Project name: 6a2188c93b44ed

Chain sequence(s)	H: QVQLVQSGSELKQPGASVKVSCKASGYTFTHYALHWLRQAPGQGLEWMGWLNTNTENPTFAQGFTGRFVFSLDTSVTTAYLQISSLKAEDTAVYYCARGDMVVPTTIWNYYHFMDVWGQGTTVTVSS; L: DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTPPTFGQGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:00:49)
[INFO]       Main:     Simulation completed successfully.                                          (00:00:51)

• Minimal score value: -2.6972
• Maximal score value: 2.2093
• Average score: -0.3922
• Total score value: -91.769

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.3546
2	V	H	-0.7647
3	Q	H	-1.0697
4	L	H	0.0000
5	V	H	0.7838
6	Q	H	0.0000
7	S	H	-0.4715
8	G	H	-0.7126
9	S	H	-0.4116
11	E	H	-0.3403
12	L	H	0.6494
13	K	H	-0.8196
14	Q	H	-1.7190
15	P	H	-1.6431
16	G	H	-1.4405
17	A	H	-0.9550
18	S	H	-0.9687
19	V	H	0.0000
20	K	H	-1.1454
21	V	H	0.0000
22	S	H	-0.3132
23	C	H	0.0000
24	K	H	-0.3624
25	A	H	0.0000
26	S	H	-0.5259
27	G	H	-0.8815
28	Y	H	-0.4124
29	T	H	-0.2698
30	F	H	0.0000
35	T	H	-0.9305
36	H	H	-0.7566
37	Y	H	0.0213
38	A	H	0.0000
39	L	H	0.0000
40	H	H	0.0000
41	W	H	0.0000
42	L	H	0.0000
43	R	H	-0.4387
44	Q	H	0.0000
45	A	H	-0.9535
46	P	H	-0.9779
47	G	H	-1.2135
48	Q	H	-1.8060
49	G	H	-1.2688
50	L	H	0.0000
51	E	H	-0.8069
52	W	H	0.0000
53	M	H	0.0000
54	G	H	0.0000
55	W	H	-0.0499
56	L	H	0.0000
57	N	H	-1.5143
58	T	H	0.0000
59	N	H	-1.9989
62	T	H	-1.6987
63	E	H	-2.2076
64	N	H	-2.1042
65	P	H	-0.7412
66	T	H	-0.1160
67	F	H	0.1516
68	A	H	-0.8645
69	Q	H	-1.5758
70	G	H	-1.0339
71	F	H	-0.4055
72	T	H	-0.5812
74	G	H	-0.6795
75	R	H	-0.8299
76	F	H	0.0000
77	V	H	0.7907
78	F	H	0.0000
79	S	H	-0.4326
80	L	H	-0.6572
81	D	H	-0.4415
82	T	H	-0.4639
83	S	H	0.1998
84	V	H	0.7684
85	T	H	0.0568
86	T	H	0.0000
87	A	H	0.0000
88	Y	H	-0.1143
89	L	H	0.0000
90	Q	H	-0.5796
91	I	H	0.0000
92	S	H	-0.8885
93	S	H	-1.2247
94	L	H	0.0000
95	K	H	-2.6972
96	A	H	-1.9938
97	E	H	-2.3336
98	D	H	0.0000
99	T	H	-0.8407
100	A	H	0.0000
101	V	H	-0.1615
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	0.0000
107	G	H	0.0000
108	D	H	0.4369
109	M	H	0.9918
110	V	H	1.8354
111	V	H	2.0273
111A	P	H	1.0743
111B	T	H	0.8818
111C	T	H	1.2522
112D	I	H	2.2093
112C	W	H	2.1968
112B	N	H	1.4416
112A	Y	H	1.8171
112	Y	H	1.1149
113	H	H	0.5415
114	F	H	0.0000
115	M	H	0.0000
116	D	H	-0.3652
117	V	H	-0.4518
118	W	H	0.0000
119	G	H	0.0000
120	Q	H	-1.2509
121	G	H	-0.8107
122	T	H	0.0000
123	T	H	-0.1594
124	V	H	0.0000
125	T	H	-0.3800
126	V	H	0.0000
127	S	H	-0.9398
128	S	H	-0.6573
1	D	L	-2.2003
2	I	L	0.0000
3	Q	L	-2.1590
4	M	L	0.0000
5	T	L	-1.3391
6	Q	L	0.0000
7	S	L	-0.7415
8	P	L	-0.5467
9	S	L	-0.6840
10	S	L	-0.6091
11	L	L	-0.2628
12	S	L	-0.3733
13	A	L	0.0000
14	S	L	-0.0607
15	V	L	0.6571
16	G	L	-0.5693
17	D	L	-1.5534
18	R	L	-2.2035
19	V	L	0.0000
20	T	L	-0.6722
21	I	L	0.0000
22	T	L	-0.7803
23	C	L	0.0000
24	R	L	-2.6939
25	A	L	0.0000
26	S	L	-1.7300
27	Q	L	-1.5718
28	S	L	-1.0323
29	I	L	0.0000
36	S	L	-0.4694
37	S	L	-0.1087
38	Y	L	0.5759
39	L	L	0.0000
40	N	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	-0.4493
44	Q	L	-1.0087
45	K	L	-1.4056
46	P	L	-1.1749
47	G	L	-1.7057
48	K	L	-2.4545
49	A	L	-1.5066
50	P	L	0.0000
51	K	L	-0.9460
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.3229
56	A	L	0.2511
57	A	L	0.0000
65	S	L	-0.2463
66	S	L	0.0650
67	L	L	0.2711
68	Q	L	-0.1703
69	S	L	-0.4061
70	G	L	-0.5850
71	V	L	-0.2349
72	P	L	-0.3710
74	S	L	-0.3715
75	R	L	-0.6766
76	F	L	0.0000
77	S	L	-0.2865
78	G	L	-0.2587
79	S	L	-0.6601
80	G	L	-1.0654
83	S	L	-1.0226
84	G	L	-1.0640
85	T	L	-1.5886
86	D	L	-2.0513
87	F	L	0.0000
88	T	L	-0.7391
89	L	L	0.0000
90	T	L	-0.6497
91	I	L	0.0000
92	S	L	-1.3124
93	S	L	-1.1732
94	L	L	0.0000
95	Q	L	-1.1331
96	P	L	-0.6853
97	E	L	-1.7934
98	D	L	0.0000
99	F	L	0.1905
100	A	L	0.0000
101	T	L	-0.7533
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	S	L	0.0000
108	Y	L	0.8438
109	S	L	-0.0134
114	T	L	-0.5463
115	P	L	-0.7869
116	P	L	0.0000
117	T	L	-0.7608
118	F	L	0.0000
119	G	L	0.0000
120	Q	L	-1.3308
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-0.6368
124	V	L	0.0000
125	E	L	-0.0861
126	I	L	1.0498
127	K	L	-0.7876