
| 212 | T | A | -1.4450 | |
| 213 | R | A | -2.1116 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1656 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3575 | |
| 220 | L | A | 0.6199 | |
| 221 | K | A | -1.0821 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.8077 | |
| 224 | N | A | -1.4829 | |
| 225 | E | A | -1.2251 | |
| 226 | A | A | -0.5971 | |
| 227 | Y | A | -0.3641 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6473 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | 0.0841 | |
| 234 | F | A | 0.2691 | |
| 235 | G | A | -0.7950 | |
| 236 | R | A | -2.5579 | |
| 237 | R | A | -2.7787 | |
| 238 | E | A | -2.0649 | |
| 239 | Q | A | -0.1185 | |
| 240 | V | A | 1.4827 | |
| 241 | Y | A | 1.2197 | |
| 242 | A | A | 0.1939 | |
| 243 | R | A | -1.1232 | |
| 244 | H | A | -0.9679 | |
| 245 | F | A | 0.0841 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.8868 | |
| 249 | S | A | -1.4866 | |
| 250 | G | A | -1.2549 | |
| 251 | P | A | -1.1272 | |
| 252 | E | A | -1.3581 | |
| 253 | G | A | -1.2675 | |
| 254 | H | A | -1.4572 | |
| 255 | P | A | -1.3550 | |
| 256 | L | A | -0.3945 | |
| 257 | P | A | -0.8753 | |
| 258 | D | A | -1.7368 | |
| 259 | A | A | -0.6272 | |
| 260 | P | A | -0.6628 | |
| 261 | P | A | -0.1842 | |
| 262 | P | A | 0.0683 | |
| 263 | S | A | 0.2739 | |
| 264 | P | A | 0.6754 | |
| 265 | L | A | 1.6667 | |
| 266 | Y | A | 1.4766 | |
| 267 | V | A | 1.8998 | |
| 268 | P | A | 0.6767 | |
| 269 | P | A | 0.4584 | |
| 270 | P | A | -0.4094 | |
| 271 | A | A | -0.5095 | |
| 272 | D | A | -1.4588 | |
| 273 | S | A | -0.2503 | |
| 274 | P | A | 0.2920 | |
| 275 | F | A | 1.4819 | |
| 276 | A | A | 0.8713 | |
| 277 | V | A | 1.3966 | |
| 278 | R | A | 0.2413 | |
| 279 | P | A | -0.3917 | |
| 280 | S | A | 0.0000 | |
| 281 | T | A | -0.5233 | |
| 282 | D | A | -0.8942 | |
| 283 | Y | A | 0.8499 | |
| 284 | F | A | 0.7167 | |
| 285 | G | A | 0.2500 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.8169 | |
| 291 | L | A | 1.6197 | |
| 292 | V | A | 0.6488 | |
| 293 | S | A | -0.1490 | |
| 294 | S | A | -0.9496 | |
| 295 | D | A | -1.8428 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.0954 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6504 | |
| 301 | R | A | -1.8445 | |
| 302 | P | A | -0.9441 | |
| 303 | F | A | -0.1895 | |
| 304 | W | A | -0.5633 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0852 | |
| 307 | R | A | -2.8358 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.2720 | |
| 310 | G | A | -1.2298 | |
| 311 | N | A | -1.2650 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.8001 | |
| 319 | N | A | -0.9210 | |
| 320 | E | A | -1.0320 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3083 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.0531 | |
| 333 | N | A | 0.5747 | |
| 334 | F | A | 1.7541 | |
| 335 | T | A | 0.8889 | |
| 336 | I | A | 0.4974 | |
| 337 | S | A | -0.9257 | |
| 338 | Q | A | -1.7323 | |
| 339 | Q | A | -1.3422 | |
| 340 | L | A | 0.6574 | |
| 341 | C | A | 0.5175 | |
| 342 | T | A | 0.2104 | |
| 343 | L | A | 0.1411 | |
| 344 | P | A | -0.7179 | |
| 345 | E | A | -1.8510 | |
| 346 | N | A | -1.1062 | |
| 347 | V | A | 0.8967 | |
| 348 | Y | A | 1.2014 | |
| 349 | D | A | 0.2496 | |
| 350 | P | A | -0.4932 | |
| 351 | S | A | -0.2788 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.7854 | |
| 354 | K | A | -1.7731 | |
| 355 | N | A | -1.7405 | |
| 356 | Y | A | -0.0676 | |
| 357 | L | A | 0.6531 | |
| 358 | R | A | 0.9666 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.3791 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0920 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -2.0860 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6984 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.3025 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3168 | |
| 376 | L | A | -1.7111 | |
| 377 | D | A | -1.9906 | |
| 378 | P | A | -1.0380 | |
| 379 | G | A | -1.0155 | |
| 380 | V | A | -0.9329 | |
| 381 | L | A | -0.5319 | |
| 382 | A | A | -0.6547 | |
| 383 | H | A | -0.8029 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4111 | |
| 386 | T | A | -0.5511 | |
| 387 | M | A | -0.2988 | |
| 388 | N | A | -0.8623 | |
| 389 | P | A | -1.2376 | |
| 390 | T | A | -1.4212 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.4118 | |
| 393 | E | A | -2.7434 | |
| 394 | N | A | -2.3289 | |
| 395 | W | A | -1.3287 | |
| 396 | N | A | -1.0551 | |
| 397 | L | A | -0.1923 | |
| 398 | G | A | 0.5406 | |
| 399 | F | A | 2.4216 | |
| 400 | V | A | 1.8384 | |
| 401 | P | A | 0.0569 | |
| 402 | P | A | -1.7689 | |
| 403 | K | A | -3.3104 | |
| 404 | E | A | -3.7598 | |
| 405 | R | A | -3.8754 | |
| 406 | E | A | -3.7688 | |
| 407 | D | A | -2.8632 | |
| 408 | P | A | -1.7620 | |
| 409 | Y | A | -0.9884 | |
| 410 | K | A | -2.1098 | |
| 411 | G | A | -0.6420 | |
| 412 | L | A | 0.6686 | |
| 413 | I | A | 1.5842 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3917 | |
| 416 | E | A | -1.6844 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9449 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0480 | |
| 421 | E | A | -2.7800 | |
| 422 | R | A | -2.6311 | |
| 423 | F | A | -1.2795 | |
| 424 | S | A | -1.4719 | |
| 425 | Q | A | -1.8584 | |
| 426 | D | A | -2.9018 | |
| 427 | L | A | -1.9875 | |
| 428 | D | A | -2.7727 | |
| 429 | Q | A | -2.6175 | |
| 430 | F | A | -1.4266 | |
| 431 | A | A | -0.8990 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.5777 | |
| 435 | K | A | -0.6959 | |
| 436 | F | A | 0.1509 | |
| 437 | L | A | 1.0280 | |
| 438 | Y | A | 0.8268 | |
| 439 | Q | A | -0.2678 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine