| Chain sequence(s) |
E: NLCPFGEEVFNATTRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTTGCVIAWNSNNLDSSKVGGNYNYLYRLFRKSNLKPFERDISSTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPK
F: QVQLVESGGGLMQAGGSLRRLSCAVSGRTFSTAAMMGWFRQAPGKEREFVAAIRWSSGGSAYYADSVKGRFTISRDKAKNNTVYLQMMNSLKYEDTAVYYCARTENVRSLLSDYATWWPYDYWGQGTQVTVSS input PDB |
| Selected Chain(s) | E,F |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with all chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:04:44)
[INFO] Main: Simulation completed successfully. (00:04:47)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 334 | N | E | -0.5970 | |
| 335 | L | E | 0.8360 | |
| 336 | C | E | 0.0000 | |
| 337 | P | E | -0.8355 | |
| 338 | F | E | 0.0000 | |
| 339 | G | E | -1.3644 | |
| 340 | E | E | -2.4843 | |
| 341 | V | E | 0.0000 | |
| 342 | F | E | 0.0000 | |
| 343 | N | E | -2.2130 | |
| 344 | A | E | -1.8735 | |
| 345 | T | E | -1.2711 | |
| 346 | R | E | -1.8314 | |
| 347 | F | E | 0.0000 | |
| 348 | A | E | 0.0000 | |
| 349 | S | E | 0.0000 | |
| 350 | V | E | 0.0000 | |
| 351 | Y | E | 0.2489 | |
| 352 | A | E | -0.1147 | |
| 353 | W | E | 0.0000 | |
| 354 | N | E | -1.9513 | |
| 355 | R | E | -2.2130 | |
| 356 | K | E | -2.3159 | |
| 357 | R | E | -2.2580 | |
| 358 | I | E | 0.0000 | |
| 359 | S | E | -1.1826 | |
| 360 | N | E | -1.1979 | |
| 361 | C | E | 0.0000 | |
| 362 | V | E | 0.3336 | |
| 363 | A | E | 0.0000 | |
| 364 | D | E | 0.1067 | |
| 365 | Y | E | 0.0000 | |
| 366 | S | E | 0.2375 | |
| 367 | V | E | 1.2537 | |
| 368 | L | E | 0.0000 | |
| 369 | Y | E | 0.2181 | |
| 370 | N | E | -0.6449 | |
| 371 | S | E | -0.1030 | |
| 372 | A | E | -0.2614 | |
| 373 | S | E | -0.2645 | |
| 374 | F | E | 0.1223 | |
| 375 | S | E | -0.1765 | |
| 376 | T | E | -0.3626 | |
| 377 | F | E | -0.0827 | |
| 378 | K | E | -1.3346 | |
| 379 | C | E | -0.4944 | |
| 380 | Y | E | -0.5553 | |
| 381 | G | E | -0.6455 | |
| 382 | V | E | -0.4160 | |
| 383 | S | E | -0.8068 | |
| 384 | P | E | -0.9107 | |
| 385 | T | E | -1.3421 | |
| 386 | K | E | -2.2502 | |
| 387 | L | E | 0.0000 | |
| 388 | N | E | -1.9442 | |
| 389 | D | E | -2.6048 | |
| 390 | L | E | -0.8500 | |
| 391 | C | E | 0.4144 | |
| 392 | F | E | 0.0000 | |
| 393 | T | E | 0.0000 | |
| 394 | N | E | 0.0000 | |
| 395 | V | E | 0.0000 | |
| 396 | Y | E | -1.0226 | |
| 397 | A | E | 0.0000 | |
| 398 | D | E | 0.0000 | |
| 399 | S | E | 0.0000 | |
| 400 | F | E | 0.0000 | |
| 401 | V | E | 0.0000 | |
| 402 | I | E | 0.0000 | |
| 403 | R | E | -0.5117 | |
| 404 | G | E | -0.6054 | |
| 405 | D | E | -1.4480 | |
| 406 | E | E | -1.5896 | |
| 407 | V | E | -1.3427 | |
| 408 | R | E | -2.2796 | |
| 409 | Q | E | -1.7117 | |
| 410 | I | E | 0.0000 | |
| 411 | A | E | -1.2501 | |
| 412 | P | E | -1.7873 | |
| 413 | G | E | -1.6152 | |
| 414 | Q | E | -1.4520 | |
| 415 | T | E | -1.1799 | |
| 416 | G | E | -1.2139 | |
| 417 | K | E | -1.2529 | |
| 418 | I | E | 0.0000 | |
| 419 | A | E | 0.0000 | |
| 420 | D | E | -1.5733 | |
| 421 | Y | E | -1.3070 | |
| 422 | N | E | 0.0000 | |
| 423 | Y | E | 0.0000 | |
| 424 | K | E | -1.6194 | |
| 425 | L | E | 0.0000 | |
| 426 | P | E | -2.0064 | |
| 427 | D | E | -2.9747 | |
| 428 | D | E | -2.7763 | |
| 429 | F | E | 0.0000 | |
| 430 | T | E | -0.7133 | |
| 431 | G | E | 0.0000 | |
| 432 | C | E | 0.0000 | |
| 433 | V | E | 0.0000 | |
| 434 | I | E | 0.0000 | |
| 435 | A | E | 0.0000 | |
| 436 | W | E | -0.0066 | |
| 437 | N | E | -0.3254 | |
| 438 | S | E | 0.0000 | |
| 439 | N | E | -0.5767 | |
| 440 | N | E | -0.9951 | |
| 441 | L | E | 0.2752 | |
| 442 | D | E | 0.0000 | |
| 443 | S | E | -0.8691 | |
| 444 | K | E | -1.0851 | |
| 445 | V | E | 0.5401 | |
| 446 | G | E | -0.5282 | |
| 447 | G | E | 0.0000 | |
| 448 | N | E | -0.5262 | |
| 449 | Y | E | -0.3970 | |
| 450 | N | E | -0.0906 | |
| 451 | Y | E | 0.0000 | |
| 452 | L | E | 0.2105 | |
| 453 | Y | E | 0.2858 | |
| 454 | R | E | 0.0000 | |
| 455 | L | E | 0.2504 | |
| 456 | F | E | -0.2597 | |
| 457 | R | E | -1.5592 | |
| 458 | K | E | -2.1567 | |
| 459 | S | E | -1.9001 | |
| 460 | N | E | -2.4689 | |
| 461 | L | E | 0.0000 | |
| 462 | K | E | -2.3971 | |
| 463 | P | E | -1.6417 | |
| 464 | F | E | -0.6584 | |
| 465 | E | E | -1.5789 | |
| 466 | R | E | -1.3666 | |
| 467 | D | E | -0.0648 | |
| 468 | I | E | 0.9996 | |
| 469 | S | E | -0.0835 | |
| 470 | T | E | -0.6948 | |
| 471 | E | E | -1.8426 | |
| 472 | I | E | 0.0000 | |
| 473 | Y | E | -0.8998 | |
| 474 | Q | E | -1.4550 | |
| 475 | A | E | -0.7860 | |
| 476 | G | E | -0.6764 | |
| 477 | S | E | -0.7300 | |
| 478 | T | E | -0.6256 | |
| 479 | P | E | -0.8913 | |
| 480 | C | E | -0.6644 | |
| 481 | N | E | -1.3250 | |
| 482 | G | E | -0.8461 | |
| 483 | V | E | 0.9476 | |
| 484 | E | E | 0.0000 | |
| 485 | G | E | 0.8555 | |
| 486 | F | E | 1.4599 | |
| 487 | N | E | -0.3868 | |
| 488 | C | E | 0.0000 | |
| 489 | Y | E | 0.5019 | |
| 490 | F | E | 0.0000 | |
| 491 | P | E | 0.0000 | |
| 492 | L | E | 0.0000 | |
| 493 | Q | E | 0.1534 | |
| 494 | S | E | 0.0000 | |
| 495 | Y | E | 0.0000 | |
| 496 | G | E | -0.6092 | |
| 497 | F | E | 0.0000 | |
| 498 | Q | E | -0.8875 | |
| 499 | P | E | -0.4829 | |
| 500 | T | E | -0.0666 | |
| 501 | N | E | 0.1190 | |
| 502 | G | E | 0.6853 | |
| 503 | V | E | 1.4615 | |
| 504 | G | E | 0.4950 | |
| 505 | Y | E | 0.8697 | |
| 506 | Q | E | 0.0729 | |
| 507 | P | E | 0.0000 | |
| 508 | Y | E | 0.0340 | |
| 509 | R | E | 0.0000 | |
| 510 | V | E | 0.0000 | |
| 511 | V | E | 0.0000 | |
| 512 | V | E | 0.0000 | |
| 513 | L | E | 0.0000 | |
| 514 | S | E | -0.1317 | |
| 515 | F | E | 0.4949 | |
| 516 | E | E | 0.9061 | |
| 517 | L | E | 1.9365 | |
| 518 | L | E | 1.5752 | |
| 519 | H | E | 0.0153 | |
| 520 | A | E | 0.1950 | |
| 521 | P | E | -0.0725 | |
| 522 | A | E | 0.2978 | |
| 523 | T | E | -0.3654 | |
| 524 | V | E | 0.0000 | |
| 525 | C | E | -0.1613 | |
| 526 | G | E | 0.0000 | |
| 527 | P | E | -1.0991 | |
| 528 | K | E | -2.1925 | |
| 1 | Q | F | -1.8018 | |
| 2 | V | F | 0.0000 | |
| 3 | Q | F | -1.3374 | |
| 4 | L | F | 0.0000 | |
| 5 | V | F | 1.0171 | |
| 6 | E | F | 0.0000 | |
| 7 | S | F | -0.5463 | |
| 8 | G | F | -1.0870 | |
| 9 | G | F | -0.7701 | |
| 10 | G | F | 0.0964 | |
| 11 | L | F | 1.0416 | |
| 12 | M | F | 0.1460 | |
| 13 | Q | F | -1.0689 | |
| 14 | A | F | -1.1026 | |
| 15 | G | F | -1.1717 | |
| 16 | G | F | -1.0520 | |
| 17 | S | F | -0.9870 | |
| 18 | L | F | -0.7452 | |
| 19 | R | F | -1.7165 | |
| 20 | L | F | 0.0000 | |
| 21 | S | F | -0.3401 | |
| 22 | C | F | 0.0000 | |
| 23 | A | F | -0.1532 | |
| 24 | V | F | 0.0000 | |
| 25 | S | F | -1.1951 | |
| 26 | G | F | -1.3743 | |
| 27 | R | F | -0.9469 | |
| 28 | T | F | 0.1027 | |
| 29 | F | F | 1.6031 | |
| 30 | S | F | 0.0000 | |
| 31 | T | F | 0.3693 | |
| 32 | A | F | 0.0000 | |
| 33 | A | F | 0.0000 | |
| 34 | M | F | 0.0000 | |
| 35 | G | F | 0.0000 | |
| 36 | W | F | 0.0000 | |
| 37 | F | F | -0.2488 | |
| 38 | R | F | 0.0000 | |
| 39 | Q | F | -2.0500 | |
| 40 | A | F | -1.8973 | |
| 41 | P | F | -1.4237 | |
| 42 | G | F | -1.9565 | |
| 43 | K | F | -3.3788 | |
| 44 | E | F | -3.6591 | |
| 45 | R | F | -2.9643 | |
| 46 | E | F | -2.2972 | |
| 47 | F | F | -0.8282 | |
| 48 | V | F | 0.0000 | |
| 49 | A | F | 0.0000 | |
| 50 | A | F | 0.0000 | |
| 51 | I | F | 0.0000 | |
| 52 | R | F | 0.0000 | |
| 53 | W | F | 0.0000 | |
| 54 | S | F | -0.6863 | |
| 55 | G | F | -0.6713 | |
| 56 | G | F | -0.4761 | |
| 57 | S | F | 0.2579 | |
| 58 | A | F | 0.3828 | |
| 59 | Y | F | 0.0709 | |
| 60 | Y | F | -0.5600 | |
| 61 | A | F | -1.2009 | |
| 62 | D | F | -2.3649 | |
| 63 | S | F | -1.7538 | |
| 64 | V | F | 0.0000 | |
| 65 | K | F | -2.5336 | |
| 66 | G | F | -1.7343 | |
| 67 | R | F | -1.3139 | |
| 68 | F | F | 0.0000 | |
| 69 | T | F | -0.6960 | |
| 70 | I | F | 0.0000 | |
| 71 | S | F | -0.5781 | |
| 72 | R | F | -1.4068 | |
| 73 | D | F | -2.0822 | |
| 74 | K | F | -2.6603 | |
| 75 | A | F | -1.8273 | |
| 76 | K | F | -2.5151 | |
| 77 | N | F | -1.9675 | |
| 78 | T | F | 0.0000 | |
| 79 | V | F | 0.0000 | |
| 80 | Y | F | -0.5715 | |
| 81 | L | F | 0.0000 | |
| 82 | Q | F | -1.0139 | |
| 83 | M | F | 0.0000 | |
| 84 | N | F | -1.2944 | |
| 85 | S | F | -1.2171 | |
| 86 | L | F | 0.0000 | |
| 87 | K | F | -1.6267 | |
| 88 | Y | F | -0.3981 | |
| 89 | E | F | -1.6422 | |
| 90 | D | F | 0.0000 | |
| 91 | T | F | -0.4643 | |
| 92 | A | F | 0.0000 | |
| 93 | V | F | -0.4937 | |
| 94 | Y | F | 0.0000 | |
| 95 | Y | F | -0.1471 | |
| 96 | C | F | 0.0000 | |
| 97 | A | F | 0.0000 | |
| 98 | R | F | 0.0000 | |
| 99 | T | F | 0.0000 | |
| 100 | E | F | 0.0000 | |
| 101 | N | F | 0.0000 | |
| 102 | V | F | 0.1338 | |
| 103 | R | F | 0.2452 | |
| 104 | S | F | 0.0000 | |
| 105 | L | F | 0.9919 | |
| 106 | L | F | 0.0000 | |
| 107 | S | F | 0.4204 | |
| 108 | D | F | 0.1195 | |
| 109 | Y | F | 0.0000 | |
| 110 | A | F | 0.0278 | |
| 111 | T | F | -0.0475 | |
| 112 | W | F | 0.1115 | |
| 113 | P | F | -0.4377 | |
| 114 | Y | F | 0.0000 | |
| 115 | D | F | -1.6536 | |
| 116 | Y | F | -0.6350 | |
| 117 | W | F | -0.0013 | |
| 118 | G | F | -0.0348 | |
| 119 | Q | F | -0.8457 | |
| 120 | G | F | -0.4736 | |
| 121 | T | F | 0.0000 | |
| 122 | Q | F | -1.0294 | |
| 123 | V | F | 0.0000 | |
| 124 | T | F | -0.0353 | |
| 125 | V | F | 0.0000 | |
| 126 | S | F | -0.3450 | |
| 127 | S | F | -0.5411 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine