| Chain sequence(s) |
A: EVQLVESGGGLVQPGGSLRLSCAASGYTFTNYGMNWVRQAPGKGLEWVGWINTYTGEPTYAADFKRRFTFSLDTSKSTAYLQMNSLRAEDTAVYYCAKYPHYYGSSHWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPDIQMTQSPSSLSASVGDRVTITCSASQDISNYLNWYQQKPGKAPKVLIYFTSSLHSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSTVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:03:38)
[INFO] Main: Simulation completed successfully. (00:03:41)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | E | A | -1.9770 | |
| 2 | V | A | -1.0744 | |
| 3 | Q | A | -1.2222 | |
| 4 | L | A | 0.0000 | |
| 5 | V | A | 0.5358 | |
| 6 | E | A | 0.0000 | |
| 7 | S | A | -0.5303 | |
| 8 | G | A | -0.9294 | |
| 9 | G | A | -0.4891 | |
| 10 | G | A | -0.4911 | |
| 11 | L | A | -0.0829 | |
| 12 | V | A | 0.0000 | |
| 13 | Q | A | -1.5814 | |
| 14 | P | A | -1.5890 | |
| 15 | G | A | -1.3394 | |
| 16 | G | A | -1.0292 | |
| 17 | S | A | -1.2195 | |
| 18 | L | A | -1.1563 | |
| 19 | R | A | -2.1553 | |
| 20 | L | A | 0.0000 | |
| 21 | S | A | -0.5067 | |
| 22 | C | A | 0.0000 | |
| 23 | A | A | -0.2181 | |
| 24 | A | A | 0.0000 | |
| 25 | S | A | -0.9247 | |
| 26 | G | A | -1.1163 | |
| 27 | Y | A | -0.7466 | |
| 28 | T | A | -0.5271 | |
| 29 | F | A | 0.0000 | |
| 30 | T | A | -0.2873 | |
| 31 | N | A | -1.1842 | |
| 32 | Y | A | 0.0000 | |
| 33 | G | A | -0.4442 | |
| 34 | M | A | 0.0000 | |
| 35 | N | A | 0.0000 | |
| 36 | W | A | 0.0000 | |
| 37 | V | A | 0.0000 | |
| 38 | R | A | -0.6549 | |
| 39 | Q | A | -0.9383 | |
| 40 | A | A | -1.2505 | |
| 41 | P | A | -0.9834 | |
| 42 | G | A | -1.4661 | |
| 43 | K | A | -2.3802 | |
| 44 | G | A | -1.6567 | |
| 45 | L | A | 0.0000 | |
| 46 | E | A | -1.3896 | |
| 47 | W | A | 0.0000 | |
| 48 | V | A | 0.0000 | |
| 49 | G | A | 0.0000 | |
| 50 | W | A | -0.1466 | |
| 51 | I | A | 0.0000 | |
| 52 | N | A | -0.8660 | |
| 53 | T | A | 0.0000 | |
| 54 | Y | A | 0.5713 | |
| 55 | T | A | -0.2115 | |
| 56 | G | A | -0.8636 | |
| 57 | E | A | -1.8735 | |
| 58 | P | A | -1.2988 | |
| 59 | T | A | -0.5131 | |
| 60 | Y | A | -0.6833 | |
| 61 | A | A | 0.0000 | |
| 62 | A | A | -1.3831 | |
| 63 | D | A | -2.8232 | |
| 64 | F | A | 0.0000 | |
| 65 | K | A | -3.2130 | |
| 66 | R | A | -3.3908 | |
| 67 | R | A | -2.3682 | |
| 68 | F | A | 0.0000 | |
| 69 | T | A | -1.2465 | |
| 70 | F | A | 0.0000 | |
| 71 | S | A | -0.5085 | |
| 72 | L | A | -0.4282 | |
| 73 | D | A | -1.0901 | |
| 74 | T | A | -0.7825 | |
| 75 | S | A | -1.2168 | |
| 76 | K | A | -1.9992 | |
| 77 | S | A | -1.1297 | |
| 78 | T | A | 0.0000 | |
| 79 | A | A | 0.0000 | |
| 80 | Y | A | 0.0000 | |
| 81 | L | A | 0.0000 | |
| 82 | Q | A | -1.3775 | |
| 83 | M | A | 0.0000 | |
| 84 | N | A | -1.5281 | |
| 85 | S | A | -1.3497 | |
| 86 | L | A | 0.0000 | |
| 87 | R | A | -2.0762 | |
| 88 | A | A | -1.6193 | |
| 89 | E | A | -2.1481 | |
| 90 | D | A | 0.0000 | |
| 91 | T | A | -0.7059 | |
| 92 | A | A | 0.0000 | |
| 93 | V | A | 0.1988 | |
| 94 | Y | A | 0.0000 | |
| 95 | Y | A | 0.0000 | |
| 96 | C | A | 0.0000 | |
| 97 | A | A | 0.0000 | |
| 98 | K | A | 0.0000 | |
| 99 | Y | A | 0.1033 | |
| 100 | P | A | 0.0000 | |
| 101 | H | A | -0.3446 | |
| 102 | Y | A | 0.9997 | |
| 103 | Y | A | 0.7089 | |
| 104 | G | A | 0.2277 | |
| 105 | S | A | -0.0367 | |
| 106 | S | A | 0.2470 | |
| 107 | H | A | 0.4019 | |
| 108 | W | A | 0.7557 | |
| 109 | Y | A | 0.0000 | |
| 110 | F | A | 0.0000 | |
| 111 | D | A | -0.4957 | |
| 112 | V | A | -0.4049 | |
| 113 | W | A | 0.0000 | |
| 114 | G | A | 0.0000 | |
| 115 | Q | A | -1.4133 | |
| 116 | G | A | -0.6603 | |
| 117 | T | A | -0.0973 | |
| 118 | L | A | 0.1983 | |
| 119 | V | A | 0.0000 | |
| 120 | T | A | -0.4589 | |
| 121 | V | A | 0.0000 | |
| 122 | S | A | -0.9283 | |
| 123 | S | A | -0.6963 | |
| 124 | A | A | -0.4862 | |
| 125 | S | A | -0.6030 | |
| 126 | T | A | -0.6634 | |
| 127 | K | A | -1.3095 | |
| 128 | G | A | -1.3830 | |
| 129 | P | A | 0.0000 | |
| 130 | S | A | -0.2890 | |
| 131 | V | A | -0.3000 | |
| 132 | F | A | 0.0000 | |
| 133 | P | A | 0.0000 | |
| 134 | L | A | 0.0000 | |
| 135 | A | A | -0.7677 | |
| 136 | P | A | -0.6052 | |
| 137 | S | A | -0.5663 | |
| 138 | S | A | -0.8969 | |
| 139 | K | A | -1.1955 | |
| 140 | S | A | -0.7307 | |
| 141 | T | A | -0.7373 | |
| 142 | S | A | -0.6958 | |
| 143 | G | A | -0.8341 | |
| 144 | G | A | -0.9111 | |
| 145 | T | A | -0.6480 | |
| 146 | A | A | 0.0000 | |
| 147 | A | A | 0.0000 | |
| 148 | L | A | 0.0000 | |
| 149 | G | A | 0.0000 | |
| 150 | C | A | 0.0000 | |
| 151 | L | A | 0.0000 | |
| 152 | V | A | 0.0000 | |
| 153 | K | A | 0.0000 | |
| 154 | D | A | -0.3049 | |
| 155 | Y | A | 0.0000 | |
| 156 | F | A | 0.0000 | |
| 157 | P | A | 0.0000 | |
| 158 | E | A | -0.6716 | |
| 159 | P | A | -0.7640 | |
| 160 | V | A | -0.5385 | |
| 161 | T | A | -0.6367 | |
| 162 | V | A | -0.2298 | |
| 163 | S | A | -0.4868 | |
| 164 | W | A | 0.0000 | |
| 165 | N | A | -0.9050 | |
| 166 | S | A | -0.7472 | |
| 167 | G | A | -0.6202 | |
| 168 | A | A | -0.2834 | |
| 169 | L | A | -0.0492 | |
| 170 | T | A | -0.1962 | |
| 171 | S | A | -0.1971 | |
| 172 | G | A | -0.2511 | |
| 173 | V | A | 0.1720 | |
| 174 | H | A | -0.3032 | |
| 175 | T | A | -0.1513 | |
| 176 | F | A | 0.0000 | |
| 177 | P | A | -0.1582 | |
| 178 | A | A | 0.4305 | |
| 179 | V | A | 0.8991 | |
| 180 | L | A | 1.5692 | |
| 181 | Q | A | 0.4679 | |
| 182 | S | A | -0.0096 | |
| 183 | S | A | -0.1712 | |
| 184 | G | A | 0.1304 | |
| 185 | L | A | 0.2434 | |
| 186 | Y | A | 0.5901 | |
| 187 | S | A | 0.0000 | |
| 188 | L | A | 0.0000 | |
| 189 | S | A | 0.0000 | |
| 190 | S | A | 0.0000 | |
| 191 | V | A | 0.0000 | |
| 192 | V | A | 0.0000 | |
| 193 | T | A | -0.1368 | |
| 194 | V | A | 0.0000 | |
| 195 | P | A | -0.4831 | |
| 196 | S | A | -0.5942 | |
| 197 | S | A | -0.5596 | |
| 198 | S | A | 0.0000 | |
| 199 | L | A | -0.7345 | |
| 200 | G | A | -1.0758 | |
| 201 | T | A | -0.8381 | |
| 202 | Q | A | -1.4742 | |
| 203 | T | A | -1.3320 | |
| 204 | Y | A | 0.0000 | |
| 205 | I | A | -1.3834 | |
| 206 | C | A | 0.0000 | |
| 207 | N | A | -1.5658 | |
| 208 | V | A | 0.0000 | |
| 209 | N | A | -2.0642 | |
| 210 | H | A | 0.0000 | |
| 211 | K | A | -2.8169 | |
| 212 | P | A | -1.6349 | |
| 213 | S | A | -1.8720 | |
| 214 | N | A | -2.5857 | |
| 215 | T | A | -2.1157 | |
| 216 | K | A | -2.7312 | |
| 217 | V | A | -1.4955 | |
| 218 | D | A | -2.5185 | |
| 219 | K | A | -1.9933 | |
| 220 | K | A | -2.6784 | |
| 221 | V | A | 0.0000 | |
| 222 | E | A | -2.5407 | |
| 223 | P | A | -1.3398 | |
| 1 | D | A | -2.0119 | |
| 2 | I | A | 0.0000 | |
| 3 | Q | A | -1.9911 | |
| 4 | M | A | 0.0000 | |
| 5 | T | A | -0.8955 | |
| 6 | Q | A | 0.0000 | |
| 7 | S | A | -0.4767 | |
| 8 | P | A | -0.6165 | |
| 9 | S | A | -0.9775 | |
| 10 | S | A | -1.0183 | |
| 11 | L | A | -0.6067 | |
| 12 | S | A | -0.7092 | |
| 13 | A | A | -0.8396 | |
| 14 | S | A | -0.8294 | |
| 15 | V | A | -0.1111 | |
| 16 | G | A | -0.8094 | |
| 17 | D | A | -1.7647 | |
| 18 | R | A | -2.2912 | |
| 19 | V | A | 0.0000 | |
| 20 | T | A | -0.6218 | |
| 21 | I | A | 0.0000 | |
| 22 | T | A | -0.5981 | |
| 23 | C | A | 0.0000 | |
| 24 | S | A | -1.4403 | |
| 25 | A | A | -1.6785 | |
| 26 | S | A | -1.9392 | |
| 27 | Q | A | -2.5746 | |
| 28 | D | A | -2.7215 | |
| 29 | I | A | 0.0000 | |
| 30 | S | A | -0.9713 | |
| 31 | N | A | -0.8350 | |
| 32 | Y | A | 0.0157 | |
| 33 | L | A | 0.0000 | |
| 34 | N | A | 0.0000 | |
| 35 | W | A | 0.0000 | |
| 36 | Y | A | 0.0000 | |
| 37 | Q | A | 0.0000 | |
| 38 | Q | A | -1.4047 | |
| 39 | K | A | -1.9146 | |
| 40 | P | A | -1.4848 | |
| 41 | G | A | -1.6589 | |
| 42 | K | A | -2.5918 | |
| 43 | A | A | -1.6448 | |
| 44 | P | A | 0.0000 | |
| 45 | K | A | -1.6847 | |
| 46 | V | A | 0.0000 | |
| 47 | L | A | 0.0000 | |
| 48 | I | A | 0.0000 | |
| 49 | Y | A | 0.4249 | |
| 50 | F | A | 0.5463 | |
| 51 | T | A | 0.0000 | |
| 52 | S | A | -0.0880 | |
| 53 | S | A | 0.1634 | |
| 54 | L | A | 0.3452 | |
| 55 | H | A | -0.2961 | |
| 56 | S | A | -0.3695 | |
| 57 | G | A | -0.4985 | |
| 58 | V | A | -0.3451 | |
| 59 | P | A | -0.3518 | |
| 60 | S | A | -0.4344 | |
| 61 | R | A | -0.7426 | |
| 62 | F | A | 0.0000 | |
| 63 | S | A | -0.2876 | |
| 64 | G | A | 0.0000 | |
| 65 | S | A | -0.6985 | |
| 66 | G | A | -1.0510 | |
| 67 | S | A | -1.3491 | |
| 68 | G | A | -1.8064 | |
| 69 | T | A | -2.0856 | |
| 70 | D | A | -2.4402 | |
| 71 | F | A | 0.0000 | |
| 72 | T | A | -0.6529 | |
| 73 | L | A | 0.0000 | |
| 74 | T | A | -0.6099 | |
| 75 | I | A | 0.0000 | |
| 76 | S | A | -1.3731 | |
| 77 | S | A | -1.1639 | |
| 78 | L | A | 0.0000 | |
| 79 | Q | A | -0.9131 | |
| 80 | P | A | -1.5784 | |
| 81 | E | A | -1.8616 | |
| 82 | D | A | 0.0000 | |
| 83 | F | A | -1.4306 | |
| 84 | A | A | 0.0000 | |
| 85 | T | A | -1.0723 | |
| 86 | Y | A | 0.0000 | |
| 87 | Y | A | 0.0000 | |
| 88 | C | A | 0.0000 | |
| 89 | Q | A | 0.0000 | |
| 90 | Q | A | 0.0000 | |
| 91 | Y | A | 0.0000 | |
| 92 | S | A | -0.2262 | |
| 93 | T | A | 0.2048 | |
| 94 | V | A | 0.8090 | |
| 95 | P | A | 0.1858 | |
| 96 | W | A | 0.0000 | |
| 97 | T | A | -0.7052 | |
| 98 | F | A | 0.0000 | |
| 99 | G | A | 0.0000 | |
| 100 | Q | A | -1.6223 | |
| 101 | G | A | 0.0000 | |
| 102 | T | A | 0.0000 | |
| 103 | K | A | -1.9750 | |
| 104 | V | A | 0.0000 | |
| 105 | E | A | -1.3135 | |
| 106 | I | A | 0.0000 | |
| 107 | K | A | -1.2037 | |
| 108 | R | A | -0.9500 | |
| 109 | T | A | -0.1019 | |
| 110 | V | A | 0.4436 | |
| 111 | A | A | 0.0139 | |
| 112 | A | A | -0.1027 | |
| 113 | P | A | 0.0000 | |
| 114 | S | A | -0.1727 | |
| 115 | V | A | 0.0000 | |
| 116 | F | A | 0.0000 | |
| 117 | I | A | 0.0000 | |
| 118 | F | A | 0.0000 | |
| 119 | P | A | -0.6490 | |
| 120 | P | A | -0.7655 | |
| 121 | S | A | -1.4916 | |
| 122 | D | A | -2.7919 | |
| 123 | E | A | -2.5221 | |
| 124 | Q | A | 0.0000 | |
| 125 | L | A | -1.9766 | |
| 126 | K | A | -2.7197 | |
| 127 | S | A | -1.6560 | |
| 128 | G | A | -1.3511 | |
| 129 | T | A | -1.1514 | |
| 130 | A | A | 0.0000 | |
| 131 | S | A | 0.0000 | |
| 132 | V | A | 0.0000 | |
| 133 | V | A | 0.0000 | |
| 134 | C | A | 0.0000 | |
| 135 | L | A | 0.0000 | |
| 136 | L | A | 0.0000 | |
| 137 | N | A | 0.0000 | |
| 138 | N | A | -0.8898 | |
| 139 | F | A | 0.0000 | |
| 140 | Y | A | 0.0000 | |
| 141 | P | A | -1.5473 | |
| 142 | R | A | -2.6010 | |
| 143 | E | A | -3.0651 | |
| 144 | A | A | -2.2737 | |
| 145 | K | A | -2.5258 | |
| 146 | V | A | -1.2692 | |
| 147 | Q | A | -1.1808 | |
| 148 | W | A | 0.0000 | |
| 149 | K | A | -0.9482 | |
| 150 | V | A | 0.0000 | |
| 151 | D | A | -2.0565 | |
| 152 | N | A | -1.7018 | |
| 153 | A | A | -0.5733 | |
| 154 | L | A | -0.2257 | |
| 155 | Q | A | -0.9540 | |
| 156 | S | A | -1.1368 | |
| 157 | G | A | -1.2366 | |
| 158 | N | A | -1.5922 | |
| 159 | S | A | -1.3686 | |
| 160 | Q | A | -1.0789 | |
| 161 | E | A | -1.1961 | |
| 162 | S | A | -0.5515 | |
| 163 | V | A | -0.3545 | |
| 164 | T | A | 0.0000 | |
| 165 | E | A | -2.0292 | |
| 166 | Q | A | 0.0000 | |
| 167 | D | A | -2.2402 | |
| 168 | S | A | -2.3111 | |
| 169 | K | A | -2.7100 | |
| 170 | D | A | -2.1756 | |
| 171 | S | A | 0.0000 | |
| 172 | T | A | 0.0000 | |
| 173 | Y | A | 0.0000 | |
| 174 | S | A | 0.0000 | |
| 175 | L | A | 0.0000 | |
| 176 | S | A | 0.0000 | |
| 177 | S | A | 0.0000 | |
| 178 | T | A | -0.6071 | |
| 179 | L | A | 0.0000 | |
| 180 | T | A | -0.4612 | |
| 181 | L | A | -0.7960 | |
| 182 | S | A | -1.0805 | |
| 183 | K | A | -2.1062 | |
| 184 | A | A | -1.8912 | |
| 185 | D | A | -2.4245 | |
| 186 | Y | A | 0.0000 | |
| 187 | E | A | -3.6674 | |
| 188 | K | A | -3.5783 | |
| 189 | H | A | -2.9105 | |
| 190 | K | A | -3.2481 | |
| 191 | V | A | -1.6978 | |
| 192 | Y | A | 0.0000 | |
| 193 | A | A | 0.0000 | |
| 194 | C | A | 0.0000 | |
| 195 | E | A | -0.9168 | |
| 196 | V | A | 0.0000 | |
| 197 | T | A | -1.2971 | |
| 198 | H | A | 0.0000 | |
| 199 | Q | A | -1.6911 | |
| 200 | G | A | -0.4142 | |
| 201 | L | A | -0.2553 | |
| 202 | S | A | -0.4780 | |
| 203 | S | A | -0.4418 | |
| 204 | P | A | -0.6603 | |
| 205 | V | A | 0.0471 | |
| 206 | T | A | -0.4321 | |
| 207 | K | A | -0.5263 | |
| 208 | S | A | -0.7246 | |
| 209 | F | A | 0.0000 | |
| 210 | N | A | -2.1307 | |
| 211 | R | A | -2.3707 | |
| 212 | G | A | -1.4792 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine