Project name: 6b0eb03e6ee2e63

Chain sequence(s)	H: QVQLQESGPGLVKPSQTLSLTCTVSGGTISSGGHYWNWIRQHPGKGLEWIGYIYYSGSTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARGGYCSNGVCSPYGSGSHHFDYWGQGTLVTVSS; L: EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPPTFGQGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:15)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:16)

• Minimal score value: -2.4614
• Maximal score value: 1.6732
• Average score: -0.451
• Total score value: -107.329

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.6397
2	V	H	-1.3046
3	Q	H	-1.8271
4	L	H	0.0000
5	Q	H	-1.2371
6	E	H	0.0000
7	S	H	-0.5184
8	G	H	-0.4115
9	P	H	-0.2474
11	G	H	0.1346
12	L	H	0.2982
13	V	H	0.0000
14	K	H	-1.3398
15	P	H	-1.1419
16	S	H	-1.1245
17	Q	H	-1.5488
18	T	H	-1.2559
19	L	H	0.0000
20	S	H	-1.0188
21	L	H	0.0000
22	T	H	-0.5578
23	C	H	0.0000
24	T	H	-1.0400
25	V	H	0.0000
26	S	H	-1.4131
27	G	H	-1.3828
28	G	H	-1.0889
29	T	H	-0.7452
30	I	H	0.0000
31	S	H	-0.2466
34	S	H	-0.0983
35	G	H	0.0841
36	G	H	0.3001
37	H	H	0.2289
38	Y	H	0.3948
39	W	H	0.0000
40	N	H	0.0000
41	W	H	0.0000
42	I	H	0.0000
43	R	H	0.0000
44	Q	H	-0.8403
45	H	H	-1.0190
46	P	H	-0.9675
47	G	H	-1.5014
48	K	H	-2.4614
49	G	H	-1.6237
50	L	H	0.0000
51	E	H	-1.1980
52	W	H	0.0000
53	I	H	0.0000
54	G	H	0.0000
55	Y	H	0.0000
56	I	H	0.0000
57	Y	H	0.3886
58	Y	H	0.2008
59	S	H	-0.1208
63	G	H	-0.3010
64	S	H	0.0164
65	T	H	0.3945
66	Y	H	0.7515
67	Y	H	-0.0784
68	N	H	-0.6964
69	P	H	-0.8631
70	S	H	-0.8259
71	L	H	0.0000
72	K	H	-1.8681
74	S	H	-1.2675
75	R	H	-1.3401
76	V	H	0.0000
77	T	H	-0.9064
78	I	H	0.0000
79	S	H	-0.3986
80	V	H	-0.3631
81	D	H	-1.2397
82	T	H	-1.0672
83	S	H	-1.3496
84	K	H	-2.2057
85	N	H	-1.4700
86	Q	H	-1.2664
87	F	H	0.0000
88	S	H	-0.5903
89	L	H	0.0000
90	K	H	-1.6574
91	L	H	0.0000
92	S	H	-1.0448
93	S	H	-0.8780
94	V	H	0.0000
95	T	H	-0.4406
96	A	H	-0.1599
97	A	H	-0.0104
98	D	H	0.0000
99	T	H	0.1619
100	A	H	0.0000
101	V	H	0.4582
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	-0.2747
107	G	H	0.0000
108	G	H	0.0000
109	Y	H	0.4383
110	C	H	0.7517
111	S	H	0.0044
111A	N	H	-0.8395
111B	G	H	0.0389
111C	V	H	1.6732
111D	C	H	1.3344
111E	S	H	0.9451
112E	P	H	0.5831
112D	Y	H	1.2831
112C	G	H	0.1004
112B	S	H	0.3545
112A	G	H	-0.1161
112	S	H	0.0000
113	H	H	0.0000
114	H	H	-0.0560
115	F	H	0.0000
116	D	H	-0.3985
117	Y	H	-0.5236
118	W	H	-0.5900
119	G	H	0.0000
120	Q	H	-1.6489
121	G	H	-0.7539
122	T	H	-0.0209
123	L	H	0.8071
124	V	H	0.0000
125	T	H	0.2012
126	V	H	0.0000
127	S	H	-0.4640
128	S	H	-0.5740
1	E	L	-1.5472
2	I	L	0.0000
3	V	L	0.7485
4	L	L	0.0000
5	T	L	-0.5749
6	Q	L	0.0000
7	S	L	-0.7261
8	P	L	-0.2831
9	A	L	-0.3225
10	T	L	-0.3854
11	L	L	-0.3620
12	S	L	-0.6672
13	L	L	-0.8854
14	S	L	-1.3831
15	P	L	-1.3952
16	G	L	-1.5369
17	E	L	-2.0775
18	R	L	-2.3650
19	A	L	0.0000
20	T	L	-0.6469
21	L	L	0.0000
22	S	L	-0.8206
23	C	L	0.0000
24	R	L	-2.2015
25	A	L	0.0000
26	S	L	-0.7849
27	Q	L	-1.2645
28	S	L	-1.1848
29	V	L	0.0000
36	S	L	-0.4830
37	S	L	-0.2529
38	Y	L	0.1676
39	L	L	0.0000
40	A	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	Q	L	-0.6792
45	K	L	-0.9385
46	P	L	-0.7891
47	G	L	-1.4006
48	Q	L	-1.9975
49	A	L	-1.2356
50	P	L	0.0000
51	R	L	-0.9298
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	-0.3209
56	D	L	-0.4385
57	A	L	0.0000
65	S	L	-0.9351
66	N	L	-1.4530
67	R	L	-1.5929
68	A	L	-0.9548
69	T	L	-0.6639
70	G	L	-0.5927
71	I	L	-0.5022
72	P	L	-0.3358
74	A	L	-0.3159
75	R	L	-0.5699
76	F	L	0.0000
77	S	L	-0.6074
78	G	L	0.0000
79	S	L	-0.7034
80	G	L	-0.9448
83	S	L	-0.9338
84	G	L	-1.0072
85	T	L	-1.5507
86	D	L	-1.8839
87	F	L	0.0000
88	T	L	-0.7000
89	L	L	0.0000
90	T	L	-0.5836
91	I	L	0.0000
92	S	L	-1.2190
93	S	L	-1.5126
94	L	L	0.0000
95	E	L	-1.5079
96	P	L	-1.2665
97	E	L	-1.3942
98	D	L	0.0000
99	F	L	0.1176
100	A	L	0.0000
101	V	L	-0.0065
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	R	L	0.0000
108	S	L	-0.4558
109	N	L	-1.0970
114	W	L	-0.0673
115	P	L	0.0000
116	P	L	0.0000
117	T	L	-0.1903
118	F	L	0.0516
119	G	L	0.0000
120	Q	L	-1.1906
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-0.4778
124	V	L	0.0000
125	E	L	-0.7471
126	I	L	-0.7541
127	K	L	-1.6753