Project name: 6afa96b07de3b54

Chain sequence(s)	H: EVKLVESGGGLVQPKGSLKLSCAASGFTFNTYAMTWVRQAPGKGLEWVARIRSKSDNYATYYADSVKDRFTISRDDSQSMVYLQMNNLKTEDTAVYYCVTATGYWGQGTTLTVSS; L: DILMTQSPSSLTVTAGQKVTMSCKSSQSLLNSGNQKNYLTWYQQKPGQPPKLLIYWTSTRESGVPDRFTGSGSGTDFTLTISSVQAEDLAVYYCQNDYSSPYTFGGGTKLELK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:24)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:26)

• Minimal score value: -3.1705
• Maximal score value: 1.198
• Average score: -0.707
• Total score value: -161.2069

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-2.1416
2	V	H	-1.1663
3	K	H	-1.7459
4	L	H	0.0000
5	V	H	0.2569
6	E	H	-0.0871
7	S	H	-0.5599
8	G	H	-0.8379
9	G	H	-0.3389
11	G	H	0.3779
12	L	H	1.1980
13	V	H	-0.1766
14	Q	H	-1.7358
15	P	H	-2.3640
16	K	H	-3.1705
17	G	H	-2.0696
18	S	H	-1.6273
19	L	H	-0.6634
20	K	H	-1.3678
21	L	H	0.0000
22	S	H	-0.2715
23	C	H	0.0000
24	A	H	-0.1866
25	A	H	0.0000
26	S	H	-1.0827
27	G	H	-1.3034
28	F	H	-0.5151
29	T	H	-0.2073
30	F	H	0.0000
35	N	H	-1.5779
36	T	H	-0.8050
37	Y	H	-0.0379
38	A	H	-0.4718
39	M	H	0.0000
40	T	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.8426
45	A	H	-1.2331
46	P	H	-0.9966
47	G	H	-1.4898
48	K	H	-2.2778
49	G	H	-1.3773
50	L	H	0.0000
51	E	H	-0.9367
52	W	H	0.0000
53	V	H	0.0000
54	A	H	0.0000
55	R	H	-0.1826
56	I	H	0.0000
57	R	H	-1.5345
58	S	H	0.0000
59	K	H	-2.8774
60	S	H	-2.0254
61	D	H	-2.3750
62	N	H	-2.3918
63	Y	H	-1.4624
64	A	H	-0.9657
65	T	H	-0.2466
66	Y	H	-0.0987
67	Y	H	-0.7524
68	A	H	-1.5377
69	D	H	-2.4621
70	S	H	-1.8063
71	V	H	0.0000
72	K	H	-2.5879
74	D	H	-2.9140
75	R	H	-2.4251
76	F	H	0.0000
77	T	H	-0.8823
78	I	H	0.0000
79	S	H	-0.2921
80	R	H	0.0000
81	D	H	-1.4920
82	D	H	-1.6862
83	S	H	-1.2693
84	Q	H	-1.6909
85	S	H	-1.1194
86	M	H	-0.5826
87	V	H	0.0000
88	Y	H	-0.3004
89	L	H	0.0000
90	Q	H	-0.9530
91	M	H	0.0000
92	N	H	-2.2641
93	N	H	-3.0981
94	L	H	0.0000
95	K	H	-2.9102
96	T	H	-1.9718
97	E	H	-2.3174
98	D	H	0.0000
99	T	H	-0.6861
100	A	H	0.0000
101	V	H	0.0597
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	V	H	0.0000
106	T	H	0.0000
107	A	H	0.2196
115	T	H	0.1069
116	G	H	0.3131
117	Y	H	0.6377
118	W	H	-0.0755
119	G	H	0.0000
120	Q	H	-1.4435
121	G	H	-0.6638
122	T	H	-0.3406
123	T	H	-0.0971
124	L	H	0.0000
125	T	H	-0.0878
126	V	H	0.0000
127	S	H	-0.8616
128	S	H	-0.4860
1	D	L	-1.5241
2	I	L	-0.4357
3	L	L	0.6300
4	M	L	0.0000
5	T	L	-0.4679
6	Q	L	-0.6873
7	S	L	-0.8131
8	P	L	-0.5875
9	S	L	-0.6766
10	S	L	-0.6432
11	L	L	-0.2520
12	T	L	-0.4593
13	V	L	-0.7967
14	T	L	-1.2886
15	A	L	-1.4078
16	G	L	-1.5521
17	Q	L	-2.2031
18	K	L	-2.4240
19	V	L	0.0000
20	T	L	-0.5035
21	M	L	0.0000
22	S	L	-0.9075
23	C	L	0.0000
24	K	L	-2.1779
25	S	L	0.0000
26	S	L	-0.9962
27	Q	L	-1.5900
28	S	L	-1.0080
29	L	L	0.0000
30	L	L	-0.6229
31	N	L	-1.1192
32	S	L	-1.2839
33	G	L	-1.4794
34	N	L	-2.0545
35	Q	L	-2.1495
36	K	L	-1.5069
37	N	L	-0.6069
38	Y	L	0.1238
39	L	L	0.0000
40	T	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	Q	L	0.0000
45	K	L	-1.1453
46	P	L	-0.8603
47	G	L	-1.3529
48	Q	L	-1.8500
49	P	L	-1.1497
50	P	L	0.0000
51	K	L	-0.8884
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.1583
56	W	L	0.2426
57	T	L	0.0000
65	S	L	-0.3901
66	T	L	-0.2763
67	R	L	-1.1105
68	E	L	-0.7660
69	S	L	-0.7098
70	G	L	-0.9695
71	V	L	0.0000
72	P	L	-1.3556
74	D	L	-2.2160
75	R	L	-1.6026
76	F	L	0.0000
77	T	L	-0.8326
78	G	L	0.0000
79	S	L	-0.5920
80	G	L	-1.0909
83	S	L	-1.1323
84	G	L	-1.2226
85	T	L	-1.6583
86	D	L	-2.2295
87	F	L	0.0000
88	T	L	-0.7918
89	L	L	0.0000
90	T	L	-0.5545
91	I	L	0.0000
92	S	L	-1.6192
93	S	L	-1.7110
94	V	L	0.0000
95	Q	L	-1.3213
96	A	L	-1.0530
97	E	L	-1.6382
98	D	L	0.0000
99	L	L	0.1118
100	A	L	0.0000
101	V	L	-0.0774
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	N	L	0.0000
107	D	L	0.1318
108	Y	L	0.3518
109	S	L	-0.1810
114	S	L	-0.3152
115	P	L	-0.7072
116	Y	L	0.0000
117	T	L	-0.0413
118	F	L	0.1247
119	G	L	0.0000
120	G	L	-0.7772
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-0.9274
124	L	L	0.0000
125	E	L	-0.4412
126	L	L	-0.8480
127	K	L	-1.7370